Incidental Mutation 'R9586:Ovgp1'
ID 722788
Institutional Source Beutler Lab
Gene Symbol Ovgp1
Ensembl Gene ENSMUSG00000074340
Gene Name oviductal glycoprotein 1
Synonyms oviductin, Chit5, OGP, muc9, MOGP, mucin 9
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9586 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 105881118-105894739 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 105881138 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 3 (R3G)
Ref Sequence ENSEMBL: ENSMUSP00000000573 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000010278] [ENSMUST00000130994] [ENSMUST00000163626]
AlphaFold Q62010
Predicted Effect probably damaging
Transcript: ENSMUST00000000573
AA Change: R3G

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: R3G

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
Glyco_18 22 360 1.38e-134 SMART
low complexity region 486 515 N/A INTRINSIC
low complexity region 533 626 N/A INTRINSIC
low complexity region 637 648 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000010278
SMART Domains Protein: ENSMUSP00000010278
Gene: ENSMUSG00000000561

DomainStartEndE-ValueType
low complexity region 40 51 N/A INTRINSIC
WD40 70 107 5.11e1 SMART
WD40 115 153 1.06e-3 SMART
WD40 156 196 4.51e-7 SMART
WD40 201 241 2.75e1 SMART
WD40 244 284 9.94e-1 SMART
WD40 286 326 1.99e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000130994
SMART Domains Protein: ENSMUSP00000120517
Gene: ENSMUSG00000000561

DomainStartEndE-ValueType
PDB:4GQB|B 1 52 8e-18 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000163626
SMART Domains Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

DomainStartEndE-ValueType
Glyco_18 9 226 8.52e-21 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl6ip5 C T 6: 97,206,572 (GRCm39) A84V possibly damaging Het
Cep170 G A 1: 176,563,463 (GRCm39) P716L possibly damaging Het
Chrm3 A T 13: 9,927,480 (GRCm39) C519S probably damaging Het
Dnase1l3 A T 14: 7,967,796 (GRCm38) V299D possibly damaging Het
Dync1h1 T C 12: 110,582,975 (GRCm39) L386P probably damaging Het
Elmo3 A G 8: 106,034,760 (GRCm39) Y382C probably damaging Het
Eprs1 T C 1: 185,139,746 (GRCm39) L945P Het
Fstl4 A T 11: 53,077,729 (GRCm39) I829L probably benign Het
Gm36210 T A 7: 4,909,324 (GRCm39) R45* probably null Het
Homer2 C T 7: 81,260,113 (GRCm39) R318Q probably benign Het
Ice2 G A 9: 69,314,478 (GRCm39) E76K probably damaging Het
Ifi203 T A 1: 173,754,623 (GRCm39) R703* probably null Het
Insyn2a T C 7: 134,520,180 (GRCm39) T117A probably damaging Het
Lonp1 G A 17: 56,924,839 (GRCm39) R523C probably damaging Het
Myh10 G A 11: 68,703,820 (GRCm39) V1881I possibly damaging Het
Nfe2 T C 15: 103,157,244 (GRCm39) D249G probably damaging Het
Nvl A T 1: 180,932,635 (GRCm39) probably null Het
Oog3 A T 4: 143,884,966 (GRCm39) C323* probably null Het
Pex1 A G 5: 3,676,047 (GRCm39) I838M probably damaging Het
Rps6kc1 C A 1: 190,514,774 (GRCm39) M1006I probably benign Het
Rpusd1 A G 17: 25,947,292 (GRCm39) T37A probably damaging Het
Sema6d C A 2: 124,496,096 (GRCm39) R47S probably damaging Het
Serpini2 G A 3: 75,166,891 (GRCm39) T122I probably benign Het
Slc10a7 A G 8: 79,456,266 (GRCm39) I289M probably damaging Het
Slc25a37 G T 14: 69,482,421 (GRCm39) N293K probably benign Het
Sspo G A 6: 48,458,039 (GRCm39) A3281T probably benign Het
Stard13 A T 5: 150,985,832 (GRCm39) N559K possibly damaging Het
Tmem87b T A 2: 128,660,260 (GRCm39) M1K probably null Het
Vmn1r199 C T 13: 22,567,716 (GRCm39) R337C probably benign Het
Vmn1r55 T A 7: 5,149,770 (GRCm39) N218Y probably benign Het
Vmn2r41 T G 7: 8,141,742 (GRCm39) Q574P Het
Vmn2r45 T C 7: 8,486,050 (GRCm39) N413D probably benign Het
Wdr33 T C 18: 31,966,669 (GRCm39) S170P probably damaging Het
Zfp385a A T 15: 103,241,580 (GRCm39) I20N probably damaging Het
Zfp493 A G 13: 67,932,017 (GRCm39) S39G possibly damaging Het
Other mutations in Ovgp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00973:Ovgp1 APN 3 105,888,593 (GRCm39) nonsense probably null
IGL01152:Ovgp1 APN 3 105,893,488 (GRCm39) missense possibly damaging 0.94
IGL01458:Ovgp1 APN 3 105,882,307 (GRCm39) missense probably benign 0.01
IGL01646:Ovgp1 APN 3 105,885,665 (GRCm39) missense probably damaging 1.00
IGL01768:Ovgp1 APN 3 105,888,667 (GRCm39) critical splice donor site probably null
IGL02712:Ovgp1 APN 3 105,893,829 (GRCm39) unclassified probably benign
IGL03065:Ovgp1 APN 3 105,893,682 (GRCm39) missense probably benign 0.01
IGL03140:Ovgp1 APN 3 105,887,222 (GRCm39) missense probably damaging 1.00
IGL03272:Ovgp1 APN 3 105,888,641 (GRCm39) missense probably damaging 0.99
PIT4472001:Ovgp1 UTSW 3 105,894,306 (GRCm39) missense unknown
R0277:Ovgp1 UTSW 3 105,887,208 (GRCm39) intron probably benign
R0560:Ovgp1 UTSW 3 105,893,726 (GRCm39) unclassified probably benign
R0718:Ovgp1 UTSW 3 105,882,146 (GRCm39) splice site probably benign
R0743:Ovgp1 UTSW 3 105,882,248 (GRCm39) missense probably damaging 1.00
R1362:Ovgp1 UTSW 3 105,893,891 (GRCm39) unclassified probably benign
R1556:Ovgp1 UTSW 3 105,894,068 (GRCm39) unclassified probably benign
R1776:Ovgp1 UTSW 3 105,885,114 (GRCm39) missense possibly damaging 0.52
R1831:Ovgp1 UTSW 3 105,892,384 (GRCm39) missense probably benign 0.04
R1986:Ovgp1 UTSW 3 105,882,251 (GRCm39) missense probably damaging 1.00
R2004:Ovgp1 UTSW 3 105,894,309 (GRCm39) unclassified probably benign
R2156:Ovgp1 UTSW 3 105,885,033 (GRCm39) missense possibly damaging 0.49
R2254:Ovgp1 UTSW 3 105,894,228 (GRCm39) unclassified probably benign
R2860:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R2861:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R3117:Ovgp1 UTSW 3 105,893,768 (GRCm39) unclassified probably benign
R3793:Ovgp1 UTSW 3 105,887,487 (GRCm39) missense probably benign 0.03
R3835:Ovgp1 UTSW 3 105,893,631 (GRCm39) missense probably benign 0.00
R3894:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R3894:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R3895:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R4050:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R4050:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R4467:Ovgp1 UTSW 3 105,885,027 (GRCm39) missense probably benign 0.04
R4611:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R4628:Ovgp1 UTSW 3 105,887,639 (GRCm39) splice site probably null
R4738:Ovgp1 UTSW 3 105,887,234 (GRCm39) missense probably damaging 1.00
R4944:Ovgp1 UTSW 3 105,887,269 (GRCm39) missense possibly damaging 0.66
R5110:Ovgp1 UTSW 3 105,885,099 (GRCm39) missense probably damaging 1.00
R6531:Ovgp1 UTSW 3 105,894,387 (GRCm39) unclassified probably benign
R6540:Ovgp1 UTSW 3 105,893,897 (GRCm39) nonsense probably null
R6562:Ovgp1 UTSW 3 105,887,589 (GRCm39) missense probably damaging 1.00
R6601:Ovgp1 UTSW 3 105,893,747 (GRCm39) unclassified probably benign
R6906:Ovgp1 UTSW 3 105,894,189 (GRCm39) unclassified probably benign
R7313:Ovgp1 UTSW 3 105,894,387 (GRCm39) missense unknown
R7430:Ovgp1 UTSW 3 105,893,619 (GRCm39) missense possibly damaging 0.62
R7430:Ovgp1 UTSW 3 105,893,618 (GRCm39) missense probably damaging 0.99
R7566:Ovgp1 UTSW 3 105,881,626 (GRCm39) start gained probably benign
R7684:Ovgp1 UTSW 3 105,887,272 (GRCm39) missense probably damaging 0.99
R7805:Ovgp1 UTSW 3 105,894,110 (GRCm39) missense unknown
R7820:Ovgp1 UTSW 3 105,893,837 (GRCm39) unclassified probably benign
R7919:Ovgp1 UTSW 3 105,888,601 (GRCm39) missense probably damaging 1.00
R8039:Ovgp1 UTSW 3 105,883,339 (GRCm39) missense probably benign 0.26
R8483:Ovgp1 UTSW 3 105,894,311 (GRCm39) unclassified probably benign
R9259:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9261:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9262:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9359:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9389:Ovgp1 UTSW 3 105,893,841 (GRCm39) unclassified probably benign
R9390:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9444:Ovgp1 UTSW 3 105,893,841 (GRCm39) unclassified probably benign
R9445:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9466:Ovgp1 UTSW 3 105,887,484 (GRCm39) missense
Z1177:Ovgp1 UTSW 3 105,894,156 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTGGCTCTGAGAACTACAGC -3'
(R):5'- CAAGATGAAGCCCAAGCATG -3'

Sequencing Primer
(F):5'- GGCTCTGAGAACTACAGCTGTTC -3'
(R):5'- CCACCAGGTTGGAGAACTACTG -3'
Posted On 2022-08-09