Incidental Mutation 'R9601:Spryd7'
ID 726376
Institutional Source Beutler Lab
Gene Symbol Spryd7
Ensembl Gene ENSMUSG00000021930
Gene Name SPRY domain containing 7
Synonyms 6330409N04Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R9601 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 61769442-61794335 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 61783228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Proline at position 98 (H98P)
Ref Sequence ENSEMBL: ENSMUSP00000022497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022497] [ENSMUST00000100496]
AlphaFold Q3TFQ1
Predicted Effect probably benign
Transcript: ENSMUST00000022497
AA Change: H98P

PolyPhen 2 Score 0.299 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000022497
Gene: ENSMUSG00000021930
AA Change: H98P

DomainStartEndE-ValueType
SPRY 62 176 4.39e-25 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000100496
AA Change: H98P

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000098065
Gene: ENSMUSG00000021930
AA Change: H98P

DomainStartEndE-ValueType
Pfam:SPRY 62 144 1.1e-7 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd6 T C 14: 8,049,808 (GRCm38) L246S possibly damaging Het
Ahcyl A G 16: 45,975,035 (GRCm39) I114T probably benign Het
Arhgap22 C A 14: 33,020,727 (GRCm39) H107N probably damaging Het
Atp6v0a2 G A 5: 124,790,257 (GRCm39) G480D probably damaging Het
Baz2b T C 2: 59,731,847 (GRCm39) T2064A possibly damaging Het
Bop1 T A 15: 76,338,688 (GRCm39) N449I probably benign Het
C8g C T 2: 25,388,916 (GRCm39) probably null Het
Camp T G 9: 109,677,504 (GRCm39) T110P Het
Ccdc141 T C 2: 76,885,073 (GRCm39) T523A possibly damaging Het
Ccdc157 A T 11: 4,094,598 (GRCm39) I578N probably damaging Het
Ccdc187 C T 2: 26,143,445 (GRCm39) A1298T possibly damaging Het
Cdc20 C T 4: 118,290,716 (GRCm39) W428* probably null Het
Chd9 A T 8: 91,732,360 (GRCm39) R1293* probably null Het
Clca3a1 C T 3: 144,453,310 (GRCm39) G505S probably benign Het
Clptm1 C A 7: 19,369,763 (GRCm39) W382C probably damaging Het
Cnot1 A T 8: 96,482,835 (GRCm39) N739K probably benign Het
Cntnap5a T C 1: 116,508,217 (GRCm39) I1243T probably damaging Het
Col12a1 T G 9: 79,525,034 (GRCm39) D2709A probably damaging Het
Cpm T C 10: 117,511,999 (GRCm39) probably null Het
Ctsd C A 7: 141,936,373 (GRCm39) G143C probably damaging Het
Cux2 A G 5: 122,025,461 (GRCm39) V69A possibly damaging Het
Cyp2c66 A T 19: 39,175,054 (GRCm39) I485L probably benign Het
Cyp4a29 T C 4: 115,105,772 (GRCm39) V158A probably damaging Het
Dbx1 A T 7: 49,282,403 (GRCm39) D267E probably damaging Het
Dop1b A G 16: 93,544,531 (GRCm39) Y224C possibly damaging Het
Dsg3 T A 18: 20,666,578 (GRCm39) C596S probably damaging Het
Fcgbpl1 G A 7: 27,853,805 (GRCm39) V1590I possibly damaging Het
Fgd2 G A 17: 29,593,860 (GRCm39) V456I probably benign Het
Gabra1 A T 11: 42,026,401 (GRCm39) I297N probably damaging Het
Grid1 A G 14: 35,167,814 (GRCm39) E446G probably damaging Het
H2bc12 T C 13: 22,220,393 (GRCm39) S113P probably benign Het
Hmmr A T 11: 40,598,210 (GRCm39) Y667* probably null Het
Katnip A G 7: 125,442,092 (GRCm39) Q693R probably benign Het
Klhl25 A G 7: 75,515,757 (GRCm39) D221G probably damaging Het
Krtcap2 T C 3: 89,156,449 (GRCm39) probably null Het
Lipi T A 16: 75,352,706 (GRCm39) N377I possibly damaging Het
Lrp2 C A 2: 69,289,928 (GRCm39) C3637F probably damaging Het
Mrgprh T C 17: 13,096,264 (GRCm39) F168S possibly damaging Het
Naip6 T C 13: 100,436,961 (GRCm39) T521A probably benign Het
Nkpd1 A T 7: 19,257,462 (GRCm39) I414F probably damaging Het
Or4c99 T A 2: 88,330,314 (GRCm39) M295K probably damaging Het
Or52z13 A T 7: 103,246,598 (GRCm39) D25V probably benign Het
Pcdhb21 A T 18: 37,648,385 (GRCm39) I505F probably damaging Het
Plxna1 C T 6: 89,308,253 (GRCm39) R1278Q probably damaging Het
Pofut2 T C 10: 77,095,220 (GRCm39) S22P possibly damaging Het
Prrc2b C A 2: 32,090,953 (GRCm39) R442S probably damaging Het
Sema3e T A 5: 14,302,397 (GRCm39) F641I possibly damaging Het
Sfswap G A 5: 129,618,463 (GRCm39) V466I possibly damaging Het
Slc22a21 A T 11: 53,850,051 (GRCm39) V268E possibly damaging Het
Slc6a17 T C 3: 107,380,930 (GRCm39) D525G possibly damaging Het
Spata21 C T 4: 140,822,467 (GRCm39) T91I possibly damaging Het
Sptb G T 12: 76,667,763 (GRCm39) T778K probably damaging Het
Syne1 C T 10: 5,209,270 (GRCm39) R3411Q probably benign Het
Trank1 A G 9: 111,202,193 (GRCm39) I1607V probably benign Het
Ttll1 T C 15: 83,380,516 (GRCm39) D283G probably benign Het
Ufl1 G A 4: 25,275,807 (GRCm39) R199W probably benign Het
Vmn1r159 A G 7: 22,542,616 (GRCm39) S139P probably damaging Het
Vmn2r97 A G 17: 19,134,770 (GRCm39) I63V probably benign Het
Vps13a T C 19: 16,623,337 (GRCm39) S2775G possibly damaging Het
Zfp992 C T 4: 146,551,976 (GRCm39) H566Y probably damaging Het
Other mutations in Spryd7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00510:Spryd7 APN 14 61,783,190 (GRCm39) missense probably damaging 1.00
R1770:Spryd7 UTSW 14 61,777,654 (GRCm39) missense probably damaging 0.99
R7606:Spryd7 UTSW 14 61,777,607 (GRCm39) missense possibly damaging 0.89
R7821:Spryd7 UTSW 14 61,783,129 (GRCm39) critical splice donor site probably null
R9566:Spryd7 UTSW 14 61,777,639 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGGGCTTTGGAATAAACGTCACC -3'
(R):5'- TTCCAAGTCTAAGCTTGCCAG -3'

Sequencing Primer
(F):5'- TTTGGAATAAACGTCACCACCCG -3'
(R):5'- TCTAAGCTTGCCAGAGACATGACTG -3'
Posted On 2022-10-06