Incidental Mutation 'R9619:Vmn2r15'
| ID |
726579 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r15
|
| Ensembl Gene |
ENSMUSG00000091375 |
| Gene Name |
vomeronasal 2, receptor 15 |
| Synonyms |
EG211223 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.101)
|
| Stock # |
R9619 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109440622 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 412
(Y412F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
| AlphaFold |
L7N2A0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167133
AA Change: Y412F
PolyPhen 2
Score 0.576 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: Y412F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
|
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
|
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afdn |
T |
C |
17: 14,101,566 (GRCm39) |
L1033P |
probably damaging |
Het |
| Agrn |
A |
G |
4: 156,258,490 (GRCm39) |
I992T |
probably benign |
Het |
| Akap9 |
A |
T |
5: 4,094,833 (GRCm39) |
E2209V |
probably damaging |
Het |
| Arfip1 |
C |
T |
3: 84,435,081 (GRCm39) |
G76E |
probably benign |
Het |
| Arsk |
T |
C |
13: 76,223,151 (GRCm39) |
T149A |
probably damaging |
Het |
| Caap1 |
A |
G |
4: 94,444,718 (GRCm39) |
V75A |
possibly damaging |
Het |
| Cenpf |
A |
G |
1: 189,385,965 (GRCm39) |
V2105A |
probably benign |
Het |
| Cep152 |
A |
G |
2: 125,436,827 (GRCm39) |
F571S |
probably benign |
Het |
| Crx |
A |
T |
7: 15,602,185 (GRCm39) |
D164E |
probably benign |
Het |
| Csgalnact1 |
A |
G |
8: 68,854,006 (GRCm39) |
V265A |
probably damaging |
Het |
| Dchs1 |
C |
T |
7: 105,413,662 (GRCm39) |
R1051Q |
probably benign |
Het |
| Dld |
A |
T |
12: 31,382,390 (GRCm39) |
L471* |
probably null |
Het |
| Dmrtb1 |
G |
T |
4: 107,540,847 (GRCm39) |
H171Q |
probably benign |
Het |
| Dnajc12 |
G |
A |
10: 63,233,075 (GRCm39) |
R72Q |
probably damaging |
Het |
| Dpf1 |
A |
G |
7: 29,012,618 (GRCm39) |
H237R |
probably benign |
Het |
| Dsg1c |
T |
A |
18: 20,416,499 (GRCm39) |
L800Q |
probably damaging |
Het |
| Dyrk2 |
A |
T |
10: 118,696,292 (GRCm39) |
L322Q |
probably damaging |
Het |
| Ect2 |
A |
G |
3: 27,201,026 (GRCm39) |
V149A |
probably benign |
Het |
| Efhc1 |
G |
A |
1: 21,037,603 (GRCm39) |
R260H |
probably benign |
Het |
| Emp2 |
G |
T |
16: 10,102,420 (GRCm39) |
Q131K |
probably benign |
Het |
| Ephb6 |
T |
C |
6: 41,594,249 (GRCm39) |
I593T |
possibly damaging |
Het |
| Fbln5 |
A |
C |
12: 101,723,552 (GRCm39) |
I383S |
probably damaging |
Het |
| Foxq1 |
A |
T |
13: 31,743,580 (GRCm39) |
E227D |
probably benign |
Het |
| Gm8237 |
A |
T |
14: 5,863,637 (GRCm38) |
N9K |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ifi44 |
T |
C |
3: 151,451,509 (GRCm39) |
N199S |
probably damaging |
Het |
| Ifna16 |
T |
G |
4: 88,594,762 (GRCm39) |
D111A |
probably benign |
Het |
| Igdcc3 |
A |
G |
9: 65,092,552 (GRCm39) |
D793G |
probably benign |
Het |
| Igfbp5 |
A |
G |
1: 72,901,543 (GRCm39) |
V270A |
probably benign |
Het |
| Kif20b |
A |
C |
19: 34,933,429 (GRCm39) |
D1345A |
probably damaging |
Het |
| Klhl9 |
T |
C |
4: 88,639,062 (GRCm39) |
H393R |
probably benign |
Het |
| Lad1 |
G |
T |
1: 135,755,521 (GRCm39) |
A266S |
possibly damaging |
Het |
| Lama2 |
A |
G |
10: 27,064,282 (GRCm39) |
L1233P |
probably damaging |
Het |
| Limch1 |
T |
C |
5: 67,015,284 (GRCm39) |
I52T |
probably damaging |
Het |
| Loxhd1 |
T |
C |
18: 77,443,871 (GRCm39) |
F599L |
probably benign |
Het |
| Mfn1 |
A |
G |
3: 32,628,478 (GRCm39) |
D703G |
possibly damaging |
Het |
| Nexmif |
C |
T |
X: 103,129,841 (GRCm39) |
R692H |
possibly damaging |
Het |
| Ogfod2 |
G |
A |
5: 124,252,470 (GRCm39) |
G183D |
probably damaging |
Het |
| Or2z8 |
T |
C |
8: 72,811,605 (GRCm39) |
L27S |
probably damaging |
Het |
| Or5aq1b |
T |
A |
2: 86,902,140 (GRCm39) |
I113F |
possibly damaging |
Het |
| Pcgf6 |
T |
C |
19: 47,037,261 (GRCm39) |
T182A |
possibly damaging |
Het |
| Pcnx4 |
T |
A |
12: 72,622,282 (GRCm39) |
C1084S |
possibly damaging |
Het |
| Peg10 |
A |
G |
6: 4,755,316 (GRCm39) |
N366D |
probably benign |
Het |
| Prr16 |
T |
A |
18: 51,435,797 (GRCm39) |
I92K |
possibly damaging |
Het |
| Rbm39 |
A |
T |
2: 156,001,117 (GRCm39) |
N312K |
probably damaging |
Het |
| Rps10 |
G |
A |
17: 27,849,459 (GRCm39) |
R160C |
probably benign |
Het |
| Scrg1 |
G |
T |
8: 57,927,363 (GRCm39) |
V5L |
unknown |
Het |
| Slc39a4 |
T |
A |
15: 76,497,874 (GRCm39) |
H408L |
probably damaging |
Het |
| Slco1a5 |
T |
C |
6: 142,198,846 (GRCm39) |
E273G |
probably benign |
Het |
| Syne1 |
A |
C |
10: 5,090,909 (GRCm39) |
V815G |
probably benign |
Het |
| Tekt2 |
C |
T |
4: 126,217,444 (GRCm39) |
R207H |
probably damaging |
Het |
| Treml1 |
T |
A |
17: 48,672,006 (GRCm39) |
F167I |
probably benign |
Het |
| Trpv2 |
T |
C |
11: 62,480,562 (GRCm39) |
V333A |
probably damaging |
Het |
| Ubqln3 |
A |
G |
7: 103,791,053 (GRCm39) |
F346L |
probably benign |
Het |
| Vmn2r61 |
A |
G |
7: 41,926,136 (GRCm39) |
N547S |
probably damaging |
Het |
| Vopp1 |
G |
A |
6: 57,731,617 (GRCm39) |
P125S |
probably benign |
Het |
| Wwc1 |
A |
G |
11: 35,766,779 (GRCm39) |
F492S |
probably damaging |
Het |
| Zfp114 |
A |
G |
7: 23,880,077 (GRCm39) |
E142G |
probably benign |
Het |
| Zfp715 |
A |
C |
7: 42,949,104 (GRCm39) |
Y285* |
probably null |
Het |
| Zwilch |
A |
G |
9: 64,057,440 (GRCm39) |
V442A |
probably benign |
Het |
|
| Other mutations in Vmn2r15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
|
R2072:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2268:Vmn2r15
|
UTSW |
5 |
109,441,073 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4663:Vmn2r15
|
UTSW |
5 |
109,441,940 (GRCm39) |
missense |
probably benign |
|
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9372:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCATGTAAAAGAATCATCACGGAG -3'
(R):5'- ACATTTCTAAGTCTATACTGGGGTG -3'
Sequencing Primer
(F):5'- CTTTCCACTGAGAGAACAATGTC -3'
(R):5'- CTGGGGTGGAATTATTTTAATTGTTC -3'
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| Posted On |
2022-10-06 |
Incidental Mutation