Incidental Mutation 'R9593:Or8c16'
ID 723102
Institutional Source Beutler Lab
Gene Symbol Or8c16
Ensembl Gene ENSMUSG00000070311
Gene Name olfactory receptor family 8 subfamily C member 16
Synonyms Olfr894, MOR170-5, GA_x6K02T2PVTD-31898993-31899934
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R9593 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38130114-38131062 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38130868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 247 (T247A)
Ref Sequence ENSEMBL: ENSMUSP00000148501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093866] [ENSMUST00000212992]
AlphaFold Q9EQB2
Predicted Effect probably benign
Transcript: ENSMUST00000093866
AA Change: T250A

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000091389
Gene: ENSMUSG00000070311
AA Change: T250A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 8.8e-47 PFAM
Pfam:7tm_1 44 293 1.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212992
AA Change: T247A

PolyPhen 2 Score 0.196 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130010J15Rik T A 1: 192,857,087 (GRCm39) D146E probably benign Het
Acaca C T 11: 84,271,339 (GRCm39) Q2058* probably null Het
Adam39 T A 8: 41,279,744 (GRCm39) C712S possibly damaging Het
Aipl1 T C 11: 71,921,161 (GRCm39) E219G probably benign Het
Ankrd24 A G 10: 81,475,898 (GRCm39) R301G unknown Het
Arhgef17 A G 7: 100,532,009 (GRCm39) F272L probably damaging Het
B3galt2 T A 1: 143,522,604 (GRCm39) Y247N probably damaging Het
Bltp1 T C 3: 37,002,090 (GRCm39) V1345A probably damaging Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Cat T C 2: 103,285,433 (GRCm39) E503G probably benign Het
Cemip2 T C 19: 21,803,453 (GRCm39) S829P probably damaging Het
Coro1b T A 19: 4,199,497 (GRCm39) V52E probably damaging Het
D6Ertd527e G C 6: 87,088,839 (GRCm39) S334T unknown Het
Dip2c T A 13: 9,704,683 (GRCm39) M1344K possibly damaging Het
Dnah5 A G 15: 28,236,774 (GRCm39) I367V probably benign Het
Dock2 T C 11: 34,178,607 (GRCm39) T1807A probably benign Het
Dusp10 T A 1: 183,806,643 (GRCm39) F459I probably damaging Het
Elac1 A T 18: 73,872,089 (GRCm39) L302Q probably benign Het
Entrep3 T A 3: 89,091,199 (GRCm39) S57T probably benign Het
Fdx2 A T 9: 20,979,097 (GRCm39) Y165N probably damaging Het
Gabra2 C T 5: 71,165,353 (GRCm39) V206I possibly damaging Het
Gabrg1 T C 5: 70,939,808 (GRCm39) E108G probably damaging Het
Gm29394 A G 15: 57,932,722 (GRCm39) L5P probably benign Het
Gnb1l C T 16: 18,362,914 (GRCm39) P101S probably benign Het
Hectd4 C A 5: 121,424,844 (GRCm39) S749* probably null Het
Hmcn2 A G 2: 31,244,742 (GRCm39) Y733C probably damaging Het
Inafm1 G A 7: 16,007,059 (GRCm39) L53F probably damaging Het
Iqgap3 G A 3: 88,011,657 (GRCm39) R814H probably damaging Het
Map3k19 A G 1: 127,778,163 (GRCm39) C21R probably benign Het
Maz A G 7: 126,624,924 (GRCm39) F199L probably damaging Het
Mis18bp1 A G 12: 65,187,628 (GRCm39) I825T probably damaging Het
Mpp3 T A 11: 101,907,506 (GRCm39) T211S possibly damaging Het
Mtrf1 T C 14: 79,656,664 (GRCm39) Y389H probably damaging Het
Myo3b G A 2: 70,075,648 (GRCm39) G579R probably benign Het
Nlrp4e T C 7: 23,020,197 (GRCm39) V228A probably benign Het
Npepps T A 11: 97,149,179 (GRCm39) probably null Het
Ntng1 A G 3: 109,842,224 (GRCm39) L183P probably damaging Het
Pcdha4 A C 18: 37,086,740 (GRCm39) I308L probably benign Het
Pear1 G T 3: 87,658,480 (GRCm39) Q964K probably benign Het
Plekhg2 A T 7: 28,059,710 (GRCm39) D1182E possibly damaging Het
Prr27 C A 5: 87,990,994 (GRCm39) P202Q probably benign Het
Ptpn13 T A 5: 103,674,998 (GRCm39) D658E possibly damaging Het
Ptprq T C 10: 107,524,254 (GRCm39) Y493C possibly damaging Het
Rnd1 A G 15: 98,570,526 (GRCm39) W107R probably damaging Het
Scn5a G A 9: 119,315,839 (GRCm39) T1623M probably damaging Het
Sec23b T C 2: 144,410,564 (GRCm39) I288T probably benign Het
Slfn14 T A 11: 83,174,733 (GRCm39) H86L probably benign Het
Smchd1 G A 17: 71,701,828 (GRCm39) H1055Y probably damaging Het
Sox13 G A 1: 133,316,214 (GRCm39) P243S probably damaging Het
St3gal6 C A 16: 58,305,136 (GRCm39) E109* probably null Het
Traf4 T C 11: 78,056,253 (GRCm39) D5G possibly damaging Het
Trank1 G T 9: 111,191,365 (GRCm39) C458F probably benign Het
Ttc41 T C 10: 86,549,049 (GRCm39) F81S probably benign Het
Tulp1 C T 17: 28,572,802 (GRCm39) W451* probably null Het
Tyms T C 5: 30,269,110 (GRCm39) I171V Het
Vmn2r115 T A 17: 23,578,184 (GRCm39) N552K probably damaging Het
Zfp710 T A 7: 79,730,909 (GRCm39) S29T possibly damaging Het
Other mutations in Or8c16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Or8c16 APN 9 38,131,039 (GRCm39) missense probably benign 0.18
IGL01772:Or8c16 APN 9 38,130,905 (GRCm39) missense probably damaging 0.97
IGL02253:Or8c16 APN 9 38,131,031 (GRCm39) missense probably benign 0.01
IGL02279:Or8c16 APN 9 38,130,389 (GRCm39) missense probably benign 0.00
IGL03031:Or8c16 APN 9 38,130,361 (GRCm39) missense probably damaging 0.99
IGL03163:Or8c16 APN 9 38,130,710 (GRCm39) missense probably benign 0.00
R0417:Or8c16 UTSW 9 38,130,751 (GRCm39) missense probably benign 0.01
R0458:Or8c16 UTSW 9 38,130,344 (GRCm39) missense probably damaging 0.97
R1498:Or8c16 UTSW 9 38,130,676 (GRCm39) missense probably damaging 1.00
R1765:Or8c16 UTSW 9 38,130,548 (GRCm39) missense probably benign 0.01
R2020:Or8c16 UTSW 9 38,130,728 (GRCm39) missense possibly damaging 0.47
R2282:Or8c16 UTSW 9 38,130,124 (GRCm39) missense probably benign 0.01
R3928:Or8c16 UTSW 9 38,130,131 (GRCm39) start codon destroyed probably null 0.63
R4716:Or8c16 UTSW 9 38,130,714 (GRCm39) missense probably damaging 0.99
R4911:Or8c16 UTSW 9 38,130,392 (GRCm39) missense probably damaging 0.99
R5148:Or8c16 UTSW 9 38,130,317 (GRCm39) missense probably benign 0.01
R7677:Or8c16 UTSW 9 38,130,324 (GRCm39) missense probably damaging 1.00
R7971:Or8c16 UTSW 9 38,130,843 (GRCm39) missense probably benign 0.00
R8219:Or8c16 UTSW 9 38,130,668 (GRCm39) missense probably damaging 0.98
R8754:Or8c16 UTSW 9 38,130,865 (GRCm39) missense possibly damaging 0.56
R9248:Or8c16 UTSW 9 38,130,706 (GRCm39) missense probably benign 0.04
R9256:Or8c16 UTSW 9 38,130,498 (GRCm39) nonsense probably null
R9352:Or8c16 UTSW 9 38,130,683 (GRCm39) missense probably damaging 1.00
X0050:Or8c16 UTSW 9 38,130,446 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGATGTATGGTCAGGCTCAG -3'
(R):5'- CCAGGATTTCTTCATAGCAAGC -3'

Sequencing Primer
(F):5'- AGCTCTCCTGTAGTAGCACGTATG -3'
(R):5'- CATAGCAAGCTTGACATCCTTG -3'
Posted On 2022-08-09