Mutagenetix > Incidental Mutation

Incidental Mutation 'R9618:Or7e176'

724668

Institutional Source

Beutler Lab

Gene Symbol

Or7e176

Ensembl Gene

ENSMUSG00000066897

Gene Name

olfactory receptor family 7 subfamily E member 176

Synonyms

Olfr872, GA_x6K02T2PVTD-13999915-14000844, MOR145-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R9618 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20148458-20172209 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20171639 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 168 (V168M)

Ref Sequence

ENSEMBL: ENSMUSP00000083665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086474]

AlphaFold

E9PVW2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000086474
AA Change: V168M

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000083665
Gene: ENSMUSG00000066897
AA Change: V168M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	45	321	3.8e-45	PFAM
Pfam:7TM_GPCR_Srsx	49	310	1.4e-9	PFAM
Pfam:7tm_1	55	304	4.2e-21	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110032F04Rik	C	T	3: 68,777,402 (GRCm39)	P121L	probably damaging	Het
2310002L09Rik	C	A	4: 73,868,934 (GRCm39)	M1I	probably null	Het
2510039O18Rik	T	A	4: 148,029,873 (GRCm39)	Y614*	probably null	Het
4930562C15Rik	A	T	16: 4,667,418 (GRCm39)	S270C	unknown	Het
Ak9	A	C	10: 41,203,627 (GRCm39)	T173P		Het
Cfc1	T	C	1: 34,575,560 (GRCm39)	L78P	probably benign	Het
Chrd	T	G	16: 20,552,378 (GRCm39)	C82W	probably damaging	Het
Cln6	T	C	9: 62,758,111 (GRCm39)	V290A	probably damaging	Het
Cps1	A	G	1: 67,196,975 (GRCm39)	D342G	possibly damaging	Het
Cracd	A	G	5: 77,004,617 (GRCm39)	D326G	unknown	Het
Cryzl2	G	A	1: 157,289,578 (GRCm39)	R72H	probably benign	Het
Cyp2j6	A	T	4: 96,414,085 (GRCm39)	H393Q	probably benign	Het
Eefsec	T	C	6: 88,274,681 (GRCm39)	T428A	probably benign	Het
Ergic1	G	A	17: 26,827,619 (GRCm39)	G25S	probably damaging	Het
Esf1	T	C	2: 140,001,714 (GRCm39)	I378V	probably benign	Het
Fndc1	T	A	17: 7,990,313 (GRCm39)	T1128S	unknown	Het
Gabrp	A	T	11: 33,504,342 (GRCm39)	Y324*	probably null	Het
Hadha	G	A	5: 30,339,165 (GRCm39)	T270M	possibly damaging	Het
Hdac1-ps	T	C	17: 78,799,114 (GRCm39)	I35T	probably damaging	Het
Ino80d	G	A	1: 63,101,342 (GRCm39)	T428M	probably damaging	Het
Itgae	T	C	11: 73,011,171 (GRCm39)	F647S	possibly damaging	Het
Kank4	T	C	4: 98,653,732 (GRCm39)	R899G	possibly damaging	Het
Kcna4	T	A	2: 107,126,374 (GRCm39)	N369K	probably benign	Het
Kcnip3	G	T	2: 127,352,812 (GRCm39)	P69Q	probably benign	Het
Mcf2l	A	G	8: 13,034,320 (GRCm39)		probably benign	Het
Mtmr2	T	C	9: 13,707,315 (GRCm39)	V289A	probably benign	Het
Muc21	GGGGTGGGCATAGATCCTGAGGCAGAGCTGGATGCAGTGGTGGTCAGGGTGGG	GGGGTGGG	17: 35,932,935 (GRCm39)		probably benign	Het
Nxph1	T	G	6: 9,247,108 (GRCm39)	N26K	probably benign	Het
Obox1	A	G	7: 15,289,624 (GRCm39)	I138V	possibly damaging	Het
Or4c35	A	T	2: 89,808,343 (GRCm39)	T74S	probably benign	Het
Or4m1	A	T	14: 50,557,760 (GRCm39)	Y177*	probably null	Het
P2ry14	T	A	3: 59,023,251 (GRCm39)	M70L	probably damaging	Het
Pcare	T	A	17: 72,057,817 (GRCm39)	Y620F	probably damaging	Het
Pcnt	A	G	10: 76,188,794 (GRCm39)	Y2869H	probably damaging	Het
Pkd1l1	T	C	11: 8,911,420 (GRCm39)	R286G		Het
Pygb	C	T	2: 150,657,008 (GRCm39)	R320W		Het
Rsf1	G	GACGGCGGCC	7: 97,229,116 (GRCm39)		probably benign	Het
Slc15a5	A	T	6: 138,032,779 (GRCm39)	S192T	possibly damaging	Het
Tex15	A	G	8: 34,062,397 (GRCm39)	H609R	probably benign	Het
Tmem256	T	A	11: 69,730,210 (GRCm39)	S73T	possibly damaging	Het
Tpr	G	T	1: 150,321,979 (GRCm39)	A2338S	possibly damaging	Het
Trub2	A	T	2: 29,673,346 (GRCm39)	M119K	probably benign	Het
Vmn1r228	T	C	17: 20,997,045 (GRCm39)	M158V	probably benign	Het
Vmn2r100	A	T	17: 19,742,583 (GRCm39)	H319L	probably damaging	Het
Vmn2r3	T	A	3: 64,178,724 (GRCm39)	I514F	probably damaging	Het
Wnt16	T	A	6: 22,297,891 (GRCm39)	Y252*	probably null	Het
Wnt16	G	T	6: 22,297,892 (GRCm39)	E253*	probably null	Het
Xkr4	A	T	1: 3,741,201 (GRCm39)	V124E	probably damaging	Het
Zc3h13	G	T	14: 75,567,542 (GRCm39)	R945L		Het
Zfp445	T	C	9: 122,685,788 (GRCm39)	N251D	probably damaging	Het
Zfp683	A	T	4: 133,782,965 (GRCm39)	D143V	probably benign	Het

Other mutations in Or7e176

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01904:Or7e176	APN	9	20,171,586 (GRCm39)	missense	probably damaging	0.99
IGL02048:Or7e176	APN	9	20,171,784 (GRCm39)	missense	possibly damaging	0.79
IGL02232:Or7e176	APN	9	20,171,511 (GRCm39)	missense	probably damaging	1.00
IGL02314:Or7e176	APN	9	20,171,774 (GRCm39)	missense	probably benign	0.03
IGL03290:Or7e176	APN	9	20,171,556 (GRCm39)	missense	probably damaging	1.00
R0410:Or7e176	UTSW	9	20,171,797 (GRCm39)	missense	probably benign	0.03
R1482:Or7e176	UTSW	9	20,172,020 (GRCm39)	missense	possibly damaging	0.89
R1521:Or7e176	UTSW	9	20,171,728 (GRCm39)	missense	possibly damaging	0.91
R4930:Or7e176	UTSW	9	20,171,313 (GRCm39)	missense	probably damaging	1.00
R5457:Or7e176	UTSW	9	20,171,574 (GRCm39)	missense	probably damaging	1.00
R5870:Or7e176	UTSW	9	20,171,874 (GRCm39)	missense	probably benign
R6141:Or7e176	UTSW	9	20,171,754 (GRCm39)	missense	probably benign	0.00
R7283:Or7e176	UTSW	9	20,171,555 (GRCm39)	missense	probably damaging	0.98
R8691:Or7e176	UTSW	9	20,171,747 (GRCm39)	missense	probably benign	0.36
R8882:Or7e176	UTSW	9	20,171,256 (GRCm39)	missense	probably benign	0.06
R9556:Or7e176	UTSW	9	20,171,651 (GRCm39)	missense	probably benign	0.00
R9752:Or7e176	UTSW	9	20,171,204 (GRCm39)	missense	probably benign	0.10
X0025:Or7e176	UTSW	9	20,171,782 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GCTGCCTAACACAGATGTCC -3'
(R):5'- CCATCTTTTGTTGGAATTCTCAGG -3'

Sequencing Primer
(F):5'- CCTAACACAGATGTCCATGTTTATAG -3'
(R):5'- TGTTGGAATTCTCAGGATGGAAG -3'

Posted On

2022-09-12