Incidental Mutation 'R9037:Mpo'
ID 726259
Institutional Source Beutler Lab
Gene Symbol Mpo
Ensembl Gene ENSMUSG00000009350
Gene Name myeloperoxidase
Synonyms
MMRRC Submission 068969-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9037 (G1)
Quality Score 182.009
Status Validated
Chromosome 11
Chromosomal Location 87684610-87695238 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 87688557 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128484 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020779] [ENSMUST00000107930] [ENSMUST00000121303] [ENSMUST00000143021] [ENSMUST00000146650]
AlphaFold P11247
Predicted Effect probably benign
Transcript: ENSMUST00000020779
SMART Domains Protein: ENSMUSP00000020779
Gene: ENSMUSG00000009350

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:An_peroxidase 147 692 4.2e-183 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107930
SMART Domains Protein: ENSMUSP00000103563
Gene: ENSMUSG00000009350

DomainStartEndE-ValueType
SCOP:g1cxp.1 82 99 1e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121303
SMART Domains Protein: ENSMUSP00000112837
Gene: ENSMUSG00000009350

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:An_peroxidase 147 692 4.2e-183 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000143021
SMART Domains Protein: ENSMUSP00000123371
Gene: ENSMUSG00000009350

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
PDB:4C1M|B 139 167 4e-11 PDB
SCOP:g1cxp.1 141 167 4e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146650
SMART Domains Protein: ENSMUSP00000128484
Gene: ENSMUSG00000009350

DomainStartEndE-ValueType
Pfam:An_peroxidase 1 112 2.4e-32 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim3 T A 18: 61,952,066 (GRCm39) I432F probably benign Het
Aco2 C G 15: 81,756,620 (GRCm39) probably benign Het
Adcy1 A G 11: 7,087,325 (GRCm39) T400A possibly damaging Het
Afap1l2 A T 19: 56,918,403 (GRCm39) probably benign Het
Anapc4 C A 5: 53,021,843 (GRCm39) Q642K probably benign Het
Ano8 A G 8: 71,937,088 (GRCm39) F160S probably damaging Het
Apob T C 12: 8,066,501 (GRCm39) V4490A probably benign Het
Bcar1 A C 8: 112,447,522 (GRCm39) F152V probably benign Het
Cacna2d2 A G 9: 107,386,395 (GRCm39) D174G probably benign Het
Capn11 T C 17: 45,950,357 (GRCm39) K328R probably benign Het
Colq C A 14: 31,279,744 (GRCm39) probably benign Het
Coro1a A C 7: 126,299,772 (GRCm39) M350R probably benign Het
Ctbp1 T A 5: 33,424,352 (GRCm39) M24L probably benign Het
Cyp2c55 T A 19: 39,030,537 (GRCm39) F456L probably damaging Het
Dnah5 A T 15: 28,248,104 (GRCm39) K747M probably benign Het
Efcab3 A G 11: 104,803,791 (GRCm39) D3048G unknown Het
Esp36 C T 17: 38,729,840 (GRCm39) G60D unknown Het
Gast A G 11: 100,227,436 (GRCm39) E43G probably damaging Het
Gm5849 T G 3: 90,685,155 (GRCm39) N10T probably benign Het
Gulp1 T C 1: 44,793,524 (GRCm39) S62P probably benign Het
Hectd1 T C 12: 51,832,665 (GRCm39) D903G possibly damaging Het
Hk2 T A 6: 82,720,339 (GRCm39) I201F probably benign Het
Ifna2 T C 4: 88,601,664 (GRCm39) D118G probably benign Het
Ift172 T C 5: 31,420,400 (GRCm39) K1079E possibly damaging Het
Igsf9 T C 1: 172,312,081 (GRCm39) V9A probably benign Het
Ints2 G A 11: 86,106,530 (GRCm39) T960I probably benign Het
Klk12 T C 7: 43,419,139 (GRCm39) W35R probably damaging Het
Ly6c1 C A 15: 74,917,300 (GRCm39) G116V probably damaging Het
Macf1 T C 4: 123,365,518 (GRCm39) N3081S probably benign Het
Mal2 A G 15: 54,434,939 (GRCm39) N12S unknown Het
Mgat1 T G 11: 49,152,256 (GRCm39) N246K probably damaging Het
Mpeg1 T A 19: 12,439,190 (GRCm39) V216E probably damaging Het
Mtmr9 T A 14: 63,761,532 (GRCm39) T541S possibly damaging Het
Or4a73 C T 2: 89,421,051 (GRCm39) R136Q probably benign Het
Or51b6b T A 7: 103,310,382 (GRCm39) H25L probably benign Het
Or5ak25 T C 2: 85,269,139 (GRCm39) D121G possibly damaging Het
Or8k3 G T 2: 86,059,042 (GRCm39) T91K probably benign Het
P2rx6 A G 16: 17,388,307 (GRCm39) T328A possibly damaging Het
Pcdhb12 A C 18: 37,569,229 (GRCm39) E125A probably benign Het
Pde3a C A 6: 141,416,832 (GRCm39) Q569K probably damaging Het
Pepd A T 7: 34,720,398 (GRCm39) Q227L probably benign Het
Piezo2 T A 18: 63,225,902 (GRCm39) E911D probably benign Het
Pnpla6 A T 8: 3,592,379 (GRCm39) R1241* probably null Het
Pold1 T C 7: 44,188,339 (GRCm39) D513G probably damaging Het
Polr1d A T 5: 147,015,490 (GRCm39) I58L probably benign Het
Ppif T C 14: 25,694,828 (GRCm39) L58P probably damaging Het
Preb T C 5: 31,116,590 (GRCm39) K101R probably benign Het
Psma8 G T 18: 14,854,251 (GRCm39) V44L probably benign Het
Ptf1a A G 2: 19,451,036 (GRCm39) Y122C possibly damaging Het
Ranbp6 T C 19: 29,790,317 (GRCm39) T12A probably benign Het
Rasal3 C A 17: 32,614,094 (GRCm39) R587L probably benign Het
Rnf146 T C 10: 29,223,676 (GRCm39) K70R probably benign Het
Serpinb6b G T 13: 33,161,998 (GRCm39) E266* probably null Het
Slc15a2 A T 16: 36,582,725 (GRCm39) M252K probably benign Het
Slc2a1 T C 4: 118,993,494 (GRCm39) F444L probably damaging Het
Sox9 A G 11: 112,675,650 (GRCm39) S280G probably damaging Het
Spata31e4 A G 13: 50,856,944 (GRCm39) K861E probably benign Het
Trappc8 A G 18: 20,961,539 (GRCm39) V1243A probably benign Het
Trpv2 A T 11: 62,475,231 (GRCm39) T215S probably damaging Het
Ttc39a A G 4: 109,299,981 (GRCm39) E490G probably damaging Het
Ush2a A T 1: 187,995,487 (GRCm39) D86V possibly damaging Het
Usp24 A G 4: 106,236,251 (GRCm39) T980A probably damaging Het
Vwa7 T C 17: 35,236,268 (GRCm39) V74A probably benign Het
Zan A G 5: 137,452,578 (GRCm39) V1501A unknown Het
Zfp105 A G 9: 122,758,836 (GRCm39) E169G possibly damaging Het
Zfp788 C T 7: 41,298,315 (GRCm39) T317I probably damaging Het
Other mutations in Mpo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Mpo APN 11 87,693,443 (GRCm39) missense probably benign
IGL00668:Mpo APN 11 87,688,160 (GRCm39) missense probably benign 0.01
IGL01016:Mpo APN 11 87,688,436 (GRCm39) splice site probably null
IGL01517:Mpo APN 11 87,686,647 (GRCm39) missense possibly damaging 0.83
IGL01530:Mpo APN 11 87,692,017 (GRCm39) missense probably benign 0.00
IGL02123:Mpo APN 11 87,685,621 (GRCm39) missense probably benign 0.05
BB001:Mpo UTSW 11 87,685,666 (GRCm39) missense probably damaging 1.00
BB011:Mpo UTSW 11 87,685,666 (GRCm39) missense probably damaging 1.00
R0091:Mpo UTSW 11 87,692,436 (GRCm39) missense probably benign 0.06
R0458:Mpo UTSW 11 87,687,123 (GRCm39) missense probably benign 0.35
R0506:Mpo UTSW 11 87,694,330 (GRCm39) missense probably benign 0.00
R0574:Mpo UTSW 11 87,686,902 (GRCm39) missense probably damaging 0.99
R0850:Mpo UTSW 11 87,688,328 (GRCm39) missense probably damaging 1.00
R1488:Mpo UTSW 11 87,688,256 (GRCm39) missense probably damaging 1.00
R1753:Mpo UTSW 11 87,686,707 (GRCm39) missense probably benign 0.06
R1785:Mpo UTSW 11 87,688,187 (GRCm39) missense possibly damaging 0.90
R1891:Mpo UTSW 11 87,692,106 (GRCm39) nonsense probably null
R1989:Mpo UTSW 11 87,694,298 (GRCm39) missense probably damaging 1.00
R2107:Mpo UTSW 11 87,686,901 (GRCm39) missense probably damaging 1.00
R2108:Mpo UTSW 11 87,686,901 (GRCm39) missense probably damaging 1.00
R2130:Mpo UTSW 11 87,688,187 (GRCm39) missense possibly damaging 0.90
R2132:Mpo UTSW 11 87,688,187 (GRCm39) missense possibly damaging 0.90
R3930:Mpo UTSW 11 87,691,866 (GRCm39) missense probably damaging 1.00
R3931:Mpo UTSW 11 87,691,866 (GRCm39) missense probably damaging 1.00
R3941:Mpo UTSW 11 87,688,175 (GRCm39) missense probably benign 0.02
R4323:Mpo UTSW 11 87,686,865 (GRCm39) missense probably damaging 1.00
R4857:Mpo UTSW 11 87,687,107 (GRCm39) missense probably benign
R4892:Mpo UTSW 11 87,693,507 (GRCm39) missense probably benign 0.00
R5224:Mpo UTSW 11 87,687,283 (GRCm39) unclassified probably benign
R5250:Mpo UTSW 11 87,694,259 (GRCm39) missense probably benign 0.03
R5373:Mpo UTSW 11 87,694,437 (GRCm39) critical splice donor site probably null
R5374:Mpo UTSW 11 87,694,437 (GRCm39) critical splice donor site probably null
R5408:Mpo UTSW 11 87,691,851 (GRCm39) splice site probably null
R5708:Mpo UTSW 11 87,692,581 (GRCm39) splice site probably null
R6354:Mpo UTSW 11 87,688,172 (GRCm39) missense possibly damaging 0.89
R6598:Mpo UTSW 11 87,690,798 (GRCm39) missense probably benign 0.43
R6713:Mpo UTSW 11 87,686,194 (GRCm39) missense probably damaging 1.00
R7053:Mpo UTSW 11 87,694,336 (GRCm39) missense probably damaging 0.99
R7395:Mpo UTSW 11 87,691,950 (GRCm39) missense probably damaging 1.00
R7573:Mpo UTSW 11 87,688,403 (GRCm39) missense probably benign 0.01
R7924:Mpo UTSW 11 87,685,666 (GRCm39) missense probably damaging 1.00
R8152:Mpo UTSW 11 87,692,475 (GRCm39) missense probably benign
R8285:Mpo UTSW 11 87,688,393 (GRCm39) missense probably benign 0.05
R8776:Mpo UTSW 11 87,693,538 (GRCm39) missense possibly damaging 0.50
R8776-TAIL:Mpo UTSW 11 87,693,538 (GRCm39) missense possibly damaging 0.50
R8807:Mpo UTSW 11 87,687,165 (GRCm39) missense probably benign 0.05
R8829:Mpo UTSW 11 87,694,250 (GRCm39) missense probably damaging 1.00
R9272:Mpo UTSW 11 87,686,693 (GRCm39) missense probably benign 0.01
R9535:Mpo UTSW 11 87,690,794 (GRCm39) missense probably damaging 1.00
R9746:Mpo UTSW 11 87,694,349 (GRCm39) missense probably benign
RF018:Mpo UTSW 11 87,688,465 (GRCm39) missense probably damaging 1.00
Z1088:Mpo UTSW 11 87,686,071 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CTTCCAAGACAATGGCAGGG -3'
(R):5'- TTTCCACAGTCCACAGGAGG -3'

Sequencing Primer
(F):5'- GCCCTGATGCCCTTTGACAG -3'
(R):5'- TCCATCCAACTCGTTACCA -3'
Posted On 2022-09-14