Incidental Mutation 'R9619:Rps10'
ID 726613
Institutional Source Beutler Lab
Gene Symbol Rps10
Ensembl Gene ENSMUSG00000052146
Gene Name ribosomal protein S10
Synonyms 2210402A09Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.966) question?
Stock # R9619 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 27849389-27854218 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27849459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 160 (R160C)
Ref Sequence ENSEMBL: ENSMUSP00000110532 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025052] [ENSMUST00000114881] [ENSMUST00000114882] [ENSMUST00000152982] [ENSMUST00000155071] [ENSMUST00000178774]
AlphaFold P63325
Predicted Effect probably benign
Transcript: ENSMUST00000025052
AA Change: T141M

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000025052
Gene: ENSMUSG00000052146
AA Change: T141M

DomainStartEndE-ValueType
Pfam:S10_plectin 3 101 1.2e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114881
AA Change: R160C

PolyPhen 2 Score 0.226 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000110531
Gene: ENSMUSG00000052146
AA Change: R160C

DomainStartEndE-ValueType
Pfam:S10_plectin 3 101 1.3e-48 PFAM
low complexity region 150 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114882
AA Change: R160C

PolyPhen 2 Score 0.226 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000110532
Gene: ENSMUSG00000052146
AA Change: R160C

DomainStartEndE-ValueType
Pfam:S10_plectin 3 98 2.3e-52 PFAM
low complexity region 150 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000152982
Predicted Effect probably benign
Transcript: ENSMUST00000155071
Predicted Effect probably benign
Transcript: ENSMUST00000178774
AA Change: R160C

PolyPhen 2 Score 0.226 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000136042
Gene: ENSMUSG00000052146
AA Change: R160C

DomainStartEndE-ValueType
Pfam:S10_plectin 3 101 1.3e-48 PFAM
low complexity region 150 165 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afdn T C 17: 14,101,566 (GRCm39) L1033P probably damaging Het
Agrn A G 4: 156,258,490 (GRCm39) I992T probably benign Het
Akap9 A T 5: 4,094,833 (GRCm39) E2209V probably damaging Het
Arfip1 C T 3: 84,435,081 (GRCm39) G76E probably benign Het
Arsk T C 13: 76,223,151 (GRCm39) T149A probably damaging Het
Caap1 A G 4: 94,444,718 (GRCm39) V75A possibly damaging Het
Cenpf A G 1: 189,385,965 (GRCm39) V2105A probably benign Het
Cep152 A G 2: 125,436,827 (GRCm39) F571S probably benign Het
Crx A T 7: 15,602,185 (GRCm39) D164E probably benign Het
Csgalnact1 A G 8: 68,854,006 (GRCm39) V265A probably damaging Het
Dchs1 C T 7: 105,413,662 (GRCm39) R1051Q probably benign Het
Dld A T 12: 31,382,390 (GRCm39) L471* probably null Het
Dmrtb1 G T 4: 107,540,847 (GRCm39) H171Q probably benign Het
Dnajc12 G A 10: 63,233,075 (GRCm39) R72Q probably damaging Het
Dpf1 A G 7: 29,012,618 (GRCm39) H237R probably benign Het
Dsg1c T A 18: 20,416,499 (GRCm39) L800Q probably damaging Het
Dyrk2 A T 10: 118,696,292 (GRCm39) L322Q probably damaging Het
Ect2 A G 3: 27,201,026 (GRCm39) V149A probably benign Het
Efhc1 G A 1: 21,037,603 (GRCm39) R260H probably benign Het
Emp2 G T 16: 10,102,420 (GRCm39) Q131K probably benign Het
Ephb6 T C 6: 41,594,249 (GRCm39) I593T possibly damaging Het
Fbln5 A C 12: 101,723,552 (GRCm39) I383S probably damaging Het
Foxq1 A T 13: 31,743,580 (GRCm39) E227D probably benign Het
Gm8237 A T 14: 5,863,637 (GRCm38) N9K probably damaging Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Ifi44 T C 3: 151,451,509 (GRCm39) N199S probably damaging Het
Ifna16 T G 4: 88,594,762 (GRCm39) D111A probably benign Het
Igdcc3 A G 9: 65,092,552 (GRCm39) D793G probably benign Het
Igfbp5 A G 1: 72,901,543 (GRCm39) V270A probably benign Het
Kif20b A C 19: 34,933,429 (GRCm39) D1345A probably damaging Het
Klhl9 T C 4: 88,639,062 (GRCm39) H393R probably benign Het
Lad1 G T 1: 135,755,521 (GRCm39) A266S possibly damaging Het
Lama2 A G 10: 27,064,282 (GRCm39) L1233P probably damaging Het
Limch1 T C 5: 67,015,284 (GRCm39) I52T probably damaging Het
Loxhd1 T C 18: 77,443,871 (GRCm39) F599L probably benign Het
Mfn1 A G 3: 32,628,478 (GRCm39) D703G possibly damaging Het
Nexmif C T X: 103,129,841 (GRCm39) R692H possibly damaging Het
Ogfod2 G A 5: 124,252,470 (GRCm39) G183D probably damaging Het
Or2z8 T C 8: 72,811,605 (GRCm39) L27S probably damaging Het
Or5aq1b T A 2: 86,902,140 (GRCm39) I113F possibly damaging Het
Pcgf6 T C 19: 47,037,261 (GRCm39) T182A possibly damaging Het
Pcnx4 T A 12: 72,622,282 (GRCm39) C1084S possibly damaging Het
Peg10 A G 6: 4,755,316 (GRCm39) N366D probably benign Het
Prr16 T A 18: 51,435,797 (GRCm39) I92K possibly damaging Het
Rbm39 A T 2: 156,001,117 (GRCm39) N312K probably damaging Het
Scrg1 G T 8: 57,927,363 (GRCm39) V5L unknown Het
Slc39a4 T A 15: 76,497,874 (GRCm39) H408L probably damaging Het
Slco1a5 T C 6: 142,198,846 (GRCm39) E273G probably benign Het
Syne1 A C 10: 5,090,909 (GRCm39) V815G probably benign Het
Tekt2 C T 4: 126,217,444 (GRCm39) R207H probably damaging Het
Treml1 T A 17: 48,672,006 (GRCm39) F167I probably benign Het
Trpv2 T C 11: 62,480,562 (GRCm39) V333A probably damaging Het
Ubqln3 A G 7: 103,791,053 (GRCm39) F346L probably benign Het
Vmn2r15 T A 5: 109,440,622 (GRCm39) Y412F possibly damaging Het
Vmn2r61 A G 7: 41,926,136 (GRCm39) N547S probably damaging Het
Vopp1 G A 6: 57,731,617 (GRCm39) P125S probably benign Het
Wwc1 A G 11: 35,766,779 (GRCm39) F492S probably damaging Het
Zfp114 A G 7: 23,880,077 (GRCm39) E142G probably benign Het
Zfp715 A C 7: 42,949,104 (GRCm39) Y285* probably null Het
Zwilch A G 9: 64,057,440 (GRCm39) V442A probably benign Het
Other mutations in Rps10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1509:Rps10 UTSW 17 27,850,182 (GRCm39) missense probably benign 0.06
R2213:Rps10 UTSW 17 27,849,473 (GRCm39) unclassified probably benign
R2344:Rps10 UTSW 17 27,853,081 (GRCm39) missense possibly damaging 0.93
R5054:Rps10 UTSW 17 27,849,454 (GRCm39) missense probably damaging 1.00
R8163:Rps10 UTSW 17 27,853,085 (GRCm39) missense probably benign 0.00
R8462:Rps10 UTSW 17 27,853,208 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAAACCCTGACAGCTGAGG -3'
(R):5'- AGGTTTAACAGTGGGAAACAGACTC -3'

Sequencing Primer
(F):5'- TGAACCCACTCTGCAGGGAG -3'
(R):5'- TTAACAGTGGGAAACAGACTCAAAAC -3'
Posted On 2022-10-06