Incidental Mutation 'R9587:Krt10'
ID 722842
Institutional Source Beutler Lab
Gene Symbol Krt10
Ensembl Gene ENSMUSG00000019761
Gene Name keratin 10
Synonyms K10, cytokeratin 10, keratin 10, K1C1, Krt-1.10, suprabasal cytokeratin 10, D130054E02Rik, Krt1-10
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.322) question?
Stock # R9587 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 99276080-99280190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99277420 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 426 (D426G)
Ref Sequence ENSEMBL: ENSMUSP00000099420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103131] [ENSMUST00000211768]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000103131
AA Change: D426G

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000099420
Gene: ENSMUSG00000019761
AA Change: D426G

DomainStartEndE-ValueType
low complexity region 2 133 N/A INTRINSIC
Filament 134 448 6e-166 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000211768
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutations may result in hyperkeratosis and blistering of the skin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 T A 5: 4,119,149 (GRCm39) L3552Q probably damaging Het
Atat1 T C 17: 36,209,182 (GRCm39) E353G probably benign Het
Banf2 A G 2: 143,907,452 (GRCm39) K42R probably damaging Het
Cabp7 T A 11: 4,688,865 (GRCm39) M202L probably damaging Het
Cage1 T C 13: 38,207,233 (GRCm39) E204G probably damaging Het
Caprin2 A G 6: 148,770,500 (GRCm39) V498A probably benign Het
Cfap161 A G 7: 83,440,878 (GRCm39) F150L probably damaging Het
Cyb5r1 G A 1: 134,335,387 (GRCm39) G141R probably damaging Het
Dnah8 CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT CGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTTTGACTTTCCTGTGTCTTCAATATTTTGTTCCCTTTCCCGTAGGTGCCGTCCTT 17: 30,979,841 (GRCm39) probably null Het
Dnah9 T C 11: 65,999,217 (GRCm39) Q974R probably null Het
Eps8l3 G A 3: 107,798,683 (GRCm39) R523Q probably benign Het
Ext1 T C 15: 52,955,808 (GRCm39) I430V possibly damaging Het
Gga3 T C 11: 115,481,717 (GRCm39) K202R probably damaging Het
Gm11567 T C 11: 99,770,136 (GRCm39) W25R unknown Het
Gpr3 G A 4: 132,937,988 (GRCm39) A228V probably damaging Het
Krt24 T A 11: 99,174,453 (GRCm39) I205F probably damaging Het
Krt33a T C 11: 99,906,733 (GRCm39) N81D probably damaging Het
Mapkbp1 T C 2: 119,847,277 (GRCm39) S505P possibly damaging Het
Matr3 A G 18: 35,717,876 (GRCm39) D696G probably null Het
Mov10 C T 3: 104,711,899 (GRCm39) G158S probably benign Het
Myh1 T A 11: 67,102,196 (GRCm39) M829K probably benign Het
Ncam2 T C 16: 81,262,501 (GRCm39) V318A probably benign Het
Ndufv3 A G 17: 31,747,106 (GRCm39) E332G probably benign Het
Ngdn C T 14: 55,254,578 (GRCm39) T43M probably benign Het
Nop2 T A 6: 125,117,785 (GRCm39) D445E probably damaging Het
Or2y17 C T 11: 49,232,007 (GRCm39) S216F probably benign Het
Or3a10 G A 11: 73,935,360 (GRCm39) H247Y probably damaging Het
Or5w17 A T 2: 87,584,184 (GRCm39) M51K possibly damaging Het
Or8u8 A T 2: 86,011,564 (GRCm39) V297E probably damaging Het
Prl2b1 G A 13: 27,567,601 (GRCm39) A181V probably benign Het
Ptprg T A 14: 12,215,992 (GRCm38) L1147Q probably damaging Het
Rubcn T C 16: 32,663,679 (GRCm39) D319G probably damaging Het
Sfswap G A 5: 129,618,427 (GRCm39) D454N probably benign Het
Slc38a6 G T 12: 73,388,513 (GRCm39) K242N probably benign Het
Tmigd3 A G 3: 105,824,088 (GRCm39) D19G probably damaging Het
Trim36 T C 18: 46,308,722 (GRCm39) E380G probably benign Het
Ttn T A 2: 76,624,976 (GRCm39) I15201F probably damaging Het
Vmn2r12 A G 5: 109,239,322 (GRCm39) S414P probably damaging Het
Vmn2r82 A T 10: 79,214,936 (GRCm39) K306N possibly damaging Het
Wdfy4 A T 14: 32,769,230 (GRCm39) Y2232* probably null Het
Wdr53 A G 16: 32,075,830 (GRCm39) D345G probably damaging Het
Zfp26 G A 9: 20,348,213 (GRCm39) R784C probably damaging Het
Zfp58 A T 13: 67,639,823 (GRCm39) C223S probably damaging Het
Zfp618 A G 4: 63,051,916 (GRCm39) H899R Het
Zfp963 A G 8: 70,195,692 (GRCm39) Y254H probably benign Het
Zfp994 T C 17: 22,421,764 (GRCm39) D17G probably damaging Het
Other mutations in Krt10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03179:Krt10 APN 11 99,280,044 (GRCm39) unclassified probably benign
Rough-fur UTSW 11 99,279,644 (GRCm39) missense probably damaging 0.99
FR4304:Krt10 UTSW 11 99,280,100 (GRCm39) unclassified probably benign
FR4304:Krt10 UTSW 11 99,277,025 (GRCm39) unclassified probably benign
FR4340:Krt10 UTSW 11 99,280,100 (GRCm39) unclassified probably benign
FR4340:Krt10 UTSW 11 99,277,028 (GRCm39) unclassified probably benign
FR4340:Krt10 UTSW 11 99,277,029 (GRCm39) unclassified probably benign
FR4342:Krt10 UTSW 11 99,277,029 (GRCm39) unclassified probably benign
FR4342:Krt10 UTSW 11 99,277,025 (GRCm39) unclassified probably benign
FR4449:Krt10 UTSW 11 99,280,093 (GRCm39) unclassified probably benign
FR4548:Krt10 UTSW 11 99,280,102 (GRCm39) unclassified probably benign
FR4548:Krt10 UTSW 11 99,280,099 (GRCm39) unclassified probably benign
FR4589:Krt10 UTSW 11 99,280,102 (GRCm39) unclassified probably benign
FR4737:Krt10 UTSW 11 99,280,105 (GRCm39) unclassified probably benign
FR4737:Krt10 UTSW 11 99,277,023 (GRCm39) unclassified probably benign
FR4737:Krt10 UTSW 11 99,280,099 (GRCm39) unclassified probably benign
R1386:Krt10 UTSW 11 99,276,746 (GRCm39) splice site probably benign
R1553:Krt10 UTSW 11 99,276,806 (GRCm39) nonsense probably null
R1737:Krt10 UTSW 11 99,278,213 (GRCm39) missense possibly damaging 0.81
R2082:Krt10 UTSW 11 99,279,701 (GRCm39) missense probably damaging 1.00
R2420:Krt10 UTSW 11 99,277,933 (GRCm39) missense possibly damaging 0.53
R3409:Krt10 UTSW 11 99,278,087 (GRCm39) missense probably damaging 1.00
R4027:Krt10 UTSW 11 99,277,019 (GRCm39) unclassified probably benign
R4042:Krt10 UTSW 11 99,277,819 (GRCm39) splice site probably null
R4043:Krt10 UTSW 11 99,277,819 (GRCm39) splice site probably null
R4915:Krt10 UTSW 11 99,278,334 (GRCm39) missense probably damaging 0.99
R5818:Krt10 UTSW 11 99,279,597 (GRCm39) missense probably damaging 1.00
R6546:Krt10 UTSW 11 99,278,221 (GRCm39) splice site probably null
R6762:Krt10 UTSW 11 99,277,883 (GRCm39) missense possibly damaging 0.90
R6925:Krt10 UTSW 11 99,279,677 (GRCm39) missense probably damaging 0.99
R6985:Krt10 UTSW 11 99,276,456 (GRCm39) missense possibly damaging 0.66
R7196:Krt10 UTSW 11 99,278,371 (GRCm39) missense probably damaging 1.00
R7772:Krt10 UTSW 11 99,279,913 (GRCm39) missense unknown
R7849:Krt10 UTSW 11 99,278,432 (GRCm39) missense probably damaging 1.00
R8354:Krt10 UTSW 11 99,280,086 (GRCm39) unclassified probably benign
R8404:Krt10 UTSW 11 99,278,359 (GRCm39) missense probably damaging 1.00
R8502:Krt10 UTSW 11 99,278,359 (GRCm39) missense probably damaging 1.00
R8969:Krt10 UTSW 11 99,278,434 (GRCm39) missense probably damaging 1.00
R9437:Krt10 UTSW 11 99,276,390 (GRCm39) missense probably benign 0.04
R9753:Krt10 UTSW 11 99,279,792 (GRCm39) missense unknown
RF057:Krt10 UTSW 11 99,277,025 (GRCm39) unclassified probably benign
RF062:Krt10 UTSW 11 99,280,090 (GRCm39) unclassified probably benign
RF062:Krt10 UTSW 11 99,277,025 (GRCm39) unclassified probably benign
X0024:Krt10 UTSW 11 99,278,848 (GRCm39) missense probably damaging 1.00
X0062:Krt10 UTSW 11 99,278,325 (GRCm39) missense probably null 1.00
Z1177:Krt10 UTSW 11 99,277,058 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCAGCCATTCGTAACGGATATTC -3'
(R):5'- CTACGAGGTCTTCCTGAATCCC -3'

Sequencing Primer
(F):5'- GCCATTCGTAACGGATATTCATACAC -3'
(R):5'- GAGGTCTTCCTGAATCCCATGTTTC -3'
Posted On 2022-08-09