Incidental Mutation 'R9587:Gpr3'
ID 722826
Institutional Source Beutler Lab
Gene Symbol Gpr3
Ensembl Gene ENSMUSG00000049649
Gene Name G-protein coupled receptor 3
Synonyms Gpcr3, Gpcr21
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # R9587 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 132936651-132939847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 132937988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 228 (A228V)
Ref Sequence ENSEMBL: ENSMUSP00000062083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052090] [ENSMUST00000105911] [ENSMUST00000151025]
AlphaFold P35413
Predicted Effect probably damaging
Transcript: ENSMUST00000052090
AA Change: A228V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062083
Gene: ENSMUSG00000049649
AA Change: A228V

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2.4e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105911
AA Change: A228V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101531
Gene: ENSMUSG00000049649
AA Change: A228V

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000151025
SMART Domains Protein: ENSMUSP00000116032
Gene: ENSMUSG00000049649

DomainStartEndE-ValueType
SCOP:d1l9ha_ 20 95 3e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 T A 5: 4,119,149 (GRCm39) L3552Q probably damaging Het
Atat1 T C 17: 36,209,182 (GRCm39) E353G probably benign Het
Banf2 A G 2: 143,907,452 (GRCm39) K42R probably damaging Het
Cabp7 T A 11: 4,688,865 (GRCm39) M202L probably damaging Het
Cage1 T C 13: 38,207,233 (GRCm39) E204G probably damaging Het
Caprin2 A G 6: 148,770,500 (GRCm39) V498A probably benign Het
Cfap161 A G 7: 83,440,878 (GRCm39) F150L probably damaging Het
Cyb5r1 G A 1: 134,335,387 (GRCm39) G141R probably damaging Het
Dnah8 CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT 17: 30,979,841 (GRCm39) probably null Het
Dnah9 T C 11: 65,999,217 (GRCm39) Q974R probably null Het
Eps8l3 G A 3: 107,798,683 (GRCm39) R523Q probably benign Het
Ext1 T C 15: 52,955,808 (GRCm39) I430V possibly damaging Het
Gga3 T C 11: 115,481,717 (GRCm39) K202R probably damaging Het
Gm11567 T C 11: 99,770,136 (GRCm39) W25R unknown Het
Krt10 T C 11: 99,277,420 (GRCm39) D426G possibly damaging Het
Krt24 T A 11: 99,174,453 (GRCm39) I205F probably damaging Het
Krt33a T C 11: 99,906,733 (GRCm39) N81D probably damaging Het
Mapkbp1 T C 2: 119,847,277 (GRCm39) S505P possibly damaging Het
Matr3 A G 18: 35,717,876 (GRCm39) D696G probably null Het
Mov10 C T 3: 104,711,899 (GRCm39) G158S probably benign Het
Myh1 T A 11: 67,102,196 (GRCm39) M829K probably benign Het
Ncam2 T C 16: 81,262,501 (GRCm39) V318A probably benign Het
Ndufv3 A G 17: 31,747,106 (GRCm39) E332G probably benign Het
Ngdn C T 14: 55,254,578 (GRCm39) T43M probably benign Het
Nop2 T A 6: 125,117,785 (GRCm39) D445E probably damaging Het
Or2y17 C T 11: 49,232,007 (GRCm39) S216F probably benign Het
Or3a10 G A 11: 73,935,360 (GRCm39) H247Y probably damaging Het
Or5w17 A T 2: 87,584,184 (GRCm39) M51K possibly damaging Het
Or8u8 A T 2: 86,011,564 (GRCm39) V297E probably damaging Het
Prl2b1 G A 13: 27,567,601 (GRCm39) A181V probably benign Het
Ptprg T A 14: 12,215,992 (GRCm38) L1147Q probably damaging Het
Rubcn T C 16: 32,663,679 (GRCm39) D319G probably damaging Het
Sfswap G A 5: 129,618,427 (GRCm39) D454N probably benign Het
Slc38a6 G T 12: 73,388,513 (GRCm39) K242N probably benign Het
Tmigd3 A G 3: 105,824,088 (GRCm39) D19G probably damaging Het
Trim36 T C 18: 46,308,722 (GRCm39) E380G probably benign Het
Ttn T A 2: 76,624,976 (GRCm39) I15201F probably damaging Het
Vmn2r12 A G 5: 109,239,322 (GRCm39) S414P probably damaging Het
Vmn2r82 A T 10: 79,214,936 (GRCm39) K306N possibly damaging Het
Wdfy4 A T 14: 32,769,230 (GRCm39) Y2232* probably null Het
Wdr53 A G 16: 32,075,830 (GRCm39) D345G probably damaging Het
Zfp26 G A 9: 20,348,213 (GRCm39) R784C probably damaging Het
Zfp58 A T 13: 67,639,823 (GRCm39) C223S probably damaging Het
Zfp618 A G 4: 63,051,916 (GRCm39) H899R Het
Zfp963 A G 8: 70,195,692 (GRCm39) Y254H probably benign Het
Zfp994 T C 17: 22,421,764 (GRCm39) D17G probably damaging Het
Other mutations in Gpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Gpr3 APN 4 132,938,405 (GRCm39) missense probably damaging 1.00
IGL02974:Gpr3 APN 4 132,938,220 (GRCm39) missense possibly damaging 0.90
R0095:Gpr3 UTSW 4 132,938,597 (GRCm39) missense probably benign 0.01
R0532:Gpr3 UTSW 4 132,937,796 (GRCm39) missense probably damaging 1.00
R1831:Gpr3 UTSW 4 132,938,454 (GRCm39) missense possibly damaging 0.80
R2127:Gpr3 UTSW 4 132,937,932 (GRCm39) missense probably damaging 0.96
R4077:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R4078:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R5306:Gpr3 UTSW 4 132,938,490 (GRCm39) missense probably damaging 1.00
R5602:Gpr3 UTSW 4 132,937,805 (GRCm39) missense probably damaging 1.00
R5712:Gpr3 UTSW 4 132,937,719 (GRCm39) missense probably benign 0.01
R5913:Gpr3 UTSW 4 132,938,489 (GRCm39) missense probably damaging 1.00
R7434:Gpr3 UTSW 4 132,938,448 (GRCm39) missense probably benign 0.45
R7645:Gpr3 UTSW 4 132,938,640 (GRCm39) missense probably damaging 1.00
R7709:Gpr3 UTSW 4 132,937,748 (GRCm39) missense probably damaging 1.00
R8043:Gpr3 UTSW 4 132,938,271 (GRCm39) missense probably damaging 1.00
R8818:Gpr3 UTSW 4 132,938,538 (GRCm39) missense possibly damaging 0.95
R9015:Gpr3 UTSW 4 132,938,390 (GRCm39) missense possibly damaging 0.80
R9027:Gpr3 UTSW 4 132,938,209 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCGTAGATGACAGGGTTGATC -3'
(R):5'- CGGACTTATGTGATGCTGGC -3'

Sequencing Primer
(F):5'- AGATGACAGGGTTGATCATGGAGTTG -3'
(R):5'- ACTTATGTGATGCTGGCCTTGG -3'
Posted On 2022-08-09