Incidental Mutation 'R9630:Pik3c2g'
| ID |
725426 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R9630 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
139587221-139969284 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 139622239 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 118
(Q118K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141141
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032353]
[ENSMUST00000185968]
[ENSMUST00000187618]
[ENSMUST00000188066]
[ENSMUST00000190962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032353
AA Change: Q118K
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000032353
Gene: ENSMUSG00000030228
AA Change: Q118K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185968
AA Change: Q118K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140368
Gene: ENSMUSG00000030228
AA Change: Q118K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
371 |
2e-42 |
SMART |
|
Blast:PI3K_rbd
|
272 |
371 |
2e-64 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000187618
AA Change: Q118K
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000141025
Gene: ENSMUSG00000030228
AA Change: Q118K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188066
AA Change: Q118K
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190962
AA Change: Q118K
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000141141
Gene: ENSMUSG00000030228
AA Change: Q118K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9530053A07Rik |
T |
C |
7: 28,137,199 (GRCm38) |
L181P |
probably damaging |
Het |
| Arhgap17 |
A |
G |
7: 123,308,317 (GRCm38) |
M274T |
probably benign |
Het |
| Bco2 |
T |
C |
9: 50,545,457 (GRCm38) |
T128A |
possibly damaging |
Het |
| Bcr |
T |
A |
10: 75,131,118 (GRCm38) |
L519Q |
probably damaging |
Het |
| Cadps2 |
A |
T |
6: 23,587,572 (GRCm38) |
S306R |
probably benign |
Het |
| Cage1 |
T |
C |
13: 38,022,879 (GRCm38) |
E330G |
probably damaging |
Het |
| Ccdc8 |
A |
G |
7: 16,994,808 (GRCm38) |
K74R |
possibly damaging |
Het |
| Cdc42ep2 |
C |
A |
19: 5,918,335 (GRCm38) |
G114V |
|
Het |
| Celsr3 |
T |
C |
9: 108,827,097 (GRCm38) |
S260P |
probably benign |
Het |
| Clic4 |
G |
A |
4: 135,217,165 (GRCm38) |
T233I |
probably damaging |
Het |
| Clip2 |
C |
A |
5: 134,503,080 (GRCm38) |
D624Y |
probably damaging |
Het |
| Clock |
A |
G |
5: 76,245,434 (GRCm38) |
S221P |
probably benign |
Het |
| Creb3l2 |
G |
T |
6: 37,379,873 (GRCm38) |
S86R |
possibly damaging |
Het |
| Cspp1 |
G |
A |
1: 10,038,067 (GRCm38) |
|
probably benign |
Het |
| Doxl2 |
A |
G |
6: 48,975,822 (GRCm38) |
D227G |
probably damaging |
Het |
| Dusp13 |
A |
T |
14: 21,734,906 (GRCm38) |
N128K |
probably benign |
Het |
| Efnb2 |
T |
C |
8: 8,620,617 (GRCm38) |
S328G |
probably damaging |
Het |
| Egf |
A |
G |
3: 129,725,195 (GRCm38) |
L335P |
possibly damaging |
Het |
| Eml4 |
T |
A |
17: 83,410,143 (GRCm38) |
V48D |
probably damaging |
Het |
| Fat2 |
A |
C |
11: 55,256,779 (GRCm38) |
V3879G |
probably benign |
Het |
| Flnb |
T |
A |
14: 7,926,438 (GRCm38) |
Y1827* |
probably null |
Het |
| Fuca2 |
A |
T |
10: 13,503,076 (GRCm38) |
Y71F |
probably benign |
Het |
| Gcn1l1 |
C |
A |
5: 115,603,290 (GRCm38) |
H1463N |
probably damaging |
Het |
| Ifitm10 |
C |
T |
7: 142,371,172 (GRCm38) |
A48T |
probably damaging |
Het |
| Iqce |
T |
C |
5: 140,680,836 (GRCm38) |
D385G |
possibly damaging |
Het |
| Kdm5b |
T |
A |
1: 134,585,233 (GRCm38) |
|
probably null |
Het |
| Kdm7a |
A |
T |
6: 39,173,305 (GRCm38) |
S178T |
probably damaging |
Het |
| Mmp12 |
T |
A |
9: 7,347,516 (GRCm38) |
M31K |
probably benign |
Het |
| Mon2 |
C |
T |
10: 123,038,510 (GRCm38) |
R311H |
probably damaging |
Het |
| Myh15 |
A |
G |
16: 49,159,978 (GRCm38) |
T1488A |
probably benign |
Het |
| Myo15 |
T |
A |
11: 60,517,162 (GRCm38) |
C3159S |
probably damaging |
Het |
| Nf1 |
T |
C |
11: 79,411,644 (GRCm38) |
V346A |
probably damaging |
Het |
| Nfkbib |
A |
T |
7: 28,761,879 (GRCm38) |
Y114* |
probably null |
Het |
| Nr2c1 |
T |
A |
10: 94,162,423 (GRCm38) |
D76E |
probably benign |
Het |
| Obscn |
G |
A |
11: 59,052,571 (GRCm38) |
R4251C |
probably benign |
Het |
| Olfr1022 |
A |
G |
2: 85,869,149 (GRCm38) |
M186V |
probably benign |
Het |
| Olfr1097 |
A |
C |
2: 86,890,612 (GRCm38) |
S188A |
probably damaging |
Het |
| Olfr1247 |
C |
A |
2: 89,610,005 (GRCm38) |
M32I |
probably benign |
Het |
| Olfr356 |
T |
C |
2: 36,937,641 (GRCm38) |
I174T |
probably damaging |
Het |
| Olfr820 |
T |
C |
10: 130,017,541 (GRCm38) |
F60S |
probably damaging |
Het |
| Pced1a |
A |
T |
2: 130,419,189 (GRCm38) |
I416N |
probably benign |
Het |
| Pdzd2 |
G |
T |
15: 12,374,357 (GRCm38) |
D1897E |
probably benign |
Het |
| Pign |
A |
T |
1: 105,553,866 (GRCm38) |
F802I |
probably benign |
Het |
| Plcl2 |
A |
G |
17: 50,640,119 (GRCm38) |
M1009V |
probably benign |
Het |
| Ppil6 |
T |
A |
10: 41,494,554 (GRCm38) |
D59E |
probably benign |
Het |
| Rad23a |
T |
C |
8: 84,838,290 (GRCm38) |
D152G |
probably benign |
Het |
| Rif1 |
A |
G |
2: 52,089,595 (GRCm38) |
I430V |
probably damaging |
Het |
| Rint1 |
T |
C |
5: 23,815,812 (GRCm38) |
V611A |
possibly damaging |
Het |
| Rsf1 |
GGCG |
GGCGACGGCCGCG |
7: 97,579,906 (GRCm38) |
|
probably benign |
Het |
| Sall4 |
A |
G |
2: 168,754,488 (GRCm38) |
S811P |
probably benign |
Het |
| Scaf11 |
G |
A |
15: 96,418,168 (GRCm38) |
P1172S |
probably damaging |
Het |
| Sel1l3 |
T |
G |
5: 53,184,775 (GRCm38) |
N368H |
possibly damaging |
Het |
| Sele |
C |
A |
1: 164,051,954 (GRCm38) |
P352Q |
probably damaging |
Het |
| Serpinf1 |
T |
A |
11: 75,411,026 (GRCm38) |
T268S |
probably benign |
Het |
| Sez6 |
G |
A |
11: 77,974,295 (GRCm38) |
E623K |
possibly damaging |
Het |
| Sis |
A |
T |
3: 72,921,389 (GRCm38) |
N1152K |
probably benign |
Het |
| Slc16a13 |
T |
C |
11: 70,217,771 (GRCm38) |
E411G |
possibly damaging |
Het |
| Slc22a23 |
T |
C |
13: 34,195,407 (GRCm38) |
N459S |
possibly damaging |
Het |
| Srpk1 |
C |
A |
17: 28,600,430 (GRCm38) |
K268N |
probably benign |
Het |
| Ssbp3 |
A |
G |
4: 107,038,229 (GRCm38) |
Y258C |
probably damaging |
Het |
| Ssc5d |
C |
T |
7: 4,936,427 (GRCm38) |
P621S |
probably damaging |
Het |
| Strada |
T |
C |
11: 106,186,955 (GRCm38) |
Q61R |
unknown |
Het |
| Strn3 |
G |
A |
12: 51,610,230 (GRCm38) |
T755I |
probably damaging |
Het |
| Taf4b |
C |
G |
18: 14,797,020 (GRCm38) |
P150A |
probably damaging |
Het |
| Tmem236 |
T |
A |
2: 14,219,004 (GRCm38) |
H201Q |
probably benign |
Het |
| Top3b |
A |
G |
16: 16,892,490 (GRCm38) |
E728G |
probably benign |
Het |
| Tshr |
C |
T |
12: 91,537,635 (GRCm38) |
P449L |
probably damaging |
Het |
| Ugt2b36 |
C |
T |
5: 87,091,914 (GRCm38) |
G204D |
possibly damaging |
Het |
| Vldlr |
A |
T |
19: 27,230,223 (GRCm38) |
Q37L |
probably damaging |
Het |
| Zfat |
A |
T |
15: 68,118,944 (GRCm38) |
I1031N |
probably benign |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,896,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,852,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,622,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,622,409 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,860,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,918,004 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,852,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,736,973 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,967,828 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,772,407 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,635,654 (GRCm38) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,626,564 (GRCm38) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,859,370 (GRCm38) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,768,745 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,957,793 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,662,443 (GRCm38) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,629,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,957,699 (GRCm38) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,896,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,772,428 (GRCm38) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,844,070 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,748,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,635,636 (GRCm38) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,844,042 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1970:Pik3c2g
|
UTSW |
6 |
139,900,386 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,622,548 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,855,286 (GRCm38) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,852,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,855,292 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,852,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,635,610 (GRCm38) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,730,370 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,841,681 (GRCm38) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,633,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,720,006 (GRCm38) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,720,018 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,768,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,967,802 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,896,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,635,625 (GRCm38) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,622,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,896,257 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,622,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,720,082 (GRCm38) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,736,943 (GRCm38) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,715,855 (GRCm38) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,626,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,737,007 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,622,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,896,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,622,139 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,626,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,719,998 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,730,469 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,896,173 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,957,776 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,622,063 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,629,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,860,264 (GRCm38) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,754,863 (GRCm38) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,896,255 (GRCm38) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,967,894 (GRCm38) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,855,353 (GRCm38) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,967,917 (GRCm38) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,622,072 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,896,744 (GRCm38) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,882,060 (GRCm38) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,622,069 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,936,056 (GRCm38) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,967,893 (GRCm38) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,768,700 (GRCm38) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,730,366 (GRCm38) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,875,367 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,622,403 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,875,435 (GRCm38) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,882,016 (GRCm38) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,629,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,896,200 (GRCm38) |
missense |
|
|
|
R9697:Pik3c2g
|
UTSW |
6 |
139,967,791 (GRCm38) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,629,867 (GRCm38) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,896,184 (GRCm38) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,754,771 (GRCm38) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,635,658 (GRCm38) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,860,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATCAGCTGGTGGAAGAGATC -3'
(R):5'- GGGAGATTGCCTTCATGTTCTC -3'
Sequencing Primer
(F):5'- TAAGACTCCACTGTCTGAGAGTG -3'
(R):5'- CATGTTCTCCACAGTAGTTATGATG -3'
|
| Posted On |
2022-09-12 |
Incidental Mutation