Incidental Mutation 'R9613:Zmynd19'
ID 724362
Institutional Source Beutler Lab
Gene Symbol Zmynd19
Ensembl Gene ENSMUSG00000026974
Gene Name zinc finger, MYND domain containing 19
Synonyms 2700064H14Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9613 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 24839789-24850882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24848217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 177 (I177V)
Ref Sequence ENSEMBL: ENSMUSP00000028350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028350] [ENSMUST00000028351] [ENSMUST00000124383] [ENSMUST00000126909] [ENSMUST00000135339] [ENSMUST00000143253] [ENSMUST00000148042] [ENSMUST00000153375]
AlphaFold Q9CQG3
Predicted Effect
SMART Domains Protein: ENSMUSP00000028350
Gene: ENSMUSG00000026974
AA Change: I177V

DomainStartEndE-ValueType
Pfam:HNH_3 66 105 1.9e-10 PFAM
Pfam:zf-MYND 167 212 1.2e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000028351
SMART Domains Protein: ENSMUSP00000028351
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
Blast:WD40 74 118 3e-10 BLAST
Blast:WD40 128 175 3e-15 BLAST
WD40 183 223 7.43e-1 SMART
WD40 227 267 1.08e-4 SMART
WD40 271 310 1.37e2 SMART
WD40 420 455 1.97e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000124383
Predicted Effect probably benign
Transcript: ENSMUST00000126909
Predicted Effect probably benign
Transcript: ENSMUST00000135339
SMART Domains Protein: ENSMUSP00000142067
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
low complexity region 54 67 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143253
SMART Domains Protein: ENSMUSP00000142315
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
low complexity region 54 67 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000148042
AA Change: I138V

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000141788
Gene: ENSMUSG00000026974
AA Change: I138V

DomainStartEndE-ValueType
Pfam:HNH_3 27 66 1.4e-10 PFAM
Pfam:zf-MYND 124 173 5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000153375
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G A 3: 137,771,126 (GRCm39) R105H probably damaging Het
Baz2b A T 2: 59,731,824 (GRCm39) N2071K probably benign Het
Chd9 C A 8: 91,683,150 (GRCm39) S530* probably null Het
Col6a6 G A 9: 105,616,401 (GRCm39) H1558Y probably benign Het
Cyp7a1 A G 4: 6,272,587 (GRCm39) F209L probably damaging Het
D430041D05Rik A G 2: 104,060,737 (GRCm39) Y702H probably benign Het
Ddx46 T A 13: 55,787,749 (GRCm39) probably null Het
Dgat2 C G 7: 98,831,692 (GRCm39) G10R probably benign Het
Dync2h1 T A 9: 7,075,769 (GRCm39) M3033L probably damaging Het
Eef1g A G 19: 8,955,018 (GRCm39) N367S probably benign Het
Eef2kmt T G 16: 5,067,272 (GRCm39) E94A possibly damaging Het
Ermp1 C A 19: 29,617,256 (GRCm39) probably null Het
Ewsr1 A C 11: 5,028,924 (GRCm39) D346E unknown Het
Fam227a G A 15: 79,518,284 (GRCm39) T340M probably benign Het
Fxr1 G A 3: 34,100,352 (GRCm39) V104I probably benign Het
Gm6176 A G 7: 21,750,529 (GRCm39) V134A possibly damaging Het
Igdcc4 G A 9: 65,027,522 (GRCm39) V195I possibly damaging Het
Ighv2-5 A G 12: 113,649,189 (GRCm39) I88T Het
Irf8 A T 8: 121,481,207 (GRCm39) T355S probably benign Het
Kif20b T A 19: 34,919,934 (GRCm39) S751T possibly damaging Het
Kitl A G 10: 99,916,781 (GRCm39) N195D probably damaging Het
Kmt2d CTGTTG CTG 15: 98,743,057 (GRCm39) probably benign Het
Macf1 A G 4: 123,420,288 (GRCm39) F322S probably benign Het
Map6 T C 7: 98,918,384 (GRCm39) S386P possibly damaging Het
Nup214 A G 2: 31,901,035 (GRCm39) D906G possibly damaging Het
Oacyl A C 18: 65,864,524 (GRCm39) T356P probably damaging Het
Or1e28-ps1 A T 11: 73,615,639 (GRCm39) D70E probably damaging Het
Or2at1 A G 7: 99,416,536 (GRCm39) T56A probably benign Het
Plekha1 C A 7: 130,479,488 (GRCm39) P2H probably damaging Het
Plekhg4 T A 8: 106,107,620 (GRCm39) D1050E probably damaging Het
Plxnb2 T C 15: 89,048,496 (GRCm39) T638A probably benign Het
Pole4 T C 6: 82,629,099 (GRCm39) Q89R probably benign Het
Prg4 T C 1: 150,331,660 (GRCm39) T338A unknown Het
Prpf3 G A 3: 95,758,931 (GRCm39) R74* probably null Het
Prss44 C A 9: 110,643,806 (GRCm39) A150E probably damaging Het
Prss51 T A 14: 64,332,461 (GRCm39) V2E possibly damaging Het
Ptpn12 A G 5: 21,203,621 (GRCm39) Y386H probably damaging Het
Septin4 A T 11: 87,469,823 (GRCm39) H3L possibly damaging Het
Spata16 G A 3: 26,932,814 (GRCm39) V347M probably damaging Het
Spata31f1e A G 4: 42,792,992 (GRCm39) V380A probably benign Het
Spinkl T A 18: 44,301,212 (GRCm39) Y42F probably damaging Het
Suds3 A T 5: 117,243,234 (GRCm39) M168K possibly damaging Het
Tdrd6 A G 17: 43,939,518 (GRCm39) I510T probably damaging Het
Tnfrsf22 T C 7: 143,198,583 (GRCm39) H44R probably benign Het
Trh G A 6: 92,219,840 (GRCm39) R159* probably null Het
Ubr4 C A 4: 139,149,073 (GRCm39) S457R Het
Usp54 T C 14: 20,600,438 (GRCm39) Y1433C probably damaging Het
Vmn1r120 G A 7: 20,787,046 (GRCm39) L222F probably benign Het
Vmn2r22 T C 6: 123,615,075 (GRCm39) I172V probably damaging Het
Vmn2r84 A G 10: 130,226,591 (GRCm39) S416P probably damaging Het
Wapl T C 14: 34,453,520 (GRCm39) V855A probably benign Het
Zscan4e G A 7: 11,040,898 (GRCm39) Q325* probably null Het
Other mutations in Zmynd19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01905:Zmynd19 APN 2 24,841,541 (GRCm39) missense probably benign 0.04
watson UTSW 2 24,848,201 (GRCm39) nonsense probably null
R0432:Zmynd19 UTSW 2 24,848,134 (GRCm39) missense probably benign 0.01
R1531:Zmynd19 UTSW 2 24,848,123 (GRCm39) missense probably benign 0.02
R2130:Zmynd19 UTSW 2 24,842,648 (GRCm39) nonsense probably null
R2408:Zmynd19 UTSW 2 24,848,937 (GRCm39) missense possibly damaging 0.54
R3612:Zmynd19 UTSW 2 24,841,492 (GRCm39) missense probably damaging 1.00
R4595:Zmynd19 UTSW 2 24,849,000 (GRCm39) missense probably damaging 1.00
R5165:Zmynd19 UTSW 2 24,848,201 (GRCm39) nonsense probably null
R6133:Zmynd19 UTSW 2 24,848,131 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TGGGCGGAACTTACTTGTCC -3'
(R):5'- GCTGAAGGGATTAAATACTGTCTGG -3'

Sequencing Primer
(F):5'- CTGCTTTCTTTCAGGGAGCAAAGC -3'
(R):5'- GGATTAAATACTGTCTGGATGGAAC -3'
Posted On 2022-09-12