Incidental Mutation 'R9617:Olfr965'
ID 726519
Institutional Source Beutler Lab
Gene Symbol Olfr965
Ensembl Gene ENSMUSG00000095839
Gene Name olfactory receptor 965
Synonyms GA_x6K02T2PVTD-33416730-33417668, MOR171-28
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R9617 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39711353-39720614 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39719382 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 52 (S52G)
Ref Sequence ENSEMBL: ENSMUSP00000150401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069342] [ENSMUST00000213335] [ENSMUST00000215164]
AlphaFold Q7TRA7
Predicted Effect possibly damaging
Transcript: ENSMUST00000069342
AA Change: S52G

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000069696
Gene: ENSMUSG00000095839
AA Change: S52G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-47 PFAM
Pfam:7tm_1 41 290 4.2e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213335
AA Change: S52G

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215164
AA Change: S52G

PolyPhen 2 Score 0.803 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik C T 3: 68,870,069 P121L probably damaging Het
4930442H23Rik C T 10: 81,183,142 V16I unknown Het
4930444P10Rik T C 1: 16,068,827 M97V probably benign Het
Abcb1a A T 5: 8,747,353 probably null Het
Abhd5 T C 9: 122,367,970 I74T probably benign Het
Ankle2 T A 5: 110,251,543 F590I probably damaging Het
C2cd6 T C 1: 59,058,689 S414G probably benign Het
Catsperd G A 17: 56,661,252 D546N probably benign Het
Cep295nl G T 11: 118,333,174 H281Q possibly damaging Het
Cfap69 T C 5: 5,589,164 E670G probably damaging Het
Cfh A T 1: 140,162,980 V90E possibly damaging Het
Cnksr3 A C 10: 7,129,021 probably null Het
Cntrl T A 2: 35,145,065 F901L probably benign Het
Coch T A 12: 51,598,251 M196K probably damaging Het
Crygd T C 1: 65,063,210 N34S probably damaging Het
Ctdp1 A T 18: 80,449,747 I511N probably benign Het
Dhx30 C T 9: 110,097,118 A142T probably damaging Het
Dlg2 T C 7: 92,438,076 probably null Het
Dmxl1 A G 18: 49,865,161 D776G probably damaging Het
Dnm3 C T 1: 162,321,785 G197D probably damaging Het
Eif4g3 A G 4: 138,096,879 H91R probably damaging Het
Ephb6 A G 6: 41,619,324 M844V probably damaging Het
Erc1 T C 6: 119,796,941 E351G probably benign Het
Etfbkmt G A 6: 149,144,246 G33R probably benign Het
Fnbp4 T C 2: 90,758,394 I503T probably benign Het
Gm6370 A T 5: 146,493,183 Q143L probably benign Het
Gnas T C 2: 174,300,195 V719A possibly damaging Het
H13 C A 2: 152,688,953 D219E probably damaging Het
Hhatl G A 9: 121,789,125 T188I possibly damaging Het
Ifi27l2b C T 12: 103,456,424 A45T probably damaging Het
Kbtbd8 T C 6: 95,126,893 C585R possibly damaging Het
Limk2 A G 11: 3,347,715 S473P probably damaging Het
Lrba G A 3: 86,359,862 G1620S probably benign Het
Lrrtm2 T C 18: 35,213,437 T271A probably benign Het
Map3k4 A G 17: 12,257,984 S759P possibly damaging Het
Mybphl G T 3: 108,375,636 V247F possibly damaging Het
Myh10 T A 11: 68,791,989 V1120D probably benign Het
Naip1 T C 13: 100,433,313 N271S probably benign Het
Napepld C T 5: 21,670,563 V328I probably damaging Het
Nucb1 A G 7: 45,498,735 V218A probably benign Het
Nup107 A T 10: 117,757,333 D813E probably benign Het
Olfr114 T A 17: 37,590,162 K64* probably null Het
Olfr781 A T 10: 129,332,925 T15S probably damaging Het
Olfr998 T A 2: 85,590,935 Y132N probably damaging Het
Pabpc2 T C 18: 39,774,549 I289T probably benign Het
Parg A G 14: 32,238,612 I600V probably benign Het
Patj T C 4: 98,505,754 F975L probably benign Het
Pcdhb17 A G 18: 37,485,165 T3A probably benign Het
Piezo2 T C 18: 63,115,037 E464G probably benign Het
Pkd1 T A 17: 24,581,367 V3034D probably damaging Het
Pld2 A G 11: 70,557,118 E869G probably damaging Het
Plek T A 11: 16,995,311 L29F possibly damaging Het
Prelp A G 1: 133,914,678 L243P probably damaging Het
Rapgef5 T A 12: 117,658,310 D231E probably benign Het
Riok1 A G 13: 38,060,040 E514G probably benign Het
Rmdn2 T C 17: 79,621,361 M14T probably benign Het
Rorb G A 19: 18,962,135 Q228* probably null Het
Scmh1 T A 4: 120,483,630 M171K probably damaging Het
Scn9a A G 2: 66,562,465 L261P probably damaging Het
Senp7 A T 16: 56,151,289 N263I probably benign Het
Slc11a1 G T 1: 74,379,882 A162S probably benign Het
Slc6a17 A G 3: 107,477,369 V305A probably damaging Het
Snph A T 2: 151,593,502 V502E probably damaging Het
Sost G T 11: 101,964,066 A139E possibly damaging Het
Srp54a A T 12: 55,089,276 E25D probably benign Het
Tmeff1 T A 4: 48,636,940 C213S probably damaging Het
Tmem232 A T 17: 65,500,185 Y4* probably null Het
Tmem63c T G 12: 87,056,587 I45S probably benign Het
Ttbk1 C T 17: 46,447,072 G879S probably damaging Het
Ugt1a7c A G 1: 88,095,230 H37R probably damaging Het
Vmn1r236 T C 17: 21,286,791 L57P probably damaging Het
Wnk2 T A 13: 49,038,977 E675V unknown Het
Wnt10b T C 15: 98,776,728 T43A probably damaging Het
Wnt8a C A 18: 34,547,110 T176K probably benign Het
Zfp937 T A 2: 150,238,532 C161S probably damaging Het
Other mutations in Olfr965
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01705:Olfr965 APN 9 39719581 missense possibly damaging 0.95
IGL02365:Olfr965 APN 9 39719674 missense possibly damaging 0.60
IGL02365:Olfr965 APN 9 39720100 missense probably damaging 0.98
IGL03062:Olfr965 APN 9 39720035 missense probably benign 0.26
IGL03330:Olfr965 APN 9 39719488 missense probably benign 0.08
R0011:Olfr965 UTSW 9 39719627 missense probably benign 0.26
R0462:Olfr965 UTSW 9 39719410 missense probably benign 0.01
R1505:Olfr965 UTSW 9 39719478 missense probably damaging 1.00
R1995:Olfr965 UTSW 9 39719413 missense probably damaging 1.00
R2049:Olfr965 UTSW 9 39720115 missense probably damaging 1.00
R2110:Olfr965 UTSW 9 39719722 missense probably benign 0.30
R3817:Olfr965 UTSW 9 39720108 missense possibly damaging 0.95
R4152:Olfr965 UTSW 9 39720000 missense probably benign 0.10
R4153:Olfr965 UTSW 9 39720000 missense probably benign 0.10
R4351:Olfr965 UTSW 9 39719569 missense probably damaging 0.99
R4377:Olfr965 UTSW 9 39719807 missense probably benign 0.04
R4667:Olfr965 UTSW 9 39719709 missense probably benign 0.09
R5526:Olfr965 UTSW 9 39719596 missense possibly damaging 0.95
R5816:Olfr965 UTSW 9 39719230 start codon destroyed probably null 1.00
R7113:Olfr965 UTSW 9 39719677 missense probably benign
R7336:Olfr965 UTSW 9 39719610 missense probably benign 0.28
R8153:Olfr965 UTSW 9 39719658 missense possibly damaging 0.68
R8291:Olfr965 UTSW 9 39719545 missense probably benign 0.00
R8779:Olfr965 UTSW 9 39719340 missense probably damaging 0.99
R9631:Olfr965 UTSW 9 39719865 missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- ATTGTTCAGGAAGAAATGGCTG -3'
(R):5'- TACCTCAAGGGGTTACAGATGG -3'

Sequencing Primer
(F):5'- CTGAAGGCAATCAGTCCACAGTG -3'
(R):5'- GGTCATACGCCATTGCAGAC -3'
Posted On 2022-10-06