Incidental Mutation 'R9620:Orc6'
ID 724717
Institutional Source Beutler Lab
Gene Symbol Orc6
Ensembl Gene ENSMUSG00000031697
Gene Name origin recognition complex, subunit 6
Synonyms 6720420I10Rik, Orc6l
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9620 (G1)
Quality Score 185.009
Status Not validated
Chromosome 8
Chromosomal Location 86026261-86034907 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to T at 86026430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147901 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034131] [ENSMUST00000034132] [ENSMUST00000170141] [ENSMUST00000210146] [ENSMUST00000211396] [ENSMUST00000211597]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000034131
SMART Domains Protein: ENSMUSP00000034131
Gene: ENSMUSG00000031696

DomainStartEndE-ValueType
Pfam:Vps35 15 753 6.8e-303 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000034132
SMART Domains Protein: ENSMUSP00000034132
Gene: ENSMUSG00000031697

DomainStartEndE-ValueType
Pfam:ORC6 6 108 1.5e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170141
SMART Domains Protein: ENSMUSP00000126925
Gene: ENSMUSG00000031697

DomainStartEndE-ValueType
PDB:3M03|C 18 111 2e-51 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000210146
Predicted Effect probably benign
Transcript: ENSMUST00000211396
Predicted Effect probably benign
Transcript: ENSMUST00000211597
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd3 G T 18: 10,704,605 (GRCm39) T151K possibly damaging Het
Acsf2 C T 11: 94,463,412 (GRCm39) W130* probably null Het
Aldh16a1 G A 7: 44,797,413 (GRCm39) R132* probably null Het
Amer3 C T 1: 34,628,043 (GRCm39) P761S probably benign Het
Amotl1 G T 9: 14,459,969 (GRCm39) D886E probably damaging Het
Cacna1s T C 1: 136,035,909 (GRCm39) F1383S probably damaging Het
Col14a1 T A 15: 55,225,781 (GRCm39) V148E unknown Het
Col9a2 T A 4: 120,910,403 (GRCm39) probably null Het
Cyp2a5 T A 7: 26,536,636 (GRCm39) M205K possibly damaging Het
Dcst2 A T 3: 89,277,825 (GRCm39) Q466L possibly damaging Het
Ecel1 T C 1: 87,080,853 (GRCm39) I350V possibly damaging Het
Enthd1 G A 15: 80,336,901 (GRCm39) T511I probably benign Het
Exoc6b T A 6: 84,988,302 (GRCm39) K92* probably null Het
Fam181a T G 12: 103,282,591 (GRCm39) Y165* probably null Het
Fbxo34 A G 14: 47,768,725 (GRCm39) Y746C probably damaging Het
Fgfr4 T A 13: 55,308,994 (GRCm39) S372T possibly damaging Het
Fmo1 A G 1: 162,661,390 (GRCm39) F298L probably benign Het
Gad1 A C 2: 70,404,620 (GRCm39) D170A possibly damaging Het
Garin2 A C 12: 78,762,077 (GRCm39) D247A probably damaging Het
Golgb1 T C 16: 36,739,811 (GRCm39) S2758P probably benign Het
Golm2 T C 2: 121,737,242 (GRCm39) V261A probably benign Het
H2az2 A T 11: 6,379,094 (GRCm39) probably null Het
Ilkap A G 1: 91,303,973 (GRCm39) C163R Het
Krt9 A T 11: 100,079,186 (GRCm39) D735E unknown Het
Lipo3 A T 19: 33,559,629 (GRCm39) C80* probably null Het
Lpcat3 C T 6: 124,680,543 (GRCm39) P478L probably damaging Het
Luc7l3 G A 11: 94,212,545 (GRCm39) R24C unknown Het
Mafa T A 15: 75,619,161 (GRCm39) H204L probably benign Het
Mapk10 A C 5: 103,114,473 (GRCm39) V305G probably damaging Het
Mgat1 T C 11: 49,152,122 (GRCm39) F202L probably benign Het
Mical2 A T 7: 111,980,403 (GRCm39) T126S probably benign Het
Mill1 G A 7: 17,997,027 (GRCm39) R206H probably benign Het
Nlrc5 A T 8: 95,203,034 (GRCm39) Y378F probably benign Het
Nlrp9a G T 7: 26,250,469 (GRCm39) R78L probably damaging Het
Or10b1 G T 10: 78,356,128 (GRCm39) A229S probably benign Het
Or52i2 A T 7: 102,320,011 (GRCm39) I295F possibly damaging Het
Or8g50 A T 9: 39,648,287 (GRCm39) M59L Het
Pate14 A G 9: 36,548,498 (GRCm39) probably null Het
Pcdhgb5 C T 18: 37,864,486 (GRCm39) Q94* probably null Het
Pcnx1 A G 12: 81,996,960 (GRCm39) D952G probably damaging Het
Ppfia2 A T 10: 106,749,519 (GRCm39) H1135L Het
Prmt2 A T 10: 76,061,213 (GRCm39) I91N probably damaging Het
Ptprm A G 17: 67,116,484 (GRCm39) Y932H probably damaging Het
Qrich2 T C 11: 116,337,946 (GRCm39) K154R probably damaging Het
Rapgef4 A G 2: 72,036,051 (GRCm39) T515A probably benign Het
Rgmb G A 17: 16,041,279 (GRCm39) R103* probably null Het
Ripk1 T G 13: 34,210,806 (GRCm39) S334A possibly damaging Het
Rnf5 C T 17: 34,820,721 (GRCm39) G147S possibly damaging Het
Ryr1 T C 7: 28,715,138 (GRCm39) Y4662C unknown Het
Secisbp2l A G 2: 125,589,394 (GRCm39) M718T probably damaging Het
Slc16a6 T C 11: 109,354,322 (GRCm39) T100A probably benign Het
Slc27a6 T A 18: 58,742,887 (GRCm39) M525K probably damaging Het
Slco2a1 G C 9: 102,962,065 (GRCm39) C579S probably damaging Het
Snx14 A G 9: 88,263,794 (GRCm39) S864P probably damaging Het
Spata31f3 TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG 4: 42,871,823 (GRCm39) probably benign Het
Sptbn2 T C 19: 4,800,535 (GRCm39) L2250P probably damaging Het
Tlr6 A T 5: 65,112,146 (GRCm39) S254T possibly damaging Het
Trap1 A T 16: 3,858,083 (GRCm39) Y675* probably null Het
Ttc9b C A 7: 27,353,512 (GRCm39) A54E probably damaging Het
Unc45a A C 7: 79,975,403 (GRCm39) Y934D probably damaging Het
Usp17ld A G 7: 102,900,179 (GRCm39) L251P possibly damaging Het
Usp42 A G 5: 143,703,154 (GRCm39) V489A probably damaging Het
Vars1 A G 17: 35,235,001 (GRCm39) T1277A unknown Het
Vmn2r117 A G 17: 23,697,450 (GRCm39) S81P probably damaging Het
Vmn2r69 T A 7: 85,061,504 (GRCm39) I157F probably benign Het
Zfp697 A G 3: 98,335,182 (GRCm39) S316G probably damaging Het
Zfp729b T A 13: 67,739,787 (GRCm39) H826L probably damaging Het
Other mutations in Orc6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01893:Orc6 APN 8 86,034,272 (GRCm39) missense probably damaging 1.00
IGL02531:Orc6 APN 8 86,029,998 (GRCm39) missense probably damaging 1.00
IGL02713:Orc6 APN 8 86,034,215 (GRCm39) missense probably benign 0.00
IGL02997:Orc6 APN 8 86,032,837 (GRCm39) unclassified probably benign
R0685:Orc6 UTSW 8 86,027,783 (GRCm39) missense possibly damaging 0.93
R1667:Orc6 UTSW 8 86,031,914 (GRCm39) missense possibly damaging 0.94
R3619:Orc6 UTSW 8 86,026,623 (GRCm39) critical splice donor site probably null
R3810:Orc6 UTSW 8 86,026,613 (GRCm39) missense probably benign 0.05
R4707:Orc6 UTSW 8 86,029,579 (GRCm39) missense probably damaging 1.00
R4784:Orc6 UTSW 8 86,029,579 (GRCm39) missense probably damaging 1.00
R5743:Orc6 UTSW 8 86,029,585 (GRCm39) missense probably benign 0.02
R7062:Orc6 UTSW 8 86,029,537 (GRCm39) missense probably damaging 1.00
R7199:Orc6 UTSW 8 86,029,590 (GRCm39) critical splice donor site probably null
R7803:Orc6 UTSW 8 86,030,037 (GRCm39) missense possibly damaging 0.77
R7880:Orc6 UTSW 8 86,031,873 (GRCm39) missense probably benign 0.01
R9512:Orc6 UTSW 8 86,029,522 (GRCm39) missense
R9521:Orc6 UTSW 8 86,026,615 (GRCm39) missense possibly damaging 0.95
Y5406:Orc6 UTSW 8 86,034,302 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAATCTCGCGTAGTTTGGGG -3'
(R):5'- ACTCACCTCAGTACACTCGG -3'

Sequencing Primer
(F):5'- CAGCCGGCGGTGTATAGTG -3'
(R):5'- AGTACACTCGGCTCCGCAAG -3'
Posted On 2022-09-12