Mutagenetix > Incidental Mutation

Incidental Mutation 'R9640:Cyp2c37'

725952

Institutional Source

Beutler Lab

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R9640 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

39992424-40012243 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40011736 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 434 (I434K)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably benign
Transcript: ENSMUST00000049178
AA Change: I434K

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: I434K

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530077C05Rik	A	T	9: 22,439,932	I457L	possibly damaging	Het
A630010A05Rik	T	C	16: 14,618,725	V214A		Het
A830018L16Rik	A	G	1: 11,950,976	K403R	probably damaging	Het
Abhd17c	A	T	7: 84,151,606	L80Q	probably damaging	Het
Adam30	T	A	3: 98,162,304	D484E	probably damaging	Het
Aspm	T	A	1: 139,480,272	V2299E	possibly damaging	Het
Atp6v1c1	C	T	15: 38,689,137	R281W	probably damaging	Het
Bclaf1	T	C	10: 20,325,807		probably null	Het
Ccdc50	T	C	16: 27,406,711	V58A	probably damaging	Het
Cep162	A	G	9: 87,244,299	S187P	probably benign	Het
Clip4	C	T	17: 71,856,269	T612M	possibly damaging	Het
Corin	C	T	5: 72,435,254	V267I	probably benign	Het
Ddx43	T	G	9: 78,396,107	D76E	probably benign	Het
Dusp5	A	G	19: 53,537,620	E231G	probably damaging	Het
Fam114a1	G	A	5: 65,009,051	V242I	probably damaging	Het
Frem1	T	A	4: 82,913,659	R1973S	probably benign	Het
Gas2l3	A	T	10: 89,430,912	D55E	probably damaging	Het
Gm436	T	A	4: 144,686,239	R44W	possibly damaging	Het
Grwd1	T	C	7: 45,827,879	I195V	probably benign	Het
H2-M1	G	T	17: 36,672,139	T20K	probably benign	Het
H2-Q2	T	G	17: 35,343,230	L151R	probably damaging	Het
Hbegf	T	C	18: 36,507,590	Y138C	probably damaging	Het
Hectd1	C	A	12: 51,748,414	E2411*	probably null	Het
Igkv11-125	T	A	6: 67,913,799	S34T	possibly damaging	Het
Jam2	A	T	16: 84,813,072	T191S	probably benign	Het
Kcnh8	T	C	17: 52,878,061	I457T	probably damaging	Het
Khk	A	G	5: 30,921,959	D15G	probably damaging	Het
Lrba	T	A	3: 86,619,568	Y2244*	probably null	Het
Lrp1b	T	C	2: 41,188,917	N1841S		Het
Lrp4	A	G	2: 91,485,951	T805A	probably benign	Het
Lrp6	C	T	6: 134,464,451	R1184Q	probably damaging	Het
Map3k1	A	T	13: 111,764,165	L442*	probably null	Het
Mapk8ip3	T	C	17: 24,936,673	N61S	possibly damaging	Het
Mdn1	T	A	4: 32,754,539	V4685E	probably damaging	Het
Mib2	T	C	4: 155,660,868	E134G	possibly damaging	Het
Mtss1l	T	C	8: 110,737,943	V403A	probably benign	Het
Ndst4	C	A	3: 125,438,547	T255K	probably damaging	Het
Olfr1357	G	C	10: 78,612,477	L55V	probably damaging	Het
Olfr166	A	T	16: 19,487,011	M58L	probably damaging	Het
Olfr291	G	A	7: 84,856,906	C181Y	probably damaging	Het
Olfr44	A	G	9: 39,485,100	L51P	probably damaging	Het
Pak1	T	A	7: 97,866,148	D126E	probably benign	Het
Rgl1	T	C	1: 152,521,391	T675A	probably damaging	Het
Rgs1	T	C	1: 144,245,378	D185G	probably damaging	Het
Rnase2a	G	A	14: 51,255,660	R83C	probably damaging	Het
Sfmbt2	A	G	2: 10,579,183	T784A	probably damaging	Het
Slc6a21	A	T	7: 45,287,765	T272S		Het
Sorcs2	G	T	5: 36,065,421	S330*	probably null	Het
Spdef	G	T	17: 27,717,209	H253Q		Het
Tas2r144	A	G	6: 42,215,494	E56G	probably benign	Het
Trim66	A	G	7: 109,475,618	C479R	probably damaging	Het
Ttc36	A	T	9: 44,802,737	L28Q	probably benign	Het
Ugt1a5	T	C	1: 88,166,376	S109P	possibly damaging	Het
Vamp5	G	A	6: 72,370,293		probably benign	Het
Wwox	A	G	8: 114,439,800	D10G	possibly damaging	Het
Zfp40	T	C	17: 23,175,519	Y698C	probably damaging	Het
Zfp62	A	G	11: 49,215,631	D183G	probably benign	Het
Zfp932	T	C	5: 110,009,198	V254A	probably benign	Het
Zfp943	T	A	17: 21,990,918	L57H	probably damaging	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cyp2c37	APN	19	40001997	missense	probably benign	0.00
IGL01307:Cyp2c37	APN	19	39992579	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39995833	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39994498	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39993865	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39994102	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39994506	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39995794	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39993825	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39994098	missense	probably benign	0.21
R1637:Cyp2c37	UTSW	19	40001982	nonsense	probably null
R1688:Cyp2c37	UTSW	19	39994443	splice site	probably null
R2258:Cyp2c37	UTSW	19	39995859	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	40000545	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40011832	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40011762	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	40001887	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39994152	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40011732	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39994581	missense	probably benign
R6631:Cyp2c37	UTSW	19	40009843	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39995546	splice site	probably null
R7937:Cyp2c37	UTSW	19	39993758	missense	probably damaging	1.00
R9779:Cyp2c37	UTSW	19	40009879	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	40000499	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AATGTGACCCACTTTTGTCAACTTG -3'
(R):5'- ATCACAGAAGATGTCCCAGCTG -3'

Sequencing Primer
(F):5'- GCCTAATAGGGTATCTTCTCAGC -3'
(R):5'- AGCCAGGCATTTGATTTTCAGGAAG -3'

Posted On

2022-09-12