Incidental Mutation 'R9640:Olfr291'
ID 725921
Institutional Source Beutler Lab
Gene Symbol Olfr291
Ensembl Gene ENSMUSG00000070460
Gene Name olfactory receptor 291
Synonyms GA_x6K02T2NHDJ-11231385-11230438, MOR254-2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R9640 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 84853553-84859612 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 84856906 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 181 (C181Y)
Ref Sequence ENSEMBL: ENSMUSP00000148266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000211582] [ENSMUST00000217039]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000211582
AA Change: C181Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217039
AA Change: C179Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik A T 9: 22,439,932 I457L possibly damaging Het
A630010A05Rik T C 16: 14,618,725 V214A Het
A830018L16Rik A G 1: 11,950,976 K403R probably damaging Het
Abhd17c A T 7: 84,151,606 L80Q probably damaging Het
Adam30 T A 3: 98,162,304 D484E probably damaging Het
Aspm T A 1: 139,480,272 V2299E possibly damaging Het
Atp6v1c1 C T 15: 38,689,137 R281W probably damaging Het
Bclaf1 T C 10: 20,325,807 probably null Het
Ccdc50 T C 16: 27,406,711 V58A probably damaging Het
Cep162 A G 9: 87,244,299 S187P probably benign Het
Clip4 C T 17: 71,856,269 T612M possibly damaging Het
Corin C T 5: 72,435,254 V267I probably benign Het
Cyp2c37 T A 19: 40,011,736 I434K probably benign Het
Ddx43 T G 9: 78,396,107 D76E probably benign Het
Dusp5 A G 19: 53,537,620 E231G probably damaging Het
Fam114a1 G A 5: 65,009,051 V242I probably damaging Het
Frem1 T A 4: 82,913,659 R1973S probably benign Het
Gas2l3 A T 10: 89,430,912 D55E probably damaging Het
Gm436 T A 4: 144,686,239 R44W possibly damaging Het
Grwd1 T C 7: 45,827,879 I195V probably benign Het
H2-M1 G T 17: 36,672,139 T20K probably benign Het
H2-Q2 T G 17: 35,343,230 L151R probably damaging Het
Hbegf T C 18: 36,507,590 Y138C probably damaging Het
Hectd1 C A 12: 51,748,414 E2411* probably null Het
Igkv11-125 T A 6: 67,913,799 S34T possibly damaging Het
Jam2 A T 16: 84,813,072 T191S probably benign Het
Kcnh8 T C 17: 52,878,061 I457T probably damaging Het
Khk A G 5: 30,921,959 D15G probably damaging Het
Lrba T A 3: 86,619,568 Y2244* probably null Het
Lrp1b T C 2: 41,188,917 N1841S Het
Lrp4 A G 2: 91,485,951 T805A probably benign Het
Lrp6 C T 6: 134,464,451 R1184Q probably damaging Het
Map3k1 A T 13: 111,764,165 L442* probably null Het
Mapk8ip3 T C 17: 24,936,673 N61S possibly damaging Het
Mdn1 T A 4: 32,754,539 V4685E probably damaging Het
Mib2 T C 4: 155,660,868 E134G possibly damaging Het
Mtss1l T C 8: 110,737,943 V403A probably benign Het
Ndst4 C A 3: 125,438,547 T255K probably damaging Het
Olfr1357 G C 10: 78,612,477 L55V probably damaging Het
Olfr166 A T 16: 19,487,011 M58L probably damaging Het
Olfr44 A G 9: 39,485,100 L51P probably damaging Het
Pak1 T A 7: 97,866,148 D126E probably benign Het
Rgl1 T C 1: 152,521,391 T675A probably damaging Het
Rgs1 T C 1: 144,245,378 D185G probably damaging Het
Rnase2a G A 14: 51,255,660 R83C probably damaging Het
Sfmbt2 A G 2: 10,579,183 T784A probably damaging Het
Slc6a21 A T 7: 45,287,765 T272S Het
Sorcs2 G T 5: 36,065,421 S330* probably null Het
Spdef G T 17: 27,717,209 H253Q Het
Tas2r144 A G 6: 42,215,494 E56G probably benign Het
Trim66 A G 7: 109,475,618 C479R probably damaging Het
Ttc36 A T 9: 44,802,737 L28Q probably benign Het
Ugt1a5 T C 1: 88,166,376 S109P possibly damaging Het
Vamp5 G A 6: 72,370,293 probably benign Het
Wwox A G 8: 114,439,800 D10G possibly damaging Het
Zfp40 T C 17: 23,175,519 Y698C probably damaging Het
Zfp62 A G 11: 49,215,631 D183G probably benign Het
Zfp932 T C 5: 110,009,198 V254A probably benign Het
Zfp943 T A 17: 21,990,918 L57H probably damaging Het
Other mutations in Olfr291
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01863:Olfr291 APN 7 84856411 missense probably damaging 1.00
IGL02643:Olfr291 APN 7 84857031 missense probably damaging 1.00
IGL02928:Olfr291 APN 7 84857065 missense probably benign 0.08
IGL03124:Olfr291 APN 7 84856723 missense probably damaging 0.99
R0129:Olfr291 UTSW 7 84856988 missense probably benign
R0605:Olfr291 UTSW 7 84857137 missense probably damaging 1.00
R1085:Olfr291 UTSW 7 84856779 missense probably benign 0.05
R1477:Olfr291 UTSW 7 84857017 missense probably damaging 1.00
R1834:Olfr291 UTSW 7 84856482 missense probably damaging 0.99
R1839:Olfr291 UTSW 7 84856548 missense probably damaging 1.00
R2036:Olfr291 UTSW 7 84856358 start gained probably benign
R4214:Olfr291 UTSW 7 84857289 missense probably benign
R4386:Olfr291 UTSW 7 84856548 missense probably damaging 1.00
R4679:Olfr291 UTSW 7 84856904 nonsense probably null
R4789:Olfr291 UTSW 7 84857301 missense probably benign 0.09
R4841:Olfr291 UTSW 7 84857120 missense probably damaging 1.00
R5011:Olfr291 UTSW 7 84856438 missense probably damaging 1.00
R5013:Olfr291 UTSW 7 84856438 missense probably damaging 1.00
R6127:Olfr291 UTSW 7 84857202 missense probably damaging 1.00
R7164:Olfr291 UTSW 7 84857043 missense possibly damaging 0.73
R7328:Olfr291 UTSW 7 84857299 missense probably benign 0.01
R8347:Olfr291 UTSW 7 84856755 missense probably damaging 0.99
R8434:Olfr291 UTSW 7 84857289 missense probably benign
R8882:Olfr291 UTSW 7 84856473 missense probably damaging 1.00
R9242:Olfr291 UTSW 7 84856878 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCTGGGACTGAAGTCTTCTTGC -3'
(R):5'- ATGTGGAGAAAGCTTTGCGC -3'

Sequencing Primer
(F):5'- GCTTATGACCGGTATGTGGCC -3'
(R):5'- GCTTTCCTTCTGCTGACCGG -3'
Posted On 2022-09-12