Incidental Mutation 'R9603:Slc14a1'
ID 723810
Institutional Source Beutler Lab
Gene Symbol Slc14a1
Ensembl Gene ENSMUSG00000059336
Gene Name solute carrier family 14 (urea transporter), member 1
Synonyms 2610507K20Rik, UT-B, 3021401A05Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9603 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 78143306-78185334 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 78152807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 367 (A367S)
Ref Sequence ENSEMBL: ENSMUSP00000125114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091813] [ENSMUST00000160292] [ENSMUST00000160639]
AlphaFold Q8VHL0
Predicted Effect probably damaging
Transcript: ENSMUST00000091813
AA Change: A311S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000089421
Gene: ENSMUSG00000059336
AA Change: A311S

DomainStartEndE-ValueType
Pfam:UT 52 356 1.6e-120 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000160292
AA Change: A367S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125114
Gene: ENSMUSG00000059336
AA Change: A367S

DomainStartEndE-ValueType
Pfam:UT 110 405 6.3e-112 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000160639
AA Change: A311S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125367
Gene: ENSMUSG00000059336
AA Change: A311S

DomainStartEndE-ValueType
Pfam:UT 52 356 1.6e-120 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for disruptions in this gene display a grossly normal phenotype although they have an inability to concentrate urea in urine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A T 11: 54,225,911 (GRCm39) N317I probably damaging Het
Adam18 T A 8: 25,118,147 (GRCm39) S590C possibly damaging Het
Btrc G A 19: 45,459,526 (GRCm39) E103K probably benign Het
Cars1 A G 7: 143,112,929 (GRCm39) M766T possibly damaging Het
Cavin4 T C 4: 48,671,999 (GRCm39) V148A probably benign Het
Cdcp3 T C 7: 130,830,643 (GRCm39) V359A probably damaging Het
Cdkn2d T C 9: 21,202,139 (GRCm39) D36G possibly damaging Het
Cubn A T 2: 13,292,510 (GRCm39) D3224E probably damaging Het
Ebf1 A G 11: 44,509,006 (GRCm39) M1V probably null Het
Eif1ad7 T G 12: 88,238,727 (GRCm39) N11T unknown Het
Fcgbp A G 7: 27,802,563 (GRCm39) D1497G probably damaging Het
Foxs1 A C 2: 152,774,281 (GRCm39) C257W probably damaging Het
Fstl5 C T 3: 76,496,260 (GRCm39) P341L probably damaging Het
Fzd10 G A 5: 128,678,771 (GRCm39) G164S probably benign Het
Hrh3 C A 2: 179,742,444 (GRCm39) E395* probably null Het
Hsf4 G A 8: 105,999,435 (GRCm39) V318M probably damaging Het
Il21 T C 3: 37,281,949 (GRCm39) E65G possibly damaging Het
Kank1 A G 19: 25,408,289 (GRCm39) D1256G possibly damaging Het
Klhl22 A G 16: 17,594,915 (GRCm39) N348S possibly damaging Het
Krr1 T C 10: 111,812,672 (GRCm39) I94T probably damaging Het
Lpin2 A G 17: 71,550,410 (GRCm39) D724G probably damaging Het
Mn1 C A 5: 111,566,393 (GRCm39) P121Q probably damaging Het
Mphosph9 A T 5: 124,463,015 (GRCm39) L10* probably null Het
Mtus1 A T 8: 41,536,795 (GRCm39) V307E probably benign Het
Muc20 A G 16: 32,615,155 (GRCm39) L74P probably damaging Het
Nnat A G 2: 157,403,701 (GRCm39) *113W probably null Het
Or13a25 G T 7: 140,247,794 (GRCm39) C191F probably damaging Het
Or2f1b C T 6: 42,739,672 (GRCm39) Q229* probably null Het
Or4f14 A G 2: 111,743,128 (GRCm39) V49A possibly damaging Het
Or6b6 A T 7: 106,571,103 (GRCm39) Y149* probably null Het
Pkm T A 9: 59,577,831 (GRCm39) V216E probably damaging Het
Pla2g12a G A 3: 129,674,900 (GRCm39) V19I unknown Het
Pramel27 T C 4: 143,578,267 (GRCm39) S176P Het
Rai14 G A 15: 10,595,116 (GRCm39) Q136* probably null Het
Rnf150 T A 8: 83,717,208 (GRCm39) N238K possibly damaging Het
Rrp1 A G 10: 78,240,757 (GRCm39) probably null Het
Scaf8 T A 17: 3,246,070 (GRCm39) L720M possibly damaging Het
Slamf1 G T 1: 171,625,771 (GRCm39) V316L probably damaging Het
Slc25a20 T C 9: 108,549,675 (GRCm39) F86L probably benign Het
Slc4a5 T G 6: 83,217,714 (GRCm39) S131A probably benign Het
Slitrk3 A G 3: 72,958,649 (GRCm39) I41T probably benign Het
Sntg1 A T 1: 8,748,198 (GRCm39) L94Q probably damaging Het
St18 T C 1: 6,915,811 (GRCm39) C819R probably damaging Het
St6galnac3 T A 3: 153,117,177 (GRCm39) D182V probably benign Het
Tubgcp2 T A 7: 139,584,789 (GRCm39) T549S probably benign Het
Vim A T 2: 13,579,148 (GRCm39) probably benign Het
Vmn2r118 C A 17: 55,899,837 (GRCm39) R689I probably damaging Het
Zbtb41 A T 1: 139,375,255 (GRCm39) E905V probably damaging Het
Zfyve9 A T 4: 108,499,288 (GRCm39) D1284E possibly damaging Het
Other mutations in Slc14a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Slc14a1 APN 18 78,147,288 (GRCm39) missense probably damaging 1.00
Glen_eyrie UTSW 18 78,153,273 (GRCm39) critical splice acceptor site probably null
R1726:Slc14a1 UTSW 18 78,159,681 (GRCm39) missense probably benign 0.21
R1889:Slc14a1 UTSW 18 78,152,912 (GRCm39) missense possibly damaging 0.95
R1895:Slc14a1 UTSW 18 78,152,912 (GRCm39) missense possibly damaging 0.95
R3946:Slc14a1 UTSW 18 78,154,607 (GRCm39) missense probably benign 0.00
R4066:Slc14a1 UTSW 18 78,154,592 (GRCm39) missense probably damaging 0.99
R5511:Slc14a1 UTSW 18 78,145,686 (GRCm39) missense probably benign 0.01
R5763:Slc14a1 UTSW 18 78,159,629 (GRCm39) missense probably benign 0.33
R6228:Slc14a1 UTSW 18 78,159,614 (GRCm39) missense probably damaging 1.00
R6294:Slc14a1 UTSW 18 78,153,273 (GRCm39) critical splice acceptor site probably null
R7157:Slc14a1 UTSW 18 78,145,626 (GRCm39) missense probably benign 0.00
R7486:Slc14a1 UTSW 18 78,154,739 (GRCm39) missense probably benign 0.00
R7657:Slc14a1 UTSW 18 78,156,879 (GRCm39) critical splice donor site probably null
R8010:Slc14a1 UTSW 18 78,159,704 (GRCm39) missense probably benign 0.09
R8028:Slc14a1 UTSW 18 78,159,727 (GRCm39) missense probably benign 0.00
R8322:Slc14a1 UTSW 18 78,145,656 (GRCm39) missense possibly damaging 0.73
R8347:Slc14a1 UTSW 18 78,154,646 (GRCm39) missense probably benign
R8996:Slc14a1 UTSW 18 78,156,911 (GRCm39) missense possibly damaging 0.47
R9058:Slc14a1 UTSW 18 78,145,785 (GRCm39) critical splice acceptor site probably null
R9183:Slc14a1 UTSW 18 78,154,598 (GRCm39) missense probably benign 0.04
R9490:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9602:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9604:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9605:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9607:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9609:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9658:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9660:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9661:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9663:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9728:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9730:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9731:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9733:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
R9788:Slc14a1 UTSW 18 78,152,807 (GRCm39) missense probably damaging 1.00
Z1177:Slc14a1 UTSW 18 78,147,275 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCTCTGCTCACACAGTTAGC -3'
(R):5'- GGGATGTTTCTCCTGATCCCAC -3'

Sequencing Primer
(F):5'- CTGCTCACACAGTTAGCTAGTGG -3'
(R):5'- AGAACAGCCTGCTCATTGTC -3'
Posted On 2022-09-12