Incidental Mutation 'R9593:Map3k19'
| ID |
723073 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Map3k19
|
| Ensembl Gene |
ENSMUSG00000051590 |
| Gene Name |
mitogen-activated protein kinase kinase kinase 19 |
| Synonyms |
Ysk4 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
R9593 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
127742528-127782768 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 127778163 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 21
(C21R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146463
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000208183]
|
| AlphaFold |
E9Q3S4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208183
AA Change: C21R
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A130010J15Rik |
T |
A |
1: 192,857,087 (GRCm39) |
D146E |
probably benign |
Het |
| Acaca |
C |
T |
11: 84,271,339 (GRCm39) |
Q2058* |
probably null |
Het |
| Adam39 |
T |
A |
8: 41,279,744 (GRCm39) |
C712S |
possibly damaging |
Het |
| Aipl1 |
T |
C |
11: 71,921,161 (GRCm39) |
E219G |
probably benign |
Het |
| Ankrd24 |
A |
G |
10: 81,475,898 (GRCm39) |
R301G |
unknown |
Het |
| Arhgef17 |
A |
G |
7: 100,532,009 (GRCm39) |
F272L |
probably damaging |
Het |
| B3galt2 |
T |
A |
1: 143,522,604 (GRCm39) |
Y247N |
probably damaging |
Het |
| Bltp1 |
T |
C |
3: 37,002,090 (GRCm39) |
V1345A |
probably damaging |
Het |
| Bnip3l |
G |
A |
14: 67,246,214 (GRCm39) |
P7L |
possibly damaging |
Het |
| Cat |
T |
C |
2: 103,285,433 (GRCm39) |
E503G |
probably benign |
Het |
| Cemip2 |
T |
C |
19: 21,803,453 (GRCm39) |
S829P |
probably damaging |
Het |
| Coro1b |
T |
A |
19: 4,199,497 (GRCm39) |
V52E |
probably damaging |
Het |
| D6Ertd527e |
G |
C |
6: 87,088,839 (GRCm39) |
S334T |
unknown |
Het |
| Dip2c |
T |
A |
13: 9,704,683 (GRCm39) |
M1344K |
possibly damaging |
Het |
| Dnah5 |
A |
G |
15: 28,236,774 (GRCm39) |
I367V |
probably benign |
Het |
| Dock2 |
T |
C |
11: 34,178,607 (GRCm39) |
T1807A |
probably benign |
Het |
| Dusp10 |
T |
A |
1: 183,806,643 (GRCm39) |
F459I |
probably damaging |
Het |
| Elac1 |
A |
T |
18: 73,872,089 (GRCm39) |
L302Q |
probably benign |
Het |
| Entrep3 |
T |
A |
3: 89,091,199 (GRCm39) |
S57T |
probably benign |
Het |
| Fdx2 |
A |
T |
9: 20,979,097 (GRCm39) |
Y165N |
probably damaging |
Het |
| Gabra2 |
C |
T |
5: 71,165,353 (GRCm39) |
V206I |
possibly damaging |
Het |
| Gabrg1 |
T |
C |
5: 70,939,808 (GRCm39) |
E108G |
probably damaging |
Het |
| Gm29394 |
A |
G |
15: 57,932,722 (GRCm39) |
L5P |
probably benign |
Het |
| Gnb1l |
C |
T |
16: 18,362,914 (GRCm39) |
P101S |
probably benign |
Het |
| Hectd4 |
C |
A |
5: 121,424,844 (GRCm39) |
S749* |
probably null |
Het |
| Hmcn2 |
A |
G |
2: 31,244,742 (GRCm39) |
Y733C |
probably damaging |
Het |
| Inafm1 |
G |
A |
7: 16,007,059 (GRCm39) |
L53F |
probably damaging |
Het |
| Iqgap3 |
G |
A |
3: 88,011,657 (GRCm39) |
R814H |
probably damaging |
Het |
| Maz |
A |
G |
7: 126,624,924 (GRCm39) |
F199L |
probably damaging |
Het |
| Mis18bp1 |
A |
G |
12: 65,187,628 (GRCm39) |
I825T |
probably damaging |
Het |
| Mpp3 |
T |
A |
11: 101,907,506 (GRCm39) |
T211S |
possibly damaging |
Het |
| Mtrf1 |
T |
C |
14: 79,656,664 (GRCm39) |
Y389H |
probably damaging |
Het |
| Myo3b |
G |
A |
2: 70,075,648 (GRCm39) |
G579R |
probably benign |
Het |
| Nlrp4e |
T |
C |
7: 23,020,197 (GRCm39) |
V228A |
probably benign |
Het |
| Npepps |
T |
A |
11: 97,149,179 (GRCm39) |
|
probably null |
Het |
| Ntng1 |
A |
G |
3: 109,842,224 (GRCm39) |
L183P |
probably damaging |
Het |
| Or8c16 |
A |
G |
9: 38,130,868 (GRCm39) |
T247A |
probably benign |
Het |
| Pcdha4 |
A |
C |
18: 37,086,740 (GRCm39) |
I308L |
probably benign |
Het |
| Pear1 |
G |
T |
3: 87,658,480 (GRCm39) |
Q964K |
probably benign |
Het |
| Plekhg2 |
A |
T |
7: 28,059,710 (GRCm39) |
D1182E |
possibly damaging |
Het |
| Prr27 |
C |
A |
5: 87,990,994 (GRCm39) |
P202Q |
probably benign |
Het |
| Ptpn13 |
T |
A |
5: 103,674,998 (GRCm39) |
D658E |
possibly damaging |
Het |
| Ptprq |
T |
C |
10: 107,524,254 (GRCm39) |
Y493C |
possibly damaging |
Het |
| Rnd1 |
A |
G |
15: 98,570,526 (GRCm39) |
W107R |
probably damaging |
Het |
| Scn5a |
G |
A |
9: 119,315,839 (GRCm39) |
T1623M |
probably damaging |
Het |
| Sec23b |
T |
C |
2: 144,410,564 (GRCm39) |
I288T |
probably benign |
Het |
| Slfn14 |
T |
A |
11: 83,174,733 (GRCm39) |
H86L |
probably benign |
Het |
| Smchd1 |
G |
A |
17: 71,701,828 (GRCm39) |
H1055Y |
probably damaging |
Het |
| Sox13 |
G |
A |
1: 133,316,214 (GRCm39) |
P243S |
probably damaging |
Het |
| St3gal6 |
C |
A |
16: 58,305,136 (GRCm39) |
E109* |
probably null |
Het |
| Traf4 |
T |
C |
11: 78,056,253 (GRCm39) |
D5G |
possibly damaging |
Het |
| Trank1 |
G |
T |
9: 111,191,365 (GRCm39) |
C458F |
probably benign |
Het |
| Ttc41 |
T |
C |
10: 86,549,049 (GRCm39) |
F81S |
probably benign |
Het |
| Tulp1 |
C |
T |
17: 28,572,802 (GRCm39) |
W451* |
probably null |
Het |
| Tyms |
T |
C |
5: 30,269,110 (GRCm39) |
I171V |
|
Het |
| Vmn2r115 |
T |
A |
17: 23,578,184 (GRCm39) |
N552K |
probably damaging |
Het |
| Zfp710 |
T |
A |
7: 79,730,909 (GRCm39) |
S29T |
possibly damaging |
Het |
|
| Other mutations in Map3k19 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01126:Map3k19
|
APN |
1 |
127,752,068 (GRCm39) |
nonsense |
probably null |
|
|
IGL01367:Map3k19
|
APN |
1 |
127,752,088 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01443:Map3k19
|
APN |
1 |
127,766,244 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01481:Map3k19
|
APN |
1 |
127,750,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01530:Map3k19
|
APN |
1 |
127,749,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01603:Map3k19
|
APN |
1 |
127,758,010 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02044:Map3k19
|
APN |
1 |
127,751,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02159:Map3k19
|
APN |
1 |
127,750,907 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02296:Map3k19
|
APN |
1 |
127,751,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Map3k19
|
APN |
1 |
127,751,506 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02823:Map3k19
|
APN |
1 |
127,750,001 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02965:Map3k19
|
APN |
1 |
127,751,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03137:Map3k19
|
APN |
1 |
127,752,052 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0125:Map3k19
|
UTSW |
1 |
127,750,837 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0265:Map3k19
|
UTSW |
1 |
127,749,919 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0389:Map3k19
|
UTSW |
1 |
127,750,152 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0443:Map3k19
|
UTSW |
1 |
127,750,152 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0465:Map3k19
|
UTSW |
1 |
127,766,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Map3k19
|
UTSW |
1 |
127,749,919 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0759:Map3k19
|
UTSW |
1 |
127,745,162 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0815:Map3k19
|
UTSW |
1 |
127,762,375 (GRCm39) |
splice site |
probably benign |
|
|
R0838:Map3k19
|
UTSW |
1 |
127,751,696 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1173:Map3k19
|
UTSW |
1 |
127,751,617 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1174:Map3k19
|
UTSW |
1 |
127,751,617 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1175:Map3k19
|
UTSW |
1 |
127,751,617 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1457:Map3k19
|
UTSW |
1 |
127,745,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1661:Map3k19
|
UTSW |
1 |
127,745,393 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1665:Map3k19
|
UTSW |
1 |
127,745,393 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1753:Map3k19
|
UTSW |
1 |
127,750,417 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1944:Map3k19
|
UTSW |
1 |
127,750,859 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2496:Map3k19
|
UTSW |
1 |
127,750,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2878:Map3k19
|
UTSW |
1 |
127,751,530 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R2895:Map3k19
|
UTSW |
1 |
127,749,835 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3025:Map3k19
|
UTSW |
1 |
127,766,290 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4577:Map3k19
|
UTSW |
1 |
127,750,550 (GRCm39) |
nonsense |
probably null |
|
|
R4612:Map3k19
|
UTSW |
1 |
127,743,037 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4888:Map3k19
|
UTSW |
1 |
127,745,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4927:Map3k19
|
UTSW |
1 |
127,749,932 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5028:Map3k19
|
UTSW |
1 |
127,750,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5050:Map3k19
|
UTSW |
1 |
127,751,299 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5131:Map3k19
|
UTSW |
1 |
127,751,427 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5556:Map3k19
|
UTSW |
1 |
127,762,284 (GRCm39) |
nonsense |
probably null |
|
|
R5606:Map3k19
|
UTSW |
1 |
127,750,694 (GRCm39) |
missense |
probably benign |
|
|
R5617:Map3k19
|
UTSW |
1 |
127,750,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5755:Map3k19
|
UTSW |
1 |
127,750,118 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5854:Map3k19
|
UTSW |
1 |
127,758,092 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5952:Map3k19
|
UTSW |
1 |
127,750,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6132:Map3k19
|
UTSW |
1 |
127,778,213 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6175:Map3k19
|
UTSW |
1 |
127,750,569 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6261:Map3k19
|
UTSW |
1 |
127,750,336 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6471:Map3k19
|
UTSW |
1 |
127,744,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Map3k19
|
UTSW |
1 |
127,748,185 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6732:Map3k19
|
UTSW |
1 |
127,751,969 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6762:Map3k19
|
UTSW |
1 |
127,775,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7366:Map3k19
|
UTSW |
1 |
127,745,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7414:Map3k19
|
UTSW |
1 |
127,766,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7686:Map3k19
|
UTSW |
1 |
127,749,985 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Map3k19
|
UTSW |
1 |
127,756,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7849:Map3k19
|
UTSW |
1 |
127,751,383 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8129:Map3k19
|
UTSW |
1 |
127,750,420 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8134:Map3k19
|
UTSW |
1 |
127,751,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Map3k19
|
UTSW |
1 |
127,751,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8264:Map3k19
|
UTSW |
1 |
127,751,528 (GRCm39) |
missense |
|
|
|
R8305:Map3k19
|
UTSW |
1 |
127,745,007 (GRCm39) |
missense |
|
|
|
R8511:Map3k19
|
UTSW |
1 |
127,775,155 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8808:Map3k19
|
UTSW |
1 |
127,751,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Map3k19
|
UTSW |
1 |
127,750,363 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9025:Map3k19
|
UTSW |
1 |
127,758,175 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9681:Map3k19
|
UTSW |
1 |
127,750,097 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
Z1177:Map3k19
|
UTSW |
1 |
127,749,771 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTTTGTAAGGACTAGGAACGTGAG -3'
(R):5'- ACATCCTGCTTTTCCCATATAAAAG -3'
Sequencing Primer
(F):5'- CAGGAAGCCCTCAAGTTTCAGG -3'
(R):5'- GCTTTTCCCATATAAAAGAAGGAAGC -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation