Incidental Mutation 'R9582:Vmn1r6'
ID 722596
Institutional Source Beutler Lab
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Name vomeronasal 1 receptor 6
Synonyms V1rc20
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R9582 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 56979340-56980251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 56979925 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 196 (T196A)
Ref Sequence ENSEMBL: ENSMUSP00000078611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
AlphaFold Q8R2D4
Predicted Effect probably benign
Transcript: ENSMUST00000079669
AA Change: T196A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: T196A

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226689
AA Change: T196A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227131
AA Change: T196A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227188
AA Change: T174A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227631
AA Change: T174A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227847
AA Change: T196A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000228285
AA Change: T196A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T A 3: 137,772,766 (GRCm39) F652I probably damaging Het
Adam17 A T 12: 21,386,665 (GRCm39) I457K probably benign Het
Arpin T C 7: 79,585,038 (GRCm39) probably benign Het
Bhlhe40 A G 6: 108,638,467 (GRCm39) E51G probably benign Het
Ces1a C T 8: 93,766,156 (GRCm39) D153N probably benign Het
Cog7 T C 7: 121,536,200 (GRCm39) M547V probably benign Het
Csrnp2 C T 15: 100,386,067 (GRCm39) R57K possibly damaging Het
Dact1 A T 12: 71,365,619 (GRCm39) K763M probably damaging Het
Ddost A T 4: 138,035,583 (GRCm39) I101F possibly damaging Het
Dyrk1b C T 7: 27,882,028 (GRCm39) R130W probably damaging Het
Ep400 A C 5: 110,824,315 (GRCm39) probably null Het
Fam227a A G 15: 79,501,978 (GRCm39) V532A probably benign Het
Flnc C A 6: 29,460,736 (GRCm39) T2609K probably damaging Het
Gbp10 A G 5: 105,372,256 (GRCm39) V168A probably benign Het
Gp5 A G 16: 30,127,057 (GRCm39) V539A probably benign Het
H2-T13 T A 17: 36,392,375 (GRCm39) R33S unknown Het
Itih5 A G 2: 10,195,013 (GRCm39) E135G probably benign Het
L2hgdh A G 12: 69,739,172 (GRCm39) V433A probably benign Het
Leng9 A G 7: 4,152,263 (GRCm39) S138P probably damaging Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Ly6g6e T C 17: 35,296,159 (GRCm39) V10A probably benign Het
Lypla1 C T 1: 4,911,248 (GRCm39) P178S probably benign Het
Mark1 A G 1: 184,651,858 (GRCm39) F216L possibly damaging Het
Mertk G A 2: 128,624,527 (GRCm39) R646Q possibly damaging Het
Mmp9 A C 2: 164,791,235 (GRCm39) D135A probably benign Het
Nefl A G 14: 68,324,849 (GRCm39) K529E unknown Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nwd1 A G 8: 73,421,917 (GRCm39) T988A probably damaging Het
P4ha2 T A 11: 54,022,065 (GRCm39) C529* probably null Het
Pcdhb4 T A 18: 37,441,417 (GRCm39) F242L probably damaging Het
Pced1b A G 15: 97,282,450 (GRCm39) N163S probably damaging Het
Pde8b A G 13: 95,169,369 (GRCm39) V585A probably damaging Het
Pknox2 T A 9: 36,804,252 (GRCm39) T432S probably damaging Het
Rad18 A G 6: 112,658,298 (GRCm39) probably null Het
Rpgrip1l C T 8: 91,996,886 (GRCm39) V665I probably benign Het
Rreb1 A G 13: 38,114,734 (GRCm39) I698V probably benign Het
Schip1 TCTGGCC TC 3: 68,525,060 (GRCm39) probably null Het
Slc2a4 C T 11: 69,837,450 (GRCm39) V32M probably damaging Het
Slc40a1 A G 1: 45,950,499 (GRCm39) Y318H probably damaging Het
Spag16 A G 1: 69,897,717 (GRCm39) T156A probably benign Het
Srebf1 C A 11: 60,097,868 (GRCm39) A103S probably benign Het
Sspn C T 6: 145,899,334 (GRCm39) probably benign Het
Stoml2 A T 4: 43,030,238 (GRCm39) probably null Het
Stra6 T A 9: 58,054,770 (GRCm39) V319E probably damaging Het
Syt7 T C 19: 10,416,780 (GRCm39) F414L probably damaging Het
Tet3 G T 6: 83,381,226 (GRCm39) P314Q probably damaging Het
Tnrc18 A T 5: 142,757,128 (GRCm39) L1313Q Het
Topors A T 4: 40,260,460 (GRCm39) D941E unknown Het
Txnip T A 3: 96,465,659 (GRCm39) C36* probably null Het
Uba3 A T 6: 97,168,491 (GRCm39) M178K probably damaging Het
Vwc2 T A 11: 11,066,129 (GRCm39) S72R probably benign Het
Wnk2 A G 13: 49,210,975 (GRCm39) S1627P probably benign Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Vmn1r6 APN 6 56,979,789 (GRCm39) missense probably damaging 1.00
IGL01011:Vmn1r6 APN 6 56,979,529 (GRCm39) missense probably benign 0.00
IGL01147:Vmn1r6 APN 6 56,979,626 (GRCm39) missense probably damaging 1.00
IGL01475:Vmn1r6 APN 6 56,979,896 (GRCm39) missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 56,980,177 (GRCm39) nonsense probably null
IGL01860:Vmn1r6 APN 6 56,979,674 (GRCm39) nonsense probably null
IGL01876:Vmn1r6 APN 6 56,979,446 (GRCm39) missense probably benign 0.12
IGL01988:Vmn1r6 APN 6 56,979,650 (GRCm39) missense probably damaging 0.99
R0531:Vmn1r6 UTSW 6 56,979,583 (GRCm39) missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 56,980,058 (GRCm39) missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 56,979,607 (GRCm39) missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 56,980,109 (GRCm39) missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 56,979,920 (GRCm39) missense probably damaging 0.96
R4353:Vmn1r6 UTSW 6 56,979,677 (GRCm39) missense possibly damaging 0.63
R4484:Vmn1r6 UTSW 6 56,980,174 (GRCm39) missense probably benign
R4854:Vmn1r6 UTSW 6 56,979,683 (GRCm39) missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 56,980,179 (GRCm39) missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 56,979,789 (GRCm39) missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 56,979,362 (GRCm39) missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 56,979,422 (GRCm39) missense possibly damaging 0.85
R8423:Vmn1r6 UTSW 6 56,979,495 (GRCm39) missense probably benign 0.30
R9249:Vmn1r6 UTSW 6 56,979,760 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGTCCTTCAGTAGTAACAGGATC -3'
(R):5'- GGCATTCATCACAAACTTCTGAAG -3'

Sequencing Primer
(F):5'- CAGTAGTAACAGGATCTTCTTTGTTG -3'
(R):5'- GACTGGATCATATCTCCATAAGAGG -3'
Posted On 2022-08-09