Incidental Mutation 'R0764:Ly6g2'
ID 72570
Institutional Source Beutler Lab
Gene Symbol Ly6g2
Ensembl Gene ENSMUSG00000047728
Gene Name lymphocyte antigen 6 family member G2
Synonyms BC025446
MMRRC Submission 038944-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0764 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 75088227-75094510 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 75092572 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 97 (F97Y)
Ref Sequence ENSEMBL: ENSMUSP00000155184 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055719] [ENSMUST00000185307] [ENSMUST00000229521]
AlphaFold A0A087WQT1
Predicted Effect probably benign
Transcript: ENSMUST00000055719
AA Change: F97Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000053396
Gene: ENSMUSG00000047728
AA Change: F97Y

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 118 1.06e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000185307
AA Change: F97Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000140330
Gene: ENSMUSG00000047728
AA Change: F97Y

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 118 5.3e-30 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000229521
AA Change: F97Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.1%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A T 11: 109,950,772 (GRCm39) Y898N probably damaging Het
Acp4 T C 7: 43,901,738 (GRCm39) probably benign Het
Adipor2 T C 6: 119,334,215 (GRCm39) I332V probably benign Het
Ago3 T A 4: 126,248,885 (GRCm39) K555N possibly damaging Het
Angpt4 A G 2: 151,753,204 (GRCm39) probably benign Het
Ano5 G T 7: 51,187,590 (GRCm39) probably benign Het
Ap3b1 C T 13: 94,616,387 (GRCm39) probably benign Het
Cbl A T 9: 44,075,449 (GRCm39) C399S probably damaging Het
Cdkl2 C A 5: 92,168,136 (GRCm39) V353L probably benign Het
Celsr3 A G 9: 108,705,017 (GRCm39) Y500C probably damaging Het
Cep162 A G 9: 87,083,798 (GRCm39) S1242P probably damaging Het
Crhr1 C T 11: 104,050,152 (GRCm39) R66W probably damaging Het
Ddx49 T C 8: 70,749,907 (GRCm39) E170G probably benign Het
Fam193a T C 5: 34,600,685 (GRCm39) F305L probably damaging Het
Fam76a C T 4: 132,638,010 (GRCm39) G198R probably damaging Het
Gm43302 T A 5: 105,428,355 (GRCm39) I130F probably benign Het
Hectd4 T A 5: 121,424,832 (GRCm39) I745N possibly damaging Het
Ina T A 19: 47,012,087 (GRCm39) *502K probably null Het
Kdm1b A T 13: 47,222,079 (GRCm39) D506V possibly damaging Het
Lrrk2 A G 15: 91,659,249 (GRCm39) probably null Het
Naip5 A T 13: 100,353,613 (GRCm39) D1215E probably benign Het
Neb A G 2: 52,106,879 (GRCm39) probably benign Het
Nectin2 T A 7: 19,483,096 (GRCm39) probably null Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or2aj5 G T 16: 19,425,182 (GRCm39) P79T probably damaging Het
Or4a71 A G 2: 89,358,340 (GRCm39) V138A probably benign Het
Osbp A G 19: 11,961,520 (GRCm39) probably benign Het
Otog A G 7: 45,949,918 (GRCm39) D2460G probably benign Het
Pcgf1 T C 6: 83,056,150 (GRCm39) C2R probably damaging Het
Per2 C T 1: 91,357,142 (GRCm39) V674M probably damaging Het
Pias3 C T 3: 96,608,611 (GRCm39) P218S probably damaging Het
Plod3 C T 5: 137,018,437 (GRCm39) probably benign Het
Purb C T 11: 6,425,661 (GRCm39) V76M probably damaging Het
Ranbp1 C A 16: 18,058,022 (GRCm39) E181* probably null Het
Rit2 T C 18: 31,286,754 (GRCm39) probably benign Het
Rnf103 C A 6: 71,486,566 (GRCm39) T399K probably damaging Het
Slc22a13 T C 9: 119,037,746 (GRCm39) probably null Het
Slc35f4 T A 14: 49,543,796 (GRCm39) probably benign Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Tnfrsf17 C T 16: 11,133,063 (GRCm39) T47M possibly damaging Het
Tram1 A G 1: 13,649,933 (GRCm39) I97T probably damaging Het
Ttc38 T C 15: 85,730,604 (GRCm39) probably benign Het
Zfp113 T A 5: 138,143,506 (GRCm39) Q248L probably damaging Het
Other mutations in Ly6g2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Ly6g2 APN 15 75,093,505 (GRCm39) utr 3 prime probably benign
R0084:Ly6g2 UTSW 15 75,089,624 (GRCm39) missense probably benign 0.01
R1736:Ly6g2 UTSW 15 75,089,569 (GRCm39) missense probably damaging 1.00
R1829:Ly6g2 UTSW 15 75,088,605 (GRCm39) critical splice donor site probably null
R5412:Ly6g2 UTSW 15 75,089,669 (GRCm39) missense probably damaging 0.98
R5793:Ly6g2 UTSW 15 75,093,493 (GRCm39) utr 3 prime probably benign
R7434:Ly6g2 UTSW 15 75,088,567 (GRCm39) missense probably benign
R8007:Ly6g2 UTSW 15 75,088,552 (GRCm39) missense probably benign 0.00
R8479:Ly6g2 UTSW 15 75,089,626 (GRCm39) missense probably damaging 0.98
R9450:Ly6g2 UTSW 15 75,092,574 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGATGCTCTGTTGTCGCTGCATAAG -3'
(R):5'- ACACGTAGGAACCCTGGATGACAC -3'

Sequencing Primer
(F):5'- CTGTTGTCGCTGCATAAGAAGTAAG -3'
(R):5'- AGTGGGGCACCTATACTTCAG -3'
Posted On 2013-09-30