Incidental Mutation 'R9610:Mrps33'
ID 724141
Institutional Source Beutler Lab
Gene Symbol Mrps33
Ensembl Gene ENSMUSG00000029918
Gene Name mitochondrial ribosomal protein S33
Synonyms MRP-S33, PTD003, Gdap3, CGI-139
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.961) question?
Stock # R9610 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 39778738-39787870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39779422 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 91 (K91M)
Ref Sequence ENSEMBL: ENSMUSP00000031978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031978] [ENSMUST00000114797] [ENSMUST00000201461]
AlphaFold Q9D2R8
Predicted Effect probably damaging
Transcript: ENSMUST00000031978
AA Change: K91M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000031978
Gene: ENSMUSG00000029918
AA Change: K91M

DomainStartEndE-ValueType
Pfam:MRP-S33 7 96 2.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114797
Predicted Effect probably benign
Transcript: ENSMUST00000201461
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A T 18: 59,023,399 (GRCm39) T265S probably benign Het
Arhgef5 A G 6: 43,257,890 (GRCm39) I1311M probably damaging Het
Bcr T A 10: 74,990,743 (GRCm39) Y750N probably damaging Het
Bcr T A 10: 74,990,745 (GRCm39) Y750* probably null Het
Btbd16 T A 7: 130,407,595 (GRCm39) M295K probably benign Het
Ccdc88a T C 11: 29,427,316 (GRCm39) L1007P possibly damaging Het
Cnep1r1 A G 8: 88,860,457 (GRCm39) *126W probably null Het
Cstf1 T A 2: 172,214,984 (GRCm39) I35N probably benign Het
Cstpp1 T C 2: 91,135,127 (GRCm39) D111G probably damaging Het
Cul9 A G 17: 46,830,823 (GRCm39) L1690P possibly damaging Het
Dnm2 A T 9: 21,414,973 (GRCm39) K677* probably null Het
Dscaml1 C A 9: 45,579,522 (GRCm39) N356K possibly damaging Het
Dvl3 A G 16: 20,346,008 (GRCm39) D446G probably damaging Het
Ecm2 A G 13: 49,668,518 (GRCm39) N74D probably benign Het
Ecm2 A G 13: 49,681,216 (GRCm39) I450M probably damaging Het
Emc1 T A 4: 139,091,035 (GRCm39) D460E probably benign Het
Fhip2b T C 14: 70,824,258 (GRCm39) Y493C probably benign Het
Fuom T A 7: 139,679,828 (GRCm39) E121V possibly damaging Het
Fyco1 T C 9: 123,657,585 (GRCm39) T864A possibly damaging Het
Galk2 T C 2: 125,817,218 (GRCm39) Y336H probably damaging Het
Gcsh T A 8: 117,720,125 (GRCm39) Y14F probably benign Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Gucy2g T C 19: 55,194,605 (GRCm39) I937M probably damaging Het
Hsp90ab1 T C 17: 45,880,600 (GRCm39) I370M possibly damaging Het
Hypk T C 2: 121,288,154 (GRCm39) S72P probably damaging Het
Izumo1r T G 9: 14,811,840 (GRCm39) I183L possibly damaging Het
Kctd13 G T 7: 126,544,180 (GRCm39) G293C probably damaging Het
Kmt2d CTGTTG CTG 15: 98,743,057 (GRCm39) probably benign Het
Krt13 T C 11: 100,012,318 (GRCm39) S2G probably benign Het
Mark4 C A 7: 19,167,338 (GRCm39) R467L possibly damaging Het
Muc5ac T A 7: 141,350,078 (GRCm39) V608D possibly damaging Het
Myb G A 10: 21,030,627 (GRCm39) Q57* probably null Het
Or51f1 T G 7: 102,506,147 (GRCm39) H114P probably damaging Het
Peg10 GCAC GCACCAC 6: 4,756,452 (GRCm39) probably benign Het
Phldb3 G A 7: 24,328,372 (GRCm39) V639M probably damaging Het
Pip4k2c A C 10: 127,036,069 (GRCm39) L266R probably damaging Het
Plg T C 17: 12,609,213 (GRCm39) Y173H probably benign Het
Pmp22 G T 11: 63,024,065 (GRCm39) V25F probably benign Het
Ppp1r16b T A 2: 158,537,998 (GRCm39) Y40N probably damaging Het
Prl5a1 A G 13: 28,329,492 (GRCm39) E57G possibly damaging Het
Psmb10 A G 8: 106,664,144 (GRCm39) F75S probably benign Het
Ptprm C A 17: 67,000,483 (GRCm39) R1167M probably damaging Het
Rbm46 T C 3: 82,771,541 (GRCm39) H358R probably benign Het
Rgl1 A G 1: 152,397,115 (GRCm39) S684P probably benign Het
Rmnd5b T C 11: 51,517,869 (GRCm39) I162V probably damaging Het
Sh3d19 T C 3: 86,014,529 (GRCm39) V440A possibly damaging Het
Sik1 T A 17: 32,073,246 (GRCm39) K70M probably damaging Het
Slc44a4 C T 17: 35,147,793 (GRCm39) S611F probably benign Het
Stk32a A G 18: 43,430,620 (GRCm39) I177V probably benign Het
Syt7 G A 19: 10,421,459 (GRCm39) D548N probably benign Het
Tcf7l2 A G 19: 55,899,038 (GRCm39) D215G probably null Het
Tex14 T A 11: 87,377,084 (GRCm39) F143I probably damaging Het
Tjp3 A G 10: 81,119,411 (GRCm39) V26A possibly damaging Het
Tpx2 T A 2: 152,715,124 (GRCm39) V115D probably benign Het
Tubb2b C A 13: 34,311,742 (GRCm39) K350N probably damaging Het
Usf3 T C 16: 44,036,936 (GRCm39) V472A probably benign Het
Vps13b G T 15: 35,642,555 (GRCm39) G1389V possibly damaging Het
Vps39 T C 2: 120,172,485 (GRCm39) R183G probably damaging Het
Wnk4 G T 11: 101,159,250 (GRCm39) E556* probably null Het
Xpo7 T A 14: 70,925,617 (GRCm39) E474V probably benign Het
Zbtb18 A G 1: 177,275,341 (GRCm39) R234G probably null Het
Zc3h14 T A 12: 98,737,663 (GRCm39) I50N possibly damaging Het
Zfat A G 15: 68,051,655 (GRCm39) V713A possibly damaging Het
Zfp462 T C 4: 55,009,545 (GRCm39) S504P possibly damaging Het
Zmiz1 T C 14: 25,651,022 (GRCm39) V502A probably benign Het
Other mutations in Mrps33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Mrps33 APN 6 39,779,447 (GRCm39) nonsense probably null
R0544:Mrps33 UTSW 6 39,782,488 (GRCm39) missense possibly damaging 0.94
R1800:Mrps33 UTSW 6 39,779,429 (GRCm39) missense probably damaging 1.00
R2926:Mrps33 UTSW 6 39,782,438 (GRCm39) missense probably damaging 0.96
R6481:Mrps33 UTSW 6 39,782,304 (GRCm39) critical splice donor site probably null
R6722:Mrps33 UTSW 6 39,782,599 (GRCm39) start gained probably benign
R6781:Mrps33 UTSW 6 39,782,757 (GRCm39) start gained probably benign
R7440:Mrps33 UTSW 6 39,779,413 (GRCm39) missense probably damaging 1.00
R9233:Mrps33 UTSW 6 39,782,447 (GRCm39) missense probably benign
R9440:Mrps33 UTSW 6 39,782,364 (GRCm39) nonsense probably null
R9611:Mrps33 UTSW 6 39,779,422 (GRCm39) missense probably damaging 1.00
Z1186:Mrps33 UTSW 6 39,779,449 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TTATCTTCAAGAAACCAGTCACAGC -3'
(R):5'- ATAGGTTGGGTCCTCTCTGC -3'

Sequencing Primer
(F):5'- GCTTAACTGAAGTAAAACGTGAACAC -3'
(R):5'- TCTGTTCACCAAACTAAGCATGTGC -3'
Posted On 2022-09-12