Incidental Mutation 'R9604:Adgrg7'
ID |
723848 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrg7
|
Ensembl Gene |
ENSMUSG00000022755 |
Gene Name |
adhesion G protein-coupled receptor G7 |
Synonyms |
9130020O16Rik, Gpr128 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R9604 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
16 |
Chromosomal Location |
56544972-56616218 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 56597570 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Serine
at position 79
(F79S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000023437
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023437]
|
AlphaFold |
Q8BM96 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000023437
AA Change: F79S
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000023437 Gene: ENSMUSG00000022755 AA Change: F79S
Domain | Start | End | E-Value | Type |
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
SCOP:d1edmb_
|
52 |
76 |
1e-3 |
SMART |
GPS
|
376 |
424 |
6.16e-8 |
SMART |
Pfam:7tm_2
|
428 |
712 |
4.5e-40 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 37 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ankrd60 |
A |
T |
2: 173,412,987 (GRCm39) |
I167N |
probably benign |
Het |
Atp13a3 |
G |
T |
16: 30,168,506 (GRCm39) |
D494E |
probably damaging |
Het |
Cep83 |
A |
C |
10: 94,554,939 (GRCm39) |
H35P |
possibly damaging |
Het |
Cpne3 |
A |
G |
4: 19,555,477 (GRCm39) |
V6A |
probably benign |
Het |
Dnm3 |
G |
A |
1: 161,838,584 (GRCm39) |
A259V |
possibly damaging |
Het |
Eftud2 |
T |
C |
11: 102,737,056 (GRCm39) |
I575V |
probably benign |
Het |
Eif4g1 |
A |
G |
16: 20,500,255 (GRCm39) |
N676S |
possibly damaging |
Het |
Foxp1 |
TTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG |
TTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG |
6: 99,052,926 (GRCm39) |
|
probably benign |
Het |
Gal3st4 |
T |
A |
5: 138,264,011 (GRCm39) |
K329N |
probably benign |
Het |
Gm15446 |
T |
C |
5: 110,088,314 (GRCm39) |
V9A |
probably damaging |
Het |
Golim4 |
A |
T |
3: 75,815,435 (GRCm39) |
|
probably null |
Het |
Harbi1 |
T |
C |
2: 91,542,689 (GRCm39) |
V50A |
probably damaging |
Het |
Hcn2 |
T |
C |
10: 79,564,787 (GRCm39) |
C400R |
probably damaging |
Het |
Heatr6 |
T |
C |
11: 83,668,188 (GRCm39) |
M894T |
probably damaging |
Het |
Hid1 |
A |
T |
11: 115,243,466 (GRCm39) |
H527Q |
|
Het |
Ifitm1 |
C |
T |
7: 140,548,227 (GRCm39) |
A20V |
probably benign |
Het |
Klk1b11 |
T |
A |
7: 43,427,850 (GRCm39) |
L213Q |
|
Het |
Lepr |
A |
G |
4: 101,590,473 (GRCm39) |
Y17C |
probably benign |
Het |
N4bp3 |
A |
T |
11: 51,536,493 (GRCm39) |
V113E |
probably damaging |
Het |
Neb |
C |
T |
2: 52,182,680 (GRCm39) |
R1062K |
probably benign |
Het |
Nlrp4b |
T |
A |
7: 10,444,295 (GRCm39) |
N81K |
probably benign |
Het |
Nol6 |
A |
G |
4: 41,120,298 (GRCm39) |
I473T |
probably benign |
Het |
Nsd1 |
T |
A |
13: 55,381,807 (GRCm39) |
S344T |
probably benign |
Het |
Pals2 |
C |
A |
6: 50,173,597 (GRCm39) |
A487E |
probably benign |
Het |
Pde12 |
A |
G |
14: 26,390,008 (GRCm39) |
Y234H |
possibly damaging |
Het |
Pla2g4e |
C |
T |
2: 120,015,680 (GRCm39) |
C288Y |
probably benign |
Het |
Plekhd1 |
A |
G |
12: 80,739,731 (GRCm39) |
T27A |
probably damaging |
Het |
Pls1 |
T |
A |
9: 95,644,057 (GRCm39) |
I480F |
probably damaging |
Het |
Prom1 |
A |
G |
5: 44,187,075 (GRCm39) |
I394T |
probably damaging |
Het |
Ros1 |
A |
T |
10: 51,994,249 (GRCm39) |
C1365S |
probably damaging |
Het |
Rpgrip1l |
G |
A |
8: 92,031,433 (GRCm39) |
T148M |
possibly damaging |
Het |
Slc14a1 |
C |
A |
18: 78,152,807 (GRCm39) |
A367S |
probably damaging |
Het |
Tap1 |
A |
C |
17: 34,412,172 (GRCm39) |
D459A |
probably damaging |
Het |
Tas2r125 |
T |
C |
6: 132,887,023 (GRCm39) |
I137T |
probably benign |
Het |
Tent5a |
C |
A |
9: 85,206,677 (GRCm39) |
V374L |
probably benign |
Het |
Ubr4 |
T |
C |
4: 139,159,827 (GRCm39) |
|
probably null |
Het |
Vmn1r172 |
T |
C |
7: 23,359,193 (GRCm39) |
I26T |
possibly damaging |
Het |
|
Other mutations in Adgrg7 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01783:Adgrg7
|
APN |
16 |
56,568,282 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03122:Adgrg7
|
APN |
16 |
56,590,725 (GRCm39) |
splice site |
probably benign |
|
orchard
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
sevin
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
R0632:Adgrg7
|
UTSW |
16 |
56,562,952 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0673:Adgrg7
|
UTSW |
16 |
56,593,849 (GRCm39) |
missense |
possibly damaging |
0.48 |
R1690:Adgrg7
|
UTSW |
16 |
56,615,993 (GRCm39) |
missense |
probably damaging |
0.99 |
R2009:Adgrg7
|
UTSW |
16 |
56,582,236 (GRCm39) |
missense |
probably benign |
0.08 |
R2017:Adgrg7
|
UTSW |
16 |
56,553,169 (GRCm39) |
missense |
probably benign |
0.02 |
R2132:Adgrg7
|
UTSW |
16 |
56,588,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R2153:Adgrg7
|
UTSW |
16 |
56,572,791 (GRCm39) |
missense |
possibly damaging |
0.75 |
R2229:Adgrg7
|
UTSW |
16 |
56,572,766 (GRCm39) |
missense |
probably benign |
|
R2436:Adgrg7
|
UTSW |
16 |
56,582,308 (GRCm39) |
missense |
possibly damaging |
0.78 |
R2878:Adgrg7
|
UTSW |
16 |
56,570,817 (GRCm39) |
missense |
probably benign |
0.14 |
R2981:Adgrg7
|
UTSW |
16 |
56,570,769 (GRCm39) |
critical splice donor site |
probably null |
|
R4014:Adgrg7
|
UTSW |
16 |
56,562,651 (GRCm39) |
missense |
probably damaging |
1.00 |
R4023:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4024:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4026:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4551:Adgrg7
|
UTSW |
16 |
56,568,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R4834:Adgrg7
|
UTSW |
16 |
56,553,232 (GRCm39) |
missense |
probably damaging |
1.00 |
R5041:Adgrg7
|
UTSW |
16 |
56,550,711 (GRCm39) |
missense |
probably benign |
0.21 |
R5145:Adgrg7
|
UTSW |
16 |
56,562,682 (GRCm39) |
missense |
probably benign |
0.04 |
R5377:Adgrg7
|
UTSW |
16 |
56,550,669 (GRCm39) |
missense |
possibly damaging |
0.68 |
R5549:Adgrg7
|
UTSW |
16 |
56,570,790 (GRCm39) |
missense |
probably damaging |
1.00 |
R5915:Adgrg7
|
UTSW |
16 |
56,550,748 (GRCm39) |
splice site |
probably null |
|
R5957:Adgrg7
|
UTSW |
16 |
56,593,790 (GRCm39) |
missense |
probably damaging |
0.96 |
R6146:Adgrg7
|
UTSW |
16 |
56,593,829 (GRCm39) |
missense |
probably benign |
0.21 |
R6198:Adgrg7
|
UTSW |
16 |
56,597,556 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6233:Adgrg7
|
UTSW |
16 |
56,599,005 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6337:Adgrg7
|
UTSW |
16 |
56,572,788 (GRCm39) |
missense |
probably damaging |
0.96 |
R6633:Adgrg7
|
UTSW |
16 |
56,550,649 (GRCm39) |
missense |
probably benign |
0.05 |
R6693:Adgrg7
|
UTSW |
16 |
56,590,587 (GRCm39) |
missense |
probably damaging |
0.97 |
R6812:Adgrg7
|
UTSW |
16 |
56,616,161 (GRCm39) |
start gained |
probably benign |
|
R6841:Adgrg7
|
UTSW |
16 |
56,570,787 (GRCm39) |
missense |
probably damaging |
1.00 |
R6868:Adgrg7
|
UTSW |
16 |
56,593,839 (GRCm39) |
missense |
probably benign |
|
R7076:Adgrg7
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
R7146:Adgrg7
|
UTSW |
16 |
56,550,605 (GRCm39) |
missense |
probably damaging |
1.00 |
R7232:Adgrg7
|
UTSW |
16 |
56,597,515 (GRCm39) |
splice site |
probably null |
|
R7266:Adgrg7
|
UTSW |
16 |
56,590,674 (GRCm39) |
missense |
probably benign |
0.00 |
R7376:Adgrg7
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
R7390:Adgrg7
|
UTSW |
16 |
56,553,207 (GRCm39) |
missense |
probably damaging |
0.98 |
R7401:Adgrg7
|
UTSW |
16 |
56,562,781 (GRCm39) |
missense |
probably benign |
0.43 |
R7496:Adgrg7
|
UTSW |
16 |
56,553,220 (GRCm39) |
missense |
probably benign |
|
R7540:Adgrg7
|
UTSW |
16 |
56,570,792 (GRCm39) |
missense |
probably damaging |
1.00 |
R8147:Adgrg7
|
UTSW |
16 |
56,562,876 (GRCm39) |
missense |
probably damaging |
1.00 |
R8354:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
R8372:Adgrg7
|
UTSW |
16 |
56,616,114 (GRCm39) |
start gained |
probably benign |
|
R8393:Adgrg7
|
UTSW |
16 |
56,582,477 (GRCm39) |
missense |
probably damaging |
1.00 |
R8454:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
R8723:Adgrg7
|
UTSW |
16 |
56,582,282 (GRCm39) |
missense |
probably benign |
0.00 |
R8891:Adgrg7
|
UTSW |
16 |
56,572,762 (GRCm39) |
missense |
probably benign |
0.03 |
R9017:Adgrg7
|
UTSW |
16 |
56,553,211 (GRCm39) |
missense |
probably benign |
0.01 |
R9570:Adgrg7
|
UTSW |
16 |
56,570,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R9628:Adgrg7
|
UTSW |
16 |
56,553,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AGAGAGCTAATCCTAGTTGGGG -3'
(R):5'- AACCCAAGTCTGTATGGTGTAC -3'
Sequencing Primer
(F):5'- AGCTAATCCTAGTTGGGGGAATG -3'
(R):5'- AGTCTGTATGGTGTACATTTTAACAG -3'
|
Posted On |
2022-09-12 |