Incidental Mutation 'R9626:Prr15l'
ID 725165
Institutional Source Beutler Lab
Gene Symbol Prr15l
Ensembl Gene ENSMUSG00000047040
Gene Name proline rich 15-like
Synonyms Atad4, E230006A12Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R9626 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 96816987-96826474 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 96825440 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 23 (Y23*)
Ref Sequence ENSEMBL: ENSMUSP00000103262 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018803] [ENSMUST00000054311] [ENSMUST00000062172] [ENSMUST00000107629] [ENSMUST00000107633] [ENSMUST00000107636]
AlphaFold Q8JZM2
Predicted Effect probably benign
Transcript: ENSMUST00000018803
SMART Domains Protein: ENSMUSP00000018803
Gene: ENSMUSG00000018659

DomainStartEndE-ValueType
Pfam:Pyridox_oxase_2 59 149 3.9e-8 PFAM
Pfam:Pyridox_oxidase 60 153 2.4e-27 PFAM
Pfam:PNPOx_C 206 261 2.8e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000054311
AA Change: Y23*
SMART Domains Protein: ENSMUSP00000056614
Gene: ENSMUSG00000047040
AA Change: Y23*

DomainStartEndE-ValueType
Pfam:ATAD4 6 88 3.7e-33 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000062172
AA Change: Y23*
SMART Domains Protein: ENSMUSP00000056647
Gene: ENSMUSG00000047040
AA Change: Y23*

DomainStartEndE-ValueType
Pfam:ATAD4 6 87 1.3e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107629
SMART Domains Protein: ENSMUSP00000103255
Gene: ENSMUSG00000018659

DomainStartEndE-ValueType
PDB:1NRG|A 1 92 2e-49 PDB
SCOP:d1dnla_ 57 86 3e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000107633
AA Change: Y23*
SMART Domains Protein: ENSMUSP00000103259
Gene: ENSMUSG00000047040
AA Change: Y23*

DomainStartEndE-ValueType
Pfam:ATAD4 6 88 3.7e-33 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107636
AA Change: Y23*
SMART Domains Protein: ENSMUSP00000103262
Gene: ENSMUSG00000047040
AA Change: Y23*

DomainStartEndE-ValueType
Pfam:ATAD4 6 88 3.7e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131501
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153896
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,127,502 (GRCm39) N37I unknown Het
Abca9 T A 11: 110,011,606 (GRCm39) T1146S probably benign Het
Acnat2 G A 4: 49,380,179 (GRCm39) H400Y probably damaging Het
Adgrd1 T C 5: 129,275,721 (GRCm39) S768P probably damaging Het
Arap2 T A 5: 62,906,878 (GRCm39) H47L probably benign Het
Atxn1 T A 13: 45,710,796 (GRCm39) N712I possibly damaging Het
Bri3bp T A 5: 125,531,572 (GRCm39) S173T probably damaging Het
Camta1 A T 4: 151,168,287 (GRCm39) S254R probably damaging Het
Card9 T C 2: 26,247,294 (GRCm39) E285G probably benign Het
Celf2 G A 2: 6,590,835 (GRCm39) A320V probably benign Het
Celsr3 T C 9: 108,726,521 (GRCm39) I3250T probably damaging Het
Cfap46 C T 7: 139,230,805 (GRCm39) R941H Het
Cntrob T C 11: 69,202,167 (GRCm39) H475R possibly damaging Het
Dcaf6 G A 1: 165,227,264 (GRCm39) R288* probably null Het
Ebna1bp2 G A 4: 118,478,371 (GRCm39) probably benign Het
Erich3 A T 3: 154,444,730 (GRCm39) D302V probably benign Het
Fbxo48 T A 11: 16,904,333 (GRCm39) *162K probably null Het
Fyttd1 T C 16: 32,725,915 (GRCm39) L290S probably damaging Het
Gcc1 T C 6: 28,418,917 (GRCm39) D472G probably damaging Het
Gjb4 C T 4: 127,246,081 (GRCm39) probably benign Het
Gm5157 G T 7: 20,919,396 (GRCm39) T49K probably damaging Het
Gpr143 GTTTTTT GTTTTTTT X: 151,578,627 (GRCm39) probably null Het
Hnrnpm G T 17: 33,896,264 (GRCm39) D88E probably damaging Het
Hormad2 G A 11: 4,377,372 (GRCm39) P22L probably damaging Het
Hunk C T 16: 90,272,791 (GRCm39) T365M probably damaging Het
Lamb1 A G 12: 31,354,669 (GRCm39) D972G probably benign Het
Mamdc4 A G 2: 25,458,273 (GRCm39) L379P probably damaging Het
Mcrs1 A G 15: 99,146,353 (GRCm39) L179P probably damaging Het
Mterf2 C T 10: 84,956,295 (GRCm39) A110T probably benign Het
Mucl1 A G 15: 103,783,934 (GRCm39) S91P possibly damaging Het
Myo1d C A 11: 80,448,296 (GRCm39) G943V possibly damaging Het
Ndst4 A C 3: 125,476,829 (GRCm39) D18A probably damaging Het
Ndufv1 A T 19: 4,058,064 (GRCm39) C382* probably null Het
Npc1l1 T C 11: 6,177,854 (GRCm39) K519E probably benign Het
Nphs1 A G 7: 30,166,991 (GRCm39) K747E probably benign Het
Nubp2 C G 17: 25,103,374 (GRCm39) probably null Het
Odad2 G T 18: 7,211,422 (GRCm39) C817* probably null Het
Or13a19 T C 7: 139,903,236 (GRCm39) V208A probably benign Het
Or5b97 A T 19: 12,878,600 (GRCm39) D181E possibly damaging Het
Or7a36 T G 10: 78,820,213 (GRCm39) D196E probably benign Het
Or7a40 A G 16: 16,491,491 (GRCm39) M118T probably damaging Het
Or8b48 A G 9: 38,492,977 (GRCm39) T135A probably benign Het
Pcdhac2 T G 18: 37,279,555 (GRCm39) L845R probably damaging Het
Pcdhb14 A C 18: 37,581,787 (GRCm39) T298P probably damaging Het
Phldb2 A T 16: 45,592,547 (GRCm39) L957Q possibly damaging Het
Pole A G 5: 110,459,959 (GRCm39) D1121G possibly damaging Het
Ppp1r3g C A 13: 36,153,612 (GRCm39) T344K probably benign Het
Prpf8 A G 11: 75,385,681 (GRCm39) K954R possibly damaging Het
Sap18b A G 8: 96,552,098 (GRCm39) E36G possibly damaging Het
Slc46a2 A T 4: 59,914,241 (GRCm39) F227L probably benign Het
Spata13 C T 14: 60,944,349 (GRCm39) P581S probably benign Het
Spmip4 T A 6: 50,550,930 (GRCm39) K506N Het
Ssc5d C A 7: 4,946,568 (GRCm39) T974K probably benign Het
Tenm4 C A 7: 96,545,345 (GRCm39) R2491S probably damaging Het
Tex2 T C 11: 106,437,579 (GRCm39) E697G unknown Het
Tmem44 A T 16: 30,366,226 (GRCm39) F67I possibly damaging Het
Trpm6 A T 19: 18,790,846 (GRCm39) Q627L probably damaging Het
Ttc39a A G 4: 109,278,570 (GRCm39) D77G possibly damaging Het
Ttc9 A G 12: 81,710,301 (GRCm39) I198V probably benign Het
Ttn C T 2: 76,661,550 (GRCm39) V11942M unknown Het
Uqcrc2 T A 7: 120,237,118 (GRCm39) Y55* probably null Het
Vmn1r160 A T 7: 22,571,273 (GRCm39) M209L probably benign Het
Vmn2r50 A T 7: 9,771,960 (GRCm39) C580* probably null Het
Vmn2r96 A G 17: 18,793,758 (GRCm39) E34G probably benign Het
Zmynd8 C T 2: 165,654,268 (GRCm39) probably null Het
Other mutations in Prr15l
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0389:Prr15l UTSW 11 96,825,440 (GRCm39) nonsense probably null
R4933:Prr15l UTSW 11 96,825,588 (GRCm39) missense probably damaging 1.00
R6815:Prr15l UTSW 11 96,825,433 (GRCm39) missense probably damaging 1.00
R7776:Prr15l UTSW 11 96,825,390 (GRCm39) missense possibly damaging 0.48
R9336:Prr15l UTSW 11 96,825,599 (GRCm39) missense probably damaging 1.00
Z1176:Prr15l UTSW 11 96,825,589 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCTCTATGAAGGAGCCTAGATAGG -3'
(R):5'- AGCGCTATGGTTCTCTTCGG -3'

Sequencing Primer
(F):5'- AGCCTAGATAGGGCTGGC -3'
(R):5'- TGTTCTCTCTGTCATCAAAGAGG -3'
Posted On 2022-09-12