Incidental Mutation 'R9624:Foxj3'
ID 725017
Institutional Source Beutler Lab
Gene Symbol Foxj3
Ensembl Gene ENSMUSG00000032998
Gene Name forkhead box J3
Synonyms C330039G02Rik, Fhd6
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.482) question?
Stock # R9624 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 119396858-119486316 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 119483589 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 620 (D620E)
Ref Sequence ENSEMBL: ENSMUSP00000035746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044564] [ENSMUST00000106310]
AlphaFold Q8BUR3
Predicted Effect unknown
Transcript: ENSMUST00000044564
AA Change: D620E
SMART Domains Protein: ENSMUSP00000035746
Gene: ENSMUSG00000032998
AA Change: D620E

DomainStartEndE-ValueType
FH 76 164 6.03e-50 SMART
low complexity region 226 239 N/A INTRINSIC
low complexity region 263 274 N/A INTRINSIC
low complexity region 317 346 N/A INTRINSIC
low complexity region 372 434 N/A INTRINSIC
low complexity region 611 620 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000106310
AA Change: D586E
SMART Domains Protein: ENSMUSP00000101917
Gene: ENSMUSG00000032998
AA Change: D586E

DomainStartEndE-ValueType
FH 76 164 6.03e-50 SMART
low complexity region 192 205 N/A INTRINSIC
low complexity region 229 240 N/A INTRINSIC
low complexity region 283 312 N/A INTRINSIC
low complexity region 338 400 N/A INTRINSIC
low complexity region 577 586 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice have an abnormal skeletal muscle fiber type ratio in males as well as defects in muscle regeneration following injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6a A T 12: 113,509,070 (GRCm39) N481I probably damaging Het
Ahnak T A 19: 8,989,846 (GRCm39) L3710Q unknown Het
Anapc15-ps T C 10: 95,508,965 (GRCm39) D105G probably benign Het
Ankfn1 T C 11: 89,414,033 (GRCm39) N114S probably benign Het
Ankrd27 A T 7: 35,301,891 (GRCm39) T137S possibly damaging Het
Atp1b3 A G 9: 96,222,293 (GRCm39) S165P probably benign Het
Atxn7l3 T C 11: 102,182,852 (GRCm39) D256G probably benign Het
B430305J03Rik C A 3: 61,271,408 (GRCm39) L112F unknown Het
Bub1 A T 2: 127,646,766 (GRCm39) I838K probably damaging Het
C3 T A 17: 57,527,189 (GRCm39) E753D probably benign Het
Cacnb4 T C 2: 52,364,942 (GRCm39) D107G probably benign Het
Cenpj A T 14: 56,802,387 (GRCm39) H59Q probably benign Het
Cxxc1 A T 18: 74,352,512 (GRCm39) H364L possibly damaging Het
Dapk1 T C 13: 60,895,937 (GRCm39) I675T probably benign Het
Eln A G 5: 134,738,991 (GRCm39) S663P unknown Het
Epha8 G T 4: 136,659,065 (GRCm39) P863Q probably damaging Het
Erich6 G T 3: 58,536,766 (GRCm39) T278N possibly damaging Het
Fam47e G C 5: 92,726,395 (GRCm39) R111P probably benign Het
Fam83g C T 11: 61,575,328 (GRCm39) probably benign Het
Fanci A T 7: 79,085,117 (GRCm39) I848L probably benign Het
Gm14443 T A 2: 175,012,129 (GRCm39) N106Y possibly damaging Het
Gm17654 T C 14: 43,815,492 (GRCm39) D105G Het
Gps1 C A 11: 120,677,434 (GRCm39) A216D probably damaging Het
Hs3st3b1 T C 11: 63,780,110 (GRCm39) K339R probably benign Het
Ikzf1 A G 11: 11,719,219 (GRCm39) T396A probably damaging Het
Lratd2 A T 15: 60,694,993 (GRCm39) I251N probably damaging Het
Lrrc9 A G 12: 72,497,586 (GRCm39) I135V probably benign Het
Mylk C A 16: 34,699,677 (GRCm39) Q347K probably benign Het
Myo1e A G 9: 70,303,156 (GRCm39) Y1059C probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Or10d1b A G 9: 39,613,822 (GRCm39) F81S probably benign Het
Or10j3 A T 1: 173,031,672 (GRCm39) I250F probably benign Het
Or2y1 T A 11: 49,385,834 (GRCm39) I158N possibly damaging Het
Or6c33 T C 10: 129,853,866 (GRCm39) V212A possibly damaging Het
Or8g23 T A 9: 38,971,453 (GRCm39) N170Y probably benign Het
Or8g30 G T 9: 39,230,848 (GRCm39) Q21K probably benign Het
Piezo2 G A 18: 63,197,767 (GRCm39) P1590S possibly damaging Het
Prl7a2 T A 13: 27,849,869 (GRCm39) K68* probably null Het
Prss33 A G 17: 24,054,656 (GRCm39) V14A probably benign Het
Rad17 T C 13: 100,773,503 (GRCm39) N162S probably damaging Het
Sbf2 A T 7: 109,963,857 (GRCm39) V1042E probably damaging Het
Scn1a A T 2: 66,153,766 (GRCm39) M689K probably benign Het
Senp7 A T 16: 55,990,075 (GRCm39) I608F probably damaging Het
Sh2b1 AGCTCAGCCACGGGGAC AGCTCAGCCACGGGGACACGCTCAGCCACGGGGAC 7: 126,066,750 (GRCm39) probably benign Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sh2b1 GGGACCAGCTCAGCCACG GGGACCAGCTCAGCCACGTGGACCAGCTCAGCCACG 7: 126,066,744 (GRCm39) probably benign Het
Slc38a3 A G 9: 107,532,510 (GRCm39) V370A probably damaging Het
Sorbs2 A G 8: 46,228,690 (GRCm39) I307V possibly damaging Het
Spata13 C T 14: 60,944,349 (GRCm39) P581S probably benign Het
Spindoc G A 19: 7,352,197 (GRCm39) T50M probably benign Het
Sppl2b T A 10: 80,699,373 (GRCm39) F269Y probably benign Het
Stab1 C T 14: 30,863,345 (GRCm39) V2114M Het
Tcerg1l A G 7: 137,995,923 (GRCm39) V195A possibly damaging Het
Tent4a A T 13: 69,651,787 (GRCm39) W545R probably damaging Het
Tmem128 G T 5: 38,422,236 (GRCm39) R105L possibly damaging Het
Tns3 G A 11: 8,401,142 (GRCm39) T1052M possibly damaging Het
Vmn1r194 T A 13: 22,428,671 (GRCm39) I96N probably damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vmn1r78 G A 7: 11,886,410 (GRCm39) S7N probably benign Het
Wapl T A 14: 34,414,063 (GRCm39) N308K possibly damaging Het
Other mutations in Foxj3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Foxj3 APN 4 119,467,226 (GRCm39) missense probably benign 0.03
IGL01452:Foxj3 APN 4 119,478,825 (GRCm39) missense unknown
IGL02056:Foxj3 APN 4 119,442,954 (GRCm39) missense probably damaging 1.00
IGL02455:Foxj3 APN 4 119,477,434 (GRCm39) missense unknown
IGL02542:Foxj3 APN 4 119,477,540 (GRCm39) missense unknown
IGL02625:Foxj3 APN 4 119,482,114 (GRCm39) missense unknown
IGL03216:Foxj3 APN 4 119,467,180 (GRCm39) intron probably benign
R0087:Foxj3 UTSW 4 119,483,597 (GRCm39) missense unknown
R0488:Foxj3 UTSW 4 119,477,187 (GRCm39) nonsense probably null
R0512:Foxj3 UTSW 4 119,443,033 (GRCm39) splice site probably benign
R1531:Foxj3 UTSW 4 119,477,398 (GRCm39) missense unknown
R1799:Foxj3 UTSW 4 119,476,548 (GRCm39) missense probably benign 0.06
R1883:Foxj3 UTSW 4 119,467,226 (GRCm39) missense probably benign 0.20
R3690:Foxj3 UTSW 4 119,473,839 (GRCm39) splice site probably benign
R3691:Foxj3 UTSW 4 119,473,839 (GRCm39) splice site probably benign
R3838:Foxj3 UTSW 4 119,473,821 (GRCm39) missense possibly damaging 0.49
R4065:Foxj3 UTSW 4 119,467,206 (GRCm39) missense probably benign 0.09
R4295:Foxj3 UTSW 4 119,483,494 (GRCm39) nonsense probably null
R4576:Foxj3 UTSW 4 119,478,860 (GRCm39) missense unknown
R4750:Foxj3 UTSW 4 119,473,787 (GRCm39) missense probably damaging 0.99
R4782:Foxj3 UTSW 4 119,478,857 (GRCm39) missense unknown
R4799:Foxj3 UTSW 4 119,478,857 (GRCm39) missense unknown
R5305:Foxj3 UTSW 4 119,477,155 (GRCm39) missense possibly damaging 0.73
R5358:Foxj3 UTSW 4 119,476,596 (GRCm39) missense probably damaging 1.00
R5362:Foxj3 UTSW 4 119,477,340 (GRCm39) missense unknown
R5728:Foxj3 UTSW 4 119,430,959 (GRCm39) missense probably damaging 1.00
R5732:Foxj3 UTSW 4 119,443,008 (GRCm39) missense probably damaging 1.00
R6151:Foxj3 UTSW 4 119,480,468 (GRCm39) missense unknown
R6352:Foxj3 UTSW 4 119,442,975 (GRCm39) missense probably damaging 1.00
R6377:Foxj3 UTSW 4 119,430,945 (GRCm39) splice site probably null
R7034:Foxj3 UTSW 4 119,476,497 (GRCm39) missense probably damaging 0.97
R7672:Foxj3 UTSW 4 119,477,429 (GRCm39) missense unknown
R7912:Foxj3 UTSW 4 119,477,252 (GRCm39) missense possibly damaging 0.63
R8215:Foxj3 UTSW 4 119,478,808 (GRCm39) missense unknown
R9190:Foxj3 UTSW 4 119,477,538 (GRCm39) nonsense probably null
R9762:Foxj3 UTSW 4 119,483,540 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGACAAGCTCTCAGCCTACTTG -3'
(R):5'- TCAGTCTGGCACTTGTGGTC -3'

Sequencing Primer
(F):5'- GACAAGCTCTCAGCCTACTTGATCTC -3'
(R):5'- GCACTTGTGGTCAACATCAAACTG -3'
Posted On 2022-09-12