Incidental Mutation 'R9008:Lcorl'
ID 723626
Institutional Source Beutler Lab
Gene Symbol Lcorl
Ensembl Gene ENSMUSG00000015882
Gene Name ligand dependent nuclear receptor corepressor-like
Synonyms A830039H10Rik, Mlr1
MMRRC Submission 068838-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.305) question?
Stock # R9008 (G1)
Quality Score 196.009
Status Validated
Chromosome 5
Chromosomal Location 45854523-46014957 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 45931516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140503 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016026] [ENSMUST00000045586] [ENSMUST00000087164] [ENSMUST00000121573] [ENSMUST00000186633] [ENSMUST00000189859] [ENSMUST00000190036]
AlphaFold Q3U285
Predicted Effect probably benign
Transcript: ENSMUST00000016026
SMART Domains Protein: ENSMUSP00000016026
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Pfam:HTH_psq 276 313 5.1e-9 PFAM
Pfam:HTH_psq 525 570 1.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000045586
SMART Domains Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000087164
SMART Domains Protein: ENSMUSP00000084408
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Pfam:HTH_psq 193 230 3.4e-7 PFAM
Pfam:HTH_psq 442 487 9.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121573
SMART Domains Protein: ENSMUSP00000112416
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186633
Predicted Effect probably benign
Transcript: ENSMUST00000187615
Predicted Effect probably benign
Transcript: ENSMUST00000189859
SMART Domains Protein: ENSMUSP00000139996
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
Blast:ZnF_C2H2 16 38 1e-5 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000190036
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency 98% (78/80)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A T 14: 118,849,162 (GRCm39) S536R probably damaging Het
Acacb G A 5: 114,386,815 (GRCm39) silent Het
Acsm1 T C 7: 119,258,325 (GRCm39) Y473H probably benign Het
Adam30 T A 3: 98,070,034 (GRCm39) C622* probably null Het
Adprs C T 4: 126,210,632 (GRCm39) V283M probably damaging Het
AI606181 G T 19: 41,582,032 (GRCm39) R67S unknown Het
Btbd3 A G 2: 138,125,453 (GRCm39) I212M probably benign Het
C1s1 C T 6: 124,509,499 (GRCm39) probably null Het
C7 T A 15: 5,040,409 (GRCm39) T539S Het
Cd5l A C 3: 87,275,972 (GRCm39) D314A probably damaging Het
Celsr3 T A 9: 108,706,151 (GRCm39) V878E possibly damaging Het
Cfap74 T C 4: 155,503,121 (GRCm39) S38P Het
Chst2 C T 9: 95,288,347 (GRCm39) probably benign Het
Deaf1 T C 7: 140,904,078 (GRCm39) T103A probably damaging Het
Deup1 T A 9: 15,511,140 (GRCm39) D213V probably damaging Het
Dhrs1 A G 14: 55,978,638 (GRCm39) probably null Het
Dnah7a A G 1: 53,701,501 (GRCm39) V218A possibly damaging Het
Dock7 G A 4: 98,833,448 (GRCm39) Q1950* probably null Het
Ehf G A 2: 103,097,173 (GRCm39) R283W Het
Elovl3 A T 19: 46,123,087 (GRCm39) N221I possibly damaging Het
Gm11938 A T 11: 99,493,966 (GRCm39) V43E probably damaging Het
Hmcn1 T C 1: 150,630,795 (GRCm39) probably benign Het
Hnf4g A G 3: 3,708,096 (GRCm39) N115S probably benign Het
Hnrnpr A T 4: 136,056,737 (GRCm39) N246Y probably damaging Het
Itpka A G 2: 119,579,894 (GRCm39) E211G probably damaging Het
Krt78 TAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCACATTCTCCTCTAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCAGATTCTCTTCCAGGCATGGTCACCTGGCCTCCATATTCTCTTCCAGGCACGGTCACCTGGCCTCCA TAGGCACGGTCACCTGGCCTCCACATTCTCCTCTAGGCACGGTCACCTGGCCTCCATATTCTCTCCCAGGCACGGTCACCTGGCCTCCAGATTCTCTTCCAGGCATGGTCACCTGGCCTCCATATTCTCTTCCAGGCACGGTCACCTGGCCTCCA 15: 101,855,211 (GRCm39) probably benign Het
Lypd9 T A 11: 58,338,209 (GRCm39) E61V probably benign Het
Mgat5 T C 1: 127,407,308 (GRCm39) I658T probably damaging Het
Mier2 G A 10: 79,384,274 (GRCm39) R166W probably damaging Het
Mov10 A G 3: 104,707,332 (GRCm39) Y606H probably benign Het
Naa38 T G 11: 69,287,148 (GRCm39) V76G probably damaging Het
Nelfe C A 17: 35,073,334 (GRCm39) P290T possibly damaging Het
Nfil3 A T 13: 53,121,609 (GRCm39) Y432N probably damaging Het
Nipbl T C 15: 8,356,608 (GRCm39) K1593E probably damaging Het
Nlrc3 G C 16: 3,776,807 (GRCm39) L56V possibly damaging Het
Nlrp1a A T 11: 71,014,735 (GRCm39) F172I possibly damaging Het
Ntn4 T A 10: 93,569,466 (GRCm39) probably benign Het
Nudt2 G A 4: 41,480,288 (GRCm39) R57Q probably damaging Het
Obsl1 A C 1: 75,482,027 (GRCm39) L281W probably benign Het
Olfm4 A T 14: 80,255,607 (GRCm39) N250I unknown Het
Or10aa3 T A 1: 173,878,413 (GRCm39) V158E probably damaging Het
Or1x6 G A 11: 50,938,938 (GRCm39) M1I probably null Het
Or2m13 T A 16: 19,226,173 (GRCm39) I198F probably benign Het
Or2r2 T C 6: 42,463,903 (GRCm39) S75G probably damaging Het
Or5p50 A G 7: 107,422,628 (GRCm39) I16T possibly damaging Het
Pappa A T 4: 65,074,426 (GRCm39) T327S probably damaging Het
Pcdhb4 T G 18: 37,440,714 (GRCm39) M8R probably benign Het
Phf21b T A 15: 84,671,563 (GRCm39) I444F probably damaging Het
Pkd1l2 A C 8: 117,769,037 (GRCm39) V1205G probably benign Het
Plec T C 15: 76,060,232 (GRCm39) Y3235C probably damaging Het
Pnmt C T 11: 98,278,832 (GRCm39) T266I possibly damaging Het
Ppfia2 T A 10: 106,655,220 (GRCm39) D262E probably benign Het
Rabggta A T 14: 55,955,913 (GRCm39) L448Q probably damaging Het
Rap1gds1 C T 3: 138,661,177 (GRCm39) R449H probably benign Het
Rictor T A 15: 6,801,610 (GRCm39) probably benign Het
Rttn T C 18: 89,027,556 (GRCm39) F557S probably damaging Het
Ryr3 A G 2: 112,465,748 (GRCm39) C4809R probably damaging Het
Sacs A C 14: 61,441,992 (GRCm39) D1346A probably benign Het
Slain1 T A 14: 103,923,191 (GRCm39) S261T probably damaging Het
Slc22a4 C T 11: 53,881,664 (GRCm39) W351* probably null Het
Smpd3 C T 8: 106,984,058 (GRCm39) G554S probably benign Het
Spag17 C T 3: 99,934,942 (GRCm39) S716F possibly damaging Het
Spata31f1e C T 4: 42,792,546 (GRCm39) G529S probably benign Het
Spg11 C T 2: 121,900,413 (GRCm39) M1546I probably benign Het
Spmip11 T G 15: 98,486,493 (GRCm39) S88A possibly damaging Het
Stac3 C T 10: 127,339,454 (GRCm39) L117F probably damaging Het
Surf6 A G 2: 26,782,536 (GRCm39) W264R probably damaging Het
Taar7e T C 10: 23,913,810 (GRCm39) V100A probably damaging Het
Tenm3 T C 8: 48,795,688 (GRCm39) H534R probably damaging Het
Tinagl1 C A 4: 130,067,823 (GRCm39) R57L probably damaging Het
Tnfrsf11a G A 1: 105,754,854 (GRCm39) A309T possibly damaging Het
Traf6 A G 2: 101,527,333 (GRCm39) Y361C possibly damaging Het
Ttn A T 2: 76,777,334 (GRCm39) probably benign Het
Ufl1 A T 4: 25,254,778 (GRCm39) Y559* probably null Het
Upk1b A T 16: 38,607,570 (GRCm39) N52K probably damaging Het
Uqcrb A G 13: 67,053,363 (GRCm39) S5P probably benign Het
Use1 A G 8: 71,819,688 (GRCm39) Y3C unknown Het
Usp9y T A Y: 1,434,993 (GRCm39) I279L possibly damaging Het
Vmn1r142 A G 7: 21,862,796 (GRCm39) L222P probably damaging Het
Vmn1r184 A C 7: 25,967,177 (GRCm39) N308H probably benign Het
Vmn2r14 C A 5: 109,367,893 (GRCm39) M366I probably benign Het
Vmn2r73 G T 7: 85,521,904 (GRCm39) S145Y probably damaging Het
Wdfy1 A T 1: 79,692,697 (GRCm39) W207R probably damaging Het
Zbtb38 A T 9: 96,569,100 (GRCm39) N661K probably benign Het
Zkscan3 G T 13: 21,572,383 (GRCm39) H416Q possibly damaging Het
Other mutations in Lcorl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00780:Lcorl APN 5 45,904,637 (GRCm39) missense probably damaging 1.00
IGL01611:Lcorl APN 5 45,904,434 (GRCm39) missense probably damaging 1.00
IGL03014:Lcorl UTSW 5 45,931,371 (GRCm39) intron probably benign
R0070:Lcorl UTSW 5 45,891,043 (GRCm39) missense probably damaging 1.00
R0070:Lcorl UTSW 5 45,891,043 (GRCm39) missense probably damaging 1.00
R0499:Lcorl UTSW 5 45,891,711 (GRCm39) missense probably benign 0.00
R1518:Lcorl UTSW 5 45,891,543 (GRCm39) missense possibly damaging 0.94
R1817:Lcorl UTSW 5 45,952,688 (GRCm39) missense probably damaging 1.00
R1977:Lcorl UTSW 5 45,932,762 (GRCm39) missense probably null 0.16
R2171:Lcorl UTSW 5 45,904,493 (GRCm39) missense probably damaging 0.99
R3737:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3738:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3739:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3825:Lcorl UTSW 5 45,932,729 (GRCm39) splice site probably benign
R4035:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R4199:Lcorl UTSW 5 45,891,130 (GRCm39) missense possibly damaging 0.83
R4583:Lcorl UTSW 5 45,890,931 (GRCm39) nonsense probably null
R4647:Lcorl UTSW 5 45,890,931 (GRCm39) nonsense probably null
R4803:Lcorl UTSW 5 45,904,623 (GRCm39) unclassified probably null
R5524:Lcorl UTSW 5 45,932,865 (GRCm39) critical splice acceptor site probably null
R5524:Lcorl UTSW 5 45,932,864 (GRCm39) critical splice acceptor site probably null
R5526:Lcorl UTSW 5 45,891,069 (GRCm39) missense probably benign
R5533:Lcorl UTSW 5 45,891,219 (GRCm39) missense possibly damaging 0.47
R5772:Lcorl UTSW 5 45,952,709 (GRCm39) splice site probably null
R5927:Lcorl UTSW 5 45,882,766 (GRCm39) intron probably benign
R6175:Lcorl UTSW 5 45,933,832 (GRCm39) missense probably damaging 1.00
R6734:Lcorl UTSW 5 45,890,839 (GRCm39) missense probably damaging 0.98
R6864:Lcorl UTSW 5 45,904,546 (GRCm39) missense probably damaging 1.00
R7078:Lcorl UTSW 5 45,904,566 (GRCm39) missense probably damaging 1.00
R7396:Lcorl UTSW 5 46,014,801 (GRCm39) splice site probably null
R7624:Lcorl UTSW 5 45,859,307 (GRCm39) missense probably benign
R9354:Lcorl UTSW 5 45,890,968 (GRCm39) nonsense probably null
R9497:Lcorl UTSW 5 45,891,339 (GRCm39) missense probably benign
X0023:Lcorl UTSW 5 45,891,354 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTCCCAAACTGAGAGGTCAC -3'
(R):5'- TTCCCTGTGTGTTACTGAAATAGTG -3'

Sequencing Primer
(F):5'- TCCCAAACTGAGAGGTCACTAATATC -3'
(R):5'- GTGTGTTACTGAAATAGTGTTGGAG -3'
Posted On 2022-09-08