Incidental Mutation 'R9635:Or6c5c'
ID 725763
Institutional Source Beutler Lab
Gene Symbol Or6c5c
Ensembl Gene ENSMUSG00000096497
Gene Name olfactory receptor family 6 subfamily C member 5C
Synonyms MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R9635 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129297809-129299485 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129299463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 306 (V306A)
Ref Sequence ENSEMBL: ENSMUSP00000149391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077836] [ENSMUST00000213329]
AlphaFold Q7TRI1
Predicted Effect probably benign
Transcript: ENSMUST00000077836
AA Change: V306A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077005
Gene: ENSMUSG00000096497
AA Change: V306A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4e-49 PFAM
Pfam:7tm_1 39 288 2.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213329
AA Change: V306A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 A T 5: 4,100,545 (GRCm39) T2736S probably benign Het
AW209491 T C 13: 14,811,957 (GRCm39) V270A probably benign Het
Best3 A T 10: 116,838,450 (GRCm39) K169N probably damaging Het
Cabyr A G 18: 12,883,816 (GRCm39) K101R probably damaging Het
Cfhr4 C T 1: 139,701,764 (GRCm39) V117I probably damaging Het
Chd5 A T 4: 152,461,079 (GRCm39) D1223V possibly damaging Het
Commd2 T C 3: 57,559,064 (GRCm39) D4G probably benign Het
Cox5b-ps T C 13: 21,685,294 (GRCm39) T99A probably benign Het
Cyp3a41a A T 5: 145,652,320 (GRCm39) F60I possibly damaging Het
D6Ertd527e G C 6: 87,088,839 (GRCm39) S334T unknown Het
Dnmbp C A 19: 43,855,974 (GRCm39) A261S probably benign Het
Fcgbp A C 7: 27,800,832 (GRCm39) T1293P probably benign Het
Gal3st2b A C 1: 93,868,777 (GRCm39) N336T probably benign Het
Gm10309 T C 17: 86,806,494 (GRCm39) T7A unknown Het
Gm10322 A T 10: 59,451,931 (GRCm39) H16L possibly damaging Het
Gpr17 A G 18: 32,080,199 (GRCm39) L288P probably damaging Het
Ighe T C 12: 113,235,899 (GRCm39) I142M Het
Lrrc7 T C 3: 157,946,138 (GRCm39) K187R probably benign Het
Lrrk2 T A 15: 91,696,527 (GRCm39) D2438E probably benign Het
Map3k20 G A 2: 72,232,403 (GRCm39) S353N possibly damaging Het
Moxd2 T A 6: 40,863,000 (GRCm39) D102V possibly damaging Het
Obscn T C 11: 58,972,686 (GRCm39) E2120G possibly damaging Het
Or4f4-ps1 T A 2: 111,330,267 (GRCm39) C223* probably null Het
Or5p79 A G 7: 108,221,654 (GRCm39) I212V probably benign Het
Pcdhb5 A T 18: 37,454,510 (GRCm39) T297S probably benign Het
Pdcd2l A C 7: 33,892,356 (GRCm39) L171R possibly damaging Het
Ppp4r3b T C 11: 29,138,113 (GRCm39) S154P probably benign Het
Prc1 T G 7: 79,962,047 (GRCm39) M515R probably benign Het
Rbm34 A G 8: 127,696,872 (GRCm39) S77P probably damaging Het
Samsn1 T G 16: 75,673,457 (GRCm39) T140P probably damaging Het
Slc34a1 G A 13: 55,556,940 (GRCm39) V379M probably damaging Het
Stab2 T A 10: 86,686,651 (GRCm39) R2298* probably null Het
Trim10 G A 17: 37,187,890 (GRCm39) V369M probably damaging Het
Trpv6 T C 6: 41,599,901 (GRCm39) N585S possibly damaging Het
Ttn C T 2: 76,586,617 (GRCm39) D21765N possibly damaging Het
Ubxn6 A G 17: 56,376,189 (GRCm39) L349P probably damaging Het
Vdac3 A T 8: 23,077,575 (GRCm39) S37R probably damaging Het
Vmn1r124 G A 7: 20,993,720 (GRCm39) L275F probably benign Het
Wdr17 A T 8: 55,101,375 (GRCm39) I964N probably damaging Het
Zdhhc22 A G 12: 87,030,396 (GRCm39) F184S possibly damaging Het
Zfp512 A G 5: 31,623,669 (GRCm39) H124R probably benign Het
Zswim4 T C 8: 84,939,354 (GRCm39) T843A probably damaging Het
Other mutations in Or6c5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0384:Or6c5c UTSW 10 129,298,909 (GRCm39) nonsense probably null
R1851:Or6c5c UTSW 10 129,299,370 (GRCm39) missense probably damaging 1.00
R2211:Or6c5c UTSW 10 129,298,809 (GRCm39) missense probably damaging 1.00
R3613:Or6c5c UTSW 10 129,298,937 (GRCm39) missense probably benign 0.29
R3701:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R3702:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R4496:Or6c5c UTSW 10 129,299,430 (GRCm39) missense possibly damaging 0.93
R5745:Or6c5c UTSW 10 129,299,307 (GRCm39) missense probably damaging 1.00
R6791:Or6c5c UTSW 10 129,299,023 (GRCm39) missense probably benign 0.00
R7190:Or6c5c UTSW 10 129,298,626 (GRCm39) missense probably benign 0.00
R7278:Or6c5c UTSW 10 129,298,620 (GRCm39) missense probably damaging 1.00
R7313:Or6c5c UTSW 10 129,298,856 (GRCm39) missense probably damaging 0.98
R7369:Or6c5c UTSW 10 129,299,390 (GRCm39) missense probably benign
R7824:Or6c5c UTSW 10 129,298,665 (GRCm39) missense probably damaging 1.00
R7851:Or6c5c UTSW 10 129,299,429 (GRCm39) missense probably benign 0.36
R8961:Or6c5c UTSW 10 129,299,225 (GRCm39) missense probably damaging 1.00
R9775:Or6c5c UTSW 10 129,298,677 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATTCTGAGGTTCCCATCTGC -3'
(R):5'- GCAACCATACTGTAGCATCTTTCAG -3'

Sequencing Primer
(F):5'- CAGAGGAAAAAGGCTTTCTCCACTTG -3'
(R):5'- GCATAGATGCCTGAGAGA -3'
Posted On 2022-09-12