Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01285:Zfp979'

72665

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp979

Ensembl Gene

ENSMUSG00000066000

Gene Name

zinc finger protein 979

Synonyms

Ssm1, 2610305D13Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.190) question?

Stock #

IGL01285

Quality Score

Status

Chromosome

Chromosomal Location

147696394-147726970 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 147699853 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Asparagine at position 29 (T29N)

Ref Sequence

ENSEMBL: ENSMUSP00000114677 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037565] [ENSMUST00000105720] [ENSMUST00000133006]

AlphaFold

A2A799

Predicted Effect

probably damaging
Transcript: ENSMUST00000037565
AA Change: T29N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000038153
Gene: ENSMUSG00000066000
AA Change: T29N

Domain	Start	End	E-Value	Type
KRAB	28	88	2.06e-16	SMART
ZnF_C2H2	257	279	2.06e1	SMART
ZnF_C2H2	285	307	2.53e-2	SMART
ZnF_C2H2	313	335	1.95e-3	SMART
ZnF_C2H2	341	363	1.4e1	SMART
ZnF_C2H2	369	391	9.08e-4	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000105720
AA Change: T29N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000101345
Gene: ENSMUSG00000066000
AA Change: T29N

Domain	Start	End	E-Value	Type
KRAB	28	88	2.06e-16	SMART
ZnF_C2H2	257	279	2.06e1	SMART
ZnF_C2H2	285	307	2.53e-2	SMART
ZnF_C2H2	313	335	1.95e-3	SMART
ZnF_C2H2	341	363	1.4e1	SMART
ZnF_C2H2	369	391	9.08e-4	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000133006
AA Change: T29N

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000114677
Gene: ENSMUSG00000066000
AA Change: T29N

Domain	Start	End	E-Value	Type
KRAB	28	88	2.06e-16	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,271,610 (GRCm39)	N599S	probably benign	Het
Adam6a	A	T	12: 113,509,893 (GRCm39)	*755Y	probably null	Het
Adgrb3	G	T	1: 25,132,868 (GRCm39)	T1166K	probably benign	Het
Ano1	T	C	7: 144,198,479 (GRCm39)	Y345C	probably benign	Het
Ano1	A	G	7: 144,149,275 (GRCm39)	V862A	probably damaging	Het
Asap2	C	T	12: 21,279,264 (GRCm39)	A382V	probably damaging	Het
Asb18	A	G	1: 89,923,963 (GRCm39)	V100A	probably benign	Het
Bdnf	G	A	2: 109,553,931 (GRCm39)	A102T	probably benign	Het
Ccser2	G	A	14: 36,660,626 (GRCm39)	T509M	probably damaging	Het
Cfap47	A	G	X: 78,532,764 (GRCm39)	I767T	possibly damaging	Het
Des	G	A	1: 75,339,227 (GRCm39)	A251T	probably benign	Het
Dmd	C	T	X: 84,153,590 (GRCm39)	Q3224*	probably null	Het
Endog	G	T	2: 30,061,975 (GRCm39)		probably null	Het
Ggt7	A	G	2: 155,342,691 (GRCm39)	V269A	probably damaging	Het
Gucy2c	A	G	6: 136,686,739 (GRCm39)	F808S	probably damaging	Het
Hira	A	G	16: 18,730,930 (GRCm39)	T210A	probably benign	Het
Ifitm5	C	A	7: 140,530,076 (GRCm39)	R16L	probably benign	Het
Igdcc4	T	C	9: 65,031,273 (GRCm39)	C404R	probably damaging	Het
Ints7	G	A	1: 191,347,890 (GRCm39)	R754H	probably benign	Het
Irf9	A	G	14: 55,845,058 (GRCm39)	E258G	probably damaging	Het
Megf11	T	C	9: 64,567,728 (GRCm39)	C406R	probably damaging	Het
Olfml1	A	G	7: 107,189,364 (GRCm39)	N143S	possibly damaging	Het
Or4m1	A	G	14: 50,557,713 (GRCm39)	F193S	possibly damaging	Het
Or6c66b	T	A	10: 129,376,711 (GRCm39)	F102I	probably benign	Het
Or7g30	A	G	9: 19,352,266 (GRCm39)	D19G	probably benign	Het
Otof	G	T	5: 30,562,527 (GRCm39)	Q254K	probably damaging	Het
Pate7	A	T	9: 35,688,044 (GRCm39)	N65K	possibly damaging	Het
Plcd3	A	G	11: 102,968,696 (GRCm39)	F332L	probably benign	Het
Plxnc1	T	C	10: 94,635,230 (GRCm39)	D1332G	probably damaging	Het
Rnasel	A	T	1: 153,634,130 (GRCm39)	D521V	probably benign	Het
Sema5a	T	A	15: 32,575,143 (GRCm39)	V417D	possibly damaging	Het
Senp6	G	A	9: 80,044,000 (GRCm39)	R877Q	probably benign	Het
Shroom2	A	T	X: 151,442,353 (GRCm39)	D937E	probably damaging	Het
Slc35a3	A	G	3: 116,488,262 (GRCm39)	S142P	probably damaging	Het
Srpx	A	T	X: 9,905,298 (GRCm39)	V398E	probably damaging	Het
Stk10	A	T	11: 32,560,653 (GRCm39)	K669N	possibly damaging	Het
Sumf2	A	G	5: 129,878,811 (GRCm39)	D49G	probably damaging	Het
Syde1	T	A	10: 78,424,721 (GRCm39)	E370D	probably damaging	Het
Tas2r115	G	T	6: 132,714,641 (GRCm39)	S103R	probably damaging	Het
Top2a	G	A	11: 98,896,985 (GRCm39)		probably benign	Het
Ttn	T	A	2: 76,550,842 (GRCm39)	T23190S	probably damaging	Het
Ttyh3	C	A	5: 140,615,167 (GRCm39)	C407F	probably damaging	Het
Vmn2r27	G	T	6: 124,169,370 (GRCm39)	H587N	possibly damaging	Het
Vmn2r74	A	G	7: 85,606,692 (GRCm39)	I218T	possibly damaging	Het
Vsig10	A	G	5: 117,462,954 (GRCm39)	N60S	probably benign	Het
Zc3h7a	A	G	16: 10,956,979 (GRCm39)	S877P	probably damaging	Het
Znfx1	G	A	2: 166,880,615 (GRCm39)	R390C	possibly damaging	Het

Other mutations in Zfp979

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01865:Zfp979	APN	4	147,699,774 (GRCm39)	missense	probably benign	0.03
IGL02336:Zfp979	APN	4	147,699,808 (GRCm39)	missense	probably damaging	1.00
R0336:Zfp979	UTSW	4	147,697,592 (GRCm39)	missense	possibly damaging	0.86
R1365:Zfp979	UTSW	4	147,697,681 (GRCm39)	missense	probably benign	0.00
R1440:Zfp979	UTSW	4	147,698,493 (GRCm39)	missense	possibly damaging	0.96
R1714:Zfp979	UTSW	4	147,698,442 (GRCm39)	missense	probably damaging	1.00
R1796:Zfp979	UTSW	4	147,697,740 (GRCm39)	missense	probably damaging	0.99
R2155:Zfp979	UTSW	4	147,697,915 (GRCm39)	missense	possibly damaging	0.86
R3735:Zfp979	UTSW	4	147,697,939 (GRCm39)	missense	possibly damaging	0.93
R3963:Zfp979	UTSW	4	147,697,588 (GRCm39)	missense	probably benign	0.34
R3972:Zfp979	UTSW	4	147,702,876 (GRCm39)	nonsense	probably null
R4471:Zfp979	UTSW	4	147,697,913 (GRCm39)	nonsense	probably null
R4983:Zfp979	UTSW	4	147,698,371 (GRCm39)	missense	possibly damaging	0.94
R5310:Zfp979	UTSW	4	147,698,375 (GRCm39)	missense	possibly damaging	0.95
R5805:Zfp979	UTSW	4	147,698,067 (GRCm39)	missense	probably damaging	0.99
R5861:Zfp979	UTSW	4	147,697,966 (GRCm39)	nonsense	probably null
R6598:Zfp979	UTSW	4	147,698,223 (GRCm39)	missense	probably damaging	0.99
R6599:Zfp979	UTSW	4	147,698,083 (GRCm39)	missense	probably benign	0.40
R6925:Zfp979	UTSW	4	147,697,999 (GRCm39)	missense	possibly damaging	0.86
R7684:Zfp979	UTSW	4	147,697,799 (GRCm39)	missense	probably damaging	0.99
R7801:Zfp979	UTSW	4	147,698,435 (GRCm39)	missense	probably damaging	0.96
R8035:Zfp979	UTSW	4	147,697,763 (GRCm39)	missense	probably damaging	1.00
R8086:Zfp979	UTSW	4	147,698,004 (GRCm39)	missense	probably damaging	0.99
R8244:Zfp979	UTSW	4	147,697,933 (GRCm39)	missense	possibly damaging	0.92
R8369:Zfp979	UTSW	4	147,697,548 (GRCm39)	missense	possibly damaging	0.73
R8880:Zfp979	UTSW	4	147,697,836 (GRCm39)	missense	probably benign	0.00
R8887:Zfp979	UTSW	4	147,698,219 (GRCm39)	missense	probably damaging	0.96
R8988:Zfp979	UTSW	4	147,697,984 (GRCm39)	missense	probably benign
R9016:Zfp979	UTSW	4	147,697,504 (GRCm39)	missense	possibly damaging	0.68
R9356:Zfp979	UTSW	4	147,698,358 (GRCm39)	missense	probably damaging	0.96

Posted On

2013-10-07