Incidental Mutation 'R9588:Cyp3a25'
ID 722881
Institutional Source Beutler Lab
Gene Symbol Cyp3a25
Ensembl Gene ENSMUSG00000029630
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 25
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R9588 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 145914004-145946428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 145921699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 412 (Q412K)
Ref Sequence ENSEMBL: ENSMUSP00000065585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]
AlphaFold O09158
Predicted Effect probably benign
Transcript: ENSMUST00000068317
AA Change: Q412K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: Q412K

DomainStartEndE-ValueType
Pfam:p450 38 493 9.4e-129 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138870
SMART Domains Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 126 2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145062
SMART Domains Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 148 3.9e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 T C 2: 158,468,328 (GRCm39) F153L possibly damaging Het
Ano3 T C 2: 110,528,342 (GRCm39) K491E possibly damaging Het
Arhgap21 C A 2: 20,858,938 (GRCm39) C1252F possibly damaging Het
Bcat1 T C 6: 144,950,126 (GRCm39) N424S probably benign Het
Ccdc61 A G 7: 18,644,266 (GRCm39) probably benign Het
Cecr2 T C 6: 120,733,770 (GRCm39) S586P possibly damaging Het
Chd3 A G 11: 69,241,046 (GRCm39) C1516R probably damaging Het
Cops5 C A 1: 10,108,222 (GRCm39) R5L unknown Het
Cpne2 C A 8: 95,286,781 (GRCm39) P369Q possibly damaging Het
Dbn1 A G 13: 55,622,785 (GRCm39) V612A probably benign Het
Dnah17 T C 11: 118,012,783 (GRCm39) D426G probably benign Het
Dolpp1 T A 2: 30,282,515 (GRCm39) Y23N probably damaging Het
Egf T C 3: 129,511,617 (GRCm39) M517V probably benign Het
Fbxw27 ATGT AT 9: 109,602,322 (GRCm39) probably null Het
Foxc1 A T 13: 31,992,587 (GRCm39) H466L unknown Het
Hsf2bp A G 17: 32,241,810 (GRCm39) L78P probably damaging Het
Ikbkb G A 8: 23,151,410 (GRCm39) A738V unknown Het
Itgb8 G T 12: 119,140,754 (GRCm39) N374K probably benign Het
Kif16b T A 2: 142,553,804 (GRCm39) Q998L possibly damaging Het
Krtap11-1 A C 16: 89,368,062 (GRCm39) probably benign Het
Lamp3 T A 16: 19,494,832 (GRCm39) probably null Het
Lrrc43 A T 5: 123,641,307 (GRCm39) H497L probably damaging Het
Mmp1a C T 9: 7,467,225 (GRCm39) T267I probably benign Het
Mroh2b T A 15: 4,978,130 (GRCm39) D1299E probably benign Het
Ndst4 A C 3: 125,476,808 (GRCm39) H11P probably damaging Het
Oas1c A G 5: 120,946,202 (GRCm39) F99L probably benign Het
Or10s1 T C 9: 39,986,353 (GRCm39) L254P probably damaging Het
Or14c39 T A 7: 86,343,948 (GRCm39) C95S probably damaging Het
Or1j11 G T 2: 36,311,784 (GRCm39) A125S probably damaging Het
Or5w15 G A 2: 87,568,644 (GRCm39) T8I probably benign Het
Pcdhga3 A G 18: 37,808,564 (GRCm39) D339G probably damaging Het
Pcsk1 A T 13: 75,259,039 (GRCm39) N271I probably damaging Het
Pdilt A T 7: 119,100,870 (GRCm39) D160E probably benign Het
Psma4 A T 9: 54,862,245 (GRCm39) Q123L probably damaging Het
Selenbp2 A T 3: 94,605,368 (GRCm39) I127F possibly damaging Het
Setd5 A G 6: 113,121,025 (GRCm39) N1078S probably damaging Het
Sorl1 A C 9: 41,993,105 (GRCm39) Y306* probably null Het
Spata17 T C 1: 186,849,471 (GRCm39) K255E possibly damaging Het
Surf4 C A 2: 26,823,622 (GRCm39) probably benign Het
Tbc1d16 G T 11: 119,101,335 (GRCm39) H58Q probably damaging Het
Tfdp2 A G 9: 96,169,663 (GRCm39) T5A probably damaging Het
Thsd7b T G 1: 130,108,223 (GRCm39) C1313G probably damaging Het
Trmt44 A T 5: 35,727,256 (GRCm39) C320S probably damaging Het
Unc119b G A 5: 115,272,827 (GRCm39) T48M probably benign Het
Vit T A 17: 78,930,079 (GRCm39) I348N probably damaging Het
Vmn1r184 T A 7: 25,966,347 (GRCm39) M31K probably null Het
Vmn2r81 A G 10: 79,129,205 (GRCm39) T699A possibly damaging Het
Xrn1 A G 9: 95,920,756 (GRCm39) T1339A probably benign Het
Zfp827 T A 8: 79,905,604 (GRCm39) H860Q probably damaging Het
Other mutations in Cyp3a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Cyp3a25 APN 5 145,938,273 (GRCm39) nonsense probably null
IGL00430:Cyp3a25 APN 5 145,930,170 (GRCm39) missense probably damaging 1.00
IGL00803:Cyp3a25 APN 5 145,938,253 (GRCm39) splice site probably benign
IGL00928:Cyp3a25 APN 5 145,923,764 (GRCm39) missense possibly damaging 0.94
IGL01557:Cyp3a25 APN 5 145,921,711 (GRCm39) missense probably damaging 1.00
IGL01997:Cyp3a25 APN 5 145,931,766 (GRCm39) missense possibly damaging 0.92
IGL02140:Cyp3a25 APN 5 145,946,273 (GRCm39) splice site probably benign
IGL02267:Cyp3a25 APN 5 145,935,362 (GRCm39) missense possibly damaging 0.48
IGL02272:Cyp3a25 APN 5 145,930,075 (GRCm39) intron probably benign
IGL02327:Cyp3a25 APN 5 145,923,731 (GRCm39) missense possibly damaging 0.50
IGL02411:Cyp3a25 APN 5 145,938,257 (GRCm39) critical splice donor site probably benign
IGL02504:Cyp3a25 APN 5 145,930,141 (GRCm39) missense probably benign 0.03
IGL02653:Cyp3a25 APN 5 145,939,920 (GRCm39) missense possibly damaging 0.95
R0378:Cyp3a25 UTSW 5 145,923,652 (GRCm39) missense probably damaging 1.00
R0403:Cyp3a25 UTSW 5 145,935,323 (GRCm39) missense probably damaging 1.00
R0685:Cyp3a25 UTSW 5 145,935,356 (GRCm39) missense probably damaging 1.00
R0725:Cyp3a25 UTSW 5 145,931,746 (GRCm39) missense probably damaging 1.00
R0798:Cyp3a25 UTSW 5 145,928,343 (GRCm39) missense probably damaging 0.98
R1061:Cyp3a25 UTSW 5 145,923,643 (GRCm39) missense probably benign
R1519:Cyp3a25 UTSW 5 145,938,257 (GRCm39) critical splice donor site probably null
R1628:Cyp3a25 UTSW 5 145,938,273 (GRCm39) nonsense probably null
R1822:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1824:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1864:Cyp3a25 UTSW 5 145,931,739 (GRCm39) missense probably damaging 0.98
R2062:Cyp3a25 UTSW 5 145,923,779 (GRCm39) splice site probably benign
R2401:Cyp3a25 UTSW 5 145,923,778 (GRCm39) critical splice acceptor site probably null
R2516:Cyp3a25 UTSW 5 145,939,837 (GRCm39) splice site probably null
R3080:Cyp3a25 UTSW 5 145,935,341 (GRCm39) missense probably benign 0.33
R3236:Cyp3a25 UTSW 5 145,939,938 (GRCm39) splice site probably benign
R3694:Cyp3a25 UTSW 5 145,926,786 (GRCm39) splice site probably null
R3730:Cyp3a25 UTSW 5 145,939,891 (GRCm39) missense probably damaging 1.00
R4112:Cyp3a25 UTSW 5 145,939,841 (GRCm39) missense probably benign 0.18
R4258:Cyp3a25 UTSW 5 145,928,248 (GRCm39) missense probably damaging 1.00
R4651:Cyp3a25 UTSW 5 145,931,701 (GRCm39) missense probably benign 0.01
R4788:Cyp3a25 UTSW 5 145,921,892 (GRCm39) nonsense probably null
R4899:Cyp3a25 UTSW 5 145,914,481 (GRCm39) missense possibly damaging 0.59
R4926:Cyp3a25 UTSW 5 145,928,266 (GRCm39) missense probably damaging 1.00
R4952:Cyp3a25 UTSW 5 145,928,334 (GRCm39) missense probably benign 0.01
R5270:Cyp3a25 UTSW 5 145,918,312 (GRCm39) missense probably benign 0.36
R5595:Cyp3a25 UTSW 5 145,931,673 (GRCm39) critical splice donor site probably null
R5659:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R5787:Cyp3a25 UTSW 5 145,935,313 (GRCm39) missense probably benign 0.14
R6307:Cyp3a25 UTSW 5 145,931,766 (GRCm39) missense possibly damaging 0.92
R6380:Cyp3a25 UTSW 5 145,935,357 (GRCm39) missense probably damaging 0.99
R7055:Cyp3a25 UTSW 5 145,929,801 (GRCm39) missense probably benign 0.00
R7140:Cyp3a25 UTSW 5 145,939,855 (GRCm39) missense probably benign
R7189:Cyp3a25 UTSW 5 145,939,870 (GRCm39) missense probably benign 0.37
R7201:Cyp3a25 UTSW 5 145,939,868 (GRCm39) missense probably benign 0.00
R7201:Cyp3a25 UTSW 5 145,928,257 (GRCm39) missense probably benign 0.22
R7332:Cyp3a25 UTSW 5 145,929,817 (GRCm39) missense probably damaging 1.00
R7404:Cyp3a25 UTSW 5 145,923,635 (GRCm39) missense probably damaging 1.00
R7548:Cyp3a25 UTSW 5 145,923,735 (GRCm39) missense probably damaging 0.98
R7607:Cyp3a25 UTSW 5 145,921,791 (GRCm39) missense possibly damaging 0.87
R8022:Cyp3a25 UTSW 5 145,914,478 (GRCm39) missense probably benign 0.33
R8266:Cyp3a25 UTSW 5 145,929,796 (GRCm39) missense probably damaging 1.00
R8894:Cyp3a25 UTSW 5 145,931,670 (GRCm39) splice site probably benign
R9249:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R9691:Cyp3a25 UTSW 5 145,931,732 (GRCm39) missense probably benign 0.41
R9694:Cyp3a25 UTSW 5 145,923,685 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGCCACACCTTTTCTAAAAGTAC -3'
(R):5'- CATGGAGTACCTGGACATGG -3'

Sequencing Primer
(F):5'- GTACATCCCTCATAAGAGTGCC -3'
(R):5'- ACCTGGACATGGTGGTGAATG -3'
Posted On 2022-08-09