Incidental Mutation 'R9628:Lpar5'
ID 725278
Institutional Source Beutler Lab
Gene Symbol Lpar5
Ensembl Gene ENSMUSG00000067714
Gene Name lysophosphatidic acid receptor 5
Synonyms LPA5, LOC381810, Gpr92, GPR93
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R9628 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 125067920-125082472 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 125081985 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 223 (V223G)
Ref Sequence ENSEMBL: ENSMUSP00000085630 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088292] [ENSMUST00000140346] [ENSMUST00000171989]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000088292
AA Change: V223G

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000085630
Gene: ENSMUSG00000067714
AA Change: V223G

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 7.4e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140346
SMART Domains Protein: ENSMUSP00000119904
Gene: ENSMUSG00000067714

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 164 1.5e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000171989
AA Change: V223G

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000132511
Gene: ENSMUSG00000067714
AA Change: V223G

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Pfam:7tm_1 55 313 1.1e-48 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to neuropathic pain and myelin sheath alterations. Mice homozygous for a different targeted allele exhibit decreased nociception sensitivity, decreased anxiety-related response and enhanced coordination and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg7 T C 16: 56,732,830 N635D probably damaging Het
Ankrd13c G C 3: 157,947,676 K50N probably benign Het
Arhgef38 T C 3: 133,132,264 Y635C unknown Het
Avl9 T A 6: 56,736,475 Y239* probably null Het
C2cd3 T A 7: 100,448,754 H1449Q Het
C530008M17Rik A G 5: 76,857,076 E428G unknown Het
Ccdc141 G A 2: 77,014,494 P1410S probably damaging Het
Ccz1 G A 5: 143,988,225 T471M possibly damaging Het
Cdh26 T C 2: 178,441,420 S27P Het
Cdk11b T G 4: 155,649,697 D756E unknown Het
Celsr3 C A 9: 108,826,360 S14* probably null Het
Cntrob T C 11: 69,322,956 T3A possibly damaging Het
Csde1 T C 3: 103,055,509 V738A probably benign Het
Dazap1 T C 10: 80,283,165 Y230H unknown Het
Dgcr14 A T 16: 17,902,893 M363K probably damaging Het
Dip2a A G 10: 76,307,159 I264T probably damaging Het
Dleu7 C A 14: 62,292,695 A86S possibly damaging Het
Dnmbp T A 19: 43,870,207 D132V probably damaging Het
Dppa4 T C 16: 48,291,309 V219A probably benign Het
Dsg1c T A 18: 20,264,316 I27N probably damaging Het
Egr4 T C 6: 85,512,310 Y256C probably benign Het
Fam124a A G 14: 62,587,561 E168G probably damaging Het
Gata4 T C 14: 63,241,096 Y18C probably damaging Het
Gckr C A 5: 31,300,590 A147D probably damaging Het
H1foo G A 6: 115,947,739 V69I probably damaging Het
Hook1 T C 4: 96,013,323 L506P probably damaging Het
Hormad2 G A 11: 4,427,372 P22L probably damaging Het
Larp1b T C 3: 40,961,668 probably null Het
Ldhb T C 6: 142,494,136 E226G probably damaging Het
Lrrc37a A G 11: 103,503,504 V365A probably benign Het
Lrrtm3 T C 10: 64,087,997 K464E probably damaging Het
Ly75 A G 2: 60,327,941 I1000T probably damaging Het
Myo1d C A 11: 80,557,470 G943V possibly damaging Het
Nicn1 C T 9: 108,294,509 R163C possibly damaging Het
Nphp4 T C 4: 152,484,509 L35P probably damaging Het
Nptx2 G A 5: 144,553,451 R230H probably benign Het
Ntsr1 G A 2: 180,541,481 R328H probably damaging Het
Olfr1216 A G 2: 89,013,326 V246A probably damaging Het
Olfr384 G A 11: 73,603,038 V153I probably benign Het
Olfr906 T G 9: 38,488,575 L182R probably benign Het
Padi6 G A 4: 140,737,315 T201I probably damaging Het
Plscr4 C T 9: 92,472,932 T13I possibly damaging Het
Ppp6r1 G A 7: 4,633,113 A782V probably benign Het
Rab18 G A 18: 6,788,647 V205M probably benign Het
Rhobtb1 T C 10: 69,270,823 V468A probably damaging Het
Rhox8 GCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCT GCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCT X: 37,878,114 probably benign Het
Scaf11 A T 15: 96,419,517 I722N probably benign Het
Slc17a4 A G 13: 23,905,529 V135A possibly damaging Het
Slc30a5 A G 13: 100,824,914 probably null Het
Slc5a6 T C 5: 31,040,402 Y321C probably benign Het
Spag7 A T 11: 70,664,360 D178E probably benign Het
Swsap1 T G 9: 21,955,876 S39A Het
Tank A G 2: 61,653,532 T441A probably benign Het
Tor1aip1 C A 1: 156,017,574 G276* probably null Het
Usp47 G A 7: 112,106,792 M1220I probably benign Het
Vmn1r43 G A 6: 89,869,895 T203M probably damaging Het
Vmn2r35 A G 7: 7,812,703 V489A probably benign Het
Wif1 T C 10: 121,096,644 V309A possibly damaging Het
Xpo4 T C 14: 57,605,173 N434D probably damaging Het
Zfp462 A T 4: 55,009,423 H463L probably benign Het
Other mutations in Lpar5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01719:Lpar5 APN 6 125082006 missense possibly damaging 0.94
IGL01830:Lpar5 APN 6 125081822 missense probably benign 0.01
IGL01975:Lpar5 APN 6 125081787 missense probably damaging 0.99
IGL02021:Lpar5 APN 6 125081992 nonsense probably null
IGL02718:Lpar5 APN 6 125082244 missense probably damaging 1.00
IGL03027:Lpar5 APN 6 125082240 missense probably damaging 1.00
IGL03300:Lpar5 APN 6 125082240 missense probably damaging 1.00
F5770:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
R0633:Lpar5 UTSW 6 125081991 missense probably benign 0.25
R1639:Lpar5 UTSW 6 125081601 missense probably damaging 1.00
R1822:Lpar5 UTSW 6 125081415 missense possibly damaging 0.76
R2227:Lpar5 UTSW 6 125081135 critical splice acceptor site probably null
R4019:Lpar5 UTSW 6 125081675 missense probably damaging 1.00
R4288:Lpar5 UTSW 6 125081864 missense probably benign 0.00
R4705:Lpar5 UTSW 6 125082207 missense possibly damaging 0.64
R4787:Lpar5 UTSW 6 125082498 splice site probably null
R5027:Lpar5 UTSW 6 125082147 missense possibly damaging 0.69
R6114:Lpar5 UTSW 6 125081676 missense probably damaging 1.00
R7197:Lpar5 UTSW 6 125082384 missense probably benign 0.00
R7779:Lpar5 UTSW 6 125082244 missense probably damaging 1.00
R8193:Lpar5 UTSW 6 125081339 missense probably benign
R8264:Lpar5 UTSW 6 125081502 missense probably damaging 1.00
R9460:Lpar5 UTSW 6 125081271 start gained probably benign
V7580:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
V7581:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
V7582:Lpar5 UTSW 6 125081727 missense possibly damaging 0.88
Z1176:Lpar5 UTSW 6 125081379 missense possibly damaging 0.92
Z1176:Lpar5 UTSW 6 125082072 missense probably damaging 1.00
Z1177:Lpar5 UTSW 6 125082018 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATCAACGTGGACCGCTATG -3'
(R):5'- TGTTCTTCACCAAGTTGGCC -3'

Sequencing Primer
(F):5'- TATGCGGCCATCGTGCAC -3'
(R):5'- TTCACCAAGTTGGCCCGTAG -3'
Posted On 2022-09-12