Incidental Mutation 'R9647:Dido1'
| ID |
726771 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R9647 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 180315068 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 795
(T795S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084794
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037764]
[ENSMUST00000087517]
[ENSMUST00000103056]
[ENSMUST00000103057]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037764
AA Change: T255S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000048315
Gene: ENSMUSG00000038914
AA Change: T255S
| Domain | Start | End | E-Value | Type |
|---|
|
TFS2M
|
129 |
230 |
1.16e-45 |
SMART |
|
low complexity region
|
397 |
422 |
N/A |
INTRINSIC |
|
low complexity region
|
483 |
497 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
512 |
618 |
4.9e-23 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087517
AA Change: T795S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: T795S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103056
AA Change: T795S
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: T795S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103057
AA Change: T795S
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: T795S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc5 |
C |
A |
16: 20,195,310 (GRCm39) |
R729L |
probably benign |
Het |
| Actr3b |
T |
C |
5: 26,037,408 (GRCm39) |
S295P |
probably benign |
Het |
| Alb |
G |
A |
5: 90,620,544 (GRCm39) |
|
probably null |
Het |
| Ank2 |
T |
A |
3: 126,792,623 (GRCm39) |
N756I |
possibly damaging |
Het |
| Ankar |
A |
G |
1: 72,689,307 (GRCm39) |
Y1275H |
probably damaging |
Het |
| Ankrd11 |
C |
T |
8: 123,617,682 (GRCm39) |
A2057T |
probably benign |
Het |
| Birc6 |
G |
A |
17: 74,999,305 (GRCm39) |
V4678M |
probably damaging |
Het |
| Bmpr1a |
A |
G |
14: 34,136,694 (GRCm39) |
V499A |
probably benign |
Het |
| Ccdc142 |
A |
G |
6: 83,079,259 (GRCm39) |
N199D |
probably benign |
Het |
| Ccdc179 |
G |
T |
7: 51,663,311 (GRCm39) |
Y38* |
probably null |
Het |
| Cdhr2 |
A |
T |
13: 54,867,394 (GRCm39) |
M438L |
probably benign |
Het |
| Cfap74 |
A |
T |
4: 155,549,373 (GRCm39) |
Q78L |
unknown |
Het |
| Crocc |
A |
T |
4: 140,774,335 (GRCm39) |
S155T |
probably benign |
Het |
| Depdc5 |
T |
A |
5: 33,081,567 (GRCm39) |
H576Q |
possibly damaging |
Het |
| Dhx30 |
A |
T |
9: 109,922,214 (GRCm39) |
L156Q |
probably damaging |
Het |
| Dlx1 |
T |
C |
2: 71,360,476 (GRCm39) |
S47P |
probably benign |
Het |
| Dspp |
G |
A |
5: 104,323,636 (GRCm39) |
A260T |
possibly damaging |
Het |
| Ephx2 |
T |
C |
14: 66,326,957 (GRCm39) |
T413A |
probably benign |
Het |
| Erp44 |
A |
C |
4: 48,205,166 (GRCm39) |
L276V |
probably benign |
Het |
| Fastkd5 |
T |
A |
2: 130,457,729 (GRCm39) |
Q287L |
probably damaging |
Het |
| Foxh1 |
T |
A |
15: 76,553,460 (GRCm39) |
H114L |
possibly damaging |
Het |
| Fry |
A |
T |
5: 150,292,984 (GRCm39) |
L410F |
probably damaging |
Het |
| Gamt |
T |
A |
10: 80,095,672 (GRCm39) |
H86L |
probably damaging |
Het |
| Gdpd5 |
G |
T |
7: 99,104,241 (GRCm39) |
R483L |
probably benign |
Het |
| Gm17067 |
A |
C |
7: 42,357,569 (GRCm39) |
V311G |
probably benign |
Het |
| Gpatch2 |
C |
T |
1: 187,054,542 (GRCm39) |
T422I |
probably damaging |
Het |
| Gpi1 |
A |
G |
7: 33,901,879 (GRCm39) |
I546T |
probably damaging |
Het |
| Gyg1 |
A |
C |
3: 20,177,007 (GRCm39) |
S328A |
probably benign |
Het |
| Heatr1 |
T |
A |
13: 12,441,679 (GRCm39) |
V1491E |
probably benign |
Het |
| Hrob |
A |
T |
11: 102,146,586 (GRCm39) |
Q287H |
possibly damaging |
Het |
| Ildr2 |
T |
C |
1: 166,137,038 (GRCm39) |
S626P |
probably benign |
Het |
| Insr |
T |
G |
8: 3,205,874 (GRCm39) |
E1305A |
probably benign |
Het |
| Iqca1 |
T |
A |
1: 89,998,258 (GRCm39) |
T572S |
probably benign |
Het |
| Kdm4a |
A |
T |
4: 118,003,790 (GRCm39) |
M762K |
probably benign |
Het |
| Kdm4a |
T |
A |
4: 118,017,399 (GRCm39) |
T556S |
probably benign |
Het |
| Lama1 |
A |
G |
17: 68,024,170 (GRCm39) |
I89M |
|
Het |
| Larp7 |
T |
C |
3: 127,334,211 (GRCm39) |
K539E |
probably damaging |
Het |
| Mmadhc |
C |
A |
2: 50,186,482 (GRCm39) |
|
probably benign |
Het |
| Mmp2 |
A |
G |
8: 93,567,114 (GRCm39) |
D478G |
probably damaging |
Het |
| Nat10 |
T |
C |
2: 103,578,538 (GRCm39) |
Q222R |
probably benign |
Het |
| Nlgn1 |
A |
T |
3: 25,488,182 (GRCm39) |
Y718N |
probably damaging |
Het |
| Nlrp5 |
A |
T |
7: 23,107,576 (GRCm39) |
E83V |
probably benign |
Het |
| Odc1 |
T |
C |
12: 17,598,614 (GRCm39) |
V218A |
possibly damaging |
Het |
| Or10al4 |
A |
T |
17: 38,037,796 (GRCm39) |
I294F |
probably damaging |
Het |
| Or11g26 |
G |
C |
14: 50,753,552 (GRCm39) |
R297T |
probably damaging |
Het |
| Or9r3 |
A |
G |
10: 129,948,029 (GRCm39) |
I210T |
probably damaging |
Het |
| Oxsr1 |
G |
A |
9: 119,083,932 (GRCm39) |
S324F |
probably damaging |
Het |
| Pclo |
C |
T |
5: 14,731,788 (GRCm39) |
T304M |
|
Het |
| Pgghg |
A |
G |
7: 140,526,743 (GRCm39) |
R687G |
possibly damaging |
Het |
| Plxna4 |
A |
G |
6: 32,228,044 (GRCm39) |
S521P |
probably damaging |
Het |
| Rasgrp4 |
A |
G |
7: 28,839,917 (GRCm39) |
S172G |
probably damaging |
Het |
| Rora |
A |
G |
9: 69,255,450 (GRCm39) |
D78G |
probably damaging |
Het |
| Sec1 |
G |
T |
7: 45,328,556 (GRCm39) |
R164S |
probably benign |
Het |
| Sesn3 |
A |
G |
9: 14,225,999 (GRCm39) |
N245D |
probably benign |
Het |
| Slc44a5 |
T |
A |
3: 153,953,370 (GRCm39) |
W251R |
possibly damaging |
Het |
| Ssr2 |
T |
C |
3: 88,487,206 (GRCm39) |
V7A |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,151,875 (GRCm39) |
D1912G |
possibly damaging |
Het |
| Tcea2 |
C |
A |
2: 181,322,984 (GRCm39) |
T1N |
probably benign |
Het |
| Tmem131l |
T |
C |
3: 83,836,018 (GRCm39) |
Y697C |
probably damaging |
Het |
| Tmx4 |
T |
C |
2: 134,481,588 (GRCm39) |
M112V |
probably benign |
Het |
| Tom1 |
G |
T |
8: 75,785,495 (GRCm39) |
A330S |
probably benign |
Het |
| Trip4 |
A |
T |
9: 65,765,616 (GRCm39) |
L361* |
probably null |
Het |
| Trmt9b |
T |
C |
8: 36,979,210 (GRCm39) |
I271T |
probably benign |
Het |
| Trp73 |
T |
G |
4: 154,165,788 (GRCm39) |
T142P |
probably damaging |
Het |
| Trpm5 |
T |
A |
7: 142,634,498 (GRCm39) |
D683V |
possibly damaging |
Het |
| Trpm7 |
T |
C |
2: 126,667,562 (GRCm39) |
I810V |
probably damaging |
Het |
| Trps1 |
A |
T |
15: 50,524,944 (GRCm39) |
S995R |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,608,269 (GRCm39) |
E17885* |
probably null |
Het |
| Uggt2 |
A |
T |
14: 119,256,312 (GRCm39) |
Y1120N |
probably damaging |
Het |
| Unc13a |
A |
T |
8: 72,104,882 (GRCm39) |
N793K |
probably damaging |
Het |
| Vcf1 |
T |
C |
11: 113,568,146 (GRCm39) |
D103G |
probably damaging |
Het |
| Vmn2r94 |
T |
C |
17: 18,463,884 (GRCm39) |
H802R |
probably benign |
Het |
| Vmn2r-ps158 |
T |
C |
7: 42,697,171 (GRCm39) |
C743R |
probably damaging |
Het |
| Zdhhc5 |
A |
T |
2: 84,524,750 (GRCm39) |
M190K |
probably benign |
Het |
| Zfp719 |
A |
T |
7: 43,233,602 (GRCm39) |
N7I |
possibly damaging |
Het |
| Zfp735 |
A |
G |
11: 73,580,600 (GRCm39) |
Y33C |
probably damaging |
Het |
| Zgrf1 |
C |
T |
3: 127,355,251 (GRCm39) |
T159I |
probably benign |
Het |
| Zzef1 |
A |
T |
11: 72,760,651 (GRCm39) |
T1325S |
probably benign |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGGCACTTAGAAAGCATTG -3'
(R):5'- ATGTGGACAGAGAAGCCCAC -3'
Sequencing Primer
(F):5'- CACTTAGAAAGCATTGCCACGGTG -3'
(R):5'- CCCACAAAATCTGTAAGTGCTGAGG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation