Mutagenetix > Incidental Mutation

Incidental Mutation 'R9628:Vmn2r35'

725281

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r35

Ensembl Gene

ENSMUSG00000096399

Gene Name

vomeronasal 2, receptor 35

Synonyms

EG625353

MMRRC Submission

Accession Numbers

Essential gene?

Not available question?

Stock #

R9628 (G1)

Quality Score

219.009

Status

Not validated

Chromosome

Chromosomal Location

7786151-7819867 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 7812703 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 489 (V489A)

Ref Sequence

ENSEMBL: ENSMUSP00000133007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169683]

AlphaFold

E9Q7U8

Predicted Effect

probably benign
Transcript: ENSMUST00000169683
AA Change: V489A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133007
Gene: ENSMUSG00000096399
AA Change: V489A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1.8e-32	PFAM
Pfam:NCD3G	512	565	1.2e-18	PFAM
Pfam:7tm_3	595	833	2.4e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg7	T	C	16: 56,732,830	N635D	probably damaging	Het
Ankrd13c	G	C	3: 157,947,676	K50N	probably benign	Het
Arhgef38	T	C	3: 133,132,264	Y635C	unknown	Het
Avl9	T	A	6: 56,736,475	Y239*	probably null	Het
C2cd3	T	A	7: 100,448,754	H1449Q		Het
C530008M17Rik	A	G	5: 76,857,076	E428G	unknown	Het
Ccdc141	G	A	2: 77,014,494	P1410S	probably damaging	Het
Ccz1	G	A	5: 143,988,225	T471M	possibly damaging	Het
Cdh26	T	C	2: 178,441,420	S27P		Het
Cdk11b	T	G	4: 155,649,697	D756E	unknown	Het
Celsr3	C	A	9: 108,826,360	S14*	probably null	Het
Cntrob	T	C	11: 69,322,956	T3A	possibly damaging	Het
Csde1	T	C	3: 103,055,509	V738A	probably benign	Het
Dazap1	T	C	10: 80,283,165	Y230H	unknown	Het
Dgcr14	A	T	16: 17,902,893	M363K	probably damaging	Het
Dip2a	A	G	10: 76,307,159	I264T	probably damaging	Het
Dleu7	C	A	14: 62,292,695	A86S	possibly damaging	Het
Dnmbp	T	A	19: 43,870,207	D132V	probably damaging	Het
Dppa4	T	C	16: 48,291,309	V219A	probably benign	Het
Dsg1c	T	A	18: 20,264,316	I27N	probably damaging	Het
Egr4	T	C	6: 85,512,310	Y256C	probably benign	Het
Fam124a	A	G	14: 62,587,561	E168G	probably damaging	Het
Gata4	T	C	14: 63,241,096	Y18C	probably damaging	Het
Gckr	C	A	5: 31,300,590	A147D	probably damaging	Het
H1foo	G	A	6: 115,947,739	V69I	probably damaging	Het
Hook1	T	C	4: 96,013,323	L506P	probably damaging	Het
Hormad2	G	A	11: 4,427,372	P22L	probably damaging	Het
Larp1b	T	C	3: 40,961,668		probably null	Het
Ldhb	T	C	6: 142,494,136	E226G	probably damaging	Het
Lpar5	T	G	6: 125,081,985	V223G	probably damaging	Het
Lrrc37a	A	G	11: 103,503,504	V365A	probably benign	Het
Lrrtm3	T	C	10: 64,087,997	K464E	probably damaging	Het
Ly75	A	G	2: 60,327,941	I1000T	probably damaging	Het
Myo1d	C	A	11: 80,557,470	G943V	possibly damaging	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nphp4	T	C	4: 152,484,509	L35P	probably damaging	Het
Nptx2	G	A	5: 144,553,451	R230H	probably benign	Het
Ntsr1	G	A	2: 180,541,481	R328H	probably damaging	Het
Olfr1216	A	G	2: 89,013,326	V246A	probably damaging	Het
Olfr384	G	A	11: 73,603,038	V153I	probably benign	Het
Olfr906	T	G	9: 38,488,575	L182R	probably benign	Het
Padi6	G	A	4: 140,737,315	T201I	probably damaging	Het
Plscr4	C	T	9: 92,472,932	T13I	possibly damaging	Het
Ppp6r1	G	A	7: 4,633,113	A782V	probably benign	Het
Rab18	G	A	18: 6,788,647	V205M	probably benign	Het
Rhobtb1	T	C	10: 69,270,823	V468A	probably damaging	Het
Rhox8	GCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCT	GCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCT	X: 37,878,114		probably benign	Het
Scaf11	A	T	15: 96,419,517	I722N	probably benign	Het
Slc17a4	A	G	13: 23,905,529	V135A	possibly damaging	Het
Slc30a5	A	G	13: 100,824,914		probably null	Het
Slc5a6	T	C	5: 31,040,402	Y321C	probably benign	Het
Spag7	A	T	11: 70,664,360	D178E	probably benign	Het
Swsap1	T	G	9: 21,955,876	S39A		Het
Tank	A	G	2: 61,653,532	T441A	probably benign	Het
Tor1aip1	C	A	1: 156,017,574	G276*	probably null	Het
Usp47	G	A	7: 112,106,792	M1220I	probably benign	Het
Vmn1r43	G	A	6: 89,869,895	T203M	probably damaging	Het
Wif1	T	C	10: 121,096,644	V309A	possibly damaging	Het
Xpo4	T	C	14: 57,605,173	N434D	probably damaging	Het
Zfp462	A	T	4: 55,009,423	H463L	probably benign	Het

Other mutations in Vmn2r35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01875:Vmn2r35	APN	7	7816773	splice site	probably benign
IGL03334:Vmn2r35	APN	7	7786494	missense	probably damaging	1.00
R1858:Vmn2r35	UTSW	7	7816806	missense	possibly damaging	0.46
R5505:Vmn2r35	UTSW	7	7786480	missense	probably damaging	1.00
R6150:Vmn2r35	UTSW	7	7786556	missense	probably damaging	1.00
R6211:Vmn2r35	UTSW	7	7786528	missense	probably damaging	0.99
R7439:Vmn2r35	UTSW	7	7817014	missense	probably damaging	1.00
R8399:Vmn2r35	UTSW	7	7816898	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTTCCAGAGGTTTAATTAAGGGAG -3'
(R):5'- CAGAATGCATTTTATGACTTGAAGG -3'

Sequencing Primer
(F):5'- AGGAGATTACATTGTCAAAAGAGC -3'
(R):5'- ATCCTCTTGGGGACAAAG -3'

Posted On

2022-09-12