Incidental Mutation 'R9603:Foxs1'
ID 723770
Institutional Source Beutler Lab
Gene Symbol Foxs1
Ensembl Gene ENSMUSG00000074676
Gene Name forkhead box S1
Synonyms FREAC10, Fkh3, Fkhl18
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.319) question?
Stock # R9603 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 152773818-152775128 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 152774281 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 257 (C257W)
Ref Sequence ENSEMBL: ENSMUSP00000096806 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099200]
AlphaFold Q61574
Predicted Effect probably damaging
Transcript: ENSMUST00000099200
AA Change: C257W

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000096806
Gene: ENSMUSG00000074676
AA Change: C257W

DomainStartEndE-ValueType
FH 16 106 1.88e-60 SMART
low complexity region 269 283 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for one reporter allele display enhanced rotarod performance and increased male resistance to diet-induced obesity. Homozygotes for another reporter allele show impaired testicular vasculature, including blood accumulation in fetal testis and marked apoptosis of periendothelial cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A T 11: 54,225,911 (GRCm39) N317I probably damaging Het
Adam18 T A 8: 25,118,147 (GRCm39) S590C possibly damaging Het
Btrc G A 19: 45,459,526 (GRCm39) E103K probably benign Het
Cars1 A G 7: 143,112,929 (GRCm39) M766T possibly damaging Het
Cavin4 T C 4: 48,671,999 (GRCm39) V148A probably benign Het
Cdcp3 T C 7: 130,830,643 (GRCm39) V359A probably damaging Het
Cdkn2d T C 9: 21,202,139 (GRCm39) D36G possibly damaging Het
Cubn A T 2: 13,292,510 (GRCm39) D3224E probably damaging Het
Ebf1 A G 11: 44,509,006 (GRCm39) M1V probably null Het
Eif1ad7 T G 12: 88,238,727 (GRCm39) N11T unknown Het
Fcgbp A G 7: 27,802,563 (GRCm39) D1497G probably damaging Het
Fstl5 C T 3: 76,496,260 (GRCm39) P341L probably damaging Het
Fzd10 G A 5: 128,678,771 (GRCm39) G164S probably benign Het
Hrh3 C A 2: 179,742,444 (GRCm39) E395* probably null Het
Hsf4 G A 8: 105,999,435 (GRCm39) V318M probably damaging Het
Il21 T C 3: 37,281,949 (GRCm39) E65G possibly damaging Het
Kank1 A G 19: 25,408,289 (GRCm39) D1256G possibly damaging Het
Klhl22 A G 16: 17,594,915 (GRCm39) N348S possibly damaging Het
Krr1 T C 10: 111,812,672 (GRCm39) I94T probably damaging Het
Lpin2 A G 17: 71,550,410 (GRCm39) D724G probably damaging Het
Mn1 C A 5: 111,566,393 (GRCm39) P121Q probably damaging Het
Mphosph9 A T 5: 124,463,015 (GRCm39) L10* probably null Het
Mtus1 A T 8: 41,536,795 (GRCm39) V307E probably benign Het
Muc20 A G 16: 32,615,155 (GRCm39) L74P probably damaging Het
Nnat A G 2: 157,403,701 (GRCm39) *113W probably null Het
Or13a25 G T 7: 140,247,794 (GRCm39) C191F probably damaging Het
Or2f1b C T 6: 42,739,672 (GRCm39) Q229* probably null Het
Or4f14 A G 2: 111,743,128 (GRCm39) V49A possibly damaging Het
Or6b6 A T 7: 106,571,103 (GRCm39) Y149* probably null Het
Pkm T A 9: 59,577,831 (GRCm39) V216E probably damaging Het
Pla2g12a G A 3: 129,674,900 (GRCm39) V19I unknown Het
Pramel27 T C 4: 143,578,267 (GRCm39) S176P Het
Rai14 G A 15: 10,595,116 (GRCm39) Q136* probably null Het
Rnf150 T A 8: 83,717,208 (GRCm39) N238K possibly damaging Het
Rrp1 A G 10: 78,240,757 (GRCm39) probably null Het
Scaf8 T A 17: 3,246,070 (GRCm39) L720M possibly damaging Het
Slamf1 G T 1: 171,625,771 (GRCm39) V316L probably damaging Het
Slc14a1 C A 18: 78,152,807 (GRCm39) A367S probably damaging Het
Slc25a20 T C 9: 108,549,675 (GRCm39) F86L probably benign Het
Slc4a5 T G 6: 83,217,714 (GRCm39) S131A probably benign Het
Slitrk3 A G 3: 72,958,649 (GRCm39) I41T probably benign Het
Sntg1 A T 1: 8,748,198 (GRCm39) L94Q probably damaging Het
St18 T C 1: 6,915,811 (GRCm39) C819R probably damaging Het
St6galnac3 T A 3: 153,117,177 (GRCm39) D182V probably benign Het
Tubgcp2 T A 7: 139,584,789 (GRCm39) T549S probably benign Het
Vim A T 2: 13,579,148 (GRCm39) probably benign Het
Vmn2r118 C A 17: 55,899,837 (GRCm39) R689I probably damaging Het
Zbtb41 A T 1: 139,375,255 (GRCm39) E905V probably damaging Het
Zfyve9 A T 4: 108,499,288 (GRCm39) D1284E possibly damaging Het
Other mutations in Foxs1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01641:Foxs1 APN 2 152,774,232 (GRCm39) missense probably benign
IGL02304:Foxs1 APN 2 152,774,270 (GRCm39) missense probably benign 0.01
IGL02491:Foxs1 APN 2 152,774,721 (GRCm39) missense probably damaging 1.00
IGL03009:Foxs1 APN 2 152,774,849 (GRCm39) missense probably damaging 1.00
IGL03046:Foxs1 UTSW 2 152,774,484 (GRCm39) missense probably benign 0.00
R0158:Foxs1 UTSW 2 152,774,330 (GRCm39) missense probably damaging 1.00
R0324:Foxs1 UTSW 2 152,774,607 (GRCm39) missense probably benign 0.02
R1616:Foxs1 UTSW 2 152,774,559 (GRCm39) missense probably benign 0.37
R1915:Foxs1 UTSW 2 152,774,760 (GRCm39) missense probably damaging 0.99
R3113:Foxs1 UTSW 2 152,774,156 (GRCm39) missense probably benign 0.00
R4885:Foxs1 UTSW 2 152,774,301 (GRCm39) missense probably benign 0.00
R6084:Foxs1 UTSW 2 152,774,762 (GRCm39) missense possibly damaging 0.81
R6265:Foxs1 UTSW 2 152,774,098 (GRCm39) nonsense probably null
R6720:Foxs1 UTSW 2 152,774,640 (GRCm39) missense probably damaging 0.99
R6828:Foxs1 UTSW 2 152,775,048 (GRCm39) nonsense probably null
R6845:Foxs1 UTSW 2 152,774,619 (GRCm39) missense probably benign
R7456:Foxs1 UTSW 2 152,775,045 (GRCm39) missense probably benign
R7577:Foxs1 UTSW 2 152,774,361 (GRCm39) missense probably benign 0.01
R7746:Foxs1 UTSW 2 152,775,028 (GRCm39) missense probably benign
R7841:Foxs1 UTSW 2 152,774,907 (GRCm39) missense possibly damaging 0.88
R8985:Foxs1 UTSW 2 152,775,058 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AAGAAGAACATTCCCGGAGTC -3'
(R):5'- AGATGTGCTCGGCAAAGTC -3'

Sequencing Primer
(F):5'- CGGAGTCCGGTAAAGACAG -3'
(R):5'- TGCTCGGCAAAGTCTGGAG -3'
Posted On 2022-09-12