Mutagenetix > Incidental Mutation

Incidental Mutation 'R9642:Dmxl1'

726109

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably essential (E-score: 0.951) question?

Stock #

R9642 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

49965737-50098540 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 50013825 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 1538 (G1538R)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000041772
AA Change: G1538R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: G1538R

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000180611
AA Change: G1538R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: G1538R

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	C	18: 6,619,412 (GRCm39)		probably null	Het
Aadacl3	A	G	4: 144,182,512 (GRCm39)	S319P	probably benign	Het
Abcc6	C	A	7: 45,639,765 (GRCm39)	D907Y	probably benign	Het
Apol7b	T	C	15: 77,308,103 (GRCm39)	S131G	probably benign	Het
Atg2a	C	T	19: 6,300,198 (GRCm39)	R669*	probably null	Het
Atr	T	A	9: 95,821,294 (GRCm39)	I2260N	probably damaging	Het
Bmper	T	A	9: 23,395,198 (GRCm39)	V643E	probably benign	Het
Cacna2d2	A	G	9: 107,392,627 (GRCm39)	I524V	possibly damaging	Het
Ccdc171	C	A	4: 83,599,525 (GRCm39)	A780E	probably benign	Het
Cdcp3	C	A	7: 130,848,257 (GRCm39)	Q688K	probably benign	Het
Cfhr2	A	G	1: 139,738,620 (GRCm39)	S314P	probably damaging	Het
Cops2	A	T	2: 125,682,410 (GRCm39)	D190E	probably benign	Het
Dyrk4	A	T	6: 126,893,253 (GRCm39)	V43E	probably benign	Het
Eif4a3l2	A	G	6: 116,528,350 (GRCm39)	R76G	probably damaging	Het
Enoph1	T	C	5: 100,188,115 (GRCm39)	I13T	possibly damaging	Het
Eya3	A	T	4: 132,426,374 (GRCm39)	I268F	probably damaging	Het
Ezh2	A	C	6: 47,521,453 (GRCm39)	M439R	probably benign	Het
Fam83c	T	C	2: 155,672,980 (GRCm39)	N259S	probably damaging	Het
Gbf1	A	T	19: 46,258,707 (GRCm39)	M963L	probably benign	Het
Ghr	A	T	15: 3,355,469 (GRCm39)	D271E	probably benign	Het
Gm40460	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	7: 141,794,450 (GRCm39)		probably benign	Het
Gtse1	T	A	15: 85,751,697 (GRCm39)	L297I	probably damaging	Het
Hecw1	T	A	13: 14,515,394 (GRCm39)	H246L	probably damaging	Het
Hmox1	G	A	8: 75,823,881 (GRCm39)	R183H	possibly damaging	Het
Ifi202b	A	T	1: 173,799,850 (GRCm39)	Y210*	probably null	Het
Ighv1-76	A	T	12: 115,811,918 (GRCm39)	I6N	possibly damaging	Het
Ildr1	T	A	16: 36,536,490 (GRCm39)	I173N	probably damaging	Het
Jaml	T	C	9: 45,000,116 (GRCm39)	V138A	probably damaging	Het
Kmt2b	A	T	7: 30,283,340 (GRCm39)		probably null	Het
Krt87	T	C	15: 101,385,074 (GRCm39)	N341D	probably benign	Het
Map3k20	T	C	2: 72,272,181 (GRCm39)	W770R	probably damaging	Het
Mast2	A	G	4: 116,170,966 (GRCm39)	I667T	probably damaging	Het
Mdp1	T	C	14: 55,896,933 (GRCm39)	T71A	probably damaging	Het
Muc5ac	A	T	7: 141,349,601 (GRCm39)	T505S	possibly damaging	Het
Mx1	A	G	16: 97,256,376 (GRCm39)	V181A	probably damaging	Het
Myo15b	A	G	11: 115,772,335 (GRCm39)	E83G	possibly damaging	Het
Ncam2	A	T	16: 81,418,251 (GRCm39)	I769L	probably benign	Het
Notum	T	C	11: 120,550,980 (GRCm39)	D62G	probably damaging	Het
Or4c124	A	T	2: 89,155,907 (GRCm39)	C206S	possibly damaging	Het
Or5ac22	A	T	16: 59,135,610 (GRCm39)	H53Q	possibly damaging	Het
Or7a39	C	T	10: 78,715,395 (GRCm39)	P130S	probably damaging	Het
Or8g32	T	C	9: 39,305,857 (GRCm39)	S254P	probably damaging	Het
P2rx2	A	G	5: 110,489,878 (GRCm39)	S196P	possibly damaging	Het
Pcdh7	A	T	5: 57,876,717 (GRCm39)	I91F	probably damaging	Het
Peak1	A	G	9: 56,167,205 (GRCm39)	V241A	probably benign	Het
Ppl	C	A	16: 4,915,602 (GRCm39)	R623S	probably benign	Het
Prkaca	A	G	8: 84,717,088 (GRCm39)	I151V	probably benign	Het
Psmb11	A	T	14: 54,863,295 (GRCm39)	Q171L	probably benign	Het
Rab3gap2	T	G	1: 184,967,692 (GRCm39)	F166V	probably benign	Het
Rab7	G	A	6: 87,981,187 (GRCm39)	A165V	probably damaging	Het
Ranbp2	T	C	10: 58,318,907 (GRCm39)	Y2473H	probably damaging	Het
Runx3	A	G	4: 134,848,341 (GRCm39)		probably benign	Het
Sh3bp5l	T	A	11: 58,237,085 (GRCm39)	C347*	probably null	Het
Smc5	A	G	19: 23,238,752 (GRCm39)	M208T	probably damaging	Het
Stk11ip	T	C	1: 75,510,899 (GRCm39)		probably null	Het
Tas2r136	A	T	6: 132,754,462 (GRCm39)	C222S	probably benign	Het
Themis2	A	G	4: 132,513,047 (GRCm39)	V393A	possibly damaging	Het
Tln2	A	C	9: 67,157,826 (GRCm39)	V1171G	probably benign	Het
Tmem63a	T	C	1: 180,776,393 (GRCm39)	F68L	probably damaging	Het
Tpst1	T	A	5: 130,130,959 (GRCm39)	L143Q	probably damaging	Het
Trp63	C	A	16: 25,682,508 (GRCm39)	Q284K	probably benign	Het
Ttc17	T	C	2: 94,194,735 (GRCm39)	E546G	probably benign	Het
Ttn	A	G	2: 76,804,570 (GRCm39)	I234T	unknown	Het
Upp1	A	G	11: 9,085,206 (GRCm39)	K231R	probably benign	Het
Uso1	T	A	5: 92,285,967 (GRCm39)	L4H	probably damaging	Het
Vmn1r9	T	A	6: 57,048,216 (GRCm39)	L97Q	probably damaging	Het
Vmn2r107	T	C	17: 20,580,661 (GRCm39)	C533R	probably damaging	Het
Vps35l	C	A	7: 118,437,451 (GRCm39)	D909E	probably benign	Het
Wdr90	A	G	17: 26,072,694 (GRCm39)		probably null	Het
Ydjc	A	G	16: 16,966,073 (GRCm39)	H219R	probably benign	Het
Ykt6	T	C	11: 5,905,917 (GRCm39)	L6P	probably damaging	Het
Zfp236	A	G	18: 82,622,384 (GRCm39)	V1682A	probably benign	Het
Zfp35	C	T	18: 24,137,155 (GRCm39)	Q500*	probably null	Het
Zfp780b	T	A	7: 27,664,135 (GRCm39)	D140V	probably benign	Het
Zyg11b	T	C	4: 108,117,185 (GRCm39)	T352A	probably damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,984,534 (GRCm39)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	50,072,620 (GRCm39)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	50,050,735 (GRCm39)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	50,045,792 (GRCm39)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	50,045,818 (GRCm39)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,990,401 (GRCm39)	missense	probably benign
IGL01475:Dmxl1	APN	18	50,004,781 (GRCm39)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	50,054,005 (GRCm39)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	50,095,272 (GRCm39)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,996,092 (GRCm39)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,997,935 (GRCm39)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	50,011,449 (GRCm39)	nonsense	probably null
IGL01933:Dmxl1	APN	18	50,010,852 (GRCm39)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	50,023,721 (GRCm39)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	50,027,245 (GRCm39)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	50,094,230 (GRCm39)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	50,010,741 (GRCm39)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,973,566 (GRCm39)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,997,962 (GRCm39)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	50,011,247 (GRCm39)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	50,053,960 (GRCm39)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,997,885 (GRCm39)	missense	probably benign
capture	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
carnivora	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
digestion	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
drowning	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
hibiscus	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
impound	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
pitcher	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	50,065,030 (GRCm39)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	50,021,964 (GRCm39)	splice site	probably benign
R0027:Dmxl1	UTSW	18	50,090,362 (GRCm39)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	50,088,870 (GRCm39)	splice site	probably benign
R0349:Dmxl1	UTSW	18	50,012,349 (GRCm39)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	50,012,429 (GRCm39)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	50,024,534 (GRCm39)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,990,497 (GRCm39)	splice site	probably benign
R0542:Dmxl1	UTSW	18	50,026,761 (GRCm39)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	50,068,374 (GRCm39)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,984,490 (GRCm39)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	50,026,469 (GRCm39)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	50,026,678 (GRCm39)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	50,026,292 (GRCm39)	missense	probably benign
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	50,021,920 (GRCm39)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,990,316 (GRCm39)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,985,434 (GRCm39)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,992,353 (GRCm39)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	50,023,834 (GRCm39)	nonsense	probably null
R1646:Dmxl1	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	50,067,704 (GRCm39)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	50,036,055 (GRCm39)	missense	probably benign
R1732:Dmxl1	UTSW	18	50,026,511 (GRCm39)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	50,088,981 (GRCm39)	splice site	probably null
R1911:Dmxl1	UTSW	18	50,011,230 (GRCm39)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	50,022,625 (GRCm39)	nonsense	probably null
R2116:Dmxl1	UTSW	18	50,011,884 (GRCm39)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	50,050,698 (GRCm39)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	50,027,161 (GRCm39)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	50,026,990 (GRCm39)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,979,706 (GRCm39)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	50,053,043 (GRCm39)	splice site	probably null
R2343:Dmxl1	UTSW	18	50,023,745 (GRCm39)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	50,013,858 (GRCm39)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,997,029 (GRCm39)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,984,498 (GRCm39)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	50,094,264 (GRCm39)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	50,011,084 (GRCm39)	nonsense	probably null
R4406:Dmxl1	UTSW	18	50,022,620 (GRCm39)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,981,828 (GRCm39)	missense	probably benign
R4454:Dmxl1	UTSW	18	50,026,399 (GRCm39)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	50,094,283 (GRCm39)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	50,095,248 (GRCm39)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	50,011,698 (GRCm39)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	50,011,088 (GRCm39)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,996,059 (GRCm39)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,984,543 (GRCm39)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	50,090,348 (GRCm39)	intron	probably benign
R4885:Dmxl1	UTSW	18	50,011,862 (GRCm39)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	50,028,194 (GRCm39)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	50,003,990 (GRCm39)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	50,026,651 (GRCm39)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	50,084,302 (GRCm39)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,996,186 (GRCm39)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	50,000,966 (GRCm39)	splice site	probably null
R5484:Dmxl1	UTSW	18	50,022,531 (GRCm39)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,997,545 (GRCm39)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	50,024,693 (GRCm39)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	50,027,324 (GRCm39)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	50,065,008 (GRCm39)	nonsense	probably null
R5706:Dmxl1	UTSW	18	50,090,462 (GRCm39)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R5876:Dmxl1	UTSW	18	50,004,051 (GRCm39)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,990,453 (GRCm39)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	50,045,833 (GRCm39)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	50,026,402 (GRCm39)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,996,082 (GRCm39)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	50,035,434 (GRCm39)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	50,004,799 (GRCm39)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,985,367 (GRCm39)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,997,645 (GRCm39)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,992,246 (GRCm39)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	50,011,313 (GRCm39)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	50,013,847 (GRCm39)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	50,027,041 (GRCm39)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,985,355 (GRCm39)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,997,902 (GRCm39)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	50,068,372 (GRCm39)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,976,851 (GRCm39)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	50,053,969 (GRCm39)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,996,124 (GRCm39)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,984,562 (GRCm39)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	50,088,920 (GRCm39)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,997,681 (GRCm39)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	50,011,679 (GRCm39)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	50,027,024 (GRCm39)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	50,035,861 (GRCm39)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,992,337 (GRCm39)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	50,026,619 (GRCm39)	missense	probably benign
R7688:Dmxl1	UTSW	18	50,088,938 (GRCm39)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,979,685 (GRCm39)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	50,026,528 (GRCm39)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	50,011,382 (GRCm39)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	50,054,044 (GRCm39)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,973,557 (GRCm39)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	50,094,214 (GRCm39)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	50,026,474 (GRCm39)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	50,011,500 (GRCm39)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	50,021,897 (GRCm39)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,976,878 (GRCm39)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	50,031,781 (GRCm39)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	50,011,409 (GRCm39)	missense	probably benign
R8402:Dmxl1	UTSW	18	50,011,393 (GRCm39)	nonsense	probably null
R8402:Dmxl1	UTSW	18	50,011,394 (GRCm39)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,998,183 (GRCm39)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	50,004,759 (GRCm39)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	50,088,937 (GRCm39)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	50,090,406 (GRCm39)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	50,026,741 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,997,575 (GRCm39)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	50,055,679 (GRCm39)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	50,026,919 (GRCm39)	missense
R9011:Dmxl1	UTSW	18	49,997,240 (GRCm39)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	50,011,992 (GRCm39)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
R9254:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,976,919 (GRCm39)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	50,091,477 (GRCm39)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	50,010,788 (GRCm39)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	50,026,777 (GRCm39)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	50,011,271 (GRCm39)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,998,228 (GRCm39)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	50,026,461 (GRCm39)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,997,435 (GRCm39)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	50,052,966 (GRCm39)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	50,054,032 (GRCm39)	missense	probably benign
Z1188:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- ACTTAGTCATGCTCTTTTCCCTATAA -3'
(R):5'- AAGTCAGTAAATGATCCAAAGACATT -3'

Sequencing Primer
(F):5'- AGTAACAAACATTTTGCCAGTTTAAG -3'
(R):5'- ACTTCAAAATCTACGGGAAA -3'

Posted On

2022-09-12