Incidental Mutation 'R9579:Or2r3'
ID 722451
Institutional Source Beutler Lab
Gene Symbol Or2r3
Ensembl Gene ENSMUSG00000091983
Gene Name olfactory receptor family 2 subfamily R member 3
Synonyms GA_x6K02T2P3E9-5088893-5089834, Olfr457, MOR257-1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R9579 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 42448169-42449110 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 42448574 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 179 (C179*)
Ref Sequence ENSEMBL: ENSMUSP00000144914 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170504] [ENSMUST00000203396] [ENSMUST00000204324]
AlphaFold Q8VGP5
Predicted Effect probably null
Transcript: ENSMUST00000170504
AA Change: C179*
SMART Domains Protein: ENSMUSP00000127348
Gene: ENSMUSG00000091983
AA Change: C179*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000203396
AA Change: C179*
SMART Domains Protein: ENSMUSP00000145162
Gene: ENSMUSG00000091983
AA Change: C179*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000204324
AA Change: C179*
SMART Domains Protein: ENSMUSP00000144914
Gene: ENSMUSG00000091983
AA Change: C179*

DomainStartEndE-ValueType
Pfam:7tm_4 31 125 2.4e-19 PFAM
Pfam:7tm_1 41 125 3.1e-14 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 C A 11: 46,009,262 (GRCm39) H229N probably benign Het
Ak9 C A 10: 41,213,576 (GRCm39) H260Q Het
Akap3 G A 6: 126,850,974 (GRCm39) V831I probably damaging Het
Arhgap45 T C 10: 79,853,843 (GRCm39) F119S probably benign Het
Best3 A G 10: 116,829,100 (GRCm39) T127A probably damaging Het
Ccdc7a G A 8: 129,774,134 (GRCm39) Q134* probably null Het
Ceacam5 C A 7: 17,479,561 (GRCm39) S226Y probably damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Cul4a G A 8: 13,186,147 (GRCm39) E450K probably damaging Het
Cyb5a A T 18: 84,891,273 (GRCm39) R89S probably benign Het
Dnah2 A G 11: 69,368,041 (GRCm39) L1766P probably damaging Het
Gbp4 T C 5: 105,270,947 (GRCm39) E228G probably damaging Het
Ghr A G 15: 3,349,612 (GRCm39) I522T probably benign Het
Gm5225 A C 17: 24,242,897 (GRCm39) H22P possibly damaging Het
Herc2 T A 7: 55,758,500 (GRCm39) C796S probably damaging Het
Hmgxb4 G T 8: 75,756,638 (GRCm39) A588S probably damaging Het
Lats2 G A 14: 57,937,191 (GRCm39) P433S probably damaging Het
Lrfn1 C T 7: 28,166,769 (GRCm39) T721I probably damaging Het
Matcap1 A T 8: 106,012,379 (GRCm39) S23T probably benign Het
Mpzl3 G A 9: 44,973,350 (GRCm39) V30I probably benign Het
Pcdh15 A G 10: 74,457,117 (GRCm39) Y1298C possibly damaging Het
Plcd4 C A 1: 74,596,948 (GRCm39) H397N probably benign Het
Pnn G A 12: 59,117,030 (GRCm39) A201T possibly damaging Het
Ptprd C G 4: 75,872,315 (GRCm39) A1134P possibly damaging Het
Rabl3 T C 16: 37,362,230 (GRCm39) V23A probably damaging Het
Rnf157 T C 11: 116,240,822 (GRCm39) N423S probably benign Het
Rtn1 T C 12: 72,270,289 (GRCm39) D601G probably damaging Het
Rxfp1 A G 3: 79,557,946 (GRCm39) Y511H probably damaging Het
Sema5b T C 16: 35,467,582 (GRCm39) M282T probably benign Het
Slco5a1 G T 1: 12,949,383 (GRCm39) S669* probably null Het
Sphkap C G 1: 83,255,295 (GRCm39) G818A probably damaging Het
Stk26 C T X: 49,930,618 (GRCm39) probably benign Het
Syne3 T C 12: 104,942,107 (GRCm39) S12G probably damaging Het
Tmem150a C A 6: 72,334,070 (GRCm39) Q51K probably benign Het
Ttn C T 2: 76,550,196 (GRCm39) D31662N probably damaging Het
Ttn C T 2: 76,578,602 (GRCm39) G24097D probably damaging Het
Tubb4b T C 2: 25,114,139 (GRCm39) T55A probably benign Het
Vcan A T 13: 89,837,713 (GRCm39) D2610E possibly damaging Het
Xkr5 T C 8: 18,983,785 (GRCm39) T586A probably benign Het
Zfp260 T C 7: 29,805,108 (GRCm39) F336S Het
Zic1 A G 9: 91,246,790 (GRCm39) F94S probably damaging Het
Other mutations in Or2r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01417:Or2r3 APN 6 42,449,046 (GRCm39) missense probably benign 0.00
IGL01915:Or2r3 APN 6 42,448,223 (GRCm39) missense probably benign 0.01
IGL02006:Or2r3 APN 6 42,449,025 (GRCm39) missense probably benign 0.37
IGL02440:Or2r3 APN 6 42,449,100 (GRCm39) missense probably benign
R0024:Or2r3 UTSW 6 42,448,194 (GRCm39) missense probably benign
R0662:Or2r3 UTSW 6 42,448,708 (GRCm39) missense possibly damaging 0.75
R1599:Or2r3 UTSW 6 42,448,176 (GRCm39) missense probably damaging 1.00
R2087:Or2r3 UTSW 6 42,448,985 (GRCm39) missense probably damaging 1.00
R5002:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5022:Or2r3 UTSW 6 42,448,221 (GRCm39) missense possibly damaging 0.92
R5288:Or2r3 UTSW 6 42,448,186 (GRCm39) missense probably benign
R5342:Or2r3 UTSW 6 42,448,836 (GRCm39) missense probably damaging 1.00
R5823:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5824:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R6378:Or2r3 UTSW 6 42,448,687 (GRCm39) missense probably benign 0.01
R7384:Or2r3 UTSW 6 42,448,257 (GRCm39) missense possibly damaging 0.89
R7442:Or2r3 UTSW 6 42,448,434 (GRCm39) missense probably benign 0.02
R7631:Or2r3 UTSW 6 42,448,870 (GRCm39) missense probably benign 0.01
R7811:Or2r3 UTSW 6 42,448,635 (GRCm39) missense probably damaging 1.00
R7896:Or2r3 UTSW 6 42,449,100 (GRCm39) missense probably benign 0.22
R9244:Or2r3 UTSW 6 42,448,537 (GRCm39) missense possibly damaging 0.88
X0017:Or2r3 UTSW 6 42,448,752 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACATGGAGACCACAGTCAG -3'
(R):5'- CATGGCCTATGACCGCTATG -3'

Sequencing Primer
(F):5'- ACAGGTCTCAAAGGCTTTGC -3'
(R):5'- CCTATGACCGCTATGTGGCTG -3'
Posted On 2022-08-09