Incidental Mutation 'R9634:Kcnrg'
ID 725727
Institutional Source Beutler Lab
Gene Symbol Kcnrg
Ensembl Gene ENSMUSG00000046168
Gene Name potassium channel regulator
Synonyms LOC328424, E030012H22Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R9634 (G1)
Quality Score 217.468
Status Not validated
Chromosome 14
Chromosomal Location 61844906-61850275 bp(+) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CACAACAA to CACAA at 61845009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039562] [ENSMUST00000051184] [ENSMUST00000165015] [ENSMUST00000225582]
AlphaFold Q2TUM3
Predicted Effect probably benign
Transcript: ENSMUST00000039562
SMART Domains Protein: ENSMUSP00000045009
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000051184
SMART Domains Protein: ENSMUSP00000055327
Gene: ENSMUSG00000046168

DomainStartEndE-ValueType
BTB 5 106 8.7e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165015
SMART Domains Protein: ENSMUSP00000128509
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000225582
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Allele List at MGI

All alleles(1) : Gene trapped(1)
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca C A 11: 84,184,816 (GRCm39) D1277E probably benign Het
Anapc7 T C 5: 122,560,689 (GRCm39) S17P probably damaging Het
Atad2b T C 12: 5,060,332 (GRCm39) F909S probably damaging Het
Ccnb1 G A 13: 100,920,112 (GRCm39) A133V probably benign Het
Chd7 A G 4: 8,832,499 (GRCm39) T1125A probably damaging Het
Cyc1 A G 15: 76,227,794 (GRCm39) T11A probably benign Het
Ddx59 G A 1: 136,347,214 (GRCm39) A291T probably damaging Het
Dgkg T A 16: 22,338,387 (GRCm39) probably null Het
Dock8 A G 19: 25,169,585 (GRCm39) D1952G probably damaging Het
Dpf3 A G 12: 83,378,635 (GRCm39) probably null Het
Evi5 T C 5: 107,964,663 (GRCm39) I340V probably benign Het
Extl3 A T 14: 65,314,919 (GRCm39) S88T probably damaging Het
Fktn A G 4: 53,761,230 (GRCm39) H410R probably benign Het
Fyb2 A T 4: 104,856,579 (GRCm39) K596* probably null Het
Gas2l3 C T 10: 89,249,943 (GRCm39) A392T probably benign Het
Gbp7 T A 3: 142,242,115 (GRCm39) V83E probably benign Het
Gja10 A G 4: 32,601,877 (GRCm39) V169A probably damaging Het
Gnao1 A G 8: 94,682,723 (GRCm39) H303R probably benign Het
Iars2 A G 1: 185,027,727 (GRCm39) *734R probably null Het
Il2ra C T 2: 11,685,227 (GRCm39) R188* probably null Het
Inpp5f A C 7: 128,278,515 (GRCm39) D435A possibly damaging Het
Ints3 T C 3: 90,318,606 (GRCm39) T210A Het
Itpkc A G 7: 26,913,880 (GRCm39) I527T probably benign Het
Loxl3 C T 6: 83,027,835 (GRCm39) T749I probably benign Het
Lrp1b C T 2: 41,135,951 (GRCm39) probably null Het
Ncapg2 T A 12: 116,379,077 (GRCm39) H190Q probably damaging Het
Nkain2 G A 10: 32,766,262 (GRCm39) P66L unknown Het
Nubpl T C 12: 52,349,494 (GRCm39) F242L probably benign Het
Or4f4-ps1 T C 2: 111,330,131 (GRCm39) V178A possibly damaging Het
Or4x11 T C 2: 89,867,907 (GRCm39) S215P probably damaging Het
Or8b51 A G 9: 38,568,869 (GRCm39) I273T probably benign Het
Paip2b T C 6: 83,787,023 (GRCm39) D71G probably damaging Het
Plch1 T C 3: 63,605,152 (GRCm39) E1584G probably damaging Het
Poglut2 T C 1: 44,152,196 (GRCm39) D271G probably damaging Het
Prkag2 A G 5: 25,074,238 (GRCm39) I489T possibly damaging Het
Ptpn2 C T 18: 67,808,789 (GRCm39) probably null Het
Rims3 G A 4: 120,748,517 (GRCm39) R246H possibly damaging Het
Sorl1 T G 9: 41,907,590 (GRCm39) T1466P probably benign Het
Tbl3 T C 17: 24,926,531 (GRCm39) E3G probably benign Het
Tex2 A G 11: 106,458,978 (GRCm39) S151P unknown Het
Tmem260 C A 14: 48,709,816 (GRCm39) A123E probably damaging Het
Trim45 T C 3: 100,839,306 (GRCm39) V736A unknown Het
Vps8 T C 16: 21,372,893 (GRCm39) L1033P probably damaging Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Wwc2 GCC GCCC 8: 48,304,959 (GRCm39) probably null Het
Ythdc2 A G 18: 45,006,037 (GRCm39) T1177A probably benign Het
Zfp36l2 A G 17: 84,494,056 (GRCm39) Y194H probably damaging Het
Other mutations in Kcnrg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Kcnrg APN 14 61,845,359 (GRCm39) missense probably damaging 1.00
IGL01311:Kcnrg APN 14 61,849,274 (GRCm39) missense probably damaging 1.00
D4216:Kcnrg UTSW 14 61,849,242 (GRCm39) nonsense probably null
R1081:Kcnrg UTSW 14 61,845,163 (GRCm39) missense possibly damaging 0.87
R1346:Kcnrg UTSW 14 61,849,144 (GRCm39) missense probably benign 0.31
R3147:Kcnrg UTSW 14 61,845,140 (GRCm39) missense probably damaging 1.00
R4690:Kcnrg UTSW 14 61,849,176 (GRCm39) missense probably damaging 1.00
R4820:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R5068:Kcnrg UTSW 14 61,845,266 (GRCm39) missense probably damaging 1.00
R5914:Kcnrg UTSW 14 61,849,280 (GRCm39) missense probably benign
R7234:Kcnrg UTSW 14 61,845,531 (GRCm39) missense unknown
R8232:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R8821:Kcnrg UTSW 14 61,844,981 (GRCm39) missense possibly damaging 0.55
R9442:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9475:Kcnrg UTSW 14 61,845,106 (GRCm39) missense possibly damaging 0.95
R9633:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9703:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- ACTTGCAAACACAGCTATGGATAC -3'
(R):5'- TCCGAGGGTAACAGAAGCTC -3'

Sequencing Primer
(F):5'- GGATACACTATTTGTCTTGACGATAG -3'
(R):5'- GGGTAACAGAAGCTCATGATTTCTC -3'
Posted On 2022-09-12