Incidental Mutation 'R9619:Vmn2r61'
| ID |
726588 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.101)
|
| Stock # |
R9619 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41926136 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 547
(N547S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166131
AA Change: N547S
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: N547S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afdn |
T |
C |
17: 14,101,566 (GRCm39) |
L1033P |
probably damaging |
Het |
| Agrn |
A |
G |
4: 156,258,490 (GRCm39) |
I992T |
probably benign |
Het |
| Akap9 |
A |
T |
5: 4,094,833 (GRCm39) |
E2209V |
probably damaging |
Het |
| Arfip1 |
C |
T |
3: 84,435,081 (GRCm39) |
G76E |
probably benign |
Het |
| Arsk |
T |
C |
13: 76,223,151 (GRCm39) |
T149A |
probably damaging |
Het |
| Caap1 |
A |
G |
4: 94,444,718 (GRCm39) |
V75A |
possibly damaging |
Het |
| Cenpf |
A |
G |
1: 189,385,965 (GRCm39) |
V2105A |
probably benign |
Het |
| Cep152 |
A |
G |
2: 125,436,827 (GRCm39) |
F571S |
probably benign |
Het |
| Crx |
A |
T |
7: 15,602,185 (GRCm39) |
D164E |
probably benign |
Het |
| Csgalnact1 |
A |
G |
8: 68,854,006 (GRCm39) |
V265A |
probably damaging |
Het |
| Dchs1 |
C |
T |
7: 105,413,662 (GRCm39) |
R1051Q |
probably benign |
Het |
| Dld |
A |
T |
12: 31,382,390 (GRCm39) |
L471* |
probably null |
Het |
| Dmrtb1 |
G |
T |
4: 107,540,847 (GRCm39) |
H171Q |
probably benign |
Het |
| Dnajc12 |
G |
A |
10: 63,233,075 (GRCm39) |
R72Q |
probably damaging |
Het |
| Dpf1 |
A |
G |
7: 29,012,618 (GRCm39) |
H237R |
probably benign |
Het |
| Dsg1c |
T |
A |
18: 20,416,499 (GRCm39) |
L800Q |
probably damaging |
Het |
| Dyrk2 |
A |
T |
10: 118,696,292 (GRCm39) |
L322Q |
probably damaging |
Het |
| Ect2 |
A |
G |
3: 27,201,026 (GRCm39) |
V149A |
probably benign |
Het |
| Efhc1 |
G |
A |
1: 21,037,603 (GRCm39) |
R260H |
probably benign |
Het |
| Emp2 |
G |
T |
16: 10,102,420 (GRCm39) |
Q131K |
probably benign |
Het |
| Ephb6 |
T |
C |
6: 41,594,249 (GRCm39) |
I593T |
possibly damaging |
Het |
| Fbln5 |
A |
C |
12: 101,723,552 (GRCm39) |
I383S |
probably damaging |
Het |
| Foxq1 |
A |
T |
13: 31,743,580 (GRCm39) |
E227D |
probably benign |
Het |
| Gm8237 |
A |
T |
14: 5,863,637 (GRCm38) |
N9K |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ifi44 |
T |
C |
3: 151,451,509 (GRCm39) |
N199S |
probably damaging |
Het |
| Ifna16 |
T |
G |
4: 88,594,762 (GRCm39) |
D111A |
probably benign |
Het |
| Igdcc3 |
A |
G |
9: 65,092,552 (GRCm39) |
D793G |
probably benign |
Het |
| Igfbp5 |
A |
G |
1: 72,901,543 (GRCm39) |
V270A |
probably benign |
Het |
| Kif20b |
A |
C |
19: 34,933,429 (GRCm39) |
D1345A |
probably damaging |
Het |
| Klhl9 |
T |
C |
4: 88,639,062 (GRCm39) |
H393R |
probably benign |
Het |
| Lad1 |
G |
T |
1: 135,755,521 (GRCm39) |
A266S |
possibly damaging |
Het |
| Lama2 |
A |
G |
10: 27,064,282 (GRCm39) |
L1233P |
probably damaging |
Het |
| Limch1 |
T |
C |
5: 67,015,284 (GRCm39) |
I52T |
probably damaging |
Het |
| Loxhd1 |
T |
C |
18: 77,443,871 (GRCm39) |
F599L |
probably benign |
Het |
| Mfn1 |
A |
G |
3: 32,628,478 (GRCm39) |
D703G |
possibly damaging |
Het |
| Nexmif |
C |
T |
X: 103,129,841 (GRCm39) |
R692H |
possibly damaging |
Het |
| Ogfod2 |
G |
A |
5: 124,252,470 (GRCm39) |
G183D |
probably damaging |
Het |
| Or2z8 |
T |
C |
8: 72,811,605 (GRCm39) |
L27S |
probably damaging |
Het |
| Or5aq1b |
T |
A |
2: 86,902,140 (GRCm39) |
I113F |
possibly damaging |
Het |
| Pcgf6 |
T |
C |
19: 47,037,261 (GRCm39) |
T182A |
possibly damaging |
Het |
| Pcnx4 |
T |
A |
12: 72,622,282 (GRCm39) |
C1084S |
possibly damaging |
Het |
| Peg10 |
A |
G |
6: 4,755,316 (GRCm39) |
N366D |
probably benign |
Het |
| Prr16 |
T |
A |
18: 51,435,797 (GRCm39) |
I92K |
possibly damaging |
Het |
| Rbm39 |
A |
T |
2: 156,001,117 (GRCm39) |
N312K |
probably damaging |
Het |
| Rps10 |
G |
A |
17: 27,849,459 (GRCm39) |
R160C |
probably benign |
Het |
| Scrg1 |
G |
T |
8: 57,927,363 (GRCm39) |
V5L |
unknown |
Het |
| Slc39a4 |
T |
A |
15: 76,497,874 (GRCm39) |
H408L |
probably damaging |
Het |
| Slco1a5 |
T |
C |
6: 142,198,846 (GRCm39) |
E273G |
probably benign |
Het |
| Syne1 |
A |
C |
10: 5,090,909 (GRCm39) |
V815G |
probably benign |
Het |
| Tekt2 |
C |
T |
4: 126,217,444 (GRCm39) |
R207H |
probably damaging |
Het |
| Treml1 |
T |
A |
17: 48,672,006 (GRCm39) |
F167I |
probably benign |
Het |
| Trpv2 |
T |
C |
11: 62,480,562 (GRCm39) |
V333A |
probably damaging |
Het |
| Ubqln3 |
A |
G |
7: 103,791,053 (GRCm39) |
F346L |
probably benign |
Het |
| Vmn2r15 |
T |
A |
5: 109,440,622 (GRCm39) |
Y412F |
possibly damaging |
Het |
| Vopp1 |
G |
A |
6: 57,731,617 (GRCm39) |
P125S |
probably benign |
Het |
| Wwc1 |
A |
G |
11: 35,766,779 (GRCm39) |
F492S |
probably damaging |
Het |
| Zfp114 |
A |
G |
7: 23,880,077 (GRCm39) |
E142G |
probably benign |
Het |
| Zfp715 |
A |
C |
7: 42,949,104 (GRCm39) |
Y285* |
probably null |
Het |
| Zwilch |
A |
G |
9: 64,057,440 (GRCm39) |
V442A |
probably benign |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCATGTAGCCCAAAACCTG -3'
(R):5'- GTATTCAGGGAAAATATGGTCAGC -3'
Sequencing Primer
(F):5'- TGTAGCCCAAAACCTGATAAAATTAG -3'
(R):5'- ATATGGTCAGCAATGTAAGTCAAG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation