Incidental Mutation 'R9612:Tns2'
| ID |
724349 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tns2
|
| Ensembl Gene |
ENSMUSG00000037003 |
| Gene Name |
tensin 2 |
| Synonyms |
nep, Tenc1, nph |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9612 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
102008848-102024836 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 102015577 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 160
(E160K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129146
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046144]
[ENSMUST00000169627]
[ENSMUST00000228958]
[ENSMUST00000229592]
[ENSMUST00000230474]
|
| AlphaFold |
Q8CGB6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000046144
AA Change: E160K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000041087
Gene: ENSMUSG00000037003
AA Change: E160K
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
79 |
2.78e-9 |
SMART |
|
SCOP:d1d5ra2
|
128 |
295 |
8e-24 |
SMART |
|
PTEN_C2
|
297 |
424 |
6.63e-40 |
SMART |
|
low complexity region
|
494 |
513 |
N/A |
INTRINSIC |
|
SH2
|
1136 |
1236 |
1.69e-16 |
SMART |
|
PTB
|
1269 |
1407 |
6.66e-28 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169627
AA Change: E160K
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000129146
Gene: ENSMUSG00000037003
AA Change: E160K
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
79 |
2.78e-9 |
SMART |
|
SCOP:d1d5ra2
|
128 |
295 |
8e-24 |
SMART |
|
PTEN_C2
|
297 |
424 |
6.63e-40 |
SMART |
|
low complexity region
|
494 |
513 |
N/A |
INTRINSIC |
|
SH2
|
1129 |
1229 |
1.69e-16 |
SMART |
|
PTB
|
1262 |
1400 |
6.66e-28 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228958
AA Change: E160K
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000229592
AA Change: E137K
PolyPhen 2
Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000230474
AA Change: E152K
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Affected mice homozygous for a spontaneous deletion show reduced female fertility, increased blood urea nitrogen, low hematocrit, proteinuria, hypoproteinemia, hypercholesterolemia, small kidneys with a yellowish granular surface, glomerular lesions and premature death; some develop systemic edema. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610021A01Rik |
T |
C |
7: 41,276,327 (GRCm39) |
S677P |
possibly damaging |
Het |
| 5730480H06Rik |
A |
G |
5: 48,531,872 (GRCm39) |
I67V |
probably benign |
Het |
| Adam15 |
T |
A |
3: 89,249,247 (GRCm39) |
Y736F |
probably damaging |
Het |
| Adam29 |
A |
T |
8: 56,325,118 (GRCm39) |
F445L |
possibly damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,641,082 (GRCm39) |
Y3318H |
probably damaging |
Het |
| Akap6 |
A |
G |
12: 52,958,690 (GRCm39) |
Y815C |
probably damaging |
Het |
| Ankar |
T |
A |
1: 72,704,294 (GRCm39) |
D876V |
possibly damaging |
Het |
| Atp6v1g2 |
G |
A |
17: 35,456,733 (GRCm39) |
V106I |
probably benign |
Het |
| Bdp1 |
A |
G |
13: 100,214,370 (GRCm39) |
S490P |
probably benign |
Het |
| Bet1 |
A |
T |
6: 4,077,918 (GRCm39) |
V107D |
probably damaging |
Het |
| Bri3bp |
T |
C |
5: 125,531,390 (GRCm39) |
V112A |
probably damaging |
Het |
| Cage1 |
T |
A |
13: 38,216,351 (GRCm39) |
D33V |
probably damaging |
Het |
| Ccdc146 |
G |
T |
5: 21,535,577 (GRCm39) |
A159E |
probably damaging |
Het |
| Ccnl1 |
C |
A |
3: 65,865,404 (GRCm39) |
G49V |
probably damaging |
Het |
| Cdk13 |
A |
C |
13: 17,926,440 (GRCm39) |
F787V |
|
Het |
| Cdk5r1 |
T |
C |
11: 80,368,480 (GRCm39) |
V49A |
probably benign |
Het |
| Cdon |
G |
A |
9: 35,398,201 (GRCm39) |
V973I |
probably damaging |
Het |
| Cfap298 |
A |
T |
16: 90,724,275 (GRCm39) |
M166K |
probably benign |
Het |
| Chd1l |
T |
A |
3: 97,488,463 (GRCm39) |
K518* |
probably null |
Het |
| Col24a1 |
A |
G |
3: 145,250,960 (GRCm39) |
D1653G |
probably benign |
Het |
| Cstf3 |
G |
T |
2: 104,483,370 (GRCm39) |
V359F |
possibly damaging |
Het |
| Dchs2 |
T |
C |
3: 83,178,193 (GRCm39) |
I1082T |
probably damaging |
Het |
| Dlec1 |
A |
T |
9: 118,956,533 (GRCm39) |
I736F |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,818,475 (GRCm39) |
N3288D |
probably benign |
Het |
| Dpcd |
G |
T |
19: 45,560,422 (GRCm39) |
E82* |
probably null |
Het |
| Ehbp1 |
T |
C |
11: 22,119,124 (GRCm39) |
D182G |
probably damaging |
Het |
| Eif1ad13 |
A |
G |
12: 87,762,507 (GRCm39) |
I76V |
probably benign |
Het |
| Evc2 |
G |
T |
5: 37,544,130 (GRCm39) |
E626D |
probably benign |
Het |
| Evi5 |
T |
C |
5: 107,943,578 (GRCm39) |
E589G |
probably benign |
Het |
| Exoc4 |
T |
C |
6: 33,226,161 (GRCm39) |
I25T |
probably benign |
Het |
| Extl2 |
T |
A |
3: 115,821,145 (GRCm39) |
*331R |
probably null |
Het |
| Fkbp8 |
G |
A |
8: 70,984,324 (GRCm39) |
R225H |
probably damaging |
Het |
| Foxred2 |
A |
T |
15: 77,836,206 (GRCm39) |
S384T |
probably damaging |
Het |
| Garre1 |
A |
T |
7: 33,947,656 (GRCm39) |
C451S |
probably damaging |
Het |
| Glmn |
T |
C |
5: 107,741,731 (GRCm39) |
E18G |
probably damaging |
Het |
| Gm7489 |
A |
C |
15: 53,749,369 (GRCm39) |
Q147P |
unknown |
Het |
| Gm7489 |
C |
A |
15: 53,749,368 (GRCm39) |
Q147K |
unknown |
Het |
| Gm8005 |
T |
A |
14: 42,260,355 (GRCm39) |
I94F |
|
Het |
| Golgb1 |
G |
A |
16: 36,739,967 (GRCm39) |
V2810M |
probably benign |
Het |
| Gpr21 |
T |
C |
2: 37,408,399 (GRCm39) |
L315P |
probably damaging |
Het |
| Grip1 |
G |
A |
10: 119,874,569 (GRCm39) |
E778K |
possibly damaging |
Het |
| Herc6 |
T |
G |
6: 57,629,017 (GRCm39) |
S643A |
probably benign |
Het |
| Igkv14-100 |
T |
A |
6: 68,496,317 (GRCm39) |
I70N |
probably damaging |
Het |
| Kcnn3 |
A |
G |
3: 89,516,703 (GRCm39) |
M371V |
probably benign |
Het |
| Kif1a |
T |
A |
1: 92,953,416 (GRCm39) |
H1256L |
probably damaging |
Het |
| Klhdc4 |
A |
G |
8: 122,527,917 (GRCm39) |
S266P |
possibly damaging |
Het |
| Kmt2d |
CTGTTG |
CTG |
15: 98,743,057 (GRCm39) |
|
probably benign |
Het |
| Lefty2 |
T |
A |
1: 180,722,286 (GRCm39) |
L208Q |
probably damaging |
Het |
| Lingo2 |
T |
C |
4: 35,708,450 (GRCm39) |
Y510C |
probably damaging |
Het |
| Lrif1 |
T |
A |
3: 106,639,200 (GRCm39) |
V70D |
probably damaging |
Het |
| Lrrc74a |
A |
T |
12: 86,805,345 (GRCm39) |
K389I |
possibly damaging |
Het |
| Megf8 |
A |
T |
7: 25,054,488 (GRCm39) |
E1868V |
probably benign |
Het |
| Mmp1a |
TG |
TGG |
9: 7,465,083 (GRCm38) |
|
probably null |
Het |
| Mmp8 |
A |
G |
9: 7,560,608 (GRCm39) |
D95G |
probably damaging |
Het |
| Mmrn1 |
T |
A |
6: 60,953,408 (GRCm39) |
I563N |
probably damaging |
Het |
| Mroh3 |
T |
C |
1: 136,118,713 (GRCm39) |
T535A |
probably benign |
Het |
| Mroh9 |
A |
G |
1: 162,866,498 (GRCm39) |
L715P |
probably damaging |
Het |
| Myh6 |
G |
T |
14: 55,201,054 (GRCm39) |
A136E |
probably benign |
Het |
| Myom1 |
G |
T |
17: 71,412,475 (GRCm39) |
E1231* |
probably null |
Het |
| Nod2 |
G |
T |
8: 89,397,101 (GRCm39) |
C837F |
probably benign |
Het |
| Nos2 |
T |
A |
11: 78,839,984 (GRCm39) |
W698R |
probably damaging |
Het |
| Nup210l |
C |
T |
3: 90,107,173 (GRCm39) |
P1570L |
probably benign |
Het |
| Oas1a |
A |
T |
5: 121,040,028 (GRCm39) |
S188T |
possibly damaging |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Opa1 |
T |
C |
16: 29,430,255 (GRCm39) |
M394T |
|
Het |
| Or1e1d-ps1 |
T |
A |
11: 73,819,375 (GRCm39) |
D108E |
possibly damaging |
Het |
| Or5an6 |
A |
T |
19: 12,371,983 (GRCm39) |
M119L |
probably damaging |
Het |
| Or5p66 |
A |
G |
7: 107,885,487 (GRCm39) |
M282T |
probably benign |
Het |
| Or7g21 |
T |
A |
9: 19,032,760 (GRCm39) |
S167T |
probably benign |
Het |
| Or7g29 |
A |
G |
9: 19,286,677 (GRCm39) |
S167P |
possibly damaging |
Het |
| Oxct2a |
T |
A |
4: 123,217,129 (GRCm39) |
D84V |
probably damaging |
Het |
| Oxct2b |
A |
C |
4: 123,011,019 (GRCm39) |
D313A |
probably damaging |
Het |
| Phldb3 |
G |
A |
7: 24,328,372 (GRCm39) |
V639M |
probably damaging |
Het |
| Plppr4 |
T |
A |
3: 117,115,610 (GRCm39) |
N749I |
probably benign |
Het |
| Pmp22 |
G |
T |
11: 63,024,065 (GRCm39) |
V25F |
probably benign |
Het |
| Pofut2 |
A |
T |
10: 77,101,763 (GRCm39) |
M267L |
probably benign |
Het |
| Ppp1r42 |
T |
A |
1: 10,039,067 (GRCm39) |
N351I |
possibly damaging |
Het |
| Prl2b1 |
T |
C |
13: 27,572,479 (GRCm39) |
E37G |
probably benign |
Het |
| Ptpro |
G |
T |
6: 137,391,318 (GRCm39) |
V813F |
probably benign |
Het |
| Rnaseh2c |
T |
C |
19: 5,652,343 (GRCm39) |
F99L |
probably benign |
Het |
| Scn9a |
T |
A |
2: 66,363,708 (GRCm39) |
I857F |
probably damaging |
Het |
| Slf1 |
A |
G |
13: 77,197,204 (GRCm39) |
|
probably null |
Het |
| Smyd2 |
T |
C |
1: 189,612,983 (GRCm39) |
*434W |
probably null |
Het |
| Spata31h1 |
T |
A |
10: 82,125,453 (GRCm39) |
N2519I |
possibly damaging |
Het |
| Stk40 |
A |
G |
4: 126,030,650 (GRCm39) |
D290G |
probably damaging |
Het |
| Tdo2 |
C |
A |
3: 81,879,001 (GRCm39) |
W82C |
probably damaging |
Het |
| Tmem101 |
A |
G |
11: 102,044,194 (GRCm39) |
V231A |
probably damaging |
Het |
| Trim31 |
A |
T |
17: 37,212,551 (GRCm39) |
D174V |
probably benign |
Het |
| Unc13d |
A |
T |
11: 115,961,144 (GRCm39) |
Y404* |
probably null |
Het |
| Ush2a |
C |
A |
1: 188,092,063 (GRCm39) |
Y531* |
probably null |
Het |
| Vapa |
G |
A |
17: 65,889,736 (GRCm39) |
P144S |
probably benign |
Het |
| Vmn1r212 |
C |
T |
13: 23,067,443 (GRCm39) |
V297M |
possibly damaging |
Het |
| Vmn2r80 |
A |
C |
10: 79,030,712 (GRCm39) |
N846T |
probably damaging |
Het |
| Zfp811 |
A |
G |
17: 33,017,740 (GRCm39) |
V100A |
probably benign |
Het |
| Zfp958 |
T |
A |
8: 4,678,298 (GRCm39) |
C108S |
probably damaging |
Het |
| Zic5 |
G |
A |
14: 122,697,100 (GRCm39) |
T505I |
unknown |
Het |
|
| Other mutations in Tns2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01575:Tns2
|
APN |
15 |
102,021,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01935:Tns2
|
APN |
15 |
102,020,069 (GRCm39) |
splice site |
probably null |
|
|
IGL01994:Tns2
|
APN |
15 |
102,019,814 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02025:Tns2
|
APN |
15 |
102,020,484 (GRCm39) |
nonsense |
probably null |
|
|
IGL02135:Tns2
|
APN |
15 |
102,021,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Tns2
|
APN |
15 |
102,020,725 (GRCm39) |
missense |
probably benign |
|
|
IGL02362:Tns2
|
APN |
15 |
102,020,725 (GRCm39) |
missense |
probably benign |
|
|
IGL02439:Tns2
|
APN |
15 |
102,022,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02488:Tns2
|
APN |
15 |
102,021,178 (GRCm39) |
missense |
probably benign |
|
|
IGL02546:Tns2
|
APN |
15 |
102,019,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02616:Tns2
|
APN |
15 |
102,019,850 (GRCm39) |
missense |
probably benign |
|
|
IGL02628:Tns2
|
APN |
15 |
102,020,263 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02658:Tns2
|
APN |
15 |
102,016,231 (GRCm39) |
splice site |
probably benign |
|
|
IGL03267:Tns2
|
APN |
15 |
102,013,813 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0005:Tns2
|
UTSW |
15 |
102,022,491 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0586:Tns2
|
UTSW |
15 |
102,018,020 (GRCm39) |
splice site |
probably benign |
|
|
R0791:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0817:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0818:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0819:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0820:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1452:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1454:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1455:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1510:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Tns2
|
UTSW |
15 |
102,019,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1698:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1779:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Tns2
|
UTSW |
15 |
102,021,568 (GRCm39) |
splice site |
probably null |
|
|
R1923:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1924:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1927:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2087:Tns2
|
UTSW |
15 |
102,015,554 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R2100:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2103:Tns2
|
UTSW |
15 |
102,021,100 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2105:Tns2
|
UTSW |
15 |
102,015,941 (GRCm39) |
missense |
probably benign |
0.27 |
|
R2224:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2225:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2227:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2252:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2253:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2290:Tns2
|
UTSW |
15 |
102,020,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2304:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2318:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2446:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2447:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2448:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2566:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2897:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3159:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3160:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3162:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3162:Tns2
|
UTSW |
15 |
102,021,771 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3196:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3237:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3426:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3427:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3428:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Tns2
|
UTSW |
15 |
102,021,184 (GRCm39) |
missense |
probably null |
|
|
R3767:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3911:Tns2
|
UTSW |
15 |
102,022,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4113:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4394:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4395:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4396:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4439:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4441:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4537:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4538:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4541:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4599:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4600:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4602:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4773:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4774:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4775:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4776:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4880:Tns2
|
UTSW |
15 |
102,020,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4989:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5014:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5058:Tns2
|
UTSW |
15 |
102,016,295 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5253:Tns2
|
UTSW |
15 |
102,019,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Tns2
|
UTSW |
15 |
102,019,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5351:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5452:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5453:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5629:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5630:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5631:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5685:Tns2
|
UTSW |
15 |
102,015,538 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5844:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6048:Tns2
|
UTSW |
15 |
102,019,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6067:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6130:Tns2
|
UTSW |
15 |
102,019,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Tns2
|
UTSW |
15 |
102,015,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6138:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6199:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6210:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6426:Tns2
|
UTSW |
15 |
102,015,472 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6544:Tns2
|
UTSW |
15 |
102,022,269 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6594:Tns2
|
UTSW |
15 |
102,018,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6596:Tns2
|
UTSW |
15 |
102,018,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6734:Tns2
|
UTSW |
15 |
102,011,551 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7061:Tns2
|
UTSW |
15 |
102,012,914 (GRCm39) |
start codon destroyed |
probably null |
|
|
R7070:Tns2
|
UTSW |
15 |
102,012,968 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7110:Tns2
|
UTSW |
15 |
102,013,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7410:Tns2
|
UTSW |
15 |
102,018,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7447:Tns2
|
UTSW |
15 |
102,019,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7751:Tns2
|
UTSW |
15 |
102,018,163 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8052:Tns2
|
UTSW |
15 |
102,021,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Tns2
|
UTSW |
15 |
102,019,825 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8906:Tns2
|
UTSW |
15 |
102,020,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8964:Tns2
|
UTSW |
15 |
102,011,553 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9192:Tns2
|
UTSW |
15 |
102,021,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9273:Tns2
|
UTSW |
15 |
102,021,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Tns2
|
UTSW |
15 |
102,018,996 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9402:Tns2
|
UTSW |
15 |
102,021,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9655:Tns2
|
UTSW |
15 |
102,012,933 (GRCm39) |
missense |
probably benign |
0.03 |
|
U15987:Tns2
|
UTSW |
15 |
102,017,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0009:Tns2
|
UTSW |
15 |
102,020,900 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
X0026:Tns2
|
UTSW |
15 |
102,018,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCATCATACTAGCCCTCTGG -3'
(R):5'- ACCCTCAGTGAGCATCTTGC -3'
Sequencing Primer
(F):5'- GGGCGCCACGTTTCTCTG -3'
(R):5'- GGAATCCTCTGCAAGCTGC -3'
|
| Posted On |
2022-09-12 |
Incidental Mutation