Incidental Mutation 'R9638:Ptger4'
ID 725840
Institutional Source Beutler Lab
Gene Symbol Ptger4
Ensembl Gene ENSMUSG00000039942
Gene Name prostaglandin E receptor 4 (subtype EP4)
Synonyms Ptgerep4, EP4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R9638 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 5262880-5273668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5264693 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 321 (F321S)
Ref Sequence ENSEMBL: ENSMUSP00000048736 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047379] [ENSMUST00000120563]
AlphaFold P32240
Predicted Effect probably damaging
Transcript: ENSMUST00000047379
AA Change: F321S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000048736
Gene: ENSMUSG00000039942
AA Change: F321S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 50 258 1.3e-7 PFAM
Pfam:7tm_1 59 357 1.3e-35 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000120563
AA Change: F296S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000112858
Gene: ENSMUSG00000039942
AA Change: F296S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 25 233 1.9e-7 PFAM
Pfam:7tm_1 34 332 8.5e-45 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T G 4: 53,092,806 (GRCm39) E326A probably damaging Het
Aldh1a1 T A 19: 20,614,100 (GRCm39) N423K probably benign Het
Aldh4a1 T A 4: 139,371,427 (GRCm39) I447N probably damaging Het
Atg9b T C 5: 24,596,406 (GRCm39) D170G possibly damaging Het
Bnc2 C T 4: 84,332,492 (GRCm39) V75M probably damaging Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Ccdc162 C A 10: 41,437,159 (GRCm39) C1750F probably benign Het
Cdh10 T A 15: 18,964,301 (GRCm39) N154K probably damaging Het
Cdh22 T C 2: 164,988,687 (GRCm39) I223V probably damaging Het
Ces1b T A 8: 93,806,534 (GRCm39) H4L probably benign Het
Cfap46 A T 7: 139,209,763 (GRCm39) F1806I unknown Het
Cwh43 T A 5: 73,565,486 (GRCm39) V17D possibly damaging Het
Ddx3y C T Y: 1,263,599 (GRCm39) G623D probably benign Het
Dtna A T 18: 23,744,122 (GRCm39) I389L probably benign Het
F830016B08Rik A G 18: 60,432,956 (GRCm39) D13G probably benign Het
Fam161b T C 12: 84,403,187 (GRCm39) I148V probably benign Het
Fhip1a T A 3: 85,568,391 (GRCm39) N1043Y probably damaging Het
Fli1 T C 9: 32,388,020 (GRCm39) Y23C probably damaging Het
Gimap6 A G 6: 48,679,424 (GRCm39) V204A probably benign Het
Ighv4-1 T G 12: 113,911,904 (GRCm39) R116S probably damaging Het
Isx T C 8: 75,619,566 (GRCm39) L239P probably damaging Het
Krt1 AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC 15: 101,758,813 (GRCm39) probably benign Het
Krt81 T C 15: 101,358,856 (GRCm39) T299A probably benign Het
Lrrc30 A G 17: 67,939,226 (GRCm39) L118P probably damaging Het
Mapk8ip3 T C 17: 25,118,023 (GRCm39) T1290A probably benign Het
Mef2b ACCCTCACCC ACC 8: 70,619,506 (GRCm39) probably null Het
Meltf G A 16: 31,706,409 (GRCm39) E298K possibly damaging Het
Muc16 T A 9: 18,550,626 (GRCm39) E5222D probably benign Het
Nin T C 12: 70,067,618 (GRCm39) N2003S Het
Or1e23 A G 11: 73,407,875 (GRCm39) I50T probably benign Het
Or2b4 G A 17: 38,116,509 (GRCm39) V158M probably damaging Het
Or51f1d T C 7: 102,701,018 (GRCm39) L171P probably damaging Het
Palld A G 8: 62,002,788 (GRCm39) V826A unknown Het
Paxbp1 C A 16: 90,831,881 (GRCm39) V336L probably benign Het
Paxbp1 T A 16: 90,831,882 (GRCm39) E335D probably benign Het
Por C A 5: 135,754,615 (GRCm39) Q12K unknown Het
Pot1a G A 6: 25,750,106 (GRCm39) Q519* probably null Het
Psd GCC GC 19: 46,301,841 (GRCm39) probably null Het
Ptk7 A G 17: 46,890,519 (GRCm39) Y438H possibly damaging Het
Rimklb A T 6: 122,433,558 (GRCm39) N254K probably benign Het
Rpn2 A T 2: 157,125,566 (GRCm39) T26S probably benign Het
Rtn4rl2 A T 2: 84,710,760 (GRCm39) L168H probably damaging Het
Scel G T 14: 103,779,409 (GRCm39) A127S possibly damaging Het
Sema4a T A 3: 88,357,066 (GRCm39) N302Y probably damaging Het
Supt3 A G 17: 45,234,133 (GRCm39) T50A possibly damaging Het
Upf3a G A 8: 13,848,343 (GRCm39) A380T probably benign Het
Zbtb14 G A 17: 69,695,375 (GRCm39) E358K probably damaging Het
Zfp677 A T 17: 21,618,056 (GRCm39) H371L probably damaging Het
Other mutations in Ptger4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Ptger4 APN 15 5,272,614 (GRCm39) missense probably benign 0.00
IGL00848:Ptger4 APN 15 5,264,589 (GRCm39) missense probably benign 0.16
IGL01309:Ptger4 APN 15 5,272,239 (GRCm39) missense probably damaging 1.00
IGL02083:Ptger4 APN 15 5,272,655 (GRCm39) missense probably benign 0.00
IGL03245:Ptger4 APN 15 5,264,588 (GRCm39) missense probably damaging 1.00
R0369:Ptger4 UTSW 15 5,272,491 (GRCm39) missense probably benign 0.06
R0427:Ptger4 UTSW 15 5,272,382 (GRCm39) missense probably benign 0.25
R1399:Ptger4 UTSW 15 5,264,412 (GRCm39) missense possibly damaging 0.81
R1778:Ptger4 UTSW 15 5,264,576 (GRCm39) missense probably damaging 1.00
R1801:Ptger4 UTSW 15 5,272,281 (GRCm39) missense possibly damaging 0.95
R2089:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2091:Ptger4 UTSW 15 5,272,326 (GRCm39) missense possibly damaging 0.80
R2484:Ptger4 UTSW 15 5,264,654 (GRCm39) missense probably benign 0.06
R2873:Ptger4 UTSW 15 5,264,286 (GRCm39) missense probably benign 0.02
R4515:Ptger4 UTSW 15 5,271,860 (GRCm39) missense probably damaging 1.00
R4572:Ptger4 UTSW 15 5,272,614 (GRCm39) missense probably benign 0.00
R4655:Ptger4 UTSW 15 5,272,545 (GRCm39) missense probably benign 0.06
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R4860:Ptger4 UTSW 15 5,272,087 (GRCm39) missense probably benign 0.02
R6429:Ptger4 UTSW 15 5,272,478 (GRCm39) missense possibly damaging 0.76
R6960:Ptger4 UTSW 15 5,264,196 (GRCm39) missense probably benign
R7992:Ptger4 UTSW 15 5,264,381 (GRCm39) missense probably damaging 0.99
R8471:Ptger4 UTSW 15 5,271,800 (GRCm39) missense probably damaging 1.00
R8768:Ptger4 UTSW 15 5,272,138 (GRCm39) missense probably benign 0.00
R9245:Ptger4 UTSW 15 5,273,193 (GRCm39) start gained probably benign
R9790:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
R9791:Ptger4 UTSW 15 5,273,178 (GRCm39) start codon destroyed probably null 0.00
Predicted Primers PCR Primer
(F):5'- ATGTCCTCCGACTCTCTGAG -3'
(R):5'- GTAACTAGCTTGTTGTGTCAACTG -3'

Sequencing Primer
(F):5'- ACTCTCTGAGCAGTGCTGG -3'
(R):5'- GCTGTAGCAGAGCAGGCATTC -3'
Posted On 2022-09-12