Incidental Mutation 'R9586:Vmn1r55'
| ID |
722795 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r55
|
| Ensembl Gene |
ENSMUSG00000074402 |
| Gene Name |
vomeronasal 1 receptor 55 |
| Synonyms |
LOC384522, V1rd5, LOC236535 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
R9586 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5149489-5150421 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 5149770 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 218
(N218Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000096443
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098844]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098844
AA Change: N218Y
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000096443
Gene: ENSMUSG00000074402
AA Change: N218Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
286 |
3.7e-14 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
4e-8 |
PFAM |
|
Pfam:V1R
|
31 |
286 |
5.5e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arl6ip5 |
C |
T |
6: 97,206,572 (GRCm39) |
A84V |
possibly damaging |
Het |
| Cep170 |
G |
A |
1: 176,563,463 (GRCm39) |
P716L |
possibly damaging |
Het |
| Chrm3 |
A |
T |
13: 9,927,480 (GRCm39) |
C519S |
probably damaging |
Het |
| Dnase1l3 |
A |
T |
14: 7,967,796 (GRCm38) |
V299D |
possibly damaging |
Het |
| Dync1h1 |
T |
C |
12: 110,582,975 (GRCm39) |
L386P |
probably damaging |
Het |
| Elmo3 |
A |
G |
8: 106,034,760 (GRCm39) |
Y382C |
probably damaging |
Het |
| Eprs1 |
T |
C |
1: 185,139,746 (GRCm39) |
L945P |
|
Het |
| Fstl4 |
A |
T |
11: 53,077,729 (GRCm39) |
I829L |
probably benign |
Het |
| Gm36210 |
T |
A |
7: 4,909,324 (GRCm39) |
R45* |
probably null |
Het |
| Homer2 |
C |
T |
7: 81,260,113 (GRCm39) |
R318Q |
probably benign |
Het |
| Ice2 |
G |
A |
9: 69,314,478 (GRCm39) |
E76K |
probably damaging |
Het |
| Ifi203 |
T |
A |
1: 173,754,623 (GRCm39) |
R703* |
probably null |
Het |
| Insyn2a |
T |
C |
7: 134,520,180 (GRCm39) |
T117A |
probably damaging |
Het |
| Lonp1 |
G |
A |
17: 56,924,839 (GRCm39) |
R523C |
probably damaging |
Het |
| Myh10 |
G |
A |
11: 68,703,820 (GRCm39) |
V1881I |
possibly damaging |
Het |
| Nfe2 |
T |
C |
15: 103,157,244 (GRCm39) |
D249G |
probably damaging |
Het |
| Nvl |
A |
T |
1: 180,932,635 (GRCm39) |
|
probably null |
Het |
| Oog3 |
A |
T |
4: 143,884,966 (GRCm39) |
C323* |
probably null |
Het |
| Ovgp1 |
A |
G |
3: 105,881,138 (GRCm39) |
R3G |
probably damaging |
Het |
| Pex1 |
A |
G |
5: 3,676,047 (GRCm39) |
I838M |
probably damaging |
Het |
| Rps6kc1 |
C |
A |
1: 190,514,774 (GRCm39) |
M1006I |
probably benign |
Het |
| Rpusd1 |
A |
G |
17: 25,947,292 (GRCm39) |
T37A |
probably damaging |
Het |
| Sema6d |
C |
A |
2: 124,496,096 (GRCm39) |
R47S |
probably damaging |
Het |
| Serpini2 |
G |
A |
3: 75,166,891 (GRCm39) |
T122I |
probably benign |
Het |
| Slc10a7 |
A |
G |
8: 79,456,266 (GRCm39) |
I289M |
probably damaging |
Het |
| Slc25a37 |
G |
T |
14: 69,482,421 (GRCm39) |
N293K |
probably benign |
Het |
| Sspo |
G |
A |
6: 48,458,039 (GRCm39) |
A3281T |
probably benign |
Het |
| Stard13 |
A |
T |
5: 150,985,832 (GRCm39) |
N559K |
possibly damaging |
Het |
| Tmem87b |
T |
A |
2: 128,660,260 (GRCm39) |
M1K |
probably null |
Het |
| Vmn1r199 |
C |
T |
13: 22,567,716 (GRCm39) |
R337C |
probably benign |
Het |
| Vmn2r41 |
T |
G |
7: 8,141,742 (GRCm39) |
Q574P |
|
Het |
| Vmn2r45 |
T |
C |
7: 8,486,050 (GRCm39) |
N413D |
probably benign |
Het |
| Wdr33 |
T |
C |
18: 31,966,669 (GRCm39) |
S170P |
probably damaging |
Het |
| Zfp385a |
A |
T |
15: 103,241,580 (GRCm39) |
I20N |
probably damaging |
Het |
| Zfp493 |
A |
G |
13: 67,932,017 (GRCm39) |
S39G |
possibly damaging |
Het |
|
| Other mutations in Vmn1r55 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R1771:Vmn1r55
|
UTSW |
7 |
5,149,919 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2063:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2064:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2066:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2068:Vmn1r55
|
UTSW |
7 |
5,150,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3737:Vmn1r55
|
UTSW |
7 |
5,150,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn1r55
|
UTSW |
7 |
5,150,075 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4410:Vmn1r55
|
UTSW |
7 |
5,150,075 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4700:Vmn1r55
|
UTSW |
7 |
5,149,587 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4700:Vmn1r55
|
UTSW |
7 |
5,149,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Vmn1r55
|
UTSW |
7 |
5,150,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4945:Vmn1r55
|
UTSW |
7 |
5,150,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5064:Vmn1r55
|
UTSW |
7 |
5,149,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5186:Vmn1r55
|
UTSW |
7 |
5,149,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn1r55
|
UTSW |
7 |
5,149,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6487:Vmn1r55
|
UTSW |
7 |
5,149,554 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7855:Vmn1r55
|
UTSW |
7 |
5,149,623 (GRCm39) |
missense |
probably benign |
|
|
R8204:Vmn1r55
|
UTSW |
7 |
5,150,285 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8376:Vmn1r55
|
UTSW |
7 |
5,149,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9688:Vmn1r55
|
UTSW |
7 |
5,149,669 (GRCm39) |
missense |
probably benign |
0.44 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGACCCCTAGGATCCCTAAAG -3'
(R):5'- ACAATGACTCTGATTCTCAAGGC -3'
Sequencing Primer
(F):5'- TCCCTAAAGATCAACAGTAAAGGAG -3'
(R):5'- TGACTCTGATTCTCAAGGCAAGAG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation