Incidental Mutation 'R0765:Vmn1r89'
ID 72606
Institutional Source Beutler Lab
Gene Symbol Vmn1r89
Ensembl Gene ENSMUSG00000095629
Gene Name vomeronasal 1 receptor 89
Synonyms V1rj2
MMRRC Submission 038945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R0765 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 12953266-12954216 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12953467 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 68 (M68V)
Ref Sequence ENSEMBL: ENSMUSP00000154359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053008] [ENSMUST00000226717] [ENSMUST00000227176] [ENSMUST00000227239] [ENSMUST00000227276] [ENSMUST00000227319] [ENSMUST00000227390] [ENSMUST00000228587]
AlphaFold Q8R256
Predicted Effect probably benign
Transcript: ENSMUST00000053008
AA Change: M68V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: M68V

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.9e-15 PFAM
Pfam:7tm_1 25 295 1.1e-6 PFAM
Pfam:V1R 36 301 1.5e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226717
AA Change: M68V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227176
AA Change: M68V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227239
AA Change: M68V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227276
Predicted Effect probably benign
Transcript: ENSMUST00000227319
Predicted Effect probably benign
Transcript: ENSMUST00000227390
Predicted Effect probably benign
Transcript: ENSMUST00000228587
AA Change: M68V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228825
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.8%
  • 20x: 92.7%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T A 17: 35,320,827 (GRCm39) V425D probably benign Het
Ano9 T G 7: 140,687,097 (GRCm39) I381L probably damaging Het
Apob C T 12: 8,066,518 (GRCm39) L4496F probably benign Het
Arhgef38 C T 3: 132,822,344 (GRCm39) E724K probably damaging Het
Atp8b4 T A 2: 126,214,070 (GRCm39) probably null Het
Baiap2l1 G T 5: 144,214,513 (GRCm39) P394T probably damaging Het
Btbd8 T A 5: 107,654,800 (GRCm39) D354E probably benign Het
Cnbp C A 6: 87,822,155 (GRCm39) C122F probably damaging Het
Col3a1 A G 1: 45,375,811 (GRCm39) probably benign Het
Colq T G 14: 31,247,994 (GRCm39) D408A possibly damaging Het
Cuzd1 A T 7: 130,917,824 (GRCm39) S259T probably benign Het
Cyp3a57 A G 5: 145,327,220 (GRCm39) probably benign Het
Dbn1 C A 13: 55,630,107 (GRCm39) V112F probably damaging Het
Dcc T A 18: 71,496,061 (GRCm39) D1028V probably damaging Het
Dnajb11 T C 16: 22,681,318 (GRCm39) V32A probably damaging Het
Dsg4 G A 18: 20,587,703 (GRCm39) probably benign Het
Dyrk1b C T 7: 27,885,136 (GRCm39) probably benign Het
Ebf1 T A 11: 44,759,987 (GRCm39) M208K probably damaging Het
Efhc1 A G 1: 21,048,876 (GRCm39) I430V probably benign Het
Elovl2 T C 13: 41,340,942 (GRCm39) Y181C probably benign Het
Fras1 A G 5: 96,700,655 (GRCm39) Q225R probably benign Het
Frmd3 G A 4: 74,080,004 (GRCm39) R332Q probably damaging Het
Glg1 A G 8: 111,886,429 (GRCm39) probably null Het
Hmcn1 G A 1: 150,684,538 (GRCm39) T344M probably damaging Het
Il1rap T G 16: 26,529,382 (GRCm39) probably null Het
Klra1 A T 6: 130,356,055 (GRCm39) probably benign Het
Larp7 C A 3: 127,339,814 (GRCm39) K289N probably damaging Het
Lgr6 C A 1: 134,921,624 (GRCm39) G240V probably benign Het
Lrp10 G T 14: 54,705,547 (GRCm39) D246Y probably damaging Het
Map3k20 G A 2: 72,202,269 (GRCm39) V167I probably damaging Het
Med23 T C 10: 24,776,608 (GRCm39) S347P probably damaging Het
Mybph T C 1: 134,125,234 (GRCm39) V254A possibly damaging Het
Ndufv2 A G 17: 66,408,073 (GRCm39) probably benign Het
Nuf2 A T 1: 169,350,505 (GRCm39) probably benign Het
Nup210l T C 3: 90,027,184 (GRCm39) Y189H probably damaging Het
Or4c52 G A 2: 89,846,014 (GRCm39) V247I probably benign Het
Or51t4 C T 7: 102,597,939 (GRCm39) T79I probably damaging Het
Or5m13 T C 2: 85,749,049 (GRCm39) L260P probably damaging Het
Pdgfra C A 5: 75,348,648 (GRCm39) probably benign Het
Phlpp1 T C 1: 106,320,013 (GRCm39) L1336P probably damaging Het
Prpf38b T C 3: 108,818,734 (GRCm39) T9A possibly damaging Het
Rnf213 G A 11: 119,313,921 (GRCm39) probably null Het
Saal1 A T 7: 46,349,071 (GRCm39) V281E possibly damaging Het
Slc17a3 C T 13: 24,030,879 (GRCm39) Q186* probably null Het
Slc6a2 A G 8: 93,715,659 (GRCm39) T266A probably damaging Het
Snai2 T C 16: 14,524,668 (GRCm39) V58A possibly damaging Het
Srfbp1 T C 18: 52,623,507 (GRCm39) probably benign Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Tesk1 C T 4: 43,446,706 (GRCm39) P365S possibly damaging Het
Tmem127 C A 2: 127,099,069 (GRCm39) T201K probably damaging Het
Trim17 T G 11: 58,862,195 (GRCm39) V409G possibly damaging Het
Trim43c C T 9: 88,723,969 (GRCm39) T165I probably benign Het
Ush2a C A 1: 188,680,771 (GRCm39) F4916L possibly damaging Het
Vmn2r105 C T 17: 20,447,973 (GRCm39) E284K probably benign Het
Vmn2r105 T C 17: 20,448,119 (GRCm39) D235G probably damaging Het
Vmn2r-ps134 C T 17: 23,665,015 (GRCm39) noncoding transcript Het
Zdbf2 G A 1: 63,344,882 (GRCm39) S1087N possibly damaging Het
Zfp534 G A 4: 147,758,693 (GRCm39) P659S probably damaging Het
Other mutations in Vmn1r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r89 APN 7 12,953,432 (GRCm39) missense probably benign 0.28
IGL02085:Vmn1r89 APN 7 12,953,465 (GRCm39) missense probably damaging 0.96
IGL02694:Vmn1r89 APN 7 12,954,056 (GRCm39) missense probably benign 0.12
IGL02709:Vmn1r89 APN 7 12,954,131 (GRCm39) missense probably damaging 1.00
PIT4142001:Vmn1r89 UTSW 7 12,953,515 (GRCm39) missense probably benign
R1396:Vmn1r89 UTSW 7 12,953,938 (GRCm39) missense probably damaging 1.00
R2249:Vmn1r89 UTSW 7 12,954,187 (GRCm39) missense possibly damaging 0.90
R4296:Vmn1r89 UTSW 7 12,954,113 (GRCm39) missense possibly damaging 0.78
R4472:Vmn1r89 UTSW 7 12,953,799 (GRCm39) missense probably benign 0.04
R5037:Vmn1r89 UTSW 7 12,953,314 (GRCm39) missense possibly damaging 0.88
R5267:Vmn1r89 UTSW 7 12,954,140 (GRCm39) missense probably damaging 1.00
R5352:Vmn1r89 UTSW 7 12,953,284 (GRCm39) missense probably benign
R5455:Vmn1r89 UTSW 7 12,954,194 (GRCm39) missense probably benign 0.01
R5595:Vmn1r89 UTSW 7 12,953,857 (GRCm39) missense possibly damaging 0.93
R5643:Vmn1r89 UTSW 7 12,954,146 (GRCm39) missense possibly damaging 0.94
R7493:Vmn1r89 UTSW 7 12,953,632 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGCTCCTGAGCTGTCATTCAGTA -3'
(R):5'- TGTAGAGACTGGCCCACACCAT -3'

Sequencing Primer
(F):5'- TGGTCCTCTAGACTTAACAAACCTG -3'
(R):5'- CCCGTAGATGACTAGGTTAATAAGC -3'
Posted On 2013-09-30