Incidental Mutation 'R9606:Or2t29'
ID 723883
Institutional Source Beutler Lab
Gene Symbol Or2t29
Ensembl Gene ENSMUSG00000064252
Gene Name olfactory receptor family 2 subfamily T member 29
Synonyms GA_x6K02T2NKPP-882068-883006, Olfr329-ps, MOR275-6P, Olfr329
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R9606 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58433273-58434309 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 58433753 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 196 (C196Y)
Ref Sequence ENSEMBL: ENSMUSP00000104450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108822] [ENSMUST00000108823] [ENSMUST00000219448]
AlphaFold M9MMK4
Predicted Effect probably damaging
Transcript: ENSMUST00000108822
AA Change: C196Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104450
Gene: ENSMUSG00000064252
AA Change: C196Y

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.6e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000108823
AA Change: C183Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104451
Gene: ENSMUSG00000064252
AA Change: C183Y

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.4e-35 PFAM
Pfam:7tm_4 137 281 5.8e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000219448
AA Change: C183Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik A G 8: 120,880,706 (GRCm39) Y286C probably damaging Het
Cacna1c T C 6: 118,587,455 (GRCm39) T1657A Het
Ccs A T 19: 4,882,897 (GRCm39) D151E probably benign Het
Cfap74 A G 4: 155,509,133 (GRCm39) T295A Het
Chmp4c A T 3: 10,432,222 (GRCm39) E44V probably damaging Het
Crybg2 A T 4: 133,801,383 (GRCm39) K539* probably null Het
Dgkg T C 16: 22,441,011 (GRCm39) M1V probably null Het
E2f2 T A 4: 135,911,743 (GRCm39) Y251* probably null Het
Fat2 T C 11: 55,180,093 (GRCm39) Y1416C probably damaging Het
Fgl2 T C 5: 21,577,991 (GRCm39) S93P possibly damaging Het
Hivep3 C T 4: 119,989,786 (GRCm39) T2079I probably damaging Het
Igfl3 A C 7: 17,913,920 (GRCm39) K90T possibly damaging Het
Lsamp A G 16: 41,709,292 (GRCm39) D74G probably benign Het
Mmrn2 C A 14: 34,119,654 (GRCm39) T211K possibly damaging Het
Mov10 A T 3: 104,707,664 (GRCm39) V570D probably benign Het
Mrc1 A T 2: 14,313,517 (GRCm39) Y916F probably benign Het
Myo10 CAGGTATAAAG CAG 15: 25,776,401 (GRCm39) probably null Het
Ndc1 T A 4: 107,246,686 (GRCm39) C370S probably damaging Het
Nln TGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAGAACTGCCCCAGC TGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAGAACTGCCCCAGC 13: 104,186,924 (GRCm39) probably null Het
Nrcam A T 12: 44,609,240 (GRCm39) N455I probably damaging Het
Nrp1 G A 8: 129,229,029 (GRCm39) E836K probably benign Het
Or5b120 A T 19: 13,479,943 (GRCm39) K79* probably null Het
Or6c216 A T 10: 129,678,625 (GRCm39) C95* probably null Het
Or8b1d A G 9: 38,558,620 (GRCm39) S67P probably damaging Het
Pcca T C 14: 122,901,717 (GRCm39) S287P probably damaging Het
Pitpnm3 T A 11: 71,955,069 (GRCm39) T482S probably benign Het
Pld2 C T 11: 70,445,893 (GRCm39) R676* probably null Het
Ppm1k T C 6: 57,491,057 (GRCm39) Y286C possibly damaging Het
Rb1 T C 14: 73,517,573 (GRCm39) N278D probably damaging Het
Sema3g T C 14: 30,943,783 (GRCm39) L221P probably damaging Het
Skint2 C T 4: 112,483,147 (GRCm39) T184I probably benign Het
Slc38a2 A G 15: 96,591,172 (GRCm39) F232S probably damaging Het
Snx6 T C 12: 54,814,811 (GRCm39) N170S probably benign Het
Sox9 T A 11: 112,673,416 (GRCm39) N2K probably damaging Het
Sp140l1 G C 1: 85,075,344 (GRCm39) probably null Het
Srpk2 T C 5: 23,729,604 (GRCm39) E345G probably benign Het
Tbc1d21 T C 9: 58,268,487 (GRCm39) M291V possibly damaging Het
Tekt2 T C 4: 126,218,693 (GRCm39) N20S probably benign Het
Tnxb T G 17: 34,914,578 (GRCm39) I1888S possibly damaging Het
Tsnaxip1 G A 8: 106,566,685 (GRCm39) E174K probably damaging Het
Ttc28 G A 5: 111,433,140 (GRCm39) R2058Q probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Ttyh2 T A 11: 114,601,667 (GRCm39) D430E probably benign Het
Ubr2 C T 17: 47,245,020 (GRCm39) G1669R probably damaging Het
Vcan A T 13: 89,853,491 (GRCm39) S490T probably damaging Het
Vmn1r86 T A 7: 12,836,741 (GRCm39) D45V probably damaging Het
Wdr12 A G 1: 60,127,226 (GRCm39) V143A possibly damaging Het
Zbtb18 T A 1: 177,274,989 (GRCm39) Y116* probably null Het
Zdbf2 C T 1: 63,342,536 (GRCm39) T305I possibly damaging Het
Zfp384 T A 6: 125,007,802 (GRCm39) M244K possibly damaging Het
Zfp423 A T 8: 88,414,595 (GRCm39) V1241D probably damaging Het
Zfp574 A G 7: 24,780,640 (GRCm39) Y554C probably damaging Het
Zfp616 T C 11: 73,976,220 (GRCm39) S830P probably damaging Het
Zfp839 A G 12: 110,834,776 (GRCm39) Y677C probably benign Het
Other mutations in Or2t29
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Or2t29 UTSW 11 58,433,988 (GRCm39) missense possibly damaging 0.76
R2426:Or2t29 UTSW 11 58,433,920 (GRCm39) nonsense probably null
R4805:Or2t29 UTSW 11 58,433,396 (GRCm39) missense probably benign 0.03
R6498:Or2t29 UTSW 11 58,433,408 (GRCm39) missense probably damaging 1.00
R7341:Or2t29 UTSW 11 58,433,533 (GRCm39) nonsense probably null
R7768:Or2t29 UTSW 11 58,433,693 (GRCm39) missense possibly damaging 0.94
R7768:Or2t29 UTSW 11 58,433,466 (GRCm39) missense probably damaging 0.99
R7957:Or2t29 UTSW 11 58,433,624 (GRCm39) missense probably damaging 1.00
R8416:Or2t29 UTSW 11 58,433,778 (GRCm39) missense possibly damaging 0.75
R9076:Or2t29 UTSW 11 58,433,782 (GRCm39) nonsense probably null
Z1186:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1187:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1188:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1189:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1190:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1191:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Z1192:Or2t29 UTSW 11 58,434,272 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTATAGACAGCAGCGCCATAG -3'
(R):5'- GACCGCTATGTGGCCATTTG -3'

Sequencing Primer
(F):5'- CAGTCATGTGGGAGGAGC -3'
(R):5'- GACCGCTATGTGGCCATTTGTTATC -3'
Posted On 2022-09-12