Incidental Mutation 'R9583:Vmn1r196'
ID 722676
Institutional Source Beutler Lab
Gene Symbol Vmn1r196
Ensembl Gene ENSMUSG00000069295
Gene Name vomeronasal 1 receptor 196
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R9583 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 22289920-22298360 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 22293750 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 186 (M186I)
Ref Sequence ENSEMBL: ENSMUSP00000089329 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091735] [ENSMUST00000226245] [ENSMUST00000227516] [ENSMUST00000228382] [ENSMUST00000228557]
AlphaFold Q5SVD5
Predicted Effect probably damaging
Transcript: ENSMUST00000091735
AA Change: M186I

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000089329
Gene: ENSMUSG00000069295
AA Change: M186I

DomainStartEndE-ValueType
Pfam:V1R 35 297 3.9e-35 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226245
AA Change: M109I

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect probably null
Transcript: ENSMUST00000227516
AA Change: M1I

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000228382
AA Change: M186I

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000228557
AA Change: M186I

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A C 11: 23,581,642 M661R possibly damaging Het
2310057J18Rik A T 10: 28,986,096 I66N probably damaging Het
4933416C03Rik A T 10: 116,113,026 D198E probably benign Het
Adgrg3 A T 8: 95,033,443 I97F probably benign Het
AI987944 T A 7: 41,374,513 R350S probably benign Het
Arap3 T C 18: 37,976,043 T1214A probably damaging Het
Arid5a A G 1: 36,317,658 E127G possibly damaging Het
Bbx T C 16: 50,224,557 E547G possibly damaging Het
Ceacam16 T C 7: 19,853,878 I322V probably damaging Het
Chd2 G T 7: 73,480,482 N808K probably damaging Het
Copg2 A C 6: 30,810,464 L615* probably null Het
Cyp21a1 A G 17: 34,803,043 L221P probably damaging Het
Dnah9 C A 11: 65,965,681 V2885L probably damaging Het
Dnajb13 A G 7: 100,503,239 L290P probably damaging Het
Eif3e A G 15: 43,265,561 V221A probably damaging Het
Evc G A 5: 37,316,357 R511* probably null Het
Far2 C T 6: 148,157,936 P250S probably damaging Het
Fmo1 T A 1: 162,859,427 T44S Het
Gm21119 T A 8: 20,634,946 F285I possibly damaging Het
Grid1 A G 14: 35,580,535 E919G possibly damaging Het
Grip1 G A 10: 120,038,664 E778K possibly damaging Het
Hoxb2 A G 11: 96,351,899 E30G probably damaging Het
Il5ra G A 6: 106,712,370 P75L unknown Het
Il5ra T A 6: 106,744,336 M1L possibly damaging Het
Inpp4b T C 8: 81,770,926 probably null Het
Itgb8 T A 12: 119,189,973 H269L possibly damaging Het
Jrk G A 15: 74,706,554 A294V probably damaging Het
Knl1 A T 2: 119,057,301 D2V probably damaging Het
Lrrc71 T C 3: 87,742,951 I272V possibly damaging Het
Mdn1 T C 4: 32,741,372 S3825P probably damaging Het
Mex3d C A 10: 80,382,295 V363L Het
Mfsd13b C A 7: 120,998,911 H347N possibly damaging Het
Mllt1 G T 17: 56,902,572 H179Q probably benign Het
Mmp14 A T 14: 54,440,612 R563S probably benign Het
Ms4a18 T C 19: 10,997,350 T326A probably benign Het
Muc16 T C 9: 18,638,677 D5440G probably benign Het
Muc2 A T 7: 141,746,822 E294V Het
Myh7b A G 2: 155,617,721 N241S probably damaging Het
Myo1b T C 1: 51,757,245 I1007V possibly damaging Het
Olfr1250 A G 2: 89,656,661 V260A possibly damaging Het
Olfr16 T C 1: 172,957,326 F177S probably damaging Het
Olfr952 T A 9: 39,426,555 D172V possibly damaging Het
Pan2 T C 10: 128,304,266 S19P probably benign Het
Pkn3 A G 2: 30,086,711 D588G probably null Het
Pkp4 A G 2: 59,347,760 N988D possibly damaging Het
Plxdc1 T C 11: 97,934,018 D344G probably damaging Het
Plxna4 C T 6: 32,215,234 R807H possibly damaging Het
Prdm15 A T 16: 97,821,942 S237T probably benign Het
Slc9a2 G A 1: 40,681,901 V10M probably benign Het
Sytl2 T C 7: 90,375,592 S263P probably benign Het
Trrap G A 5: 144,840,520 V3043M probably damaging Het
Tshz3 C T 7: 36,771,067 T827I possibly damaging Het
Ttll1 T C 15: 83,500,025 T134A possibly damaging Het
Vrk2 C T 11: 26,483,157 probably null Het
Zfp59 T A 7: 27,855,058 V645E probably benign Het
Other mutations in Vmn1r196
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01941:Vmn1r196 APN 13 22293699 nonsense probably null
R0415:Vmn1r196 UTSW 13 22293836 missense probably damaging 1.00
R0502:Vmn1r196 UTSW 13 22293387 missense probably benign 0.01
R0503:Vmn1r196 UTSW 13 22293387 missense probably benign 0.01
R2306:Vmn1r196 UTSW 13 22293303 missense probably benign 0.08
R4463:Vmn1r196 UTSW 13 22293683 missense probably benign
R6335:Vmn1r196 UTSW 13 22293717 missense probably benign 0.18
R7664:Vmn1r196 UTSW 13 22293762 missense probably damaging 1.00
R8062:Vmn1r196 UTSW 13 22293270 missense probably damaging 1.00
R9017:Vmn1r196 UTSW 13 22294084 missense probably benign 0.00
R9434:Vmn1r196 UTSW 13 22293620 nonsense probably null
S24628:Vmn1r196 UTSW 13 22293836 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCTAAATGGCATGTGCTTCTC -3'
(R):5'- AGTCCATCCCTCTGAATCAGC -3'

Sequencing Primer
(F):5'- AAATGGCATGTGCTTCTCTCTCTG -3'
(R):5'- TCCCTCTGAATCAGCATAAATGGG -3'
Posted On 2022-08-09