Mutagenetix > Incidental Mutation

Incidental Mutation 'R9639:Vmn2r38'

725875

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r38

Ensembl Gene

ENSMUSG00000095773

Gene Name

vomeronasal 2, receptor 38

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Not available question?

Stock #

R9639 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

9077795-9100764 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 9078063 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 773 (D773A)

Ref Sequence

ENSEMBL: ENSMUSP00000104194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108554]

AlphaFold

G3UYA8

Predicted Effect

probably damaging
Transcript: ENSMUST00000108554
AA Change: D773A

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: D773A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	3.5e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	6.4e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	A	G	7: 119,893,345 (GRCm39)	D1265G	probably benign	Het
Baz2b	T	A	2: 59,731,828 (GRCm39)	N2070I	probably benign	Het
Bnip3l	G	A	14: 67,246,214 (GRCm39)	P7L	possibly damaging	Het
Chd9	A	T	8: 91,760,840 (GRCm39)	E2195V	probably null	Het
Cracd	T	C	5: 77,005,997 (GRCm39)	V786A	unknown	Het
D6Ertd527e	G	C	6: 87,088,839 (GRCm39)	S334T	unknown	Het
Ddx11	A	G	17: 66,437,012 (GRCm39)	D102G		Het
Egf	T	C	3: 129,513,949 (GRCm39)	T421A	possibly damaging	Het
Fbxo11	A	G	17: 88,316,107 (GRCm39)	V365A		Het
Gmps	T	A	3: 63,922,938 (GRCm39)	S634T	probably damaging	Het
Lrrc7	T	C	3: 157,946,138 (GRCm39)	K187R	probably benign	Het
Lyplal1	A	T	1: 185,849,409 (GRCm39)	C13*	probably null	Het
Mycbp2	A	G	14: 103,433,817 (GRCm39)	W2255R	probably damaging	Het
Myo5c	C	A	9: 75,165,477 (GRCm39)	H428Q	probably damaging	Het
Nrap	T	C	19: 56,333,948 (GRCm39)	T1005A	possibly damaging	Het
Or2bd2	A	T	7: 6,443,290 (GRCm39)	R130S	probably benign	Het
Pcdh12	C	T	18: 38,402,032 (GRCm39)	M1123I	probably damaging	Het
Pdzrn3	A	G	6: 101,146,172 (GRCm39)	S393P	probably benign	Het
Pgr	A	T	9: 8,900,994 (GRCm39)	S176C	possibly damaging	Het
Ppp2r3d	T	C	9: 101,022,713 (GRCm39)	N312S	probably benign	Het
Qrich2	G	A	11: 116,346,924 (GRCm39)	P1300L	probably benign	Het
Sap130	T	C	18: 31,844,789 (GRCm39)		probably null	Het
Slc15a3	T	A	19: 10,820,717 (GRCm39)	Y111*	probably null	Het
Slc26a9	A	G	1: 131,678,409 (GRCm39)	E25G	probably damaging	Het
Slc2a3	A	G	6: 122,714,199 (GRCm39)	F110L	probably benign	Het
Spesp1	A	T	9: 62,180,238 (GRCm39)	D223E	possibly damaging	Het
St18	T	C	1: 6,929,246 (GRCm39)	I46T		Het
Trmt6	T	A	2: 132,650,862 (GRCm39)	K249*	probably null	Het
Ttll10	A	T	4: 156,119,503 (GRCm39)	I632K	probably benign	Het
Vmn1r216	A	G	13: 23,283,518 (GRCm39)	N67S	probably benign	Het
Vmn1r28	C	T	6: 58,242,996 (GRCm39)	Q280*	probably null	Het
Vmn2r92	A	G	17: 18,372,352 (GRCm39)	Y54C	probably damaging	Het
Ywhae	G	A	11: 75,650,248 (GRCm39)	G237S	probably benign	Het
Zswim5	A	G	4: 116,836,714 (GRCm39)	E666G	probably damaging	Het

Other mutations in Vmn2r38

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02805:Vmn2r38	APN	7	9,078,546 (GRCm39)	missense	probably damaging	0.99
IGL03199:Vmn2r38	APN	7	9,078,375 (GRCm39)	missense	probably damaging	1.00
R1619:Vmn2r38	UTSW	7	9,078,532 (GRCm39)	missense	probably damaging	1.00
R3154:Vmn2r38	UTSW	7	9,097,689 (GRCm39)	missense	probably benign	0.03
R3909:Vmn2r38	UTSW	7	9,078,553 (GRCm39)	missense	probably damaging	1.00
R4302:Vmn2r38	UTSW	7	9,100,562 (GRCm39)	splice site	probably null
R5106:Vmn2r38	UTSW	7	9,078,169 (GRCm39)	missense	possibly damaging	0.85
R5187:Vmn2r38	UTSW	7	9,100,571 (GRCm39)	missense	probably benign	0.03
R5575:Vmn2r38	UTSW	7	9,078,635 (GRCm39)	nonsense	probably null
R5653:Vmn2r38	UTSW	7	9,100,764 (GRCm39)	start codon destroyed	probably null	1.00
R6156:Vmn2r38	UTSW	7	9,097,611 (GRCm39)	missense	probably damaging	0.99
R6970:Vmn2r38	UTSW	7	9,078,340 (GRCm39)	nonsense	probably null
R7107:Vmn2r38	UTSW	7	9,093,728 (GRCm39)	missense	probably benign	0.00
R7231:Vmn2r38	UTSW	7	9,100,637 (GRCm39)	missense	possibly damaging	0.88
R7419:Vmn2r38	UTSW	7	9,078,354 (GRCm39)	missense	probably damaging	1.00
R7963:Vmn2r38	UTSW	7	9,095,854 (GRCm39)	missense	probably benign	0.17
R8788:Vmn2r38	UTSW	7	9,078,482 (GRCm39)	missense	probably benign	0.02
R9773:Vmn2r38	UTSW	7	9,097,806 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAACTTTACATTGGACACAATTCC -3'
(R):5'- CTCCAATGTGTTCTGTGTGC -3'

Sequencing Primer
(F):5'- GGACACAATTCCTGAATTATTCGTTC -3'
(R):5'- GTGCTATCTGGCTAGAAGTTTCTCC -3'

Posted On

2022-09-12