Incidental Mutation 'R9602:Vmn2r88'
| ID |
723750 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r88
|
| Ensembl Gene |
ENSMUSG00000000606 |
| Gene Name |
vomeronasal 2, receptor 88 |
| Synonyms |
V2r3, V2r13 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R9602 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
51410819-51419527 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 51413732 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 168
(S168T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125126
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022438]
[ENSMUST00000159674]
[ENSMUST00000162998]
[ENSMUST00000228139]
|
| AlphaFold |
L7N1W8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022438
AA Change: S176T
PolyPhen 2
Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000022438
Gene: ENSMUSG00000000606
AA Change: S176T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
457 |
8.3e-27 |
PFAM |
|
Pfam:NCD3G
|
516 |
570 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
1.9e-55 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000125126
Gene: ENSMUSG00000000606
AA Change: S168T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
30 |
408 |
3.2e-30 |
PFAM |
|
Pfam:NCD3G
|
463 |
516 |
1.2e-19 |
PFAM |
|
Pfam:7tm_3
|
546 |
785 |
3.7e-81 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162998
|
| SMART Domains |
Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Takusan
|
35 |
115 |
2.2e-25 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000124837
Gene: ENSMUSG00000000606
AA Change: S143T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
52 |
399 |
3.7e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228139
AA Change: S168T
PolyPhen 2
Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930563M21Rik |
G |
A |
9: 56,002,977 (GRCm38) |
S125L |
possibly damaging |
Het |
| Abca3 |
T |
C |
17: 24,398,404 (GRCm38) |
V1025A |
probably benign |
Het |
| Adam5 |
T |
C |
8: 24,813,386 (GRCm38) |
K175R |
probably damaging |
Het |
| Arhgap39 |
A |
C |
15: 76,726,754 (GRCm38) |
S885R |
probably damaging |
Het |
| Arhgef12 |
A |
G |
9: 42,984,380 (GRCm38) |
Y951H |
probably damaging |
Het |
| Bbs1 |
G |
A |
19: 4,891,055 (GRCm38) |
L544F |
probably damaging |
Het |
| Bcar1 |
C |
T |
8: 111,713,866 (GRCm38) |
E499K |
probably benign |
Het |
| Brinp3 |
C |
T |
1: 146,746,496 (GRCm38) |
T212I |
probably damaging |
Het |
| Cdh20 |
A |
T |
1: 104,941,098 (GRCm38) |
I105F |
probably benign |
Het |
| Cenpp |
T |
C |
13: 49,647,573 (GRCm38) |
E123G |
probably damaging |
Het |
| Col14a1 |
C |
A |
15: 55,487,949 (GRCm38) |
D1557E |
unknown |
Het |
| Col6a3 |
A |
T |
1: 90,803,775 (GRCm38) |
N1585K |
probably benign |
Het |
| Cox6a1 |
G |
A |
5: 115,348,875 (GRCm38) |
P26S |
unknown |
Het |
| Epb41l1 |
G |
T |
2: 156,525,148 (GRCm38) |
D646Y |
probably damaging |
Het |
| Fbxw10 |
G |
T |
11: 62,859,956 (GRCm38) |
R455L |
possibly damaging |
Het |
| Fmnl2 |
T |
C |
2: 53,123,575 (GRCm38) |
|
probably null |
Het |
| Gata3 |
T |
A |
2: 9,858,486 (GRCm38) |
I406F |
possibly damaging |
Het |
| Gm14406 |
C |
T |
2: 177,569,235 (GRCm38) |
G417D |
probably damaging |
Het |
| Gpr31b |
C |
T |
17: 13,051,884 (GRCm38) |
G133S |
possibly damaging |
Het |
| Gtf2h1 |
T |
A |
7: 46,806,795 (GRCm38) |
D196E |
possibly damaging |
Het |
| Hcn2 |
A |
G |
10: 79,726,294 (GRCm38) |
I375V |
probably benign |
Het |
| Kctd20 |
T |
C |
17: 28,961,468 (GRCm38) |
M72T |
probably benign |
Het |
| Klhl2 |
A |
T |
8: 64,752,662 (GRCm38) |
F408L |
probably damaging |
Het |
| Mllt10 |
T |
C |
2: 18,207,039 (GRCm38) |
V921A |
probably damaging |
Het |
| Mn1 |
A |
T |
5: 111,417,583 (GRCm38) |
|
probably benign |
Het |
| Mov10 |
A |
T |
3: 104,800,968 (GRCm38) |
D488E |
probably benign |
Het |
| Muc5b |
G |
T |
7: 141,863,474 (GRCm38) |
D3386Y |
probably benign |
Het |
| Myo15b |
G |
A |
11: 115,878,443 (GRCm38) |
|
probably null |
Het |
| Nudt7 |
T |
C |
8: 114,151,759 (GRCm38) |
F176L |
probably damaging |
Het |
| Obscn |
A |
G |
11: 59,090,559 (GRCm38) |
Y1878H |
probably damaging |
Het |
| Olfr785 |
A |
T |
10: 129,409,933 (GRCm38) |
D189V |
probably damaging |
Het |
| Pabpn1l |
T |
A |
8: 122,620,362 (GRCm38) |
T250S |
probably benign |
Het |
| Prr11 |
C |
T |
11: 87,097,172 (GRCm38) |
D302N |
possibly damaging |
Het |
| Prx |
T |
A |
7: 27,519,020 (GRCm38) |
V1121D |
possibly damaging |
Het |
| Ptcd1 |
A |
G |
5: 145,159,638 (GRCm38) |
V215A |
probably benign |
Het |
| Rasa3 |
T |
C |
8: 13,631,844 (GRCm38) |
D35G |
probably benign |
Het |
| Rbm5 |
A |
G |
9: 107,751,953 (GRCm38) |
S348P |
probably benign |
Het |
| Rmdn2 |
G |
A |
17: 79,668,011 (GRCm38) |
G310R |
probably damaging |
Het |
| Rnf114 |
T |
A |
2: 167,511,242 (GRCm38) |
C144* |
probably null |
Het |
| Rreb1 |
T |
C |
13: 37,930,501 (GRCm38) |
I612T |
probably damaging |
Het |
| Sdk1 |
A |
T |
5: 142,085,598 (GRCm38) |
D1181V |
probably damaging |
Het |
| Secisbp2l |
A |
T |
2: 125,767,436 (GRCm38) |
M324K |
probably benign |
Het |
| Slc14a1 |
C |
A |
18: 78,109,592 (GRCm38) |
A367S |
probably damaging |
Het |
| Slc22a6 |
G |
T |
19: 8,621,196 (GRCm38) |
E206* |
probably null |
Het |
| Smg5 |
T |
C |
3: 88,342,907 (GRCm38) |
C109R |
probably damaging |
Het |
| Socs7 |
A |
G |
11: 97,377,011 (GRCm38) |
T323A |
probably benign |
Het |
| Spen |
T |
C |
4: 141,477,872 (GRCm38) |
N1148S |
unknown |
Het |
| Tek |
C |
G |
4: 94,827,731 (GRCm38) |
I463M |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,885,013 (GRCm38) |
E7912K |
unknown |
Het |
| Ugt2b34 |
T |
C |
5: 86,906,304 (GRCm38) |
D206G |
probably damaging |
Het |
| Upk3a |
C |
T |
15: 85,021,263 (GRCm38) |
P191L |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,611,518 (GRCm38) |
L592* |
probably null |
Het |
| Vmn2r82 |
A |
G |
10: 79,379,046 (GRCm38) |
I288V |
probably benign |
Het |
| Wnt5a |
C |
A |
14: 28,518,338 (GRCm38) |
N148K |
probably benign |
Het |
| Yipf5 |
T |
C |
18: 40,212,081 (GRCm38) |
Y82C |
probably damaging |
Het |
| Zfp655 |
T |
A |
5: 145,244,663 (GRCm38) |
C444S |
probably benign |
Het |
| Zpr1 |
A |
G |
9: 46,273,365 (GRCm38) |
N57D |
probably benign |
Het |
|
| Other mutations in Vmn2r88 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r88
|
APN |
14 |
51,413,256 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,413,060 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,413,125 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,416,802 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
IGL02308:Vmn2r88
|
APN |
14 |
51,417,980 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL02481:Vmn2r88
|
APN |
14 |
51,414,154 (GRCm38) |
missense |
probably benign |
|
|
IGL02483:Vmn2r88
|
APN |
14 |
51,414,154 (GRCm38) |
missense |
probably benign |
|
|
IGL03241:Vmn2r88
|
APN |
14 |
51,418,373 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0052:Vmn2r88
|
UTSW |
14 |
51,418,700 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0070:Vmn2r88
|
UTSW |
14 |
51,414,140 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0799:Vmn2r88
|
UTSW |
14 |
51,414,502 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R0906:Vmn2r88
|
UTSW |
14 |
51,418,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1322:Vmn2r88
|
UTSW |
14 |
51,414,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1352:Vmn2r88
|
UTSW |
14 |
51,418,550 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1639:Vmn2r88
|
UTSW |
14 |
51,416,787 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1780:Vmn2r88
|
UTSW |
14 |
51,418,572 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r88
|
UTSW |
14 |
51,413,030 (GRCm38) |
splice site |
probably benign |
|
|
R1911:Vmn2r88
|
UTSW |
14 |
51,418,214 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2113:Vmn2r88
|
UTSW |
14 |
51,418,194 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2120:Vmn2r88
|
UTSW |
14 |
51,413,208 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2126:Vmn2r88
|
UTSW |
14 |
51,413,807 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2348:Vmn2r88
|
UTSW |
14 |
51,414,004 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2881:Vmn2r88
|
UTSW |
14 |
51,418,689 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2884:Vmn2r88
|
UTSW |
14 |
51,413,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3081:Vmn2r88
|
UTSW |
14 |
51,418,632 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3933:Vmn2r88
|
UTSW |
14 |
51,413,978 (GRCm38) |
missense |
probably benign |
0.44 |
|
R3967:Vmn2r88
|
UTSW |
14 |
51,413,190 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4091:Vmn2r88
|
UTSW |
14 |
51,415,426 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4378:Vmn2r88
|
UTSW |
14 |
51,413,289 (GRCm38) |
nonsense |
probably null |
|
|
R4397:Vmn2r88
|
UTSW |
14 |
51,417,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4418:Vmn2r88
|
UTSW |
14 |
51,418,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4609:Vmn2r88
|
UTSW |
14 |
51,418,074 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4647:Vmn2r88
|
UTSW |
14 |
51,418,793 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4672:Vmn2r88
|
UTSW |
14 |
51,418,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4684:Vmn2r88
|
UTSW |
14 |
51,413,334 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R4686:Vmn2r88
|
UTSW |
14 |
51,413,339 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4720:Vmn2r88
|
UTSW |
14 |
51,413,245 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5046:Vmn2r88
|
UTSW |
14 |
51,413,181 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5063:Vmn2r88
|
UTSW |
14 |
51,411,146 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5619:Vmn2r88
|
UTSW |
14 |
51,413,910 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5652:Vmn2r88
|
UTSW |
14 |
51,418,572 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6020:Vmn2r88
|
UTSW |
14 |
51,418,149 (GRCm38) |
nonsense |
probably null |
|
|
R6103:Vmn2r88
|
UTSW |
14 |
51,415,369 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6674:Vmn2r88
|
UTSW |
14 |
51,414,338 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6799:Vmn2r88
|
UTSW |
14 |
51,413,969 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7089:Vmn2r88
|
UTSW |
14 |
51,418,643 (GRCm38) |
missense |
|
|
|
R7104:Vmn2r88
|
UTSW |
14 |
51,413,796 (GRCm38) |
missense |
|
|
|
R7265:Vmn2r88
|
UTSW |
14 |
51,418,319 (GRCm38) |
missense |
|
|
|
R7316:Vmn2r88
|
UTSW |
14 |
51,414,255 (GRCm38) |
missense |
|
|
|
R7552:Vmn2r88
|
UTSW |
14 |
51,410,858 (GRCm38) |
splice site |
probably null |
|
|
R7611:Vmn2r88
|
UTSW |
14 |
51,413,997 (GRCm38) |
missense |
|
|
|
R7667:Vmn2r88
|
UTSW |
14 |
51,417,989 (GRCm38) |
missense |
|
|
|
R7682:Vmn2r88
|
UTSW |
14 |
51,418,449 (GRCm38) |
missense |
|
|
|
R7755:Vmn2r88
|
UTSW |
14 |
51,413,046 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7811:Vmn2r88
|
UTSW |
14 |
51,418,703 (GRCm38) |
missense |
|
|
|
R7882:Vmn2r88
|
UTSW |
14 |
51,413,046 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7957:Vmn2r88
|
UTSW |
14 |
51,413,132 (GRCm38) |
missense |
|
|
|
R7998:Vmn2r88
|
UTSW |
14 |
51,414,108 (GRCm38) |
missense |
|
|
|
R8142:Vmn2r88
|
UTSW |
14 |
51,414,107 (GRCm38) |
missense |
|
|
|
R8186:Vmn2r88
|
UTSW |
14 |
51,418,700 (GRCm38) |
missense |
|
|
|
R8348:Vmn2r88
|
UTSW |
14 |
51,418,796 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8448:Vmn2r88
|
UTSW |
14 |
51,418,796 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8483:Vmn2r88
|
UTSW |
14 |
51,413,073 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8783:Vmn2r88
|
UTSW |
14 |
51,414,066 (GRCm38) |
missense |
|
|
|
R8859:Vmn2r88
|
UTSW |
14 |
51,418,806 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8916:Vmn2r88
|
UTSW |
14 |
51,411,136 (GRCm38) |
missense |
|
|
|
R8936:Vmn2r88
|
UTSW |
14 |
51,418,526 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R9004:Vmn2r88
|
UTSW |
14 |
51,413,167 (GRCm38) |
missense |
|
|
|
R9038:Vmn2r88
|
UTSW |
14 |
51,414,033 (GRCm38) |
missense |
|
|
|
R9063:Vmn2r88
|
UTSW |
14 |
51,410,872 (GRCm38) |
start gained |
probably benign |
|
|
R9311:Vmn2r88
|
UTSW |
14 |
51,413,046 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9382:Vmn2r88
|
UTSW |
14 |
51,418,740 (GRCm38) |
missense |
|
|
|
R9483:Vmn2r88
|
UTSW |
14 |
51,411,184 (GRCm38) |
missense |
|
|
|
V5622:Vmn2r88
|
UTSW |
14 |
51,413,127 (GRCm38) |
missense |
probably benign |
|
|
X0024:Vmn2r88
|
UTSW |
14 |
51,413,832 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
X0025:Vmn2r88
|
UTSW |
14 |
51,416,802 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
Z1177:Vmn2r88
|
UTSW |
14 |
51,418,187 (GRCm38) |
missense |
|
|
|
Z1177:Vmn2r88
|
UTSW |
14 |
51,418,046 (GRCm38) |
frame shift |
probably null |
|
|
Z1190:Vmn2r88
|
UTSW |
14 |
51,413,201 (GRCm38) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCTAGGAATTTCAGACTTGTCAG -3'
(R):5'- ACAGATCCCATGCCTTTGG -3'
Sequencing Primer
(F):5'- GGAATTTCAGACTTGTCAGGAATAG -3'
(R):5'- GGCTTTCTTCTCTTAAATCTGAGAG -3'
|
| Posted On |
2022-09-12 |
Incidental Mutation