Incidental Mutation 'R9635:Gpr17'
ID 725777
Institutional Source Beutler Lab
Gene Symbol Gpr17
Ensembl Gene ENSMUSG00000052229
Gene Name G protein-coupled receptor 17
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9635 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 32076050-32082689 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32080199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 288 (L288P)
Ref Sequence ENSEMBL: ENSMUSP00000063670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025254] [ENSMUST00000064016] [ENSMUST00000224383] [ENSMUST00000225404]
AlphaFold Q6NS65
Predicted Effect probably benign
Transcript: ENSMUST00000025254
SMART Domains Protein: ENSMUSP00000025254
Gene: ENSMUSG00000024395

DomainStartEndE-ValueType
LIM 14 67 1.15e-14 SMART
LIM 75 126 2.74e-12 SMART
LIM 139 189 3.87e-12 SMART
LIM 197 248 4.31e-19 SMART
LIM 256 308 2.67e-15 SMART
low complexity region 314 330 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000064016
AA Change: L288P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063670
Gene: ENSMUSG00000052229
AA Change: L288P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 42 289 4.7e-7 PFAM
Pfam:7tm_1 48 297 1.1e-45 PFAM
Pfam:7TM_GPCR_Srv 70 268 2.3e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000224383
Predicted Effect probably benign
Transcript: ENSMUST00000225404
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit early differentiation of oligodendroglial progenitor cells and increased myelination without any behavioral or motor deficits. Homozygotes for a different null allele show increased vascular permeability in IgE-dependent passive cutaneous anaphylaxis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 A T 5: 4,100,545 (GRCm39) T2736S probably benign Het
AW209491 T C 13: 14,811,957 (GRCm39) V270A probably benign Het
Best3 A T 10: 116,838,450 (GRCm39) K169N probably damaging Het
Cabyr A G 18: 12,883,816 (GRCm39) K101R probably damaging Het
Cfhr4 C T 1: 139,701,764 (GRCm39) V117I probably damaging Het
Chd5 A T 4: 152,461,079 (GRCm39) D1223V possibly damaging Het
Commd2 T C 3: 57,559,064 (GRCm39) D4G probably benign Het
Cox5b-ps T C 13: 21,685,294 (GRCm39) T99A probably benign Het
Cyp3a41a A T 5: 145,652,320 (GRCm39) F60I possibly damaging Het
D6Ertd527e G C 6: 87,088,839 (GRCm39) S334T unknown Het
Dnmbp C A 19: 43,855,974 (GRCm39) A261S probably benign Het
Fcgbp A C 7: 27,800,832 (GRCm39) T1293P probably benign Het
Gal3st2b A C 1: 93,868,777 (GRCm39) N336T probably benign Het
Gm10309 T C 17: 86,806,494 (GRCm39) T7A unknown Het
Gm10322 A T 10: 59,451,931 (GRCm39) H16L possibly damaging Het
Ighe T C 12: 113,235,899 (GRCm39) I142M Het
Lrrc7 T C 3: 157,946,138 (GRCm39) K187R probably benign Het
Lrrk2 T A 15: 91,696,527 (GRCm39) D2438E probably benign Het
Map3k20 G A 2: 72,232,403 (GRCm39) S353N possibly damaging Het
Moxd2 T A 6: 40,863,000 (GRCm39) D102V possibly damaging Het
Obscn T C 11: 58,972,686 (GRCm39) E2120G possibly damaging Het
Or4f4-ps1 T A 2: 111,330,267 (GRCm39) C223* probably null Het
Or5p79 A G 7: 108,221,654 (GRCm39) I212V probably benign Het
Or6c5c T C 10: 129,299,463 (GRCm39) V306A probably benign Het
Pcdhb5 A T 18: 37,454,510 (GRCm39) T297S probably benign Het
Pdcd2l A C 7: 33,892,356 (GRCm39) L171R possibly damaging Het
Ppp4r3b T C 11: 29,138,113 (GRCm39) S154P probably benign Het
Prc1 T G 7: 79,962,047 (GRCm39) M515R probably benign Het
Rbm34 A G 8: 127,696,872 (GRCm39) S77P probably damaging Het
Samsn1 T G 16: 75,673,457 (GRCm39) T140P probably damaging Het
Slc34a1 G A 13: 55,556,940 (GRCm39) V379M probably damaging Het
Stab2 T A 10: 86,686,651 (GRCm39) R2298* probably null Het
Trim10 G A 17: 37,187,890 (GRCm39) V369M probably damaging Het
Trpv6 T C 6: 41,599,901 (GRCm39) N585S possibly damaging Het
Ttn C T 2: 76,586,617 (GRCm39) D21765N possibly damaging Het
Ubxn6 A G 17: 56,376,189 (GRCm39) L349P probably damaging Het
Vdac3 A T 8: 23,077,575 (GRCm39) S37R probably damaging Het
Vmn1r124 G A 7: 20,993,720 (GRCm39) L275F probably benign Het
Wdr17 A T 8: 55,101,375 (GRCm39) I964N probably damaging Het
Zdhhc22 A G 12: 87,030,396 (GRCm39) F184S possibly damaging Het
Zfp512 A G 5: 31,623,669 (GRCm39) H124R probably benign Het
Zswim4 T C 8: 84,939,354 (GRCm39) T843A probably damaging Het
Other mutations in Gpr17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01995:Gpr17 APN 18 32,080,187 (GRCm39) missense probably damaging 1.00
R4492:Gpr17 UTSW 18 32,080,304 (GRCm39) missense possibly damaging 0.86
R5423:Gpr17 UTSW 18 32,080,694 (GRCm39) missense probably damaging 0.98
R6008:Gpr17 UTSW 18 32,080,530 (GRCm39) missense probably benign 0.00
R6363:Gpr17 UTSW 18 32,080,625 (GRCm39) missense probably damaging 0.98
R6627:Gpr17 UTSW 18 32,080,949 (GRCm39) missense probably damaging 1.00
R7806:Gpr17 UTSW 18 32,080,593 (GRCm39) missense probably benign
R8497:Gpr17 UTSW 18 32,080,173 (GRCm39) missense probably damaging 1.00
R9658:Gpr17 UTSW 18 32,080,421 (GRCm39) missense probably damaging 1.00
X0025:Gpr17 UTSW 18 32,080,168 (GRCm39) missense probably benign 0.07
Z1177:Gpr17 UTSW 18 32,080,717 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- ATGTGCCCCAGTTGATAGC -3'
(R):5'- AATAAAGCCGTCCGCATGATTG -3'

Sequencing Primer
(F):5'- TGCCCCAGTTGATAGCTGGTC -3'
(R):5'- CATGATTGCTATGGTTCTGGCCATC -3'
Posted On 2022-09-12