Incidental Mutation 'R9632:Rttn'
ID 725639
Institutional Source Beutler Lab
Gene Symbol Rttn
Ensembl Gene ENSMUSG00000023066
Gene Name rotatin
Synonyms C530033I08Rik, 4921538A15Rik
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9632 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 88989914-89149140 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89035334 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 736 (N736S)
Ref Sequence ENSEMBL: ENSMUSP00000023828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023828]
AlphaFold Q8R4Y8
Predicted Effect possibly damaging
Transcript: ENSMUST00000023828
AA Change: N736S

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000023828
Gene: ENSMUSG00000023066
AA Change: N736S

DomainStartEndE-ValueType
Pfam:RTTN_N 16 112 1.2e-36 PFAM
low complexity region 188 199 N/A INTRINSIC
Blast:ARM 216 261 9e-18 BLAST
low complexity region 302 319 N/A INTRINSIC
low complexity region 335 341 N/A INTRINSIC
SCOP:d1gw5a_ 515 952 9e-3 SMART
Blast:ARM 863 910 4e-8 BLAST
low complexity region 972 985 N/A INTRINSIC
low complexity region 1165 1176 N/A INTRINSIC
low complexity region 1213 1222 N/A INTRINSIC
low complexity region 1680 1698 N/A INTRINSIC
low complexity region 1861 1879 N/A INTRINSIC
Blast:ARM 2088 2129 1e-10 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart. [provided by MGI curators]
Allele List at MGI

All alleles(15) : Targeted(2) Gene trapped(12) Transgenic(1)

Other mutations in this stock
Total: 98 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly A G 11: 100,389,072 (GRCm39) I570T probably damaging Het
Adamtsl4 G A 3: 95,589,090 (GRCm39) T447I probably damaging Het
Ahcyl1 T A 3: 107,578,494 (GRCm39) I248F possibly damaging Het
Arhgef2 T C 3: 88,528,576 (GRCm39) I4T probably benign Het
Bin2 T C 15: 100,549,915 (GRCm39) D176G possibly damaging Het
Bptf T A 11: 106,952,545 (GRCm39) T2166S probably damaging Het
Cachd1 T A 4: 100,832,092 (GRCm39) N751K probably benign Het
Castor1 A G 11: 4,169,015 (GRCm39) K61E probably benign Het
CN725425 A T 15: 91,126,851 (GRCm39) T214S possibly damaging Het
Crtam A T 9: 40,895,671 (GRCm39) D218E probably benign Het
Ctsj C T 13: 61,151,828 (GRCm39) M76I probably benign Het
Cuedc1 C A 11: 88,060,955 (GRCm39) S99R possibly damaging Het
Cyp4a14 T A 4: 115,349,347 (GRCm39) I238F probably benign Het
Dnajb11 A T 16: 22,681,344 (GRCm39) I41F probably damaging Het
Drd3 A G 16: 43,643,135 (GRCm39) N425S probably damaging Het
Eci1 G C 17: 24,645,859 (GRCm39) G25R probably damaging Het
Etl4 A T 2: 20,666,749 (GRCm39) N52I probably benign Het
Fbxo34 T C 14: 47,768,724 (GRCm39) Y746H probably damaging Het
Fcgbpl1 A G 7: 27,841,726 (GRCm39) I554V probably benign Het
Fndc1 T C 17: 7,991,622 (GRCm39) I691M unknown Het
Fut8 A G 12: 77,440,507 (GRCm39) T165A probably benign Het
Galr1 A T 18: 82,424,103 (GRCm39) L58Q probably damaging Het
Glt28d2 T C 3: 85,779,059 (GRCm39) D138G probably benign Het
Gm11595 A T 11: 99,663,097 (GRCm39) C194* probably null Het
Gm14403 T A 2: 177,201,421 (GRCm39) N213K probably benign Het
Gmpr T C 13: 45,699,519 (GRCm39) V343A probably benign Het
Hacd1 T C 2: 14,040,678 (GRCm39) N152D possibly damaging Het
Hcn1 A G 13: 118,010,522 (GRCm39) S367G probably benign Het
Impg1 A G 9: 80,287,276 (GRCm39) V390A probably benign Het
Itpr1 T C 6: 108,382,481 (GRCm39) C1458R possibly damaging Het
Kif16b A T 2: 142,553,960 (GRCm39) V946E probably benign Het
Krt71 T C 15: 101,644,988 (GRCm39) E441G probably damaging Het
Lhcgr A G 17: 89,049,532 (GRCm39) F665L probably benign Het
Lrrc37 T A 11: 103,433,252 (GRCm39) S3306C unknown Het
Lzic T A 4: 149,573,141 (GRCm39) F98I probably damaging Het
Map3k8 A T 18: 4,339,546 (GRCm39) V275D probably damaging Het
Marchf8 C T 6: 116,378,405 (GRCm39) T113I possibly damaging Het
Mmp15 A G 8: 96,098,731 (GRCm39) probably null Het
Mpst A G 15: 78,294,469 (GRCm39) D67G probably damaging Het
Nanog T C 6: 122,684,799 (GRCm39) S20P probably benign Het
Ndufc2 T C 7: 97,056,102 (GRCm39) S67P probably damaging Het
Nrg1 T C 8: 32,407,621 (GRCm39) K204R possibly damaging Het
Nsf T A 11: 103,714,594 (GRCm39) K728N probably damaging Het
Nutm2 C A 13: 50,628,901 (GRCm39) P655H probably benign Het
Obscn G A 11: 58,943,397 (GRCm39) R4251C probably benign Het
Or10g9 A T 9: 39,912,172 (GRCm39) M117K probably damaging Het
Or11h4 C T 14: 50,974,199 (GRCm39) C140Y probably benign Het
Or4a15 T C 2: 89,193,065 (GRCm39) Y236C probably damaging Het
Or4c102 A T 2: 88,423,057 (GRCm39) Q303L probably benign Het
Or4c120 T C 2: 89,001,752 (GRCm39) probably benign Het
Or56a5 T A 7: 104,793,165 (GRCm39) T112S probably benign Het
Otog A T 7: 45,915,143 (GRCm39) Q836L probably benign Het
Pcdhb11 T C 18: 37,556,019 (GRCm39) F450L probably damaging Het
Pelp1 T C 11: 70,284,835 (GRCm39) E1011G unknown Het
Pfkfb3 T G 2: 11,486,109 (GRCm39) R459S probably benign Het
Pgm1 T C 4: 99,843,918 (GRCm39) L567P probably damaging Het
Phf2 T A 13: 48,971,292 (GRCm39) D460V unknown Het
Polr1f G A 12: 33,479,723 (GRCm39) G24R possibly damaging Het
Pou5f1 G A 17: 35,819,731 (GRCm39) probably benign Het
Pou6f2 T C 13: 18,299,848 (GRCm39) R604G Het
Pramel5 T A 4: 143,999,545 (GRCm39) I181F probably benign Het
Ptprc T C 1: 138,008,627 (GRCm39) R687G probably damaging Het
Ptprz1 T A 6: 23,007,292 (GRCm39) H1618Q probably damaging Het
Qars1 G A 9: 108,391,582 (GRCm39) D618N probably damaging Het
Ripply3 A G 16: 94,134,139 (GRCm39) T68A probably benign Het
Rrad A G 8: 105,356,320 (GRCm39) M160T probably benign Het
Rtn1 A G 12: 72,350,961 (GRCm39) V416A probably damaging Het
Sash1 A T 10: 8,615,969 (GRCm39) V631E probably damaging Het
Selenof T A 3: 144,283,370 (GRCm39) F33L probably benign Het
Serpinb6b A T 13: 33,155,532 (GRCm39) N82Y possibly damaging Het
Sez6 G A 11: 77,865,121 (GRCm39) E623K possibly damaging Het
Shpk G T 11: 73,104,238 (GRCm39) R129L probably damaging Het
Slc2a10 A C 2: 165,358,176 (GRCm39) I434L probably damaging Het
Slc30a6 G T 17: 74,730,059 (GRCm39) M316I probably benign Het
Slx4 A T 16: 3,803,969 (GRCm39) H948Q probably benign Het
Sncaip A G 18: 53,039,726 (GRCm39) E640G probably damaging Het
Sox7 G A 14: 64,185,509 (GRCm39) A182T probably benign Het
Spata31e5 T A 1: 28,817,120 (GRCm39) Y304F probably benign Het
Srcin1 A G 11: 97,442,648 (GRCm39) I60T probably benign Het
Srm C T 4: 148,676,039 (GRCm39) probably benign Het
Srrt A T 5: 137,296,689 (GRCm39) M447K possibly damaging Het
Stam A T 2: 14,122,204 (GRCm39) H101L probably damaging Het
Suz12 C T 11: 79,915,748 (GRCm39) T407M possibly damaging Het
Tbc1d10b A G 7: 126,807,036 (GRCm39) V167A probably benign Het
Trav16 T A 14: 53,980,910 (GRCm39) V33E possibly damaging Het
Tshr C T 12: 91,504,409 (GRCm39) P449L probably damaging Het
Ttc17 A G 2: 94,209,097 (GRCm39) V119A probably damaging Het
Ttc19 A G 11: 62,203,997 (GRCm39) I319M probably benign Het
Ttc6 A G 12: 57,664,299 (GRCm39) M351V probably benign Het
Ttn G A 2: 76,714,897 (GRCm39) R8026* probably null Het
Ttn A T 2: 76,750,210 (GRCm39) V3613E probably benign Het
Txndc16 T C 14: 45,400,467 (GRCm39) I345V probably benign Het
Ube3b T C 5: 114,553,370 (GRCm39) I914T probably benign Het
Vmn1r73 T C 7: 11,490,407 (GRCm39) F75S possibly damaging Het
Vmn2r54 A T 7: 12,363,753 (GRCm39) M380K possibly damaging Het
Zfp820 T C 17: 22,038,107 (GRCm39) Y407C probably damaging Het
Zic5 C T 14: 122,701,787 (GRCm39) A315T unknown Het
Zmiz1 C A 14: 25,663,411 (GRCm39) D1053E unknown Het
Other mutations in Rttn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Rttn APN 18 88,992,464 (GRCm39) missense probably benign 0.00
IGL00788:Rttn APN 18 88,990,633 (GRCm39) missense probably benign 0.00
IGL00929:Rttn APN 18 89,047,059 (GRCm39) missense probably damaging 1.00
IGL01392:Rttn APN 18 89,013,737 (GRCm39) missense probably benign 0.03
IGL01395:Rttn APN 18 89,147,894 (GRCm39) missense possibly damaging 0.89
IGL01701:Rttn APN 18 89,082,339 (GRCm39) missense probably damaging 1.00
IGL02136:Rttn APN 18 89,064,252 (GRCm39) missense possibly damaging 0.87
IGL02151:Rttn APN 18 89,038,329 (GRCm39) missense probably damaging 1.00
IGL02165:Rttn APN 18 89,061,165 (GRCm39) missense probably benign
IGL02228:Rttn APN 18 89,060,355 (GRCm39) missense probably damaging 1.00
IGL02276:Rttn APN 18 89,066,578 (GRCm39) missense possibly damaging 0.94
IGL02612:Rttn APN 18 88,991,750 (GRCm39) missense probably damaging 1.00
IGL02645:Rttn APN 18 89,128,810 (GRCm39) missense probably benign 0.04
IGL02716:Rttn APN 18 89,066,541 (GRCm39) missense possibly damaging 0.77
IGL02820:Rttn APN 18 89,047,122 (GRCm39) missense probably damaging 1.00
IGL02961:Rttn APN 18 89,071,697 (GRCm39) missense probably damaging 1.00
IGL02973:Rttn APN 18 88,990,618 (GRCm39) missense probably damaging 1.00
IGL03027:Rttn APN 18 88,997,814 (GRCm39) missense probably damaging 1.00
IGL03082:Rttn APN 18 89,002,072 (GRCm39) missense probably damaging 1.00
IGL03121:Rttn APN 18 88,993,875 (GRCm39) missense probably damaging 1.00
IGL03135:Rttn APN 18 89,033,274 (GRCm39) missense probably damaging 1.00
IGL03328:Rttn APN 18 89,061,152 (GRCm39) missense probably benign 0.19
Fascisti UTSW 18 89,027,584 (GRCm39) splice site probably benign
marcher UTSW 18 89,056,070 (GRCm39) missense probably damaging 0.99
militaristi UTSW 18 89,029,040 (GRCm39) missense probably damaging 1.00
Thoughtless UTSW 18 89,032,735 (GRCm39) missense probably damaging 1.00
twister UTSW 18 89,064,286 (GRCm39) critical splice donor site probably null
Vermiculus UTSW 18 89,108,557 (GRCm39) missense probably benign
R0062:Rttn UTSW 18 89,029,090 (GRCm39) critical splice donor site probably null
R0062:Rttn UTSW 18 89,029,090 (GRCm39) critical splice donor site probably null
R0310:Rttn UTSW 18 89,027,584 (GRCm39) splice site probably benign
R0330:Rttn UTSW 18 89,004,204 (GRCm39) splice site probably null
R0363:Rttn UTSW 18 89,029,079 (GRCm39) missense probably damaging 1.00
R0485:Rttn UTSW 18 89,108,543 (GRCm39) splice site probably benign
R0590:Rttn UTSW 18 88,997,759 (GRCm39) missense probably damaging 1.00
R0601:Rttn UTSW 18 89,061,090 (GRCm39) missense probably benign 0.00
R0604:Rttn UTSW 18 88,995,882 (GRCm39) missense probably damaging 1.00
R0631:Rttn UTSW 18 89,007,670 (GRCm39) missense probably benign 0.00
R0882:Rttn UTSW 18 88,991,813 (GRCm39) nonsense probably null
R0885:Rttn UTSW 18 89,001,934 (GRCm39) missense probably benign 0.03
R0900:Rttn UTSW 18 89,119,815 (GRCm39) missense probably benign 0.13
R1077:Rttn UTSW 18 89,082,373 (GRCm39) missense probably damaging 1.00
R1444:Rttn UTSW 18 89,060,991 (GRCm39) missense probably benign 0.04
R1460:Rttn UTSW 18 89,127,481 (GRCm39) splice site probably benign
R1517:Rttn UTSW 18 89,131,474 (GRCm39) missense probably benign 0.01
R1630:Rttn UTSW 18 89,061,078 (GRCm39) missense probably benign 0.02
R1632:Rttn UTSW 18 89,027,460 (GRCm39) missense probably benign 0.18
R1722:Rttn UTSW 18 88,991,655 (GRCm39) missense probably benign 0.34
R1755:Rttn UTSW 18 89,027,441 (GRCm39) missense probably damaging 1.00
R1881:Rttn UTSW 18 89,033,336 (GRCm39) missense probably damaging 0.96
R1971:Rttn UTSW 18 89,108,557 (GRCm39) missense probably benign
R2035:Rttn UTSW 18 89,038,340 (GRCm39) missense probably damaging 1.00
R2109:Rttn UTSW 18 89,004,197 (GRCm39) missense possibly damaging 0.93
R2191:Rttn UTSW 18 89,113,772 (GRCm39) critical splice donor site probably null
R2201:Rttn UTSW 18 89,029,067 (GRCm39) missense possibly damaging 0.88
R2266:Rttn UTSW 18 89,082,295 (GRCm39) missense probably benign 0.05
R3014:Rttn UTSW 18 89,032,744 (GRCm39) missense probably damaging 1.00
R3052:Rttn UTSW 18 89,033,370 (GRCm39) splice site probably benign
R3427:Rttn UTSW 18 89,113,775 (GRCm39) splice site probably null
R3431:Rttn UTSW 18 89,113,695 (GRCm39) missense probably benign 0.04
R3786:Rttn UTSW 18 89,056,018 (GRCm39) missense probably benign 0.00
R3803:Rttn UTSW 18 88,995,831 (GRCm39) missense probably damaging 0.96
R3980:Rttn UTSW 18 89,035,399 (GRCm39) missense probably benign 0.12
R4035:Rttn UTSW 18 89,013,777 (GRCm39) missense probably benign 0.03
R4170:Rttn UTSW 18 88,993,847 (GRCm39) missense probably damaging 1.00
R4223:Rttn UTSW 18 89,113,708 (GRCm39) missense probably damaging 1.00
R4273:Rttn UTSW 18 89,110,020 (GRCm39) missense probably benign
R4517:Rttn UTSW 18 89,047,097 (GRCm39) missense probably damaging 0.99
R4674:Rttn UTSW 18 89,029,135 (GRCm39) splice site probably null
R4837:Rttn UTSW 18 89,108,539 (GRCm39) splice site probably null
R4869:Rttn UTSW 18 89,061,138 (GRCm39) nonsense probably null
R4881:Rttn UTSW 18 89,119,809 (GRCm39) missense probably damaging 1.00
R4959:Rttn UTSW 18 89,060,292 (GRCm39) missense probably damaging 1.00
R4973:Rttn UTSW 18 89,060,292 (GRCm39) missense probably damaging 1.00
R4975:Rttn UTSW 18 89,082,209 (GRCm39) splice site probably null
R5166:Rttn UTSW 18 89,031,218 (GRCm39) missense possibly damaging 0.48
R5243:Rttn UTSW 18 89,126,187 (GRCm39) missense possibly damaging 0.74
R5594:Rttn UTSW 18 89,108,560 (GRCm39) missense possibly damaging 0.95
R5654:Rttn UTSW 18 89,066,556 (GRCm39) missense probably benign
R5794:Rttn UTSW 18 89,013,693 (GRCm39) missense probably benign 0.18
R5799:Rttn UTSW 18 89,056,070 (GRCm39) missense probably damaging 0.99
R5955:Rttn UTSW 18 89,139,133 (GRCm39) missense probably damaging 0.99
R5963:Rttn UTSW 18 89,091,819 (GRCm39) missense probably benign 0.01
R5989:Rttn UTSW 18 88,991,750 (GRCm39) missense probably damaging 1.00
R6004:Rttn UTSW 18 89,039,816 (GRCm39) missense probably damaging 0.96
R6132:Rttn UTSW 18 89,133,770 (GRCm39) critical splice donor site probably null
R6430:Rttn UTSW 18 89,039,809 (GRCm39) missense probably null 0.18
R6436:Rttn UTSW 18 89,128,853 (GRCm39) missense probably damaging 1.00
R6681:Rttn UTSW 18 89,032,735 (GRCm39) missense probably damaging 1.00
R6994:Rttn UTSW 18 89,047,023 (GRCm39) missense probably damaging 1.00
R7049:Rttn UTSW 18 89,082,340 (GRCm39) missense probably damaging 1.00
R7078:Rttn UTSW 18 89,027,546 (GRCm39) missense probably benign 0.03
R7083:Rttn UTSW 18 89,108,722 (GRCm39) missense probably damaging 1.00
R7250:Rttn UTSW 18 89,007,647 (GRCm39) missense probably benign 0.03
R7402:Rttn UTSW 18 89,004,035 (GRCm39) missense possibly damaging 0.92
R7565:Rttn UTSW 18 89,078,603 (GRCm39) missense probably damaging 1.00
R7588:Rttn UTSW 18 89,082,353 (GRCm39) missense probably damaging 0.97
R8029:Rttn UTSW 18 89,108,598 (GRCm39) missense not run
R8085:Rttn UTSW 18 89,071,672 (GRCm39) nonsense probably null
R8113:Rttn UTSW 18 89,029,040 (GRCm39) missense probably damaging 1.00
R8355:Rttn UTSW 18 89,047,016 (GRCm39) missense probably benign 0.05
R8531:Rttn UTSW 18 89,131,467 (GRCm39) missense probably benign 0.00
R8992:Rttn UTSW 18 88,995,832 (GRCm39) missense probably benign 0.24
R9008:Rttn UTSW 18 89,027,556 (GRCm39) missense probably damaging 1.00
R9139:Rttn UTSW 18 89,038,261 (GRCm39) missense probably benign 0.30
R9210:Rttn UTSW 18 89,064,286 (GRCm39) critical splice donor site probably null
R9212:Rttn UTSW 18 89,064,286 (GRCm39) critical splice donor site probably null
R9286:Rttn UTSW 18 88,995,849 (GRCm39) missense probably benign 0.06
R9368:Rttn UTSW 18 89,078,576 (GRCm39) missense probably damaging 1.00
R9710:Rttn UTSW 18 89,035,334 (GRCm39) missense possibly damaging 0.82
X0017:Rttn UTSW 18 89,131,526 (GRCm39) missense probably benign 0.01
X0022:Rttn UTSW 18 88,991,791 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATGGAGGTGCTACTGCTCAG -3'
(R):5'- GTTCTCCAGCAAAATGACACG -3'

Sequencing Primer
(F):5'- GCTACTGCTCAGATCTTGGAAGAC -3'
(R):5'- AAAGCCGTAGCACAGACT -3'
Posted On 2022-09-12