Incidental Mutation 'R9575:Zfp971'
ID 722231
Institutional Source Beutler Lab
Gene Symbol Zfp971
Ensembl Gene ENSMUSG00000074519
Gene Name zinc finger protein 971
Synonyms Etohi1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R9575 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 177665077-177675815 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 177675303 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 301 (C301S)
Ref Sequence ENSEMBL: ENSMUSP00000104554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108925] [ENSMUST00000108926]
AlphaFold A2BFG8
Predicted Effect probably benign
Transcript: ENSMUST00000108925
SMART Domains Protein: ENSMUSP00000104553
Gene: ENSMUSG00000074519

DomainStartEndE-ValueType
KRAB 4 64 1.2e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108926
AA Change: C301S

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000104554
Gene: ENSMUSG00000074519
AA Change: C301S

DomainStartEndE-ValueType
KRAB 4 66 1.6e-13 SMART
ZnF_C2H2 78 97 1.38e2 SMART
ZnF_C2H2 103 125 4.38e1 SMART
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 4.79e-3 SMART
ZnF_C2H2 187 209 2.36e-2 SMART
ZnF_C2H2 215 237 2.36e-2 SMART
ZnF_C2H2 243 265 3.69e-4 SMART
ZnF_C2H2 271 293 4.87e-4 SMART
ZnF_C2H2 299 321 4.4e-2 SMART
ZnF_C2H2 327 349 4.61e-5 SMART
ZnF_C2H2 355 377 4.94e-5 SMART
ZnF_C2H2 383 405 3.21e-4 SMART
ZnF_C2H2 411 433 4.47e-3 SMART
ZnF_C2H2 439 461 5.99e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
B4galt4 T C 16: 38,583,513 (GRCm39) Y253H probably damaging Het
Catsperd A G 17: 56,935,231 (GRCm39) R15G unknown Het
Cep350 G A 1: 155,751,113 (GRCm39) P2020S probably benign Het
Cip2a T A 16: 48,838,754 (GRCm39) M857K probably benign Het
Fancm T A 12: 65,152,314 (GRCm39) D923E possibly damaging Het
Fastk A G 5: 24,650,067 (GRCm39) S27P probably benign Het
Flnc A G 6: 29,454,399 (GRCm39) H1937R probably damaging Het
Gfm2 T C 13: 97,285,906 (GRCm39) W132R probably damaging Het
Grhl1 T C 12: 24,636,082 (GRCm39) I348T probably damaging Het
Gstcd G T 3: 132,704,708 (GRCm39) H515Q probably damaging Het
Igsf3 A G 3: 101,338,625 (GRCm39) Y313C probably damaging Het
Mbtd1 G A 11: 93,799,764 (GRCm39) probably null Het
Myo9a T C 9: 59,813,190 (GRCm39) S2130P probably damaging Het
Or3a10 A T 11: 73,935,840 (GRCm39) C87S probably benign Het
Plpp4 T A 7: 128,925,211 (GRCm39) F149I probably benign Het
Poglut1 T C 16: 38,363,285 (GRCm39) T165A probably benign Het
Potefam3b A T 8: 21,159,090 (GRCm39) D148V probably damaging Het
Rhbdf1 A G 11: 32,163,101 (GRCm39) I425T probably benign Het
Sf3a2 ACTCCAGGGGTGCACCCACCAGCTCCAGGGGTGCACCCACCAGCTCCAGGGGTGCACCCACCAGCTCCAGGGGT ACTCCAGGGGTGCACCCACCAGCTCCAGGGGTGCACCCACCAGCTCCAGGGGT 10: 80,640,271 (GRCm39) probably benign Het
Slc6a9 T C 4: 117,714,603 (GRCm39) S175P probably benign Het
Slitrk3 C T 3: 72,956,127 (GRCm39) G882S probably benign Het
Spag9 A G 11: 93,962,409 (GRCm39) I356M probably damaging Het
Spef2 A T 15: 9,596,672 (GRCm39) L1459Q probably damaging Het
Tenm3 A T 8: 48,688,796 (GRCm39) F2264I possibly damaging Het
Vmn2r3 T C 3: 64,178,735 (GRCm39) N510S probably benign Het
Zfp866 A T 8: 70,219,288 (GRCm39) C111S probably damaging Het
Zfp976 T C 7: 42,262,041 (GRCm39) T600A unknown Het
Other mutations in Zfp971
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01067:Zfp971 APN 2 177,665,175 (GRCm39) critical splice donor site probably null
R1108:Zfp971 UTSW 2 177,675,463 (GRCm39) missense probably damaging 1.00
R1759:Zfp971 UTSW 2 177,675,722 (GRCm39) missense probably damaging 0.99
R2183:Zfp971 UTSW 2 177,675,533 (GRCm39) missense probably damaging 1.00
R2343:Zfp971 UTSW 2 177,674,787 (GRCm39) missense possibly damaging 0.84
R4873:Zfp971 UTSW 2 177,674,940 (GRCm39) missense probably benign 0.24
R4875:Zfp971 UTSW 2 177,674,940 (GRCm39) missense probably benign 0.24
R5263:Zfp971 UTSW 2 177,675,555 (GRCm39) missense probably damaging 1.00
R5396:Zfp971 UTSW 2 177,675,526 (GRCm39) missense probably damaging 1.00
R6150:Zfp971 UTSW 2 177,675,247 (GRCm39) missense probably benign 0.26
R6693:Zfp971 UTSW 2 177,675,224 (GRCm39) missense probably benign 0.01
R6811:Zfp971 UTSW 2 177,675,674 (GRCm39) missense possibly damaging 0.62
R7427:Zfp971 UTSW 2 177,674,967 (GRCm39) missense probably damaging 1.00
R7428:Zfp971 UTSW 2 177,674,967 (GRCm39) missense probably damaging 1.00
R7594:Zfp971 UTSW 2 177,675,793 (GRCm39) missense possibly damaging 0.47
R7790:Zfp971 UTSW 2 177,675,292 (GRCm39) missense probably damaging 0.96
R7796:Zfp971 UTSW 2 177,673,403 (GRCm39) missense probably benign 0.00
R7934:Zfp971 UTSW 2 177,675,173 (GRCm39) missense probably benign
R7990:Zfp971 UTSW 2 177,675,361 (GRCm39) missense probably damaging 1.00
R8671:Zfp971 UTSW 2 177,675,730 (GRCm39) missense probably damaging 1.00
R9181:Zfp971 UTSW 2 177,674,736 (GRCm39) missense probably damaging 1.00
R9629:Zfp971 UTSW 2 177,675,417 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAGCTGTCATCTCAGAATCCATAAG -3'
(R):5'- AGGTCACTACTGCTTGCAAAG -3'

Sequencing Primer
(F):5'- GCAGTAAGCAGTCATCTCGGAATC -3'
(R):5'- GCTTGCAAAGGCTTTACCACATTG -3'
Posted On 2022-08-09