Incidental Mutation 'R9580:Vmn1r39'
ID 722496
Institutional Source Beutler Lab
Gene Symbol Vmn1r39
Ensembl Gene ENSMUSG00000093755
Gene Name vomeronasal 1 receptor 39
Synonyms Gm5993
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R9580 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 66781399-66782316 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 66781915 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 134 (N134K)
Ref Sequence ENSEMBL: ENSMUSP00000154221 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000226217] [ENSMUST00000226783] [ENSMUST00000227285] [ENSMUST00000227555] [ENSMUST00000228008] [ENSMUST00000228651] [ENSMUST00000228862] [ENSMUST00000228919]
AlphaFold G3UWE6
Predicted Effect probably damaging
Transcript: ENSMUST00000226217
AA Change: N134K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000226783
AA Change: N134K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000227285
AA Change: N97K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227555
AA Change: N134K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228008
AA Change: N97K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228651
AA Change: N97K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228862
AA Change: N134K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228919
AA Change: N97K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2b T C 11: 62,156,145 (GRCm39) M198T probably damaging Het
Agbl2 A G 2: 90,636,248 (GRCm39) T595A probably benign Het
Cep89 A T 7: 35,102,538 (GRCm39) I84F possibly damaging Het
Eda G T X: 99,019,775 (GRCm39) R130L unknown Het
Erp44 T A 4: 48,218,187 (GRCm39) R161* probably null Het
Fcsk A G 8: 111,616,813 (GRCm39) W446R probably damaging Het
Gm12185 T G 11: 48,799,192 (GRCm39) S434R possibly damaging Het
Hmcn2 G T 2: 31,294,875 (GRCm39) A2555S probably benign Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Ighv1-61 A G 12: 115,322,993 (GRCm39) S40P possibly damaging Het
Kif26b C T 1: 178,506,643 (GRCm39) Q240* probably null Het
Mapkap1 C T 2: 34,509,878 (GRCm39) T456M probably damaging Het
Ncapg2 A G 12: 116,424,228 (GRCm39) N1137S probably damaging Het
Nectin4 C G 1: 171,211,324 (GRCm39) R283G probably damaging Het
Nos2 A G 11: 78,828,457 (GRCm39) I259V probably benign Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Or4c119 T C 2: 88,987,465 (GRCm39) N18S probably benign Het
Pgm2 A T 5: 64,265,092 (GRCm39) N371I possibly damaging Het
Ppargc1a A T 5: 51,620,139 (GRCm39) N733K unknown Het
Ptpn5 A G 7: 46,732,622 (GRCm39) Y345H probably damaging Het
Ptprd C G 4: 75,872,315 (GRCm39) A1134P possibly damaging Het
Rbm47 A C 5: 66,183,877 (GRCm39) M242R possibly damaging Het
Slc12a5 T G 2: 164,816,896 (GRCm39) F140V probably damaging Het
Slc22a2 G T 17: 12,803,177 (GRCm39) V4L probably benign Het
Stk26 C T X: 49,930,618 (GRCm39) probably benign Het
Tas2r105 A T 6: 131,663,699 (GRCm39) I243K probably damaging Het
Tmem126b G T 7: 90,118,231 (GRCm39) Y216* probably null Het
Usp25 C T 16: 76,880,682 (GRCm39) T681I probably benign Het
Vmn1r206 C T 13: 22,804,890 (GRCm39) A106T probably damaging Het
Vmn1r9 T C 6: 57,048,812 (GRCm39) S296P probably benign Het
Zfp97 T A 17: 17,365,243 (GRCm39) F247L probably damaging Het
Other mutations in Vmn1r39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02428:Vmn1r39 APN 6 66,781,946 (GRCm39) missense probably benign 0.05
R0189:Vmn1r39 UTSW 6 66,782,181 (GRCm39) missense probably benign 0.10
R1132:Vmn1r39 UTSW 6 66,781,428 (GRCm39) missense probably benign
R1803:Vmn1r39 UTSW 6 66,781,895 (GRCm39) missense probably benign 0.00
R1839:Vmn1r39 UTSW 6 66,782,217 (GRCm39) critical splice acceptor site probably null
R2966:Vmn1r39 UTSW 6 66,781,715 (GRCm39) missense possibly damaging 0.94
R3747:Vmn1r39 UTSW 6 66,781,854 (GRCm39) missense probably benign 0.03
R3748:Vmn1r39 UTSW 6 66,781,854 (GRCm39) missense probably benign 0.03
R3756:Vmn1r39 UTSW 6 66,781,863 (GRCm39) missense probably damaging 0.97
R3905:Vmn1r39 UTSW 6 66,781,479 (GRCm39) nonsense probably null
R3912:Vmn1r39 UTSW 6 66,782,125 (GRCm39) missense probably benign
R4226:Vmn1r39 UTSW 6 66,781,703 (GRCm39) missense possibly damaging 0.78
R4426:Vmn1r39 UTSW 6 66,782,345 (GRCm39) splice site probably null
R5493:Vmn1r39 UTSW 6 66,781,754 (GRCm39) missense probably damaging 0.97
R6498:Vmn1r39 UTSW 6 66,781,841 (GRCm39) missense probably damaging 1.00
R6944:Vmn1r39 UTSW 6 66,782,205 (GRCm39) start codon destroyed probably null 0.00
R7592:Vmn1r39 UTSW 6 66,781,428 (GRCm39) missense probably benign
R8312:Vmn1r39 UTSW 6 66,781,841 (GRCm39) missense noncoding transcript
R9232:Vmn1r39 UTSW 6 66,781,580 (GRCm39) missense possibly damaging 0.95
R9517:Vmn1r39 UTSW 6 66,782,258 (GRCm39) missense possibly damaging 0.93
R9571:Vmn1r39 UTSW 6 66,781,572 (GRCm39) missense probably benign 0.37
R9629:Vmn1r39 UTSW 6 66,781,578 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGATGCTTGCATTGCCTCTGG -3'
(R):5'- GCAACTTCTTACTTAAATAGGGCG -3'

Sequencing Primer
(F):5'- GCCTCTGGTGTCTGAACAAGATAATG -3'
(R):5'- CTTAAATAGGGCGATGAGAGGTCTC -3'
Posted On 2022-08-09