Incidental Mutation 'R9605:Arhgef4'
| ID |
726389 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef4
|
| Ensembl Gene |
ENSMUSG00000037509 |
| Gene Name |
Rho guanine nucleotide exchange factor 4 |
| Synonyms |
Asef, 9330140K16Rik, C230030N03Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9605 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
34717263-34851819 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 34761745 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 334
(T334A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124213
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159747]
|
| AlphaFold |
Q7TNR9 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000159747
AA Change: T334A
|
| SMART Domains |
Protein: ENSMUSP00000124213
Gene: ENSMUSG00000037509
AA Change: T334A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
584 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1254 |
N/A |
INTRINSIC |
|
SH3
|
1361 |
1416 |
3.73e-16 |
SMART |
|
RhoGEF
|
1453 |
1632 |
3.86e-56 |
SMART |
|
PH
|
1665 |
1773 |
2.33e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Targeted, other(1) |
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430548M08Rik |
G |
A |
8: 120,872,380 (GRCm39) |
V103I |
possibly damaging |
Het |
| Aatk |
T |
C |
11: 119,902,209 (GRCm39) |
E729G |
possibly damaging |
Het |
| Acaa2 |
A |
G |
18: 74,932,230 (GRCm39) |
T290A |
probably benign |
Het |
| Acaca |
C |
T |
11: 84,183,842 (GRCm39) |
T1240I |
probably benign |
Het |
| Adgre1 |
A |
G |
17: 57,718,083 (GRCm39) |
N365S |
probably benign |
Het |
| Adipor1 |
A |
G |
1: 134,352,553 (GRCm39) |
D108G |
probably damaging |
Het |
| Aebp2 |
A |
G |
6: 140,593,736 (GRCm39) |
Q462R |
probably damaging |
Het |
| Afg2a |
C |
T |
3: 37,505,930 (GRCm39) |
P670S |
probably damaging |
Het |
| Art5 |
T |
C |
7: 101,746,412 (GRCm39) |
E280G |
probably benign |
Het |
| Bloc1s3 |
A |
G |
7: 19,241,457 (GRCm39) |
S24P |
possibly damaging |
Het |
| C2 |
T |
A |
17: 35,081,958 (GRCm39) |
N720I |
possibly damaging |
Het |
| Caprin2 |
T |
C |
6: 148,744,332 (GRCm39) |
D1031G |
probably damaging |
Het |
| Catsper1 |
A |
G |
19: 5,387,785 (GRCm39) |
T355A |
probably benign |
Het |
| Cd19 |
T |
A |
7: 126,010,057 (GRCm39) |
E398D |
possibly damaging |
Het |
| Cdca8 |
T |
C |
4: 124,830,384 (GRCm39) |
E31G |
probably damaging |
Het |
| Ceacam5 |
G |
A |
7: 17,493,520 (GRCm39) |
V848M |
probably damaging |
Het |
| Chd8 |
A |
T |
14: 52,457,055 (GRCm39) |
L971Q |
probably damaging |
Het |
| Ciao1 |
G |
A |
2: 127,087,684 (GRCm39) |
T217I |
probably damaging |
Het |
| Cldn1 |
A |
T |
16: 26,181,924 (GRCm39) |
I95N |
probably damaging |
Het |
| Clip2 |
C |
T |
5: 134,533,616 (GRCm39) |
R487Q |
probably benign |
Het |
| Cluh |
C |
T |
11: 74,558,772 (GRCm39) |
R1253C |
possibly damaging |
Het |
| Cngb3 |
A |
T |
4: 19,505,187 (GRCm39) |
Q640L |
probably benign |
Het |
| Cspg4b |
T |
C |
13: 113,456,503 (GRCm39) |
S850P |
|
Het |
| Cyp2c40 |
A |
T |
19: 39,766,443 (GRCm39) |
V384D |
probably damaging |
Het |
| Cyp2d26 |
T |
A |
15: 82,674,672 (GRCm39) |
M437L |
probably benign |
Het |
| D430041D05Rik |
A |
G |
2: 104,087,189 (GRCm39) |
S596P |
probably benign |
Het |
| Dagla |
A |
T |
19: 10,233,053 (GRCm39) |
V448D |
probably damaging |
Het |
| Ddx59 |
A |
T |
1: 136,344,594 (GRCm39) |
E88D |
probably benign |
Het |
| Dock1 |
T |
A |
7: 134,384,141 (GRCm39) |
F671I |
possibly damaging |
Het |
| Dtna |
T |
A |
18: 23,764,454 (GRCm39) |
V541D |
probably damaging |
Het |
| Eef2k |
T |
C |
7: 120,491,170 (GRCm39) |
F552S |
probably damaging |
Het |
| Erbb2 |
T |
C |
11: 98,311,746 (GRCm39) |
V94A |
possibly damaging |
Het |
| Etl4 |
A |
T |
2: 20,771,345 (GRCm39) |
I607F |
possibly damaging |
Het |
| Ets2 |
G |
T |
16: 95,516,121 (GRCm39) |
E234* |
probably null |
Het |
| Fbp1 |
A |
C |
13: 63,019,023 (GRCm39) |
V175G |
probably damaging |
Het |
| Fmn2 |
C |
T |
1: 174,436,194 (GRCm39) |
Q722* |
probably null |
Het |
| Fnip1 |
G |
T |
11: 54,381,713 (GRCm39) |
R288L |
probably benign |
Het |
| Ghr |
G |
A |
15: 3,362,993 (GRCm39) |
P160S |
probably damaging |
Het |
| Glipr1 |
A |
G |
10: 111,832,801 (GRCm39) |
S46P |
probably damaging |
Het |
| Kif19b |
A |
T |
5: 140,455,461 (GRCm39) |
T356S |
probably benign |
Het |
| Kif9 |
G |
A |
9: 110,346,710 (GRCm39) |
R616H |
probably benign |
Het |
| Krt87 |
G |
T |
15: 101,336,484 (GRCm39) |
C56* |
probably null |
Het |
| Ldlr |
A |
G |
9: 21,646,626 (GRCm39) |
D264G |
probably damaging |
Het |
| Lrrk2 |
A |
T |
15: 91,621,420 (GRCm39) |
D998V |
probably benign |
Het |
| Mcm5 |
C |
T |
8: 75,844,168 (GRCm39) |
S313F |
probably benign |
Het |
| Mrc1 |
A |
G |
2: 14,324,110 (GRCm39) |
N1149S |
probably benign |
Het |
| Myo1c |
T |
A |
11: 75,559,899 (GRCm39) |
V661E |
probably benign |
Het |
| N4bp2 |
T |
C |
5: 65,963,879 (GRCm39) |
S643P |
probably benign |
Het |
| Nbl1 |
T |
A |
4: 138,812,608 (GRCm39) |
T75S |
probably benign |
Het |
| Ndn |
C |
T |
7: 61,998,337 (GRCm39) |
P61L |
possibly damaging |
Het |
| Nqo2 |
T |
A |
13: 34,156,361 (GRCm39) |
V25E |
possibly damaging |
Het |
| Oma1 |
G |
T |
4: 103,210,726 (GRCm39) |
V411L |
possibly damaging |
Het |
| Or12e13 |
T |
G |
2: 87,663,478 (GRCm39) |
F32V |
probably benign |
Het |
| Or5v1 |
T |
A |
17: 37,810,331 (GRCm39) |
I263N |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,093 (GRCm39) |
V258A |
probably damaging |
Het |
| Osgin2 |
G |
T |
4: 15,998,427 (GRCm39) |
H398Q |
probably damaging |
Het |
| Pepd |
A |
C |
7: 34,743,218 (GRCm39) |
D419A |
probably benign |
Het |
| Pikfyve |
A |
T |
1: 65,303,561 (GRCm39) |
S1694C |
probably benign |
Het |
| Pirb |
G |
A |
7: 3,720,617 (GRCm39) |
R294C |
possibly damaging |
Het |
| Plec |
A |
T |
15: 76,065,213 (GRCm39) |
L1619Q |
unknown |
Het |
| Polq |
A |
G |
16: 36,843,173 (GRCm39) |
I236V |
probably benign |
Het |
| Pphln1-ps1 |
A |
G |
16: 13,495,087 (GRCm39) |
D62G |
probably benign |
Het |
| Prkag3 |
T |
G |
1: 74,786,378 (GRCm39) |
Q189P |
probably damaging |
Het |
| Prkcg |
A |
T |
7: 3,359,360 (GRCm39) |
M136L |
probably benign |
Het |
| Ptprn2 |
T |
C |
12: 117,125,278 (GRCm39) |
L604P |
probably benign |
Het |
| Rab6b |
A |
T |
9: 103,017,601 (GRCm39) |
T31S |
probably benign |
Het |
| Rnf213 |
A |
G |
11: 119,359,879 (GRCm39) |
N4424S |
|
Het |
| Ryr3 |
A |
T |
2: 112,491,966 (GRCm39) |
L3795Q |
probably damaging |
Het |
| Scg2 |
A |
G |
1: 79,412,936 (GRCm39) |
Y556H |
probably damaging |
Het |
| Serpina3j |
A |
G |
12: 104,286,093 (GRCm39) |
N416S |
probably damaging |
Het |
| Sik3 |
T |
A |
9: 46,120,117 (GRCm39) |
H735Q |
probably benign |
Het |
| Slain1 |
A |
C |
14: 103,902,112 (GRCm39) |
T60P |
|
Het |
| Slc14a1 |
C |
A |
18: 78,152,807 (GRCm39) |
A367S |
probably damaging |
Het |
| Slc46a2 |
A |
T |
4: 59,914,056 (GRCm39) |
V289E |
probably damaging |
Het |
| Sorcs3 |
A |
T |
19: 48,711,364 (GRCm39) |
Y643F |
probably damaging |
Het |
| Sox30 |
A |
G |
11: 45,875,640 (GRCm39) |
N464S |
possibly damaging |
Het |
| Spta1 |
A |
G |
1: 174,035,880 (GRCm39) |
Y1062C |
probably damaging |
Het |
| Srrm3 |
A |
G |
5: 135,881,105 (GRCm39) |
D135G |
probably damaging |
Het |
| Stat5b |
T |
A |
11: 100,699,276 (GRCm39) |
H25L |
possibly damaging |
Het |
| Synj2 |
A |
G |
17: 6,063,794 (GRCm39) |
I513V |
probably benign |
Het |
| Syt11 |
T |
A |
3: 88,669,325 (GRCm39) |
Q189L |
probably benign |
Het |
| Tbc1d1 |
G |
A |
5: 64,443,350 (GRCm39) |
R523Q |
probably damaging |
Het |
| Traf3ip2 |
T |
A |
10: 39,521,772 (GRCm39) |
D443E |
probably benign |
Het |
| Traf6 |
G |
T |
2: 101,524,625 (GRCm39) |
C235F |
probably damaging |
Het |
| Treh |
A |
G |
9: 44,592,416 (GRCm39) |
D47G |
probably damaging |
Het |
| Trpc4 |
C |
A |
3: 54,225,550 (GRCm39) |
H966Q |
probably benign |
Het |
| Ttbk1 |
A |
T |
17: 46,784,516 (GRCm39) |
D316E |
possibly damaging |
Het |
| Txndc16 |
A |
T |
14: 45,442,799 (GRCm39) |
F132Y |
probably damaging |
Het |
| Uggt1 |
A |
T |
1: 36,273,886 (GRCm39) |
|
probably null |
Het |
| Usp25 |
A |
T |
16: 76,874,046 (GRCm39) |
I541F |
probably damaging |
Het |
| Xirp1 |
A |
T |
9: 119,847,274 (GRCm39) |
D536E |
possibly damaging |
Het |
| Zfp51 |
A |
G |
17: 21,684,291 (GRCm39) |
E302G |
probably damaging |
Het |
| Zfp648 |
A |
T |
1: 154,080,110 (GRCm39) |
T90S |
probably benign |
Het |
| Zfp84 |
A |
G |
7: 29,476,264 (GRCm39) |
T319A |
possibly damaging |
Het |
|
| Other mutations in Arhgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Arhgef4
|
APN |
1 |
34,850,777 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02376:Arhgef4
|
APN |
1 |
34,845,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Arhgef4
|
APN |
1 |
34,850,804 (GRCm39) |
nonsense |
probably null |
|
|
IGL03240:Arhgef4
|
APN |
1 |
34,845,107 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB004:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Arhgef4
|
UTSW |
1 |
34,771,451 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Arhgef4
|
UTSW |
1 |
34,845,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Arhgef4
|
UTSW |
1 |
34,846,080 (GRCm39) |
splice site |
probably null |
|
|
R0383:Arhgef4
|
UTSW |
1 |
34,849,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Arhgef4
|
UTSW |
1 |
34,784,529 (GRCm39) |
splice site |
probably null |
|
|
R0452:Arhgef4
|
UTSW |
1 |
34,771,403 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0893:Arhgef4
|
UTSW |
1 |
34,846,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1429:Arhgef4
|
UTSW |
1 |
34,849,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Arhgef4
|
UTSW |
1 |
34,763,026 (GRCm39) |
missense |
unknown |
|
|
R1669:Arhgef4
|
UTSW |
1 |
34,771,239 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1780:Arhgef4
|
UTSW |
1 |
34,763,241 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1809:Arhgef4
|
UTSW |
1 |
34,849,636 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1879:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R1908:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1919:Arhgef4
|
UTSW |
1 |
34,850,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2020:Arhgef4
|
UTSW |
1 |
34,762,891 (GRCm39) |
missense |
unknown |
|
|
R2058:Arhgef4
|
UTSW |
1 |
34,761,458 (GRCm39) |
missense |
unknown |
|
|
R2213:Arhgef4
|
UTSW |
1 |
34,846,230 (GRCm39) |
splice site |
probably null |
|
|
R2851:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2852:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2853:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R3697:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R4012:Arhgef4
|
UTSW |
1 |
34,764,187 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4118:Arhgef4
|
UTSW |
1 |
34,771,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Arhgef4
|
UTSW |
1 |
34,845,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4535:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4581:Arhgef4
|
UTSW |
1 |
34,771,205 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4665:Arhgef4
|
UTSW |
1 |
34,845,113 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4678:Arhgef4
|
UTSW |
1 |
34,761,749 (GRCm39) |
missense |
unknown |
|
|
R4684:Arhgef4
|
UTSW |
1 |
34,850,866 (GRCm39) |
splice site |
probably null |
|
|
R4706:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4745:Arhgef4
|
UTSW |
1 |
34,846,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4747:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R4988:Arhgef4
|
UTSW |
1 |
34,762,535 (GRCm39) |
missense |
unknown |
|
|
R5063:Arhgef4
|
UTSW |
1 |
34,763,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5154:Arhgef4
|
UTSW |
1 |
34,771,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5156:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R5263:Arhgef4
|
UTSW |
1 |
34,764,078 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5450:Arhgef4
|
UTSW |
1 |
34,846,405 (GRCm39) |
intron |
probably benign |
|
|
R5807:Arhgef4
|
UTSW |
1 |
34,846,696 (GRCm39) |
intron |
probably benign |
|
|
R5863:Arhgef4
|
UTSW |
1 |
34,761,926 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6311:Arhgef4
|
UTSW |
1 |
34,763,062 (GRCm39) |
missense |
unknown |
|
|
R6315:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6316:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6318:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6323:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6324:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6325:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6340:Arhgef4
|
UTSW |
1 |
34,771,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Arhgef4
|
UTSW |
1 |
34,845,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Arhgef4
|
UTSW |
1 |
34,761,533 (GRCm39) |
missense |
unknown |
|
|
R7087:Arhgef4
|
UTSW |
1 |
34,850,767 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7297:Arhgef4
|
UTSW |
1 |
34,846,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Arhgef4
|
UTSW |
1 |
34,848,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Arhgef4
|
UTSW |
1 |
34,771,316 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7693:Arhgef4
|
UTSW |
1 |
34,763,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7892:Arhgef4
|
UTSW |
1 |
34,760,885 (GRCm39) |
missense |
unknown |
|
|
R7895:Arhgef4
|
UTSW |
1 |
34,845,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Arhgef4
|
UTSW |
1 |
34,850,762 (GRCm39) |
missense |
probably benign |
|
|
R7973:Arhgef4
|
UTSW |
1 |
34,763,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7979:Arhgef4
|
UTSW |
1 |
34,760,978 (GRCm39) |
missense |
unknown |
|
|
R8160:Arhgef4
|
UTSW |
1 |
34,762,655 (GRCm39) |
missense |
unknown |
|
|
R8175:Arhgef4
|
UTSW |
1 |
34,849,455 (GRCm39) |
missense |
probably benign |
|
|
R8178:Arhgef4
|
UTSW |
1 |
34,761,983 (GRCm39) |
missense |
unknown |
|
|
R9046:Arhgef4
|
UTSW |
1 |
34,850,846 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9077:Arhgef4
|
UTSW |
1 |
34,760,824 (GRCm39) |
missense |
unknown |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,849,576 (GRCm39) |
missense |
probably benign |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,764,241 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9355:Arhgef4
|
UTSW |
1 |
34,849,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9489:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9509:Arhgef4
|
UTSW |
1 |
34,762,772 (GRCm39) |
missense |
unknown |
|
|
R9665:Arhgef4
|
UTSW |
1 |
34,849,518 (GRCm39) |
missense |
probably benign |
|
|
R9675:Arhgef4
|
UTSW |
1 |
34,845,108 (GRCm39) |
missense |
probably benign |
|
|
R9790:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9791:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF012:Arhgef4
|
UTSW |
1 |
34,763,565 (GRCm39) |
small deletion |
probably benign |
|
|
X0062:Arhgef4
|
UTSW |
1 |
34,763,308 (GRCm39) |
missense |
probably benign |
0.35 |
|
YA93:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,844,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,762,810 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,447 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,002 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCAACCTCGATTGGGCAC -3'
(R):5'- GTTTTCCAGTGGAAGGCCTACAC -3'
Sequencing Primer
(F):5'- GATTGGGCACACCTTATCTCTTAGAC -3'
(R):5'- TGGAAGGCCTACACAGGGTG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation