Incidental Mutation 'R9597:Tafa4'
ID 723333
Institutional Source Beutler Lab
Gene Symbol Tafa4
Ensembl Gene ENSMUSG00000046500
Gene Name TAFA chemokine like family member 4
Synonyms Tafa4, Fam19a4, C130034I18Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R9597 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 96808164-97037374 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96991429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 7 (W7R)
Ref Sequence ENSEMBL: ENSMUSP00000086710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089295]
AlphaFold Q7TPG5
Predicted Effect probably benign
Transcript: ENSMUST00000089295
AA Change: W7R

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000086710
Gene: ENSMUSG00000046500
AA Change: W7R

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:TAFA 45 133 1.6e-50 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 T C 6: 142,578,813 (GRCm39) E952G possibly damaging Het
Abhd12 T C 2: 150,688,198 (GRCm39) I170V probably benign Het
Ankmy1 A G 1: 92,804,773 (GRCm39) V840A Het
Arhgap18 T A 10: 26,788,655 (GRCm39) V589D probably damaging Het
Armc7 A G 11: 115,379,712 (GRCm39) T137A probably benign Het
Bcl9 A T 3: 97,117,323 (GRCm39) I457K probably benign Het
Ccdc148 A T 2: 58,893,397 (GRCm39) Y78N probably benign Het
Ccdc24 A G 4: 117,729,348 (GRCm39) V43A probably damaging Het
Cep68 G A 11: 20,188,506 (GRCm39) T633I probably benign Het
Cfap157 T C 2: 32,669,753 (GRCm39) I277V probably benign Het
Clec4a2 C A 6: 123,116,291 (GRCm39) A152E probably benign Het
Crocc2 G T 1: 93,118,217 (GRCm39) C380F probably benign Het
Cyp2ab1 A T 16: 20,135,340 (GRCm39) M54K probably benign Het
Fbn1 C A 2: 125,187,906 (GRCm39) R1541L probably benign Het
Fem1c G T 18: 46,638,362 (GRCm39) L547I probably damaging Het
Firrm A T 1: 163,804,340 (GRCm39) L331Q probably null Het
Fras1 A G 5: 96,888,551 (GRCm39) D2699G probably damaging Het
Inpp5f A C 7: 128,278,515 (GRCm39) D435A possibly damaging Het
Kcnn2 T C 18: 45,816,149 (GRCm39) V460A probably benign Het
Krt81 T C 15: 101,358,919 (GRCm39) I278V probably benign Het
Lrp2 T A 2: 69,260,703 (GRCm39) E4509D probably benign Het
Mfsd14b C A 13: 65,221,414 (GRCm39) V293L probably benign Het
Myh2 G A 11: 67,064,302 (GRCm39) D86N possibly damaging Het
Naip6 T C 13: 100,436,646 (GRCm39) I626V probably benign Het
Neto1 T C 18: 86,422,821 (GRCm39) S93P possibly damaging Het
Obscn G T 11: 59,027,009 (GRCm39) R65S probably benign Het
Or52e8 A G 7: 104,624,413 (GRCm39) F264L probably benign Het
Pcdh7 A G 5: 57,877,197 (GRCm39) T251A possibly damaging Het
Pramel15 A T 4: 144,103,526 (GRCm39) V200E probably damaging Het
Prdm14 T C 1: 13,192,657 (GRCm39) K361E possibly damaging Het
Rgs2 A G 1: 143,877,826 (GRCm39) F125L probably damaging Het
Scd2 C A 19: 44,288,246 (GRCm39) Q213K probably damaging Het
Slc23a2 C A 2: 131,904,098 (GRCm39) R454L probably damaging Het
Smg1 T C 7: 117,812,270 (GRCm39) D31G unknown Het
Spata7 T A 12: 98,600,559 (GRCm39) N57K probably damaging Het
Spef2 T C 15: 9,599,897 (GRCm39) M1983V unknown Het
Srcap G T 7: 127,121,219 (GRCm39) R184L possibly damaging Het
Tbpl2 A G 2: 23,977,296 (GRCm39) S241P probably damaging Het
Tcaim A G 9: 122,637,830 (GRCm39) probably null Het
Tep1 G T 14: 51,100,465 (GRCm39) A351E probably damaging Het
Tiparp A G 3: 65,438,701 (GRCm39) T6A probably benign Het
Tmem62 T C 2: 120,829,567 (GRCm39) F437L probably benign Het
Tpp1 A T 7: 105,396,714 (GRCm39) H434Q probably benign Het
Vmn2r17 A G 5: 109,575,669 (GRCm39) Y180C probably damaging Het
Vmn2r52 A T 7: 9,904,719 (GRCm39) Y373* probably null Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Other mutations in Tafa4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1414:Tafa4 UTSW 6 96,991,440 (GRCm39) missense probably benign
R2427:Tafa4 UTSW 6 96,991,328 (GRCm39) splice site probably benign
R7994:Tafa4 UTSW 6 96,840,847 (GRCm39) missense probably damaging 1.00
R9497:Tafa4 UTSW 6 96,820,831 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- GCTTGTCAATCACCTGTGGC -3'
(R):5'- ATGTGTTGAAACCCAAGTCAATGTG -3'

Sequencing Primer
(F):5'- GTCAATCACCTGTGGCTAACG -3'
(R):5'- CCAAGTCAATGTGCAGGGC -3'
Posted On 2022-08-09