Incidental Mutation 'R9580:Vmn1r9'
| ID |
722495 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r9
|
| Ensembl Gene |
ENSMUSG00000091541 |
| Gene Name |
vomeronasal 1 receptor 9 |
| Synonyms |
V1rc30 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R9580 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
57047880-57048930 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 57048812 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 296
(S296P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171186]
[ENSMUST00000227399]
[ENSMUST00000228714]
|
| AlphaFold |
A2RST7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171186
AA Change: S296P
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000125762
Gene: ENSMUSG00000091541
AA Change: S296P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.1e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227399
AA Change: S296P
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228714
AA Change: S296P
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adora2b |
T |
C |
11: 62,156,145 (GRCm39) |
M198T |
probably damaging |
Het |
| Agbl2 |
A |
G |
2: 90,636,248 (GRCm39) |
T595A |
probably benign |
Het |
| Cep89 |
A |
T |
7: 35,102,538 (GRCm39) |
I84F |
possibly damaging |
Het |
| Eda |
G |
T |
X: 99,019,775 (GRCm39) |
R130L |
unknown |
Het |
| Erp44 |
T |
A |
4: 48,218,187 (GRCm39) |
R161* |
probably null |
Het |
| Fcsk |
A |
G |
8: 111,616,813 (GRCm39) |
W446R |
probably damaging |
Het |
| Gm12185 |
T |
G |
11: 48,799,192 (GRCm39) |
S434R |
possibly damaging |
Het |
| Hmcn2 |
G |
T |
2: 31,294,875 (GRCm39) |
A2555S |
probably benign |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ighv1-61 |
A |
G |
12: 115,322,993 (GRCm39) |
S40P |
possibly damaging |
Het |
| Kif26b |
C |
T |
1: 178,506,643 (GRCm39) |
Q240* |
probably null |
Het |
| Mapkap1 |
C |
T |
2: 34,509,878 (GRCm39) |
T456M |
probably damaging |
Het |
| Ncapg2 |
A |
G |
12: 116,424,228 (GRCm39) |
N1137S |
probably damaging |
Het |
| Nectin4 |
C |
G |
1: 171,211,324 (GRCm39) |
R283G |
probably damaging |
Het |
| Nos2 |
A |
G |
11: 78,828,457 (GRCm39) |
I259V |
probably benign |
Het |
| Or2n1d |
A |
T |
17: 38,646,320 (GRCm39) |
T91S |
possibly damaging |
Het |
| Or4c119 |
T |
C |
2: 88,987,465 (GRCm39) |
N18S |
probably benign |
Het |
| Pgm2 |
A |
T |
5: 64,265,092 (GRCm39) |
N371I |
possibly damaging |
Het |
| Ppargc1a |
A |
T |
5: 51,620,139 (GRCm39) |
N733K |
unknown |
Het |
| Ptpn5 |
A |
G |
7: 46,732,622 (GRCm39) |
Y345H |
probably damaging |
Het |
| Ptprd |
C |
G |
4: 75,872,315 (GRCm39) |
A1134P |
possibly damaging |
Het |
| Rbm47 |
A |
C |
5: 66,183,877 (GRCm39) |
M242R |
possibly damaging |
Het |
| Slc12a5 |
T |
G |
2: 164,816,896 (GRCm39) |
F140V |
probably damaging |
Het |
| Slc22a2 |
G |
T |
17: 12,803,177 (GRCm39) |
V4L |
probably benign |
Het |
| Stk26 |
C |
T |
X: 49,930,618 (GRCm39) |
|
probably benign |
Het |
| Tas2r105 |
A |
T |
6: 131,663,699 (GRCm39) |
I243K |
probably damaging |
Het |
| Tmem126b |
G |
T |
7: 90,118,231 (GRCm39) |
Y216* |
probably null |
Het |
| Usp25 |
C |
T |
16: 76,880,682 (GRCm39) |
T681I |
probably benign |
Het |
| Vmn1r206 |
C |
T |
13: 22,804,890 (GRCm39) |
A106T |
probably damaging |
Het |
| Vmn1r39 |
A |
T |
6: 66,781,915 (GRCm39) |
N134K |
probably damaging |
Het |
| Zfp97 |
T |
A |
17: 17,365,243 (GRCm39) |
F247L |
probably damaging |
Het |
|
| Other mutations in Vmn1r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0551:Vmn1r9
|
UTSW |
6 |
57,048,524 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1295:Vmn1r9
|
UTSW |
6 |
57,048,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1333:Vmn1r9
|
UTSW |
6 |
57,048,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Vmn1r9
|
UTSW |
6 |
57,048,300 (GRCm39) |
missense |
probably benign |
|
|
R1840:Vmn1r9
|
UTSW |
6 |
57,048,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2960:Vmn1r9
|
UTSW |
6 |
57,048,657 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R4064:Vmn1r9
|
UTSW |
6 |
57,048,306 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4694:Vmn1r9
|
UTSW |
6 |
57,048,314 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4884:Vmn1r9
|
UTSW |
6 |
57,048,294 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6023:Vmn1r9
|
UTSW |
6 |
57,048,239 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6031:Vmn1r9
|
UTSW |
6 |
57,048,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6031:Vmn1r9
|
UTSW |
6 |
57,048,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6761:Vmn1r9
|
UTSW |
6 |
57,048,291 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Vmn1r9
|
UTSW |
6 |
57,048,396 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7129:Vmn1r9
|
UTSW |
6 |
57,048,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8037:Vmn1r9
|
UTSW |
6 |
57,047,988 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8745:Vmn1r9
|
UTSW |
6 |
57,048,767 (GRCm39) |
missense |
probably benign |
0.39 |
|
R8930:Vmn1r9
|
UTSW |
6 |
57,048,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Vmn1r9
|
UTSW |
6 |
57,048,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9053:Vmn1r9
|
UTSW |
6 |
57,048,513 (GRCm39) |
missense |
probably benign |
|
|
R9144:Vmn1r9
|
UTSW |
6 |
57,048,788 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9167:Vmn1r9
|
UTSW |
6 |
57,048,138 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9642:Vmn1r9
|
UTSW |
6 |
57,048,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF009:Vmn1r9
|
UTSW |
6 |
57,048,465 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCATCTTGCTGCTGGTGTC -3'
(R):5'- AAGTGGGGCTACTCAGGATG -3'
Sequencing Primer
(F):5'- CTTTCTTTGTTGTCATGTACTGGG -3'
(R):5'- GATTCTATATAAACTGCTCTATGGGC -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation